Loading...
  • progression
  • Herein, we utilise large publicly available datasets from The Cancer Genome Atlas (TCGA) and Protein Atlas to define a novel role for BMP2 in the progression of dedifferentiated liposarcomas. (peerj.com)
  • aggressive
  • This project aims to identify the genes involved in making de-differentiated liposarcomas behave more aggressively, so that new therapies can be developed to target these genes and hopefully result in less aggressive liposarcomas. (sarcoma.org.uk)
  • metastasis
  • However, there is no adequate evidence that the combination of surgery and radiotherapy lowers the possibility of distant metastasis of the head and neck liposarcomas. (hindawi.com)
  • survival
  • Due to its rarity, survival data for liposarcoma patients are often extrapolated from small series or from adult data. (medscape.com)
  • To verify this oncogenic addiction to angiogenic pathways, we utilized VEGFR-derived ligand traps and found that autocrine VEGFR signaling was crucial to myxoid liposarcoma cell survival. (hindawi.com)
  • Overall, these findings suggest that autocrine angiogenic signaling through the VEGFR family is critical to myxoid liposarcoma cell survival and that further study of axitinib as a potential anticancer therapy is warranted. (hindawi.com)
  • nuclear
  • Approximately 50% of myxoid liposarcoma cells express nuclear FUS-CHOP [ 9 ], and cells that are negative for CHOP express high levels of proliferation markers [ 10 ]. (hindawi.com)
  • cell
  • The small molecule inhibitor axitinib, which targets angiogenesis by inhibiting the VEGFR and PDGFR families and c-Kit, inhibited cell cycle progression and induced apoptosis in vitro , as well as having significant antitumor activity against MLS 1765 myxoid liposarcoma xenografts in mice. (hindawi.com)
  • histology
  • In retrospective review of 331 liposarcoma samples, the use of molecular techniques in addition to standard histology resulted in a change in the type of liposarcoma diagnosed in approximately one-quarter of patients. (medscape.com)
  • cancer
  • [ 9 , 10 ] At a large New York Cancer Hospital, 18 cases of liposarcoma were reported in patients aged 22 years or younger over a period of 4 decades. (medscape.com)
  • If he or she identifies liposarcoma, your doctor may order tests to determine the extent of your cancer and how far it has spread. (hopkinsmedicine.org)