AnatomyDiseasesChemicals and DrugsPhenomena and Processes
LiposarcomaLiposarcoma, MyxoidNeoplasms, Adipose TissueNeoplasms, Connective and Soft TissueRNA-Binding Protein FUSLipomaRetroperitoneal NeoplasmsSoft Tissue NeoplasmsHistiocytoma, Malignant FibrousTranscription Factor CHOPChromosomes, Human, Pair 12Histiocytoma, Benign FibrousSarcomaLeiomyosarcomaHeterogeneous-Nuclear RibonucleoproteinsOncogene Proteins, FusionProto-Oncogene Proteins c-mdm2CCAAT-Enhancer-Binding ProteinsGene AmplificationTranslocation, GeneticRibonucleoproteins
SarcomaLeiomyosarcomaSubtypesTumorMyxoid liposarcomasForm of myxoidSubtypeTumorsSarcomasChemotherapy and radiotherapyComplete resectionMetastaticRadiotherapyFibromaDiagnosis1999UnresectableLipomaLipoblastsAnatomicalPrognosticSpindle cellLesionsTranslocationRetrospectiveRetroperitonealPediatricGeneCellFrequentPatientsSoft tissuesGenesResidualRareAriseThighFewerTypeCasesTreatmentCommonAggressiveVariant
Sarcoma12
  • Liposarcoma is a soft-tissue sarcoma typically seen in adults. (escholarship.org)
  • Liposarcoma is a type of cancer known as soft tissue sarcoma . (mskcc.org)
  • Moreover, metastasis in the liver, as the first and sole site, from a primary extremity soft tissue sarcoma, including pleomorphic liposarcoma, is extremely rare. (biomedcentral.com)
  • The World Health Organization defines pleomorphic liposarcoma (PLPS) as a pleomorphic, high-grade sarcoma containing a variable number of pleomorphic lipoblasts. (biomedcentral.com)
  • Magnetic resonance imaging revealed the presence of sarcoma on the posterior left thigh (Fig. 1 a, b), and differential diagnoses such as undifferentiated pleomorphic sarcoma, pleomorphic liposarcoma, dedifferentiated liposarcoma, and other higher-ranking sarcomas were considered. (biomedcentral.com)
  • Treatment patterns, and survival of patients with metastatic undifferentiated pleomorphic sarcoma: A National Cancer Database (NCDB) study. (creighton.edu)
  • The Initiative has funded four liposarcoma research grants totaling $600,000 and one study that included several types of sarcoma patients, including those with liposarcoma. (sarcomahelp.org)
  • Soft tissue sarcomas are more common and have close to 50 subtypes, including liposarcoma, synovial sarcoma, pleomorphic undifferentiated sarcoma and many others. (hopkinsmedicine.org)
  • Dr. Keung leads a translational research group focused on advancing our understanding of the molecular pathogenesis and immuno-oncology of several common subtypes of soft tissue sarcomas (liposarcoma, undifferentiated pleomorphic sarcoma, leiomyosarcoma) and improving treatments and outcomes for patients with these challenging malignancies. (mdanderson.org)
  • With an annual incidence of 2.5 cases per million population, liposarcoma is the most common soft tissue sarcoma, accounting for approximately 17% of all soft tissue sarcomas and 3% of all liposarcomas in the head and neck region (usually the neck and the cheek). (medscape.com)
  • Types of included in these are dedifferentiated liposarcoma, leiomyosarcoma, and pleomorphic sarcoma. (ap26113.com)
  • Recurrent PRDM10 Gene Fusions in Undifferentiated Pleomorphic Sarcoma. (lu.se)
Leiomyosarcoma2
  • 79% younger than age 65 years) with liposarcoma and leiomyosarcoma were included. (shu.edu)
  • In this specific article, we provides a Rabbit Polyclonal to MGST3 brief history of the modified World Health Corporation (WHO) classification of smooth cells tumors, discuss at length the radiology and administration of both most common adult non-GIST STS, specifically liposarcoma and leiomyosarcoma, and review a number of the growing histology-driven targeted treatments in non-GIST STS, concentrating on the part from the radiologist. (ap26113.com)
Subtypes3
  • Well differentiated (WDLPS), also known as atypical lipomatous tumor (ALT), and dedifferentiated liposarcomas (DDLPS) are the most common subtypes. (sarcomahelp.org)
  • These and other distinct genetic aberrations may aid in the diagnosis of particular liposarcoma subtypes, and they can potentially be targets that can be exploited therapeutically. (medscape.com)
  • Further, medication ME0328 manufacture studies discovered the multi-targeted tyrosine kinase inhibitor, ponatinib being a powerful restorative agent effective against different subtypes of liposarcoma. (molecularcircuit.com)
Tumor10
  • While liposarcoma forms are classified as being aggressive and malignant or, in the case of the atypical lipomatous tumor/well-differentiated liposarcoma, as relatively non-aggressive and benign, all five liposarcoma forms can infiltrate locally to injure nearby tissues and organs, occur in surgically inaccessible sites adjacent to vital organs (e.g. the retroperitoneum), recur after surgical removal, and progress to life-threatening diseases. (wikipedia.org)
  • Liposarcoma is a lipogenic tumor of large deep-seated connective tissue spaces. (medscape.com)
  • For myxoid/round-cell liposarcomas, the TLS-CHOP oncoprotein plays a key role in tumor formation. (medscape.com)
  • The tumor was histologically diagnosed as pleomorphic liposarcoma. (biomedcentral.com)
  • Retroperitoneal liposarcoma is a rare malignant tumor with an incidence of 2.5/1,000,000 individuals ( 1 ). (spandidos-publications.com)
  • Karyopharm's drug candidates are indicated for the treatment of various hematological and solid tumor malignancies including multiple myeloma, diffuse large B-cell lymphoma, liposarcoma, glioblastoma and endometrial cancer. (pharmaceutical-technology.com)
  • To highlight some of relevance and importance to PANO1: Wilms tumor suppressor, spermatogenic zip 1 transcription factor, signal transducer and activator of transcription, pleomorphic adenoma gene, general transcription factor IIIA, stimulating protein 1, CCAAT/enhancer binding protein, GC box elements and HMG box-containing protein 1. (wikipedia.org)
  • Spindle-cell liposarcoma is a rare variant of an atypical lipomatous tumor (ie, well-differentiated liposarcoma), and it must be distinguished from a dedifferentiated liposarcoma with metastatic potential and a benign spindle-cell lipoma. (medscape.com)
  • Background Liposarcoma, the most frequent soft tissues tumor, is certainly understudied cancers, and limited improvement has been manufactured in the treating metastatic disease. (molecularcircuit.com)
  • Conclusions Two large-scale kinase screenings discovered novel liposarcoma goals and a FDA-approved inhibitor, ponatinib with apparent anti-liposarcoma activity highlighting its potential therapy for treatment ME0328 manufacture of the dangerous tumor. (molecularcircuit.com)
Myxoid liposarcomas2
  • The round cell form of myxoid liposarcomas also appears to have a relatively poor prognosis: in various retrospective reviews, myxoid liposarcoma was usually found to be low-grade and therefore relatively responsive to chemotherapy whereas high grade (i.e. round cell) myxoid lipsarcoma had higher rates of metastasis, behaved more aggressively, and did not respond well to chemotherapy. (wikipedia.org)
  • It is important to note, however, that almost all cases of myxoid liposarcomas in pediatric patients have had excellent prognoses. (wikipedia.org)
Form of myxoid1
Subtype5
  • We present a very rare case of an anterior mediastinal liposarcoma of the pleomorphic subtype in a 17-year-old girl, along with radiological and pathological correlation. (escholarship.org)
  • Liposarcomas are the most common subtype of soft tissue sarcomas, accounting for at least 20% of all sarcomas in adults. (wikipedia.org)
  • Pleomorphic liposarcoma is the rarest subtype of liposarcoma. (biomedcentral.com)
  • PLPS is the rarest subtype of liposarcoma, accounting for approximately 5% of all liposarcomas [ 1 ]. (biomedcentral.com)
  • Although any liposarcoma subtype occasionally arises in the subcutis, involvement of the dermis appears to be exceedingly rare. (medscape.com)
Tumors2
  • Liposarcomas are generally large tumors (>10 cm) but can be of almost any size. (wikipedia.org)
  • The introduction of molecular biological analysis suggests that many of these tumors express MDM2 and CDK4 and may better be described as dedifferentiated liposarcoma. (medscape.com)
Sarcomas3
  • In children, liposarcomas are rare and comprise fewer than 5% of soft tissue sarcomas. (medscape.com)
  • Overall, liposarcomas account for less than 20% of all soft tissue sarcomas, and the average patient age at presentation is 50 years. (medscape.com)
  • Although liposarcomas account for about 17% of all soft tissue sarcomas, they are involved in only 4% of childhood soft tissue sarcomas. (medscape.com)
Chemotherapy and radiotherapy2
  • Studies to date find that all five liposarcoma forms, while usually treatable at least initially by surgical resection, are often only marginally responsive to currently used chemotherapy and radiotherapy regimens. (wikipedia.org)
  • Pleomorphic liposarcomas are generally unresponsive to chemotherapy and radiotherapy. (biomedcentral.com)
Complete resection2
Metastatic1
  • This research lays the groundwork for any clinical medication trial with ponatinib for individuals with intense metastatic liposarcoma. (molecularcircuit.com)
Radiotherapy1
  • The liposarcomas require a wide range of further studies to determine their responsiveness to various radiotherapy, chemotherapy, and more novel treatment regimens as used individually and in various combinations that would include, where possible, surgical removal. (wikipedia.org)
Fibroma3
  • We suggest the term pleomorphic sclerotic fibroma for these lesions. (karger.com)
  • Kamino H, Lee JY, Berke A: Pleomorphic fibroma of the skin: A benign neoplasm with cytologic atypia: A clinicopathologic study of eight cases. (karger.com)
  • Dermal lesions are rare and may resemble pleomorphic fibroma. (medscape.com)
Diagnosis2
19991
Unresectable1
  • Halaven (eribulin mesylate) was approved by the FDA for the treatment of patients with unresectable or advanced liposarcoma . (shu.edu)
Lipoma1
Lipoblasts1
  • Liposarcomas arise from the precursor lipoblasts of the adipocytes (i.e. fat cells) in adipose (i.e. fat) tissues. (wikipedia.org)
Anatomical2
  • Lee HG, Aurit S, Silberstein P, Gootee J. Primary anatomical site as a prognostic factor for pleomorphic liposarcoma. (creighton.edu)
  • The anatomical distribution of liposarcoma appears to be partly related to the histologic type. (medscape.com)
Prognostic1
  • PURPOSE: This study assessed the treatment outcomes of myxoid liposarcoma in the extremities and investigate the prognostic factors. (koreamed.org)
Spindle cell1
Lesions1
  • Liposarcoma normally appears as a slowly enlarging, painless, nonulcerated submucosal mass in a middle-aged person, but some lesions grow rapidly and become ulcerated early. (medscape.com)
Translocation1
Retrospective1
  • In retrospective review of 331 liposarcoma samples, the use of molecular techniques in addition to standard histology resulted in a change in the type of liposarcoma diagnosed in approximately one-quarter of patients. (medscape.com)
Retroperitoneal4
  • The 3 major locations in which liposarcomas are found are the lower extremities, the retroperitoneal region, and the shoulder area. (medscape.com)
  • In conclusion, retroperitoneal liposarcoma is a rare disease with a high rate of recurrence. (spandidos-publications.com)
  • The present study reported a case with retroperitoneal liposarcoma managed at Guihang Guiyang Hospital (Guiyang, China), and also performed a literature review on presentation, management and prognosis of this patient. (spandidos-publications.com)
  • Hematoxylin and eosin staining of tissue shows that retroperitoneal well-differentiated liposarcoma, with negative margins, full of lipocytes. (spandidos-publications.com)
Pediatric1
Gene3
  • This involves fusion of the transcription factor gene CHOP (DDIT3), which is essential for adipocytic differentiation, to the translocated in liposarcoma ( TLS ) or FUS gene on chromosome 16. (medscape.com)
  • Pleomorphic liposarcoma lacks identifiable translocations or gene amplification and was characterized by its clinical and pathologic aggressiveness. (medscape.com)
  • Small-interfering RNA display Liposarcoma cell lines had been transfected having a siRNA kinase collection (including 94 kinase gene focus on) as explained previously [21]. (molecularcircuit.com)
Cell7
  • Three distinct subgroups based on clinicopathologic and cytogenetic features have been identified: well-differentiated/dedifferentiated, myxoid/round-cell, and pleomorphic. (medscape.com)
  • myxoid and round-cell liposarcoma form a spectrum with regard to disease aggressiveness. (medscape.com)
  • Frequently mutated genes included TP53 (17% of pleomorphic liposarcomas), NF1 (10.5% of myxofibrosarcomas and 8% of pleomorphic liposarcomas) and PIK3CA (18% of myxoid/round-cell liposarcomas, or MRCs). (kb.se)
  • Furthermore, NCBI Geo profiles indicated that PANO1 is highly expressed in B-lymphocytes, liposarcomas, and the testis cell lines. (wikipedia.org)
  • The concept that round-cell liposarcoma represents the high-grade counterpart of myxoid liposarcoma is generally accepted. (medscape.com)
  • Myxoid and/or round-cell liposarcomas and pleomorphic liposarcomas have a striking predilection for the limbs, and dedifferentiated liposarcoma occurs predominantly in the retroperitoneum. (medscape.com)
  • Each one of these liposarcoma cell lines had been managed in RPMI moderate supplemented with fetal bovine serum inside a humidified incubator at 37?C with 5% CO2 [14]. (molecularcircuit.com)
Frequent1
  • Alternative lengthening of telomeres and loss of ATRX are frequent events in pleomorphic and dedifferentiated liposarcomas. (sens.org)
Patients3
  • [ 12 , 13 ] At a large New York Cancer Hospital, 18 cases of liposarcoma were reported in patients aged 22 years or younger over a period of 4 decades. (medscape.com)
  • Liposarcomas are rarely seen in the teenage years and are almost never found in patients younger than 8 years. (medscape.com)
  • Personal experience in caring for myxoid liposarcoma patients, including the opportunity, unfortunately, to directly observe therapeutic failure, has been and continues to be a powerful motivation to pursue these research opportunities. (sarcomahelp.org)
Soft tissues1
  • Well-differentiated liposarcoma tends to occur in deep soft tissues of both the limbs and the retroperitoneum. (medscape.com)
Genes2
Residual1
  • We were told two weeks ago, that the results of an extensive biopsy showed no sign of residual liposarcoma. (cancer.org)
Rare3
  • Pleomorphic liposarcoma is extremely rare. (mskcc.org)
  • Liposarcoma located in the scrotum is a very rare, and to our knowledge, only a few cases have been described in the radiologic literature. (koreamed.org)
  • Myxoid liposarcoma arose from the spermatic cord is very rare. (koreamed.org)
Arise1
  • Liposarcomas most frequently arise from the deep-seated stroma rather than the submucosal or subcutaneous fat. (medscape.com)
Thigh1
  • Rhonda spouse-diagnosed with myxoid liposarcoma in back of right thigh, stage 2 (chemo doctor said 2 or 3 does not make a difference, so you might as well say stage 3! (cancer.org)
Fewer1
  • It accounts for fewer than 5 percent of all liposarcomas. (mskcc.org)
Type2
Cases1
  • Overall, less than 150 cases of childhood liposarcoma have been reported in the literature, usually in the second decade of life. (medscape.com)
Treatment2
  • Well-differentiated liposarcoma has a tendency to regrow after initial treatment. (mskcc.org)
  • If the patient's general condition permits, anthracycline-based chemotherapy can be used for the treatment of stage 4 pleomorphic liposarcoma. (biomedcentral.com)
Common2
Aggressive1
Variant1