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  • Metabolism
  • The investigators propose to investigate the effects of LY518674 on components that may likely affect atherogenesis in patients with the metabolic syndrome including HDL-C metabolism and reverse cholesterol transport pathways, the inflammatory response, and oxidative stress in human subjects. (clinicaltrials.gov)
  • Kuang YL, Eric Paulson K, Lichtenstein AH, Lamon-Fava S (2012) Regulation of the expression of key genes involved in HDL metabolism by unsaturated fatty acids. (springer.com)
  • pathways
  • This is definitely the most total study to day of how ox-HDL would impair EPCs function, which was involved with service of CD36-p38 MAPK-TSP-1 pathways and proved by not only the inverse relationship between ox-HDL and circulating EPCs in medical center but also pro-apoptotic effects of HDL separated from individuals' serum. (monossabios.com)
  • Service of CD36-p38 MAPK-TSP-1 pathways contributes to the pathological effects of ox-HDL on EPCs' disorder, which might become one of the potential etiological factors responsible for the disrupted neovascularization in chronic ischemic disease. (monossabios.com)
  • hepatic
  • However, hepatic LDL receptor and HDL receptor expressions and HMG-CoA reductase activity were not altered by CsA therapy. (aspetjournals.org)
  • Novel
  • Together, these findings argue that HDL promotes angiogenesis via S1P3-dependent up-regulation and activation of VEGFR2 and also suggest that the S1P-S1P3-VEGFR2 signaling cascades as a novel target for HDL-modulating therapy implicated in vascular remodeling and functional recovery in atherosclerotic diseases such as myocardial infarction and ischemic stroke. (springer.com)
  • Remaley AT, Norata GD, Catapano AL (2014) Novel concepts in HDL pharmacology. (springer.com)
  • significantly
  • In the mean time, HDL separated from such individuals could significantly increase cultured EPC's caspase 3 activity, further supporting our proposal. (monossabios.com)
  • However, the correlations became significantly negative between HDL-C levels and peak levels of n-3 or area under the curve after a single large intake of n-3 ethyl esters. (springer.com)
  • ABCA1
  • Compared with controls, ABCA1 heterozygotes (six men and three women) had HDL levels that were decreased by 60%, their blood flow responses to endothelium-dependent vasodilators were blunted, and endothelium-independent responses were unaltered. (pharmaceuticalintelligence.com)
  • exert
  • 2 This review considers the potential mechanisms by which HDL-C may exert its antiatherogenic effects, discusses disorders of HDL and how to interpret them in the clinical setting, and presents current and potential treatment strategies for patients with low HDL-C. (ahajournals.org)
  • enhances
  • However, the mechanisms by which HDL enhances the formation of blood vessels remain to be defined. (springer.com)
  • ratios
  • Despite the lower Si and PON1 values, AAs preserved paradoxical relationships between the Si and HDL/apoA1/triglyceride ratios. (diabetesjournals.org)
  • severe
  • OBJECTIVE To determine whether modestly severe obesity modifies glucose homeostasis, levels of cardiometabolic markers, and HDL function in African Americans (AAs) and white Americans (WAs) with prediabetes. (diabetesjournals.org)
  • whereas
  • Whereas the functional link between HDL and eNOS has been appreciated only recently, the relationship between HDL and endothelium-dependent vasodilation has been known for some time. (pharmaceuticalintelligence.com)
  • patients
  • In a clinical trial by the Karas laboratory of niacin therapy in patients with low HDL levels (nine males and two females), flow-mediated dilation of the brachial artery was improved in association with a rise in HDL of 33% over 3 months (Kuvin et al. (pharmaceuticalintelligence.com)
  • The patients had lower preheparin free TFPI and lower HDL cholesterol (HDL-C) levels than the healthy subjects with equivalent Lp-bound forms (free TFPI, 15.9±6.5 versus 19.2±8.1 ng/mL). (ahajournals.org)
  • steady
  • In the present study, fingertip blood and plasma levels of n-3 fatty acids, both at steady state or after a large intake (12 g of LC-FA as ethyl esters) were correlated to the levels of the major lipoproteins. (springer.com)
  • major
  • HDL less than 40 mg/dL for men and less than 50 mg/dL for women is considered low and a major risk factor for heart disease. (medicineshoppe.com)