Liposomes as nanotechnology. Medical search. Frequent questions

The study also demonstrates how a new DNA-patterning technique, developed by the team last year, can help scientists rapidly characterize and conduct experiments on a variety of different types of liposomes, and their cousins, lipid nanoparticles. (sflorg.com)
One of the most important applications of nanotechnology in medicine involves use of nanoparticles to deliver drugs, and other therapeutic substances to specific types of cells (such as cancer cells). (trialx.com)
Various nanocarriers are being introduced and assessed, such as polymer nanoparticles, liposomes, and micelles. (hindawi.com)
Nanoparticles such as liposomes are able to overcome cancer treatment challenges such as multidrug resistance by increasing the bioavailability of the encapsulated drug, bypassing drug pumps or through targeting resistant cells. (eur.nl)
The general research interests in the Stulz group are concerned with supramolecular chemistry, bio-nanotechnology, medicinal chemistry, nanoparticles and microfluidics. (southampton.ac.uk)
The application of nanotechnology to CBD products has led to the development of innovative delivery systems, such as CBD nanoparticles, nanoemulsions, and transdermal patches. (420cannabiscoupons.com)
Nanomedicine uses the tools of nanotechnology (ie, biocompatible nanoparticles and nanorobots) to deliver drugs, diagnose disease, and do in vivo imaging. (msdmanuals.com)

Liposomes, hydrogels, micelles and thin films with distinct biological and mechanical properties are used as carriers in novel drug delivery systems. (cede.ch)
Nanomaterials including carbon nanotubes, polymeric micelles and liposomes have been used in cancer drug design where they have shown considerable pharmacokinetic and pharmacodynamic benefits in cancer diagnosis and treatment. (medsci.org)
In this context, nanoparticulate systems (liposomes, micelles, polymer-based NPs, etc.) have attracted the interest of many researchers and numerous systems have been developed ( 1 ). (frontiersin.org)

Nanomedicine-Nanotechnology biology and medicine. (rug.nl)
Within nanomedicine, liposomes are investigated for their ability to deliver drug cargoes specifically into subcellular compartments of target cells. (rsc.org)

UC Berkeley engineers attached SARS-CoV-2 "spike" proteins to the surface of liposomes, creating lab-made mimics of the deadly virus called "spike-liposomes," which, when paired with a new DNA-patterning technique, could enable efficient testing of antibody therapies. (sflorg.com)
In a new study , a team of engineers at the University of California, Berkeley, attached SARS-CoV-2 "spike" proteins to the surface of liposomes, creating lab-made mimics of the deadly virus which the researchers call "spike-liposomes. (sflorg.com)
The surface of liposomes can also be modified by attaching polyethylene glycol (PEG) chain to the lipid bilayer (stealth liposomes) to enhance their circulation time in the blood. (trialx.com)

Cationic liposomes are spherical structures that contain positively charged lipids. (wikipedia.org)
The use of cationic lipids helps to enhance the overall stability and efficiency of liposomes. (wikipedia.org)
Although cationic lipids themselves are able to encapsulate nucleic acids into liposomes, the transfection efficiency is low due to a process known as endosomal escape. (wikipedia.org)
Cationic liposomes with a higher transfection efficiency are composed of a cationic phospholipid, and a few neutral helper lipids. (wikipedia.org)
The properties of liposomes can be varied with composition, size, and surface charge of lipids and also the method used for preparation. (trialx.com)
Such studies are often based on flow cytometry or microscopy, where researchers rely on fluorescently labeled lipids (FLLs) incorporated into the liposomal membrane to determine the localization of the liposomes within cells. (rsc.org)

Upon interacting with nucleic acids, cationic liposomes form clusters of aggregated vesicles. (wikipedia.org)
This study explores the mechanism of GALA anchored to gel-phase lipid vesicles in both clustered (pH and non-pH responsive) and uniform presentations with the goal of optimizing GALA presentation for improving therapeutic efficacy of tumor vasculature targeted liposome compositions. (aiche.org)
Liposomes were prepared by hydrating a thin lipid film with the desired aqueous phase buffer, incubating at 55° Celsius for 2 hours, and extruding the resultant suspension through 100 nm -pore polycarbonate membranes to generate unilamellar vesicles. (aiche.org)
Liposomes are spherically shaped vesicles composed of natural phospholipids. (trialx.com)
Liposomes are lipid vesicles in which supplements can be encapsulated and through this be protected against the harsh environment of the GI tract. (relax-uk.com)

This process bypasses the endosomal-lysosomal route, which leads to the degradation of anionic liposome formulations. (wikipedia.org)
Our results suggest that myrtle liposomes were cytocompatible and improved the extract's antioxidant power in fibroblasts, suggesting a potential skin application for these formulations and confirming that nanotechnologies could be a valid tool to enhance plant extracts' potentialities. (ibecbarcelona.eu)
Controlled-release formulations enabled by nanotechnology provide a sustained release of CBD, prolonging its therapeutic effects. (420cannabiscoupons.com)

Jin C, Wang K, Oppong-Gyebi A, Hu J. Application of Nanotechnology in Cancer Diagnosis and Therapy - A Mini-Review. (medsci.org)

When applied to CBD, nanotechnology enhances the bioavailability and solubility of this compound, ultimately improving its effectiveness in the body. (420cannabiscoupons.com)
With better bioavailability, smaller amounts of CBD can produce the same or even better results compared to higher doses without nanotechnology. (420cannabiscoupons.com)

In vitro assays show that SCS liposomes were able to reverse cell resistance, and importantly, display a higher net effect on resistant than sensitive cells. (eur.nl)
Methods: Sitagliptin liposomes were prepared by the ethanol injection method and were evaluated for various physicochemical properties such as visual appearance, particle size distribution, zeta potential, % drug entrapment efficiency, % drug loading capacity and in vitro drug release studies. (benthamscience.com)

To overcome these limitations, in this work, a stabilizing strategy consisting in liposomes incorporation into polymeric granules was studied. (gruppotpp.it)

The positive charge of the phospholipids allows cationic liposomes to form complexes with negatively charged nucleic acids (DNA, mRNA, and siRNA) through ionic interactions. (wikipedia.org)
Due to the overall positive charge of cationic liposomes, they interact with negatively charged cell membranes more readily than classic liposomes. (wikipedia.org)
The fusion between positively charged cationic liposomes and negatively charged cell surfaces efficiently delivers the DNA directly across the plasma membrane. (wikipedia.org)

Nanotechnology comes in a thousand varieties and there is a rising number of "engineered nanomaterials" under development [1,8] . (beilstein-journals.org)

Through the use of nanotechnology in the form of liposomes whose building blocks, the phospholipids, naturally occur in our cell membranes. (relax-uk.com)

And, in the same way that the membranes of biological cells are dotted with a variety of proteins that help the cell interact with the outside world, researchers have learned to attach different types of proteins into the membranes of liposomes, giving the particles different functions and abilities. (sflorg.com)
Although they may be of nanosize, liposomes and virus-like particles (VLPs) are not considered to be nanotechnology. (uspto.gov)
liposome" or "virus-like particles" (VLPs). (uspto.gov)
In a new study, researchers demonstrate that catalytic nanoshuttles can readily pickup common biocompatible and biodegradable drug-loaded particles and liposomes and transport them over predefined routes towards predetermined destination. (nanowerk.com)

Excitement over liposomes has been most pronounced in the pharmaceutical industry, where drugmakers have experimented with outfitting liposomes with proteins that only interact with very specific cells in the body, allowing them to target the delivery of drug molecules to only the tissues where they are needed. (sflorg.com)
Today, pharmaceutical nanotechnology is a very dynamic and evolving research area that integrates a wide variety of disciplines such as chemical, biological and biomedical science. (beilstein-journals.org)

Liposomes are tiny, spherical vessels constructed of lipid membranes very similar to those that encase most biological cells. (sflorg.com)

These components are all biocompatible and biodegradable in the human body, making cationic liposomes a useful gene delivery vector. (wikipedia.org)

Microfluidics is a field that is currently being looked into for the purpose of forming cationic liposomes without the shear forces and damage associated with current methods. (wikipedia.org)

However, researchers must first verify that the liposome proteins are able to properly interact with their environment. (sflorg.com)
Overall, our findings suggest that it is crucial for researchers to evaluate the stability of their FLL-labeled liposomes in biological environments, and the simplicity of the SEC assay put forward here makes it very applicable for the purpose. (rsc.org)
As more research labs and classrooms dive into the field of structural nucleic acid nanotechnology, students and researchers need access to interactive, dynamic, handheld models. (allenpress.com)
Nanotechnology researchers working on self-powered nanodevices - nanoscale systems that scavenge energy from their surrounding environment - have been experimenting with various power sources ranging from piezoelectric systems to sound. (nanowerk.com)
Researchers and companies are actively exploring the vast potential of combining nanotechnology and CBD. (420cannabiscoupons.com)

Nanotechnology tackles this challenge by utilizing nanosized carriers, such as liposomes or nanoemulsions, to encapsulate CBD molecules. (420cannabiscoupons.com)
Nanoemulsions are another example of nanotechnology-enabled CBD delivery systems. (420cannabiscoupons.com)

Advances in nanotechnology resulted in the development of targeted and multifunctional nanoscale drug constructs. (preprints.org)
Nanotechnology involves dealing with materials and structures at the nanoscale level, typically ranging from 1 to 100 nanometers. (420cannabiscoupons.com)

Furthermore, SCS-modified liposomes were evaluated in a sarcoma xenograft model on drug accumulation, pharmacokinetics and efficacy. (eur.nl)
Moreover, this phenomenon translated to improved efficacy when Dxr liposomes where modified with SCSs in the drug resistant tumor model, while no benefit was seen in the sensitive tumors. (eur.nl)
The GE11/HA/TATp-irinotecan liposomes evidently increased the uptake of irinotecan and showed significant antitumor efficacy in the xenografted A549 cancer cells in nude mice by intravenous administration. (ntno.org)
Nanotechnology has improved drug delivery by targeting specific organs to optimize the efficacy and safety profiles of individual drugs. (msdmanuals.com)

The objective of this study is to design a new class of liposomes that can target tumor vasculature via Prostate-Specific Membrane Antigen (PSMA) and rapidly and extensively release therapeutic agents intracellularly by using the pH-sensitive peptide GALA conjugated to lipid moieties to destabilize the integrity of intracellular endosomes and achieve better tumor killing outcomes. (aiche.org)
Fluorescence-guided photoimmunotherapy using nanotechnology and ML7710 reduces heterogeneous therapy effects and tumor metastasis. (lifeboat.com)
Here, we merge enhanced drug delivery by nanotechnology with tumor cell membrane modulation combined in a single formulation. (eur.nl)
SCS liposomes improved Dxr levels in tumor nuclei of MES-SA/MX2 tumor cells, which was accompanied by a delay in tumor growth of the resistant model. (eur.nl)
Here we show that Dxr accumulation in tumor cells by SCS-modified liposomes was especially improved in Dxr resistant cells, rendering Dxr as effective as in sensitive cells. (eur.nl)

Cationic liposomes can deliver nucleic acids into the cell through an endocytotic pathway or through cell membrane fusion. (wikipedia.org)
Fusogenic cationic liposomes almost exclusively deliver nucleic acids through cell membrane fusion. (wikipedia.org)
Leakage of calcein (EX/EM 495 nm/515 nm) from an endosome analogue EggPC membrane incubated with GALA-bearing liposomes resulting in self-quenching fluorescence release was monitored over time over the pH range from 7.4 to 4.0 (Q t ). pH was adjusted with HCl. (aiche.org)

Consequently, the choice of FLL can dramatically influence the conclusions drawn from liposome uptake and localization studies due to uptake of dissociated FLLs. (rsc.org)

2021 ) A single-liposome assay that enables temperature-dependent measurement of proton permeability of extremophile-inspired lipid membranes. (academictree.org)

She explains how liposomes with nano-technology deliver maximum absorption, discusses the challenges of being a nutraceutical entrepreneur amid the pandemic, the advantages of being a US-based company not dependent on foreign sourcing for ingredients, and her commitment to quality when many companies are cutting corners. (drhoffman.com)

These cationic liposome-nucleic acid complexes are also referred to as lipoplexes. (wikipedia.org)
The use and application of vectors such as liposomes, nanocrystals and/or emulsions for the delivery of nucleic acid, protein and/or small molecule therapeutics in nanotechnology-enabled drug products has steadily and rapidly increased over the last 2 decades. (nas.edu)

To investigate the implications of this finding, we measured the peripheral blood leukocyte uptake of liposomes formulated with different FLLs using flow cytometry, and observed a significant difference in uptake correlating with the FLL's dissociation tendencies. (rsc.org)

These issues can be reduced by optimizing the physical and chemical properties of cationic liposomes through their lipid composition. (wikipedia.org)

There are multiple processes that can be used to form cationic liposomes, such as sonication, extrusion, and vortexing. (wikipedia.org)

These interactions allow cationic liposomes to condense and encapsulate various therapeutic and diagnostic agents in their aqueous compartment or in their lipid bilayer. (wikipedia.org)
The addition of cholesterol helps to stabilize the liposome and more efficiently encapsulate nucleic acids. (wikipedia.org)

Liposomes act as drug carriers for entrapment of hydrophilic and hydrophobic drugs. (benthamscience.com)

Liposomes can carry both hydrophobic and hydrophillic molecules inside them. (trialx.com)

2019 ) Temperature-Controlled Single-Liposome Proton Permeability Assay of Extremophile-Inspired Lipid Membranes Biophysical Journal . (academictree.org)

Here, we integrate three technological advances in targeted photo-activable multi-agent liposome (TPMAL), fluorescence-guided intervention, and laser endoscopy (ML7710) to improve photoimmunotherapy. (lifeboat.com)
The presentation will focus on recent research advances in nanotechnology applications towards sustainable agriculture, food, and the environment. (pittcon.org)

A common application for cationic liposomes is cancer drug delivery. (wikipedia.org)
With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. (hindawi.com)
Nanotechnology and materials innovation are utilized together for making improvements in drug delivery. (cede.ch)
Liposomes serve as promising active carriers of drugs to posterior segment eye disorders due to improvement in intravitreal half-life and targeted sustained drug delivery to the retina. (benthamscience.com)
Recent applications of liposomes in ophthalmic drug delivery. (benthamscience.com)
Nanotechnology has improved drug delivery. (msdmanuals.com)

Cationic liposomes are increasingly being researched for use as delivery vectors in gene therapy due to their capability to efficiently transfect cells. (wikipedia.org)

Kozminsky realized that the DNA-printing technique, which was originally developed by the Sohn Lab to "print" different types of cells into patterns that model biological tissues, could also be used to quickly verify that the spike-liposomes were presenting the SARS-CoV-2 spike protein correctly. (sflorg.com)
Over the years, immunotherapeutic agents based on nanotechnology have been used for several cancer types to reduce the invasiveness of cancerous cells while sparing healthy cells at the target site. (medsci.org)
Nanotechnology allows for precise targeting of specific tissues or cells, improving the delivery of CBD to where it's needed the most. (420cannabiscoupons.com)

As Kozminsky points out, liposomes can also be used to create simple models of viruses and other pathogens that have lipid membranes, including SARS-CoV-2. (sflorg.com)

The shape, mechanics, and thermodynamics of these structures result from their complex internal architecture, and given the extraordinary utility of structural DNA nanotechnology for advancing the field of biophysics, educational tools are needed for teaching key structural concepts fundamental to the design of DNA-based nanostructures. (allenpress.com)
Nanotechnology offers further treatment options, including the modification of nanostructures with macrophage membranes (MM) to enhance the evasion of the immune system. (bvsalud.org)

By harnessing the power of nanotechnology, CBD products are becoming increasingly efficient and effective in delivering the benefits of this popular cannabinoid. (420cannabiscoupons.com)

The research is highly interdisciplinary, and reaches into materials science, nanotechnology, analytical science, and into biological / medicinal sciences. (southampton.ac.uk)
However, liposomes can present a high tendency to degrade and aggregate into biological fluids and under storage conditions. (gruppotpp.it)

DNA in Supramolecular Chemistry and Nanotechnology (Wiley 2014). (southampton.ac.uk)

Nanotechnology, a field that involves manipulating matter at the atomic and molecular scale, is revolutionizing various industries, and the CBD industry is no exception. (420cannabiscoupons.com)

This microscope image of their technique shows that mixing spike-liposomes (top right, tagged with green fluorescent protein) with ACE2 receptor (bottom red, tagged with red fluorescent protein), results in a composite of both proteins (left), indicating that their spike-liposomes bind to ACE2 receptor in the same way as SARS-CoV-2 virus. (sflorg.com)
Shown here, DNA-directed patterning is used to test whether neutralizing antibodies interfere with the ability of ACE receptor to bind with spike-liposomes that have been created using spike protein from two different variants of the SARS-CoV-2 virus. (sflorg.com)

Nanotechnology has the potential to influence the detection, prevention, and treatment of cancer. (hindawi.com)
Fueled by first successes in the 1990s, liposomes were at the forefront of cancer therapy [12,13] . (beilstein-journals.org)
Due to increased systemic toxicities and refractoriness with conventional cancer diagnostic and therapeutic tools, other strategies including nanotechnology are being employed to improve diagnosis and mitigate disease severity. (medsci.org)

Although nanotechnology has gained significant attention in the scientific community, this is one of very few examples where targeted delivery was successfully developed to the stage of clinical translation. (beilstein-journals.org)

Nanotechnologies and regenerative medical approaches for space and terrestrial medicine. (rjstonline.com)

In the 1960s, Alec D. Bangham discovered liposomes as concentric lipid bilayers surrounding an aqueous center, based on his research at the University of Cambridge Babraham Institute. (wikipedia.org)

Organisms1

Diseases2

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Phenomena and Processes4

Disciplines and Occupations13

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture29

Information Science1

Health Care2

Nanoparticles7

Micelles3

Nanomedicine2

Surface of liposomes3

Lipids6

Vesicles5

Formulations3

Application of Nanotechnology1

Bioavailability2

Vitro2

Polymeric1

Negatively charged3

Nanomaterials1

Cell membranes1

Particles4

Pharmaceutical2

Spherical1

Biocompatible1

Microfluidics1

Researchers5

Nanoemulsions2

Nanoscale2

Efficacy4

Tumor5

Membrane3

Localization1

Measurement1

Nano-technology1

Nucleic acid2

Uptake1

Composition1

Sonication1

Encapsulate2

Hydrophilic1

Molecules1

20191

Advances2

Drug6

Vectors1

Cells3

Lipid membranes1

Nanostructures2

Increasingly1

Biological2

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Involves1

Receptor2

Cancer3

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Research1