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  • raft
  • PrPC raft association, together with raft lipid composition, appears essential for the conversion of PrPC into the scrapie isoform PrPSc, and the development of prion disease. (jove.com)
  • Indeed, lipid raft size has been estimated to be around 20 nm 6 , far under the resolution limit of conventional microscopy (around 200 nm), thus precluding their direct imaging. (jove.com)
  • FCS can be used to determine the lipid raft partitioning of various probes, as long as they are fluorescently tagged. (jove.com)
  • It can also be used to follow the dynamics of lipid raft partitioning after drug addition or membrane lipid composition change 12 . (jove.com)
  • 1982
  • He was a founder (with E.C. Whitehead) and a director of the Liposome Company, Inc. from 1982 to 2000, and two drugs based on his liposome work are now in the clinic (Abelcet and Myocet). (wikipedia.org)
  • Liposomes-A Selective Drug Delivery System for the Topical Route of Administration: Gel Dosage Form, Journal of Pharmaceutics and Pharmacology, vol. 34 (1982), pp. 473-474. (patentgenius.com)
  • fluorescence
  • This method, termed Fluorescence Correlation Spectroscopy (FCS), relies on the disparity in diffusion times of fluorescent probes located inside or outside of lipid rafts. (jove.com)
  • Molecular
  • On the molecular level, unsaturated double bonds make it harder for the lipids to pack together by putting kinks into the otherwise straightened hydrocarbon chain. (wikipedia.org)
  • Computational simulations of phospholipids are often performed using molecular dynamics with force fields such as GROMOS, CHARMM, or AMBER. (wikipedia.org)
  • Oil chemists often use spectroscopy to determine total Phosphorus abundance and then calculate approximate mass of phospholipids based on molecular weight of expected fatty acid species. (wikipedia.org)
  • structure
  • Vesosome multicompartment structure encapsulates unilamellar liposomes within a second bilayer. (wikipedia.org)
  • Vesosome structure has taken advantage of the progress in liposome development as steric stabilization, pH loading of drugs (it is loaded by pH gradient), and intrinsic biocompatibility (it can be modified with a variety of agents, for example to specifically target a disease site, or promote adhesion or fusion). (wikipedia.org)