ProteinLipolysis stimulated lipoproteinApolipoproteinGeneMetabolismApoEAtherosclerosisTotal cholesterolAcetylcholine receptorsLDLRThrombinVLDLLipidGenesFamilial hypercholesterolaemiaMyocardial infarctionProteinsScavengerBindTissueCholesterol levelsInhibitorsHumansDeficiencyRecurrentGoldsteinLRP1LevelsVitaminMedicineMechanismTissuesHigh
Protein24
- Lipolysis-stimulated lipoprotein receptor is a protein that in humans is encoded by the LSR gene. (wikipedia.org)
- The gene, termed low-density lipoprotein receptor related protein 5 (LRP5), encodes a protein of 1615 amino acids that contains conserved modules which are characteristic of the low-density lipoprotein (LDL) receptor family. (nih.gov)
- These modules include a putative signal peptide for protein export, four epidermal growth factor (EGF) repeats with associated spacer domains, three LDL-receptor (LDLR) repeats, a single transmembrane spanning domain, and a cytoplasmic domain. (nih.gov)
- The cation-independent mannose 6-phosphate receptor and the low density lipoprotein receptor, both rapidly internalized from the cell surface, and the synaptic vesicle membrane protein synaptophysin, were transported to the Golgi apparatus with equivalent, nonlinear kinetics. (rupress.org)
- relationship between vitamin D and low-density lipoprotein receptor-related protein (LRP-1) has revealed that the two may work together to possibly clear amyloid-beta (Aβ), a deposition that is linked to the progression of neurological dysfunction. (todayspractitioner.com)
- Among Aβ scavenger receptors, low density lipoprotein receptor related protein ( LRP-1 ) has been most extensively studied. (todayspractitioner.com)
- LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies. (todayspractitioner.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Low Density Lipoprotein Receptor Related Protein 4 (LRP4) in Tissue homogenates, cell lysates and other biological fluids. (noveoninc.com)
- Description: A sandwich ELISA kit for detection of Low Density Lipoprotein Receptor Related Protein 4 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (noveoninc.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Rat Low Density Lipoprotein Receptor Related Protein 8 (LRP8) in serum, plasma and other biological fluids. (thescientistconnect.com)
- The VLDLR gene provides instructions for making a protein called a very low density lipoprotein (VLDL) receptor. (medlineplus.gov)
- The VLDL receptor works together with a protein called reelin. (medlineplus.gov)
- These mutations prevent cells from producing any functional VLDL receptor protein. (medlineplus.gov)
- Here, we report that in AD patients and two mouse models of AD, overexpression of serum response factor (SRF) and myocardin (MYOCD) in cerebral vascular smooth muscle cells (VSMCs) generates an Aβ non-clearing VSMC phenotype through transactivation of sterol regulatory element binding protein-2, which downregulates low density lipoprotein receptor-related protein-1, a key Aβ clearance receptor. (nature.com)
- Ng lipoproteins are taken up by two functionally significant low-density lipoprotein (LDL) receptors: the prototypic LDL receptor (LDLR) along with the LDL receptor-related protein 1 (LRP1). (nicotinic-receptor.com)
- LRP4, lipoprotein receptor-related protein 4. (cdc.gov)
- Exposure of MM6 cells, which do not express CD36 or other scavenger receptors, to such enzymatically modified LDL (enzLDL) resulted in upregulation of CD36 surface protein and mRNA expression. (edu.au)
- Regional European differences in allele and genotype frequencies of low density lipoprotein receptor-related protein 1 polymorphism in Alzheimer's disease. (unifg.it)
- The low density lipoprotein receptor-related protein 1 (LRP1 gene) is a candidate gene for Alzheimer's disease (AD), because it is a ligand for proteins involved in ADpathogenesis, such as apolipoprotein E (APOE), a2-macroglobulin (A2M), amyloid precursor protein (APP), and is located on chromosome 12, within a region linked with AD. (unifg.it)
- INTRODUCTION: Dickkopf-related protein 1 (Dkk1) is a secreted protein ligand of low-density lipoprotein receptor-related protein 6 (LRP6), which antagonises canonical Wnt signalling. (ox.ac.uk)
- The elimination of [ 125 I]hAβ(1-40) was significantly inhibited by human receptor-associated protein (RAP) and the elimination was attenuated in either anti-low-density lipoprotein receptor-related protein (LRP)1 antibody-treated or RAP-deficient mice, suggesting that a member(s) of the low-density lipoprotein receptor gene family is involved in the elimination of hAβ(1-40) from CSF. (elsevierpure.com)
- Therefore, we have evaluated the association of the common variants in the lipoprotein lipase (LPL) (D9N, N291S, and S447X), insulin receptor substrate-1 (IRS-1) (G972R), fatty acid binding protein-2 (FABP-2) (A54T), and beta(3)-adrenergic receptor beta(3)-AR) (W64R) genes with lipid and lipoprotein levels in 30 Italian FCHL families (195 individuals). (univaq.it)
- The capsid-coat protein serves multiple functions, including (1) protecting the viral RNA from degradation by environmental RNase, (2) determining host and tissue tropism by recognition of cell-specific cell-membrane receptors, (3) penetrating target cells and delivering the viral RNA into the cell cytoplasm, and (4) selecting and packaging viral RNA. (medscape.com)
- Low-density lipoprotein receptor-related protein 5 gene polymorphisms and genetic susceptibility to abdominal aortic aneurysm. (cdc.gov)
Lipolysis stimulated lipoprotein5
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Lipolysis Stimulated Lipoprotein Receptor (LSR) in Tissue homogenates, cell lysates and other biological fluids. (tuberculosisdrugresearch.org)
- Description: A sandwich ELISA kit for detection of Lipolysis Stimulated Lipoprotein Receptor from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (tuberculosisdrugresearch.org)
- Description: A sandwich quantitative ELISA assay kit for detection of Human Lipolysis Stimulated Lipoprotein Receptor (LSR) in samples from tissue homogenates, cell lysates or other biological fluids. (tuberculosisdrugresearch.org)
- Correction: Lipolysis-stimulated lipoprotein receptor overexpression is a novel predictor of poor clinical prognosis and a potential therapeutic target in. (oncotarget.com)
- Figure 1: Immunohistochemical (IHC) staining for lipolysis-stimulated lipoprotein receptor (LSR) in gastric cancer (GC) patient samples. (oncotarget.com)
Apolipoprotein2
- Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
- The second is an apolipoprotein(a) which is bound to the LDL-like molecule at the ApoB receptor with a disulfide bond. (medscape.com)
Gene5
- Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification. (medlineplus.gov)
- Identification of a nonsense mutation in the very low-density lipoprotein receptor gene (VLDLR) in an Iranian family with dysequilibrium syndrome. (medlineplus.gov)
- This genomic region includes the VLDLR gene, which encodes the very low-density lipoprotein receptor, a component of the reelin signaling pathway involved in neuroblast migration in the cerebral cortex and cerebellum. (bilkent.edu.tr)
- Several common genetic polymorphisms in the low density lipoprotein receptor (LDL-R) gene have associated with modifications of serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels, but the results are not consistent in different populations. (biomedcentral.com)
- Since the LDL-R gene plays an important role in cholesterol homeostasis [ 28 ], it is also possible that genetic variations in this gene may exist that have only a small effect on the function of the receptor. (biomedcentral.com)
Metabolism3
- It's a member of the LDL receptor family, which plays various different roles related to enzyme activation, the entry of bacterial toxins and viruses into cells, and the metabolism of a proteins that transport and combine with fats in the blood . (todayspractitioner.com)
- The nuclear hormone receptors liver X receptor α (LXRα) and LXRβ function as physiological receptors for oxidized cholesterol metabolites (oxysterols) and regulate several aspects of cholesterol and lipid metabolism. (aspetjournals.org)
- FH is a disorder of cholesterol metabolism associated with mutations in the low-density lipoprotein (LDL) receptor and a few other genes. (cdc.gov)
ApoE8
- The purpose of the present study was to test the hypothesis that lecithin:cholesterol acyltransferase (LCAT) deficiency would accelerate atherosclerosis development in low density lipoprotein (LDL) receptor (LDLr-/-) and apoE (apoE-/-) knockout mice. (eurekamag.com)
- ApoE-/- LCAT-/- mice fed the atherogenic diet, compared with apoE-/- mice, had higher concentrations of plasma FC, EC, apoB lipoprotein cholesterol, and phospholipid, and significantly more aortic FC (149 +/- 62 versus 109 +/- 33 mg/g) and EC (101 +/- 23 versus 69 +/- 20 mg/g) than did the apoE-/- mice. (eurekamag.com)
- LCAT deficiency resulted in a 12-fold increase in the ratio of saturated + monounsaturated to polyunsaturated cholesteryl esters in apoB lipoproteins in LDLr-/- mice and a 3-fold increase in the apoE-/- mice compared with their counterparts with active LCAT. (eurekamag.com)
- We conclude that LCAT deficiency in LDLr-/- and apoE-/- mice fed an atherogenic diet resulted in increased aortic cholesterol deposition, likely due to a reduction in plasma HDL, an increased saturation of cholesteryl esters in apoB lipoproteins and, in the apoE-/- background, an increased plasma concentration of apoB lipoproteins. (eurekamag.com)
- This receptor family includes seven family members that are closely related and include the LDL receptor, very low density lipoprotein (VLDL) receptor, apoE receptor 2, multiple epidermal growth factor-like domains 7 (MEGF7), glycoprotein 330 (gp330/megalin/LRP2), LRP1 and LRP1B. (todayspractitioner.com)
- Following receptor-mediated endocytosis, ApoE is recycled for the plasma membrane, and cholesterol is used for cell membrane turnover and repair, myelin formation, synaptogenesis and neurotransmitter release [146]. (nicotinic-receptor.com)
- ApoE-mediated binding of HTG-VLDL 1 to the blotted LDL receptor is abolished or greatly decreased by thrombin treatment of HTG-VLDL 1 trypsin treatment of HTG-VLDL 1 abolishes binding. (houstonmethodist.org)
- These studies demonstrate unequivocally that HTG-VLDL 1 bind to the LDL receptor, that the binding of HTG-VLDL 1 to the isolated LDL receptor is mediated through the thrombin-accessible apoE, and that HTG-VLDL 1 which bind via potentially dissociable apoE rather than non-tranferable apoB can be used for ligand blotting. (houstonmethodist.org)
Atherosclerosis2
- To determine this role, we created chimeric atherosclerosis-susceptible low-density lipoprotein (LDL) receptor null (ldl-r -/- ) mice that were deficient in functional NK cells through expression of a transgene encoding for Ly49A. (uky.edu)
- However, deficiency of functional NK cells significantly reduced the size of atherosclerosis by 70% (P=0.0002) in cross-sectional analysis of the aortic root and by 38% (P=0.004) in en face analysis of the intimal surface of the aortic arch. (uky.edu)
Total cholesterol5
- After 8 weeks, there was no difference in either serum total cholesterol concentrations or lipoprotein cholesterol distribution in mice repopulated with nontransgenic versus Ly49A transgenic marrow cells. (uky.edu)
- Nicotinic acid raises high-density lipoprotein (HDL) cholesterol levels while lowering total cholesterol, LDL cholesterol, and triglyceride levels. (cdc.gov)
- Using data from the second phase (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III), we examined associations between 22 polymorphisms in 13 candidate genes and four serum lipids: high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG). (cdc.gov)
- Previous reports from the Framingham Heart Study suggested a strong positive relationship between coronary heart disease and elevated levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels, in addition to an inverse relationship between the disease and high-density lipoprotein cholesterol (HDL-C) levels [ 5 - 8 ]. (cdc.gov)
- Irisin has a significant negative correlation with levels of lipoprotein(a), coenzyme Q10, LDL receptor, total cholesterol and NPC1L1. (medscape.com)
Acetylcholine receptors1
- Clinical features and diagnostic usefulness of antibodies to clustered acetylcholine receptors in the diagnosis of seronegative myasthenia gravis. (cdc.gov)
LDLR1
- After 16 weeks of atherogenic diet (0.1% cholesterol, 10% calories from palm oil) consumption, LDLr-/- LCAT-/- double knockout mice, compared with LDLr-/- mice, had similar plasma concentrations of free (FC), esterified (EC), and apoB lipoprotein cholesterol, increased plasma concentrations of phospholipid and triglyceride, decreased HDL cholesterol, and 2-fold more aortic FC (142 +/- 28 versus 61 +/- 20 mg/g protein) and EC (102 +/- 27 versus 61+/- 27 mg/g). (eurekamag.com)
Thrombin1
- Pretreatment of LDL with either thrombin or trypsin does not affect apoB-mediated LDL binding to the LDL receptor. (houstonmethodist.org)
VLDL5
- The VLDL receptor appears to play a particularly important role in the developing brain. (medlineplus.gov)
- Reelin fits into the VLDL receptor like a key in a lock, which triggers a series of chemical reactions within the cell. (medlineplus.gov)
- The very low-density lipoprotein (VLDL) receptor: characterization and functions as a peripheral lipoprotein receptor. (medlineplus.gov)
- HTG-VLDL 1 , like LDL, bind with high affinity to electrophoretically transferred, isolated LDL receptors partially purified from bovine adrenal glands. (houstonmethodist.org)
- HTG-VLDL 1 does not bind in the presence of 7 mM suramin, an inhibitor of LDL binding to the LDL receptor. (houstonmethodist.org)
Lipid5
- We use our single-particle profiler to measure the messenger RNA encapsulation efficiency of lipid nanoparticles, the viral binding efficiencies of different nanobodies, and the biophysical heterogeneity of liposomes, lipoproteins, exosomes and viruses. (scilifelab.se)
- Conversely, the variants in the IRS-1, FABP2, and beta(3)-AR genes did not show any major influence on lipid and lipoprotein levels in FCHL family members. (univaq.it)
- Lipid-poor HDL precursors mature by obtaining cholesterol and phospholipids from cell membranes or triglyceride-rich lipoproteins. (jci.org)
- Results from our study contribute to a growing body of literature identifying key determinants of plasma lipoprotein concentrations and could provide insight into the biological mechanisms underlying serum lipid and cholesterol concentrations. (cdc.gov)
- The genetic basis for elevation in lipid levels is not well understood, but substantial heritability has been demonstrated in twin [ 9 ] and family-based [ 10 - 12 ] studies, which have estimated that approximately 43% to 83% of the variance in blood lipid and lipoprotein levels is attributable to genetic factors. (cdc.gov)
Genes1
- Biological actions of Vitamin D are mediated via its nuclear hormone receptor VDR and is found to regulate many genes. (todayspractitioner.com)
Familial hypercholesterolaemia1
- Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module. (expasy.org)
Myocardial infarction1
- Large observational studies, such as the INTERHEART study , which involved many nations, show that individuals with elevated lipoprotein(a) have an increased risk for myocardial infarction (MI). (medscape.com)
Proteins1
- These results suggest that one of the functions of late endosomes is constitutive recycling of cell surface receptors through the Golgi apparatus if they fail to recycle to the cell surface directly from early endosomes, and that the late endosome recycling pathway is followed frequently by many rapidly internalized proteins. (rupress.org)
Scavenger2
- A benefit of LRP-1 is that it has been identified as a Aβ scavenger receptor that can remove Aβ from the brain through the blood-brain barrier. (todayspractitioner.com)
- Upregulation of CD36 was inversely correlated to the state of cell differentiation, as showed by lower response to enzLDL of the scavenger receptor-expressing MM6-sr and THP1 cells. (edu.au)
Bind3
- Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. (usda.gov)
- Thyroid-stimulating immunoglobulins (TSIs) bind to and activate thyroid-stimulating hormone (TSH) receptors, causing the thyroid gland to grow and the thyroid follicles to increase synthesis of thyroid hormone. (medscape.com)
- Chemokines that regulate monocyte/macrophage trafficking (MIF, MCP-1) and pattern-recognition receptors that bind chitin (chitinases) and oxidized low-density lipoprotein (CD68) were also increased following isocyanate -albumin exposure. (cdc.gov)
Tissue1
- Compared with syngeneic controls, endogenous CD34(+) cells were mobilized in significant numbers after allogeneic transplantation, the majority showing sustained expression of tissue factor and protease-activated receptor-1 (PAR-1). (nih.gov)
Cholesterol levels1
- The first part of the study was focused on understanding the regulation of irisin levels based on multiple baseline parameters, such as lipoprotein(a) and cholesterol levels. (medscape.com)
Inhibitors2
- Inhibitors of oxidized low-density lipoprotein receptor 1 (LOX-1), compositions comprising inhibitors of LOX-1, and methods of using thereof are described. (bioventures.tech)
- Medicines called PCSK9 inhibitors lower cholesterol-increasing LDL receptors. (cdc.gov)
Humans1
- Ozcelik T, Akarsu N, Uz E, Caglayan S, Gulsuner S, Onat OE, Tan M, Tan U. Mutations in the very low-density lipoprotein receptor VLDLR cause cerebellar hypoplasia and quadrupedal locomotion in humans. (medlineplus.gov)
Deficiency1
- Several studies also suggest that vitamin D receptor (VDR, the receptor to which vitamin D binds to in the body) deficiency, or inhibition, could be a risk factor for neurodegenerative disease. (todayspractitioner.com)
Recurrent1
- If you look at LDL cholesterol trials where they gave statins to control LDL, the best predictor at that point of recurrent events was actually the lipoprotein(a) level, not the LDL level. (medscape.com)
Goldstein1
- The discovery of the LDL receptor mutation in FH patients-for which Goldstein and Brown won the Nobel prize in 1985-led to the development of statins as a new class of drugs to combat high cholesterol, a major cause of heart disease in populations. (cdc.gov)
LRP12
- LRP1 is a member of the LDL receptor family, which contains several structurally homologous receptors that are composed of modular structures. (todayspractitioner.com)
- Recent evidences reveal that post 1,25-(OH) 2 D 3 treatment, LRP1 expression increases significantly for both in-vivo and in-vitro studies, since Vitamin D receptors (VDR) are broadly expressed in brain. (todayspractitioner.com)
Levels1
- Niacin is a B vitamin that can improve all lipoprotein levels. (cdc.gov)
Vitamin1
- This is because so many vitamin D receptors are expressed in the brain. (todayspractitioner.com)
Medicine1
- If you have high low-density lipoprotein (LDL) cholesterol, your health care team may prescribe medicine in addition to lifestyle changes to manage your LDL cholesterol level. (cdc.gov)
Mechanism1
- Upon induction of LTP, but not other forms of short- or long-lasting plasticity, pro-MMPs are rapidly (within ∼ 15 min) converted to proteolytically active MMPs through an NMDA receptor-dependent mechanism. (nature.com)
Tissues1
- LRP-1 is a large receptor present on the body's cells and is widely expressed, or present, in several tissues . (todayspractitioner.com)
High1
- June 22, 2020 For decades, high-density lipoprotein (HDL) cholesterol has been dubbed 'good cholesterol' because of its role in moving fats and other cholesterol molecules out of artery walls. (sciencedaily.com)