lcn2 is also known as 24p3 and neutrophil gelatinase-associated lipocalin (NGAL) ( Borregaard and Cowland, 2006 ). (jneurosci.org)
Objective We aimed to investigate whether preoperative serum neutrophil gelatinase-associated lipocalin (sNGAL pre-op ) predicted postoperative acute kidney injury (AKI) during hospitalisation and 1-year cardiovascular and all-cause mortality following adult cardiac surgery. (bmj.com)
Background and aims To investigate the value of urinary neutrophil gelatinase associated lipocalin (NGAL) kidney injury molecular-1 (KIM-1) and interleukin-18 (IL-18) in the diagnosis of acute kidney injury (AKI) following childhood cardiopulmonary bypass (CPB). (bmj.com)
The search for early diagnostic methods revealed the Neutrophil gelatinase-associated lipocalin (NGAL) as a novel biomarker for detecting acute tubular injury (ATI). (fortuneonline.org)
On the other hand, the biomarker Neutrophil gelatinase-associated lipocalin (NGAL) can detect active tubular injury (ATI) from two hours after the start of the inducing event [1,2] which shows the precocity of NGAL in comparison to the traditional markers. (fortuneonline.org)
Neutrophil gelatinase-associated lipocalin (NAGL): a novel biomarker for acute kidney injury]. (biu.ac.il)
Dive into the research topics of '[Neutrophil gelatinase-associated lipocalin (NAGL): a novel biomarker for acute kidney injury]. (biu.ac.il)
The objective of this research was to investigate the application of Neutrophil Gelatinase-Associated Lipocalin (NGAL) canine biomarker, a protein that is increasing when renal tubular cells damage resulted for the acute kidney injury and kidney diseases in dogs. (tci-thaijo.org)
Serum and urine neutrophil gelatinase-associated lipocalin (NGAL) concentration in healthy dogs and dogs with chronic kidney disease. (tci-thaijo.org)
Review: neutrophil gelatinase-associated lipocalin: a troponin like biomarker for human acute kidney injury. (tci-thaijo.org)
Neutrophil Gelatinase-Associated Lipocalin in Dogs with Naturally Occurring Renal Diseases. (tci-thaijo.org)
The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. (tci-thaijo.org)
Neutrophil gelatinase-associated lipocalin, a sensitive urinary biomarker of acute kidney injury in dogs receiving gentamicin. (tci-thaijo.org)
Objective To evaluate renal tubular damage in dogs with stable MMVD by evaluation of urinary neutrophil gelatinase-associated lipocalin (NGAL). (unipr.it)
Does Whole-Blood Neutrophil Gelatinase-Associated Lipocalin Stratify Acute Kidney Injury in Critically Ill Patients? (wustl.edu)
Neutrophil gelatinase-associated lipocalin (NGAL) is a secretory protein found in neutrophils, endothelial cells and in various organs of the gastrointestinal, respiratory, excretory and reproductive systems. (edu.pl)
Mishra J., Ma Q., Prada A., Mitsnefes M., Zahedi K., Yang J., Barasch J., Devarajan P. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. (edu.pl)
Chakraborty S., Kaur S., Guha S., Batra S.K. The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer. (edu.pl)
After logistic regression analysis, urinary neutrophil gelatinase-associated lipocalin (NGAL) and serum creatinine (SCr) at diagnosis of AKI showed significant association with nonresponse to volume expansion therapy. (figshare.com)
Apart from being an acidic medium containing an assortment of antimicrobial molecules including antibodies (IgA and IgG), mucins, β-defensins, secretory leucocyte protease inhibitor (SLPI), neutrophil gelatinase-associated lipocalin (NGAL), surfactant protein etc. (frontiersin.org)
Additionally, there is concomitant production of mucins, immunoglobulins (secretory IgA and IgG), secretory leucocyte protease inhibitor (SLPI), neutrophil gelatinase-associated lipocalin (NGAL), and β-defensins, and other antimicrobial proteins, which all together provide a formidable first line of defense against infection. (frontiersin.org)
Methods and results: We measured estimated glomerular filtration rate (eGFR), urinary/serum neutrophil gelatinase-associated lipocalin (NGAL), and urinary albumin-to-creatinine ratio (u-ACR) in individuals with biopsy-proven. (lu.se)
Nevertheless, higher urine cadmium was inversely associated with estimated glomerular filtration rate (eGFR) (beta: -4.23, 95% confidence interval [CI]: -6.92, -1.54) and positively associated with neutrophil gelatinase-associated lipocalin (NGAL) (beta: 2.92, 95% CI: 1.20, 4.64). (cdc.gov)
NGAL(Neutrophil Gelatinase Associated Lipocalin) [Time Frame: The first administration time, 4 weeks and 24 weeks after the third administration. (who.int)
Balkanay enrolled adult patients undergoing CABG found a significant difference between high dose group (8 μg/kg) and low dose group (4 μg/kg) for the 24th postoperative hour in the mean values of neutrophil gelatinase-associated lipocalin (NGAL), [ 17 ] indicating that dexmedetomidine had marked effects on renoprotection in a dose-dependent fashion. (medscape.com)
Lipocalin 2 (Lcn2) also called neutrophil gelatinase B-associated lipocalin (NGAL) is an anti-microbial peptide originally identified in neutrophil granules. (healthandwellnesssource.org)
NGAL is a 25-kD protein of the lipocalin family. (medscape.com)
LCN27
citation needed] LCN2 (Lipocalin 2) acts as bone-derived hormone which crosses the BBB and acts on PVN paraventricular nucleus of hypothalamus in the brain. (wikipedia.org)
Lipocalin 2 (lcn2) is a member of the lipocalin family that binds to small hydrophobic molecules. (jneurosci.org)
OBJECTIVE- We identified lipocalin 2 ( Lcn2 ) as a gene induced by dexamethasone and tumor necrosis factor-α in cultured adipocytes. (diabetesjournals.org)
Een positieve uitkomst van dit voorstel verbetert niet alleen het begrip van deze complexe ziekte, maar zal ook het potentieel aan kunnen tonen van Lcn2 en Lcn2 receptoren als aangrijppunt voor vroegdiagnostiek in het proces van de ziekte van Alzheimer. (neurodegenerationresearch.eu)
Daarnaast heeft dit voorstel als doel om aan te tonen of Lcn2 en Lcn2 receptoren mogelijk een therapeutisch aanknopingspunt kunnen zijn. (neurodegenerationresearch.eu)
Lipocalin-2 (LCN2) is an iron-binding protein that has been associated with skeletal muscle regeneration, but details regarding its role in obese sarcopenia remain unclear. (gnu.ac.kr)
Lipocalin-2 (LCN2) deregulation has been reported in several types of cancer and is implicated in the proliferation, migration, angiogenesis, and progression of tumors . (bvsalud.org)
Proteins16
The lipocalins are a family of proteins which transport small hydrophobic molecules such as steroids, bilins, retinoids, and lipids, and most lipocalins are also able to bind to complexed iron (via siderophores or flavonoids) as well as heme. (wikipedia.org)
Lipocalin proteins are important key players of nutritional immunity by withholding and sequestering micronutrients. (wikipedia.org)
Examples of lipocalin proteins involved in immune system responses include alpha-1-microglobulin, alpha-1-acid glycoprotein, and C8gamma. (wikipedia.org)
Structural information for many immune system influencing lipocalin proteins is available, while their exact role in biological systems is still somewhat unclear. (wikipedia.org)
Lipocalins are comparatively small in size, and are thus less complicated to study as opposed to large, bulky proteins. (wikipedia.org)
Major urinary proteins, a lipocalin subfamily, are found in mouse and rat urine and may act as protein pheromones themselves. (wikipedia.org)
Retinol absorption and metabolism depends on lipocalins that act as binding proteins. (wikipedia.org)
After intake, they are converted to retinol, successively metabolized, and finally bound to retinol binding proteins (lipocalins) in the blood plasma. (wikipedia.org)
Because lipocalins are extracellular proteins, their intracellular effects are not obvious, and demand further study. (wikipedia.org)
citation needed] Although lipocalins are a broad family of greatly varied proteins, their three-dimensional structure is a unifying characteristic. (wikipedia.org)
The name "lipocalin" has been proposed for this protein family, but cytosolic fatty acid binding proteins are also included. (wikipedia.org)
The lipocalins are also part of a larger protein superfamily: the calycins, which includes the fatty acid binding proteins, avidins, a group of metalloproteinase inhibitors, and triabin. (aston.ac.uk)
Lipocalins are proteins that bind and transport various substances. (aaltoscientific.com)
Among these are lipocalins, ubiquitous barrel-shaped proteins that sequester small, typically hydrophobic molecules. (ox.ac.uk)
also called orosomucoid) is synthesized in the liver and structurally belongs to the lipocalin superfamily of secretory proteins, such as retinol-binding protein and α1-microglobulin. (cdc.gov)
Biomarker3
#Multiple Sclerosis ] - fecal Lipocalin-2 (Lcn-2), a biomarker of intestinal inflammation, was significantly elevated and predominantly produced by the gut-infiltrating neutrophils. (metabiom.org)
The lipocalin-2 and calprotectin tandem represents a significant biomarker signature for predicting NEC development. (cheoresearch.ca)
Lipocalin-2 Upregulation in Nasopharyngeal Carcinoma: A Novel Potential Diagnostic Biomarker. (bvsalud.org)
Belongs to the lipocalin1
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. (nih.gov)
Kernel lipocalins2
The sequences of most members of the family, the core or kernel lipocalins, are characterised by three short conserved stretches of residues, while others, the outlier lipocalin group, share only one or two of these. (wikipedia.org)
Most lipocalins share three characteristic conserved sequence motifs - the kernel lipocalins - while others are more divergent family members - the outlier lipocalins - typically sharing only one or two. (aston.ac.uk)
Serum1
A competitive ELISA for quantitative measurement of Canine Lipocalin Type Prostaglandin D Synthase in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. (gentaur.pl)
Protein family1
Flower D.R. The lipocalin protein family: structure and function. (edu.pl)
Acute1
Lipocalin-2 is an acute phase protein known to be upregulated in various disease models and has been observed to have a protective as well as a destructive role dependent on the model analyzed, via modulation of pro/anti-inflammatory signalling. (pcom.edu)
Secretory1
A lipocalin of approximately 200 amino acids that functions as an iron transporter and is expressed by cells of BONE MARROW and many other cells with secretory functions. (bvsalud.org)
Ligands2
Lipocalin allergens have been shown to evoke a Th2-deviated immune response, important for allergic sensitization, when applied in their apo-form (with an empty calyx devoid of ligands), whereas the holo-form seemed to exert immune-suppressive properties in vitro. (wikipedia.org)
However, lipophilic ligands, present as substituents to the lipocalins, have the ability to enter the cell, where they can act as tumor protease inhibitors. (wikipedia.org)
MeSH1
Lipocalins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
Salivary2
Substrate prediction of Ixodes ricinus salivary lipocalins differentially expressed during Borrelia afzelii infection. (ox.ac.uk)
This study was initiated by mining the Ixodes ricinus salivary gland transcriptome for specific, uncharacterized lipocalins: three were identified. (ox.ac.uk)
Prostaglandin3
Lipocalins have been associated with many biological processes, among them immune response, pheromone transport, biological prostaglandin synthesis, retinoid binding, and cancer cell interactions. (wikipedia.org)
E08L0212-48 Dog Lipocalin Type Prostaglandin D. (gentaur.pl)
Anti-Prostaglandin D Synthase (Lipocalin)/PDS antibody [EP12357] by Abcam, Cat. (lucerna-chem.ch)
Bind1
Both structural analysis and biophysical simulations generated robust predictions showing these I. ricinus lipocalins have the potential to bind monoamines similar to other tick species previously reported. (ox.ac.uk)
Abstract1
abstract = "Lipocalins are remarkably diverse at the sequence level yet have highly conserved structures. (aston.ac.uk)
Binds1
Like other members of the lipocalin family, BLG these specific interactions have been shown to be critical for has a -barrel fold with a large internal cavity that binds dimer stability (Kobayashi et al. (lu.se)
Astrocytes1
However, within the brain, lipocalin 2 was also detected in astrocytes, particularly in regions typically affected in patients with MS. The increase of lipocalin 2 in the cerebrospinal fluid and in astrocytes was reverted by natalizumab treatment. (escholarship.org)
Fatty1
A phylogenetic analysis using 803 sequences places the three I. ricinus lipocalins with tick lipocalins that sequester monoamines, leukotrienes and fatty acids. (ox.ac.uk)
Diagnosis1
Pooling the data for each infant confirmed the significance of lipocalin-2 and calprotectin, individually and in combination 1 week in advance of the NEC clinical diagnosis. (cheoresearch.ca)
Fold1
Lipocalins have an eight-stranded, antiparallel, symmetrical β-barrel fold, which is, in essence, a beta sheet which has been rolled into a cylindrical shape. (wikipedia.org)
Patients2
Most importantly, the results obtained in the murine model were translatable into humans since patients from two different cohorts presented increased cerebrospinal fluid lipocalin 2 levels. (escholarship.org)
Blood London have been providing Lipocalins on a self-referral basis to patients in Central and Greater London for over 20 years. (blood.london)
PLS31
CONCLUSION: We conclude that plasma lipocalin-2 is not altered in WNT1 or PLS3 mutation-positive subjects but is associated with FGF23 in abnormal WNT1 or PLS3 signaling and with iron status in abnormal WNT1 signaling. (harvard.edu)
Biomarkers1
Biomarkers were evaluated in all available stool samples leading to the identification of lipocalin-2 and calprotectin as the two most reliable predicting markers over the 10-day period prior to NEC development. (cheoresearch.ca)
Family1
The lipocalin family has been connected with the transport of mammalian pheromones due to easily observable protein-pheromone interactions. (wikipedia.org)
Classification1
Inside this barrel is located a ligand binding site, which plays an important role in the lipocalin classification as a transport protein. (wikipedia.org)
Diagnostic1
The findings support lipocalin 2 as a valuable molecule for the diagnostic/monitoring panel of MS. (escholarship.org)
Kidney1
Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. (edu.pl)
Role2
Differential expression of these I. ricinus lipocalins during feeding at distinct developmental stages and in response to Borrelia afzelii infection suggests a role in transmission of this Lyme disease spirochete. (ox.ac.uk)
The multidisciplinary approach employed in this study characterized unique lipocalins that play a role in tick blood-feeding and transmission of the most important tick-borne pathogen in North America and Eurasia. (ox.ac.uk)
Disease2
notably, the cerebrospinal fluid lipocalin 2 levels coincided with the active phases of the disease. (escholarship.org)
Xu S., Venge P. Lipocalins as biochemical markers of disease. (edu.pl)
Expression1
Immunostaining revealed that neutrophils infiltrating the CP were the source of the increased lipocalin 2 expression in this structure. (escholarship.org)