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  • Small dense LDL
  • The purpose of this study is to verify the possible effects of OMACOR(omega-3 fatty acid) on the percentage change of small dense LDL fraction in type 2 diabetic patients with combined hyperlipidemia, we perform open-label prospective randomized multi-institutional phase IV study. (clinicaltrials.gov)
  • Small dense LDL is very atherogenic. (clinicaltrials.gov)
  • Increased plasma triglyceride and the presence of insulin resistance are proved to be positively correlated well with the amount of small dense LDL in diabetic patients. (clinicaltrials.gov)
  • We would like to see omega-3 acid(OMACOR) which is now widely used in clinical practice to decrease plasma triglyceride could change the amount of plasma small dense LDL in type 2 diabetic patients with combined hyperlipidemia. (clinicaltrials.gov)
  • Before and after the administration of study drug, we will measure the change of the amount of plasma small dense LDL via ultracentrifuge/non-denaturing polyacrylamide gel electrophoresis followed by oil red O and coomassie blue staining. (clinicaltrials.gov)
  • metabolism
  • CONCLUSIONS Among parameters of the lipoprotein and glucose metabolism, total TG is the single most important factor affecting LDL size variability, even in young adults. (diabetesjournals.org)
  • A prospective comparative study was conducted to assess the efficacy of EPA on metabolism of remnant lipoproteins and ox-LDL in dialysis patients using two new methods: an immunoaffinity gel separation for quantifying plasma remnant lipoproteins and an enzyme-linked immunosorbent assay for measuring plasma ox-LDL levels, a marker for in vivo LDL peroxidation. (asnjournals.org)
  • Therefore, in the present study, we investigated the effects of selective introduction of CETP in BM-derived cells and thus macrophages on lipoprotein metabolism and atherosclerotic lesion development by using bone marrow transplantation. (ahajournals.org)
  • Human LDL
  • Human LDL although stable at 4 degree C for 1 week, should be stored below -15 degree C (short term i.e. (mybiosource.com)
  • Purified human LDL (d=1.019 - 1.063 g/mL) is oxidized with copper (II) sulfate and labeled with DiI (1,1'-dioctadecyl- 3,3,3',3'-tetramethylindocarbocyanine perchlorate). (creativebiomart.net)
  • proteins
  • LDL was diluted in phosphate buffered saline (PBS) to at least one 1?mg proteins/mL and dialyzed for 1 twice?h every time as soon as even more overnight against PBS at 4°C to eliminate EDTA (PBS and EDTA were bought from Sigma-Aldrich). (livingseas.org)
  • 2.3 LDL Oxidation LDL (100?mg proteins/L) was incubated with 10?may be the good path length [20 21 Fluorescence quenching may appear via two different main systems: static and active. (livingseas.org)
  • LDLR
  • LDLR and LRP1 were also required for ApoC-III ASO-induced reduction of plasma TGs in mice fed a high-fat diet, in postprandial clearance studies, and when ApoC-III-rich or ApoC-III-depleted lipoproteins were injected into mice. (jci.org)
  • LDL contaminants are 1421438-81-4 largely taken off the flow via the LDLR, which can be found on the top of hepatocytes. (colinsbraincancer.com)
  • The LDLR binds LDL as well as the complicated gets into the cell through a clathrin-coated vesicle. (colinsbraincancer.com)
  • Intracellularly, the LDL and LDLR dissociate. (colinsbraincancer.com)
  • LDL is normally sent to a lysosome and degraded, as the LDLR is normally recycled back again to the hepatocyte cell surface area (Amount 1A).29 PCSK9 inhibits this technique by avoiding the separation from the LDLR from LDL. (colinsbraincancer.com)
  • upon LDL binding and internalization, the PCSK9-destined LDLR does not separate in the LDL particle. (colinsbraincancer.com)
  • Because of this, the LDLR is normally sent to the lysosome and degraded combined with the LDL, hence bypassing the procedure of recycling towards the hepatocyte cell surface area (Amount 1B).30 The reduced LDLR focus on hepatocyte cell surfaces leads to elevated plasma LDL-C because of reduced clearance of LDL. (colinsbraincancer.com)
  • Inhibiting PCSK9 as a result leads to improved LDLR recycling, elevated option of LDLR on hepatocyte cell areas, elevated LDL plasma clearance, and decreased blood LDL-C amounts, producing PCSK9 inhibition a highly effective therapeutic technique for LDL hypercholesterolemia. (colinsbraincancer.com)
  • LDL is normally sent to a lysosome and degraded, as the LDLR is normally recycled back again to the hepatocyte cell surface area. (colinsbraincancer.com)
  • B): PCSK9 inhibits the LDLR recycling by avoiding the separation from the LDLR from LDL. (colinsbraincancer.com)
  • Because of this, the LDLR is normally sent to the lysosome and degraded combined with the LDL, hence bypassing the procedure of recycling towards the hepatocyte cell surface area. (colinsbraincancer.com)
  • levels
  • A direct relation between CETP activity levels and LDL size or composition was not observed. (diabetesjournals.org)
  • Although increasing CETP levels are combined with this particular lipoprotein profile, a direct relation to LDL size and composition is not found. (diabetesjournals.org)
  • Twenty-two hemodialysis and 16 continuous ambulatory peritoneal dialysis patients with relatively high plasma levels of remnant lipoproteins and ox-LDL were randomized to either EPA or placebo. (asnjournals.org)
  • We demonstrate here that treatment with EPA reduced both plasma remnant lipoproteins and ox-LDL levels in dialysis patients without inducing adverse reactions. (asnjournals.org)
  • The effects of a 3-mo treatment with EPA on plasma levels of remnant lipoprotein and ox-LDL were tested in dialysis patients in a randomized comparative manner. (asnjournals.org)
  • Avocados - they are an amazing source of monounsaturated fatty acids that boost HDL levels and lower LDL. (redorbit.com)
  • A study showed that running, jogging, swimming, and cycling lowered LDL levels and reduced the risk of multiple heart diseases. (redorbit.com)
  • For the most accurate results, wait at least two months after a heart attack, surgery, infection, injury or pregnancy to check LDL levels. (clevelandclinic.org)
  • inhibition
  • Due to its potency, compound 3 was tested for complementary in vitro investigations, such as lag time (140 min at 1.0 μM), relative electrophoretic mobility (REM) of ox-LDL (inhibition of 80% at 20 μM and 72% at 10 μM), and fragmentation of apoB-100 (inhibition of 93% at 20 μM) on copper-mediated LDL oxidation. (kribb.re.kr)
  • Open up in another window Amount 1 LDL Recycling, PCSK9 Function, and Aftereffect of PCSK9 Inhibition Records: (A) LDLRs are located over the hepatocyte cell surface area. (colinsbraincancer.com)
  • inflammation
  • Olive oil - the fat that is found in olive oil and olives can lower the inflammation caused by LDL in your body. (redorbit.com)
  • proteoglycan
  • Lysophosphatidylcholine (lysoPC), a main product of lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, appears to be a major determinant of the pro-atherogenic properties of oxidized LDL (oxLDL) and to induce proteoglycan synthesis, a main player in intimal thickening. (pubmedcentralcanada.ca)
  • Inhibitors
  • Experiments with myosin light chain kinase and Rho kinase inhibitors, ML-9 and Y-27632, suggest OX-LDL induced contraction is mediated by additive effects of two distinct signaling pathways activated concomitantly in the presence of calcium. (openhypertensionjournal.com)
  • Pathways
  • Both quenching pathways are referred to from the Stern-Volmer formula: will be the fluorescence intensities in the lack and existence of quencher respectively may be the quenching price continuous from the bimolecule and may be the binding continuous reflecting the amount of discussion between ApoB100/LDL as well as the polyphenols and may be the amount of binding sites specifying the amount of polyphenol molecules destined to the macromolecule. (livingseas.org)
  • metabolic
  • Although insulin resistance has been suggested to be a basic defect, little is known about the relation between this predisposing factor (and associated metabolic disturbances) and LDL size distribution in young and metabolically healthy subjects. (diabetesjournals.org)
  • In the present study, we investigated the relation between insulin sensitivity, lipoprotein distribution, and LDL patterns in young adults to increase the understanding of the development of metabolic risk factors in an early phase of the life span. (diabetesjournals.org)
  • significantly
  • The increase of CER in native LDL significantly increased cytokine release, whereas the enrichment in DAG did not show these inflammatory properties. (mdpi.com)