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  • Bangham
  • Liposomes were first discovered in England by Alec C. Bangham in 1961. (reference.com)
  • Liposomes were first described by British haematologist Alec D Bangham in 1961 (published 1964), at the Babraham Institute, in Cambridge. (wikipedia.org)
  • Weissmann - during a Cambridge pub discussion with Bangham - first named the structures "liposomes" after the lysosome, which his laboratory had been studying: a simple organelle the structure-linked latency of which could be disrupted by detergents and streptolysins. (wikipedia.org)
  • Alec Douglas Bangham FRS (10 November 1921 Manchester - 9 March 2010 Great Shelford) was a British biophysicist who first studied blood clotting mechanisms but became well known for his research on liposomes and his invention of clinically useful artificial lung surfactants. (wikipedia.org)
  • adjuvants
  • D. Davis, A. Davies and G. Gregoriadis, Liposomes as immunological adjuvants with immunopurified tetanus toxoid: The immune response, Immunol. (springer.com)
  • Two forms of nanomedicine that have already been tested in mice and are awaiting human testing will use gold nanoshells to help diagnose and treat cancer, along with liposomes as vaccine adjuvants and drug transport vehicles. (wikipedia.org)
  • membrane
  • These saponins showed different activites on liposomal membrane, and cholesterol in liposomes was an important factor to this variation of saponin activities. (springer.com)
  • By preparing liposomes in a solution of DNA or drugs (which would normally be unable to diffuse through the membrane) they can be (indiscriminately) delivered past the lipid bilayer, but are then typically distributed non-homogeneously. (wikipedia.org)
  • As the pH naturally neutralizes within the liposome (protons can pass through some membranes), the drug will also be neutralized, allowing it to freely pass through a membrane. (wikipedia.org)
  • drugs
  • Liposomes can be filled with drugs, and used to deliver drugs for cancer and other diseases. (phys.org)
  • Finally, we describe some strategies developed to overcome limitations of the "first-generation" liposomes, and liposome-based drugs on the market and in clinical trials. (dovepress.com)
  • P.A.H.M. Toonen and D.J.A. Crommelin, Immunoglobulins as targeting agents for liposome-encapsulated drugs, Pharmaceutisch Weekblad Scient. (springer.com)
  • The liposome can be used as a vehicle for administration of nutrients and pharmaceutical drugs. (wikipedia.org)
  • Liposomes can also be designed to deliver drugs in other ways. (wikipedia.org)
  • Liposomes that contain low (or high) pH can be constructed such that dissolved aqueous drugs will be charged in solution (i.e., the pH is outside the drug's pI range). (wikipedia.org)
  • A similar approach can be exploited in the biodetoxification of drugs by injecting empty liposomes with a transmembrane pH gradient. (wikipedia.org)
  • vivo
  • Moreover, we discuss the influence of the physicochemical properties of liposomes on their interaction with cells, half-life, ability to enter tissues, and final fate in vivo. (dovepress.com)
  • B. Wolff and G. Gregoriadis, The use of monoclonal anti-Thy 1 IgG 1 for the targeting of liposomes to AKR-A cells in vitro and in vivo , Biochim. (springer.com)
  • researchers
  • Using computational modeling, researchers at Carnegie Mellon University, the Colorado School of Mines and the University of California, Davis have come up with a design for a better liposome. (phys.org)
  • ligands
  • Though liposomes can vary in size from low micrometer range to tens of micrometers, unilamellar liposomes, as pictured here, are typically in the lower size range with various targeting ligands attached to their surface allowing for their surface-attachment and accumulation in pathological areas for treatment of disease. (phys.org)
  • A liposome design may employ surface ligands for attaching to unhealthy tissue. (wikipedia.org)
  • Liposomes can also be decorated with opsonins and ligands to activate endocytosis in other cell types. (wikipedia.org)
  • Liposomes can also be functionalized by attaching various ligands on the surface to enhance brain-targeted delivery. (wikipedia.org)
  • made
  • Notable progress has been made, and several biomedical applications of liposomes are either in clinical trials, are about to be put on the market, or have already been approved for public use. (dovepress.com)
  • Liposomes can be made in a particular size range that makes them viable targets for natural macrophage phagocytosis. (wikipedia.org)
  • tissue
  • The liposomal formulations of daunorubicin and doxorubicin are less toxic to cardiac tissue than the non-liposomal form because a lower proportion of drug administered in the liposome form is delivered to the heart. (wikipedia.org)
  • Research
  • This column will review new research and applications for liposomes, which are well-known and prevalent in today's skin care products. (skininc.com)
  • Research from Seoul explored how liposomes containing epidermal growth factors (EGFs) and hyaluronic acid (HA) could aid in the treatment of wounds. (skininc.com)
  • Since their discovery in the 1960s, liposomes have been studied in depth, and they continue to constitute a field of intense research. (dovepress.com)
  • The Journal of Liposome Research is a peer-reviewed academic journal that publishes original research on the topics of liposomes and related systems, lipid-based delivery systems, lipid biology, and both synthetic and physical lipid chemistry. (wikipedia.org)
  • He is best known for his research on liposomes. (wikipedia.org)
  • treatment
  • The objective is to instill liposomes reconstituted with sterile water into the bladder as a compassionate use treatment in one patient with ulcerative interstitial cystitis (IC). (clinicaltrials.gov)
  • At each treatment visit, the patients will have a solution of liposomes instilled in the bladder with a catheter, retained for 30 minutes, and be carefully monitored for at least 1 hour after the liposomes are drained. (clinicaltrials.gov)
  • Gentle yet effective daily eye treatment uses advanced peptides and liposomes to deliver time-release moisture, antioxidants and anti-inflammatory botanicals to the delicate eye area. (beautyhabit.com)
  • review
  • In this review, we briefly analyze how the efficacy of liposomes depends on the nature of their components and their size, surface charge, and lipidic organization. (dovepress.com)
  • Industry
  • 2 In parallel, there has been considerable progress in liposome technology 1 and related achievements have ensured in many cases adoption of the liposome system by the Industry. (springer.com)
  • cells
  • Hyperthermia-triggered intracellular delivery of anticancer agent to HER2+ cells by HER2-specific affibody (ZHER2-GS-Cys)-conjugated thermosensitive liposomes (HER 2 + affisomes)," Journal of Controlled Release , vol. 153, no. 2, pp. 187-194, 2011. (hindawi.com)