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  • proteins
  • Our findings show that coiled-coil proteins can promote liquid-liquid phase separation, which expands our understanding of the principles that govern the in vivo dynamics of liquid-like bodies. (jic.ac.uk)
  • FUS is one of several RNA-binding proteins that can functionally self-associate into distinct liquid-phase droplet structures. (mdpi.com)
  • RESEARCH NEWS 2018-02-16 Research News Many proteins involved in neurodegeneration have a penchant to undergo liquid phase separation, where they coalesce into highly concentrated fluid droplets. (alzforum.org)
  • Perturbations that alter liquid-liquid phase separations (LLPS) driven by intrinsically disordered protein regions (IDR) of RNA binding proteins in vitro have the opposite effect on stress granule assembly in vivo. (nih.gov)
  • In Model 1, an increase in a pool of untranslated mRNAs with bound proteins containing IDRs, could lead to the formation of a LLPS based on weak, dynamic IDR-IDR interactions and over time core formation occurs as a second phase due to the supersaturation of local concentration of core components. (nih.gov)
  • organic aerosol
  • In this work, this potential discrepancy is investigated by examining how separation between the organic and inorganic phases as well as water uptake to the organic phase affects a chemical transport model's estimation of the importance of water solubility for organic aerosol formation.The CMAQ model reproduces SEARCH, IMPROVE, and CSN network observations of organic carbon (OC) within 20% in the eastern US. (epa.gov)
  • pharmaceutical
  • Simple monitoring and control strategies as well as scaling-up/out approaches are proposed, concluding that membrane-based L-L separation may become a standard unit operation for continuous pharmaceutical manufacturing. (dtu.dk)
  • The use of the SMB concept in the fine chemicals separation field in the earlier 90s (pharmaceutical and biomolecules separations) is remarkable and led to the advent of a new age of SMB technology. (up.pt)
  • occurs
  • However, no solid hydrate can be detected by XRD, and it is shown that the true explanation is that a liquid-liquid phase separation occurs above 51 degrees C where the vanillin-rich phase has a composition close to a dihydrate. (diva-portal.org)
  • Instead, this compound solidifies into highly phase separated regions, and the liquid phase separation that occurs in the alloy also leads to phase separation in systems in which Co, Cr, and Cu are present. (mdpi.com)
  • The neutron imaging of the solidification process may resolve questions about phase separation that occurs in these alloys and those that contain Cu. These results show that neutron imaging can be utilized as a characterization technique for solidification research with the potential for imaging the liquid phases of more complex alloys, such as the HEAs which have very little published data about their liquid phases. (mdpi.com)
  • polymer
  • Practical applications, if one of the liquid components is polymerized, include mobile polymer particles trapped in porous matrix that can serve, e.g., as filters with microscopically amphiphilic pathways. (diva-portal.org)
  • A phase separation liquid crystal polymer for displays, optical shutters and memories is disclosed, having on the side chains thereof at least one liquid crystal component and at least one non-liquid crystal component, said liquid crystal component and non-liquid crystal component being present in separate phases. (google.com)
  • efficiency
  • In many cases, MCPs outperform their zeolite and activated carbon counterparts both kinetically and in efficiency of separation. (rsc.org)
  • The separation device can easily be operated by means of a back-pressure regulator ensuring flow-independent separation efficiency. (dtu.dk)
  • On the other hand, both inlet pressure and flow velocity affected the separation efficiency. (go.jp)
  • In this study, the highest separation efficiency was achieved in the core-shell column with a flow rate of 1 mm/s and inlet pressure of 6.3 MPa. (go.jp)
  • membrane
  • With the assistance of vacuum pressure, VOCs pass through the membrane wall to a condenser where they return to the liquid phase. (cpeo.org)
  • See descriptions of Membrane Separation (designed for vapor-phase separation) and Solid-Phase Separation . (cpeo.org)
  • See U.S. DOE, ñCost and Performance Report, PerVap TM Membrane Separation Groundwater Treatment, Pinellas Northeast Site,î October 1997. (cpeo.org)
  • Despite the partial THF-water miscibility, the two phases could be separated at total flow rates up to 40 mL/min at different flow ratios, using a PTFE membrane with 28 cm2 of active area. (dtu.dk)
  • molecular
  • The first method provides domain size distributions of the separating minority component while the other ones verify the segregation of the two liquids on molecular level. (diva-portal.org)
  • Curves
  • Adsorbent Evaluation Based on Experimental Breakthrough Curves: Separation of p-Xylene from C8 Isomers. (up.pt)
  • approaches
  • Since fully coupled phase separation and gas-particle partitioning calculations are computationally expensive, several simplified model approaches are tested with regard to computational costs and accuracy of predictions compared to the benchmark calculation. (atmos-chem-phys.net)
  • LSRE has studied this separation process by addressing several aspects such as the comparison of different modeling strategies, the study of the influence of mass transfer resistance in the SMB performance and the development of different design methodologies, from the equilibrium theory to more accurate approaches as the Separation Volume concept. (up.pt)
  • Many of the biggest names in the world will deliver cutting edge presentations to help identify solutions to practical problems in microfluidics, DNA sequencing and separation, multidimensional separation approaches and hyphenation to detection methods including mass spectrometry coupling (e.g. (okstate.edu)
  • equilibrium
  • Lee H.K., Myerson A.S., Levon K. (1993) Structure Formation Due to Non-Equilibrium Liquid-Liquid Phase Separation in Polypropylene Solutions. (springer.com)
  • Toward Understanding the Influence of Ethylbenzene in p-Xylene Selectivity of the Porous Titanium Amino Terephthalate MIL-125(Ti): Adsorption Equilibrium and Separation of Xylene Isomers. (up.pt)
  • techniques
  • A combination of NMR techniques, already existing and newly developed and ranging from cryoporometry to elaborate self-diffusion and spin-relaxation experiments, was applied in order to detect and quantify the effect of finite size constraints on those phase transitions. (diva-portal.org)
  • For two-phase liquid-liquid systems where extraction may be a process alternative, there are no quick and efficient design techniques which can be applied to a wide range of design problems. (umass.edu)
  • In this dissertation, we describe such techniques for the design of two-phase liquid-liquid systems. (umass.edu)
  • distillation
  • Simple distillation is a process in which heat is applied to a liquid, causing a portion of the liquid to vaporize. (cpeo.org)
  • Surprisingly, we find that the more complex flowsheet is the more economically attractive, because it avoids the difficult separation of small amounts of acetic acid from water by distillation. (umass.edu)
  • biological
  • The resulting high-IDP phase forms a major component of membraneless organelles that, by creating their own IDP-rich compartments, enables critical biological functions. (utoronto.ca)
  • protein
  • Moreover, we found the tumor suppressor protein p53 to be enriched within 53BP1 optoDroplets, and conditions that disrupt 53BP1 phase separation impair 53BP1-dependent induction of p53 and diminish p53 target gene expression. (nih.gov)
  • Chemistry
  • Computationally much more efficient calculations relying on the assumption of a complete organic/electrolyte phase separation below a certain RH successfully reproduce gas-particle partitioning in systems in which the average oxygen-to-carbon (O:C) ratio is lower than ~0.6, as in the case of α-pinene SOA, and bear the potential for implementation in atmospheric chemical transport models and chemistry-climate models. (atmos-chem-phys.net)
  • composition
  • We design the liquid extractors using a new method which exploits the geometric properties of the composition profiles in a multistage countercurrent arrangement. (umass.edu)
  • Composition profiles are determined by solving the reactor-extractor model equations, and reactive-phase holdups are determined as a function of reactant conversions, number of reactor-extractors and solvent flowrate. (umass.edu)
  • analysis
  • The Phase 3 APECS trial of Merck's flagship BACE inhibitor ends prematurely following an interim safety analysis. (alzforum.org)
  • theoretical
  • To gain physical insight into this fascinating phenomenon, I will discuss recent theoretical developments to elucidate how IDP phase separation is governed by their amino acid sequences. (utoronto.ca)