Loading...
  • biosynthesis
  • Cell biological studies of the synthesis of yolk protein precursors by the insect's metabolic tissue and their accumulation by developing oocytes were followed by biochemical investigation of vitellogenin (Vg) biosynthesis, the major yolk protein precursor. (ucr.edu)
  • The precursor-product relationship and the major steps in biosynthesis of mosquito Vg, as well as the analysis of its protein sequence, have been pursued. (ucr.edu)
  • Dolichyl monophosphate is an essential glycosyl carrier lipid for C- and O-mannosylation and N-glycosylation of proteins and for biosynthesis of glycosylphosphatidylinositol anchors in endoplasmic reticulum (ER). (wikipedia.org)
  • membrane protein
  • Compared to other classes of proteins, the determination of membrane protein structures has remained a challenge in large part due to the difficulty in establishing experimental conditions where the correct conformation of the protein in isolation from its native environment is preserved. (wikipedia.org)
  • The TIM23 complex is made up of the subunits Tim17, Tim21 and Tim23, which are thought to contribute to the structural formation of the translocation channel that spans the inner membrane, and Tim44, which is a peripheral membrane protein. (wikipedia.org)
  • synthesis
  • This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. (wikipedia.org)
  • sphingolipid
  • CLN8 has been linked to the accumulation of subunit c of mitochondrial ATP synthase and a small amount of sphingolipid activator proteins in the neurons. (wikipedia.org)
  • SCP2
  • The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. (wikipedia.org)
  • molecules
  • Two or more ions or molecules share the carrier. (brainscape.com)
  • Transport proteins move molecules and ions across the membrane. (wikipedia.org)
  • For example, in insects, the desaturase is critical in the formation of ceramide, and for complex signalling molecules (pheremones), while in fungi, the function of the enzyme, and concentration of unsaturated lipids is regulated in response to function of growth temperature by controlling membrane fluidity in cells. (wikipedia.org)
  • As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum. (wikipedia.org)
  • hydrophobic
  • It is possible that this small Tim complex is able to stabilise precursor carrier proteins by acting as a chaperone and preventing the hydrophobic precursors from aggregating in the aqueous environment of the intermembrane space. (wikipedia.org)
  • precursors
  • This was the first demonstration that subtilisin-like pro-protein convertases, which are serine proteases implicated in proteolytic processing of neurohormone precursors, are involved in the processing of a major secretory protein. (ucr.edu)
  • binds
  • What protein binds to acidic drugs? (brainscape.com)
  • Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. (wikipedia.org)
  • Polypeptide
  • Polypeptide toxins and many antibacterial peptides, such as colicins or hemolysins, and certain proteins involved in apoptosis, are sometimes considered a separate category. (wikipedia.org)
  • enzymes
  • These include enzymes called ceramide-activated Ser-Thr phosphatases (CAPPs), such as protein phosphatase 1 and 2A (PP1 and PP2A), which were found to interact with ceramide in studies done in a controlled environment outside of a living organism (in vitro). (wikipedia.org)
  • apoptosis
  • This protein likely functions as a trigger for apoptosis through upregulation of genes necessary for cell death, such as Bim and PUMA, or downregulation of anti-apoptotic proteins such as FLIP. (wikipedia.org)
  • interact
  • However, ceramide can possibly interact with other lipids to form bigger regions called microdomains which restrict its flip-flopping abilities. (wikipedia.org)