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  • mammals
  • First, in addition to the embryological and genetic benefits of zebrafish, the liver is not the site of embryonic hematopoiesis as it is in mammals, and therefore mutants in liver size or structure will not have the confounding phenotype of hematopoietic dysfunction. (biologists.org)
  • The internal environment of a living organism self-regulates CO 2 /H + . In mammals the lungs are the organs that dispose of excess CO 2 produced in the different tissues by adjusting the ventilatory pattern. (pnas.org)
  • bacteria
  • What was unknown by everyone involved in Weapon Plus is that its mastermind, John Sublime , was actually the host body for a sentient bacteria present in every living creature on the planet, save for mutants, who were genetically immune to the Sublime infection. (wikipedia.org)
  • vaccine
  • To date, the most successful brucellosis vaccine preparations (used in livestock species) have been modified live derivatives of virulent Brucella [ 7 , 8 ]. (hindawi.com)
  • Pang H, Qiu M, Zhao J, Hoare R, Monaghan S, Song D, Chang Y & Jian J (2018) Construction of a Vibrio alginolyticus hopPmaJ (hop) mutant and evaluation of its potential as a live attenuated vaccine in orange-spotted grouper (Epinephelus coioides), Fish and Shellfish Immunology, 76, pp. 93-100. (stir.ac.uk)
  • These results demonstrate that the HY9901Δhop mutant could be used as an effective live vaccine to combat V. alginolyticus in grouper. (stir.ac.uk)
  • Accepted refereed manuscript of: Pang H, Qiu M, Zhao J, Hoare R, Monaghan S, Song D, Chang Y & Jian J (2018) Construction of a Vibrio alginolyticus hopPmaJ (hop) mutant and evaluation of its potential as a live attenuated vaccine in orange-spotted grouper (Epinephelus coioides), Fish and Shellfish Immunology, 76, pp. 93-100. (stir.ac.uk)
  • These results demonstrate that C50336Δ sptP can be a live attenuated oral vaccine for salmonellosis. (beds.ac.uk)
  • parental
  • By pursuing the endocytic trafficking and subscriber base of Alexa488-ASOR, significant distinctions in endosomal blend between parental HuH-7 and the Trf mutants became obvious. (biotechnologysymposium.com)
  • Unlike parental HuH-7 cells in which the blend of endosomes into bigger vesicles was noticeable as early as 20 minutes, ASOR endocytosed into the Trf mutants continued to be within little vesicles for up to 60 minutes. (biotechnologysymposium.com)
  • By following the endocytic uptake and trafficking of Alexa488-ASOR in actual time, significant differences TG100-115 between the parental HuH-7 and the Trf mutants in homotypic fusion of endocytic vesicles became apparent. (biotechnologysymposium.com)
  • eggs
  • Nematodes are routinely fed Escherichia coli strains containing a rich supply of Q. To study the Q synthesized by C. elegans , we cultured worms on an E. coli mutant that lacks Q and found that clk-1 mutants display early developmental arrest from eggs, or sterility emerging from dauer stage. (pnas.org)
  • Allow cultures to come to room temperature before checking under low magnification for eggs and live larvae. (vwr.com)
  • cultures
  • For over 80 years, Carolina has been providing the highest-quality living organisms and cultures available. (carolina.com)
  • advantages
  • Despite being perhaps less efficacious, subunit vaccines may have safety advantages over live attenuated candidates. (hindawi.com)
  • There are several advantages to using zebrafish embryos to develop models of liver diseases. (biologists.org)
  • growth
  • beta-Catenin overexpression offers growth advantage during liver regeneration. (nih.gov)
  • However, the HY9901Δhop mutant showed no difference in morphology, growth, biofilm formation and ECPase activity. (stir.ac.uk)
  • model
  • These mutants illustrate the utility of zebrafish as a model for studying liver development and disease, and provide valuable tools for investigating the molecular pathogenesis of congenital biliary disorders and fatty liver disease. (biologists.org)
  • cancer
  • In severe cases, these metabolic changes result in the enlargement and fibrillization of the liver and are considered risk factors for cirrhosis and liver cancer. (biomedcentral.com)
  • In severe cases, these changes eventually lead to inflammation [ 4 ] and steatohepatitis [ 5 ] and are considered risk factors for cirrhosis and liver cancer in humans. (biomedcentral.com)
  • weight
  • Liver weight to body weight ratio (LW/BW) in TG and age-matched WT (n≥3) (lower panel). (nih.gov)
  • However
  • However, based on assays of respiratory function, it has been reported that the primary defect in the C. elegans clk-1 mutants is not in Q biosynthesis. (pnas.org)
  • development
  • These changes are consistent with the possibility that disturbance of circadian rhythmicity associated with the Clock mutation could be a risk factor for the development of an alcoholic fatty liver. (biomedcentral.com)
  • Thus, not only is embryogenesis rapid, but the development of a physiologically functional liver occurs within the span of a few days. (biologists.org)
  • disease
  • This number is predicted to rise because of the association of liver disease with obesity: as the numbers of obese individuals in the USA approaches one-third of the population, the incidence of fatty liver has been estimated to affect ∼25% of US citizens ( Neuschwander-Tetri and Caldwell, 2003 ). (biologists.org)
  • J. Glickman, personal communication), allowing direct comparison between zebrafish and mammalian liver disease processes. (biologists.org)
  • Learning to live with Kennedy's Disease is my journey. (blogspot.com)
  • I have used the analogy that learning to live with Kennedy's Disease is like trying to cross a stream without getting wet. (blogspot.com)
  • If I am to learn how to live with this disease I must be open ( receptive ) to both the good and the bad that accompanies these life experiences. (blogspot.com)
  • tape
  • Spanning the time frame between their earliest period that was retrospectively documented on their Chronometers CD and their first official LP Manna/Mirage (and making for a great companion piece to the live Secret Signals tape of theirs that I shared last year, which documents the same period) this fantastic hour and a half performance catches one of America's greatest and most underrated prog units at a real peak of expressiveness. (blogspot.com)
  • last
  • To prevent subsidiary programs from going rogue, Weapon Plus directly oversaw the creation of the last living weapons operating in the clandestine facilities of The World , employing Bolivar Trask 's Sentinel technology. (wikipedia.org)