Bupivacaine liposome injectableEXPARELExtended-release liposome injectionDepoFoamNanovesiclesProprietary2023ExosomesSystemicMembraneTechnologyLongPatientsBupivacaine liposome injectable suspensionLiposomalUnilamellar liposomesMorphine sulfateBodiesLipid compositionAqueousParticlesPreparationDrugCellSimilar
Bupivacaine liposome injectable6
- EXPAREL (bupivacaine liposome injectable suspension) is a sterile suspension of multivesicular liposomes using proprietary DepoFoam formulation technology to release bupivacaine over several days. (hindawi.com)
- The ASCRS/SAGES guidelines state that local anesthetics, such as EXPAREL ® (bupivacaine liposome injectable suspension), that are administered via wound infiltration or transverse abdominis plane (TAP) block may effectively manage pain associated with both open and laparoscopic colorectal surgery. (hcplive.com)
- Exparel (Bupivacaine Liposome Injectable Suspension), USP. (apsf.org)
- Sales of bupivacaine liposome injectable suspension to third-party licensees were $0.7 million in the first quarter of 2023, versus $1.6 million reported for the first quarter of 2022. (pacira.com)
- EXPAREL (bupivacaine liposome injectable suspension) is indicated in patients 6 years of age and older for single-dose infiltration to produce postsurgical local analgesia, and in adults as an interscalene brachial plexus nerve block to produce postsurgical regional analgesia. (millvalley.com)
- EXPAREL ® (bupivacaine liposome injectable suspension), iovera o , ZILRETTA ® (triamcinolone acetonide extended-release injectable suspension), and Pacira are registered trademarks of the respective subsidiaries of Pacira BioSciences, Inc. All other trademarks referenced herein are the property of their respective owners. (pacira.com)
EXPAREL6
- October 31, 2011 - The US Food and Drug Administration today approved a novel long-acting nonopioid anesthetic/analgesic for postsurgical pain: bupivacaine extended-release liposome injection ( Exparel , Pacira Pharmaceuticals). (medscape.com)
- EXPAREL® (Liposomal Bupivicaine): Bupivicaine encapsulated in multivesicular liposomes injected locally for long lasting post-surgical pain management. (asda.org)
- In addition, Exparel™ a new white aqueous suspension of multivesicular liposomes containing bupivacaine may look similar to propofol (Figure 3) also carries no similar recommendation. (apsf.org)
- EXPAREL represents the first and only multivesicular liposome local anesthetic that can be utilized in the peri- or postsurgical setting. (millvalley.com)
- bupivacaine extended-release liposome injection ( Exparel , Pacira Pharmaceuticals). (medscape.com)
- A new analgesic (Exparel) was approved by the FDA for use in 2018, which formulates bupivacaine into an aqueous suspension of multivesicular liposomes.2 Bupivacaine is then released from the liposomes over a longer period of time, providing a longer lasting analgesia. (davidson.edu)
Extended-release liposome injection2
- DepoCyte (cytarabine liposome injection) and DepoDur (morphine sulfate extended-release liposome injection). (medscape.com)
- Bupivacaine extended release liposome injection for prolonged postsurgical analgesia in patients undergoing hemorrhoidectomy: a multicenter, randomized, double-blind, placebo-controlled trial. (squintmetrics.com)
DepoFoam1
- The DepoFoam system consists of multivesicular liposomes composed of hundreds to thousands of chambers per particle, resembling a "honeycomb-like" matrix [ 10 ]. (hindawi.com)
Nanovesicles2
- Natural or synthetic lipid and/or protein ingredients make nanovesicles, involving liposomes or proteoliposomes, an ideal model of the membrane system with the advantages of an easy and low-cost production [ 2 ] . (encyclopedia.pub)
- Exosomes are nanovesicles originating from multivesicular bodies and are released by all cell types. (exosome-rna.com)
Proprietary2
- It also develops proprietary multivesicular liposome, a drug delivery technology that encapsulates drugs without altering their molecular structure. (wallstreetzen.com)
- Pacira BioSciences, Inc. is a specialty pharmaceutical company focused on the development, commercialization and manufacture of new pharmaceutical products, based on its proprietary multivesicular liposome (pMVL) drug delivery technology, for use in hospitals and ambulatory surgery centers. (pacira.com)
20231
- Ossendorp, F. & Cruz, L.J. (2023), Effective combination of liposome-targeted chemotherapy and PD-L1 blockade of murine colon cancer, Journal of Controlled Release 353: 490-506. (universiteitleiden.nl)
Exosomes1
- The epithelium secreted epididymal exosomes (50~300 nm in diameter) through apocrine secretion and the multivesicular body (MVB) pathway. (oncotarget.com)
Systemic1
- Liposomal bupivacaine may theoretically prolong the duration of action of bupivacaine because the slow release of bupivacaine from the liposome has been shown to maintain systemic plasma concentrations over 96 hours. (uic.edu)
Membrane1
- It participates in the membrane scission of the revers topology budding and participates in multivesicular body formation. (wikipedia.org)
Technology1
- The product combines bupivacaine with multivesicular liposomes, a proven product delivery technology that delivers medication over a desired time period. (millvalley.com)
Long1
- The imperative of a frontier or something can increasingly see Slashers on it, elsewhere of any long liposomes that feel the support or advance. (yourserve.com)
Patients1
- [ 1 ] LpX, an abnormal multivesicular-like lipoprotein that accumulates in patients with FLD, contributes to renal disease. (medscape.com)
Bupivacaine liposome injectable suspension3
- Pacira has donated over 3,800 vials of EXPAREL ® (bupivacaine liposome injectable suspension) to locations across the world that otherwise have no alternatives other than opioids. (pacira.com)
- EXPAREL ® (bupivacaine liposome injectable suspension), iovera o , ZILRETTA ® (triamcinolone acetonide extended-release injectable suspension), and Pacira are registered trademarks of the respective subsidiaries of Pacira BioSciences, Inc. All other trademarks referenced herein are the property of their respective owners. (pacira.com)
- NOCITA (bupivacaine liposome injectable suspension) is a long-acting, local anesthetic that provides up to 72 hours of post-operative pain relief by releasing bupivacaine (anesthetic pain relief agent) over time from multi-vesicular liposomes. (michiganveterinarysurgeons.com)
Liposomal2
- San Diego, Calif) has been utilized to create liposomal bupivacaine (Exparel), a longer-acting form of bupivacaine in which the anesthetic is delivered via a multivesicular liposomal system. (medscape.com)
- Liposome bupivacaine (Exparel) is a multivesicular liposomal formulation of bupivacaine currently approved in the United States for single-dose administration into the surgical site to provide postsurgical analgesia. (anesthesiaexperts.com)
Unilamellar liposomes1
- CPPs were anchored through a spacer to LCP-1-bearing multilamellar and unilamellar liposomes and administered to Swiss outbred mice. (omicsdi.org)
Morphine sulfate5
- DepoDur (morphine sulfate extended-release liposome) injection is an extended-release liposome injection of morphine sulfate intended for single-dose administration by the epidural route, at the lumbar level, for the treatment of pain following major surgery. (medscape.com)
- DepoDur is a sterile suspension of multivesicular liposomes containing morphine sulfate, intended for epidural administration. (medscape.com)
- DepoDur (morphine sulfate extended-release liposome injection) is a sterile suspension of multivesicular liposomes using proprietary DepoFoam ® formulation technology containing morphine sulfate, intended for epidural administration. (nih.gov)
- DepoDur is a sterile, non-pyrogenic, white to off-white, preservative-free suspension of multivesicular lipid-based particles containing Morphine Sulfate, USP. (nih.gov)
- After the administration of DepoDur into the epidural space, morphine sulfate is released from the multivesicular liposomes over a period of time. (nih.gov)
Bodies1
- With more studies conducted, now exosomes are generally accepted as small cell-derived single-membrane vesicles (30-150 nm) released by almost all types of cells into extracellular space via fusing plasma membrane and multivesicular bodies (MVBs) [ 12 ]. (biomedcentral.com)
Lipid composition2
- In our experiments, prototypic CPP HIV-1 TAT peptide did not interact with liposomes mimicking the outer leaflet of the plasma membrane, but it did induce lipid mixing and membrane leakage as it translocated into liposomes mimicking the lipid composition of late endosome. (omicsdi.org)
- HIV-1 virus-like particles and liposomes mimicking the HIV-1 lipid composition were shown to use a common internalization pathway and the same trafficking route within mDCs. (plos.org)
Aqueous2
- The lipids of the formulations comprise an amphipathic lipid, such as the phospholipids of cell membranes, and form hollow lipid vesicles, or liposomes, in aqueous systems. (justia.com)
- Substitution of BMP with its structural isomer, phosphatidylglycerol (PG), significantly reduced both leakage of the aqueous probe from liposomes and lipid mixing between liposomes. (omicsdi.org)
Particles1
- The median diameter of the liposome particles is in the range of 17 to 23 μm. (nih.gov)
Preparation2
- This review mainly focuses on the preparation of liposomes containing CUR and its use in cancer therapy. (nih.gov)
- drop-down gal and several countries -- v. USER of resources and alert PCs into metaphysics -- v. Liposome Technology, Activation Text: Liposome Preparation and Related Techniques, Third Edition, sounds a always denied and announced metaphysical Volume of a main M in the truth. (wikipark.ws)
Drug3
- 4, 5] Bupivacaine liposome was granted approval by the US Food and Drug Administration (FDA) in 2011, being used for postoperative analgesia by way of single-dose infiltration at the surgical site. (medscape.com)
- To solve these problems, researchers have tried to explore novel drug delivery systems such as liposomes, solid dispersion, microemulsion, micelles, nanogels and dendrimers. (nih.gov)
- Li Y, Shao R, Ostertag-Hill CA, Torre M, Yan R, Kohane DS: Methyl-branched liposomes as a depot for sustained drug delivery. (harvard.edu)
Cell2
- Cell-penetrating peptide induces leaky fusion of liposomes containing late endosome-specific anionic lipid. (omicsdi.org)
- These results therefore support a model of cell penetration that requires both BMP and the vicinity between bilayers, two features unique to BMP-rich and multivesicular late endosomes. (omicsdi.org)
Similar1
- Liposome bupivacaine has a similar safety and side effect profile to bupivacaine HCl and normal saline, suggesting that most of the more common AEs are related to either opioid rescue or the surgical procedure itself. (anesthesiaexperts.com)