• So, the purpose of this study is to identify the relationship between the physical activity level and the hepatic steatosis presence, metabolic syndrome and the risk of developing type 2 diabetes mellitus in men. (scirp.org)
  • Meanwhile, the relationship between adiponectin and metabolic syndrome in patients with chronic kidney disease has not been clarified. (biomedcentral.com)
  • The aim of this study was to elucidate the relationship between adiponectin level and metabolic syndrome in patients with chronic kidney disease. (biomedcentral.com)
  • Regarding the important impact on clinical outcomes of metabolic syndrome in patients with chronic kidney disease, clarification of the relationship between metabolic syndrome and adiponectin level is mandatory. (biomedcentral.com)
  • We examined the utility of body mass index (BMI) and waist circumference to identify metabolic syndrome in adolescent girls. (cdc.gov)
  • Participants were designated as having metabolic syndrome if they met criteria for 3 of 5 variables: 1) high blood pressure, 2) low high-density lipoprotein cholesterol level, 3) high fasting blood glucose level, 4) high waist circumference, and 5) high triglyceride level. (cdc.gov)
  • We predicted the likelihood of the presence of metabolic syndrome by using previously established cutpoints of BMI and waist circumference. (cdc.gov)
  • 001). Girls with a waist circumference above the cutpoint were more likely than girls with a waist circumference below the cutpoint to have metabolic syndrome ( P = .002). (cdc.gov)
  • Stepwise regression showed that only waist circumference significantly predicted metabolic syndrome. (cdc.gov)
  • Both anthropometric measures were useful screening tools to identify metabolic syndrome. (cdc.gov)
  • Waist circumference was a better predictor of metabolic syndrome than was BMI in our study sample of predominantly African American female adolescents living in an urban area. (cdc.gov)
  • This agglomeration of abnormalities has been referred to as the metabolic syndrome which can be identified by the presence of three of the five following variables: abdominal obesity, elevated triglyceride concentrations, low HDL-cholesterol levels, increased blood pressure and elevated fasting glucose. (researchgate.net)
  • Metabolic syndrome linked to abdominal obesity is also predictive of recurrent coronary events both in post-myocardial infarction patients and among coronary artery disease men who underwent a revascularization procedures. (researchgate.net)
  • It is suggested that until the epidemic progression of obesity is stopped and obesity prevented or at least properly managed, cardiologists will be confronted to an evolving contribution of risk factors where smoking, hypercholesterolemia and hypertension may be relatively less prevalent but at the expense of a much greater contribution of abdominal obesity and related features of the metabolic syndrome. (researchgate.net)
  • The severity of having one or more aggregated cardiovascular risk factors for metabolic syndrome is known as the metabolic syndrome severity (MetSS), and can be measured with the metabolic syndrome severity score (MetSSS). (biomedcentral.com)
  • Metabolic syndrome and abdominal obesity were defined according to the International Diabetes Federation criteria. (scirp.org)
  • Metabolic Syndrome (MetS) and Type 2 diabetes (T2D) are clinical conditions involving the impaired uptake and utilization of glucose, altered lipid metabolism, and the disruption of the metabolic signaling pathways that regulate insulin secretion from pancreas ( 1 ). (frontiersin.org)
  • The term metabolic syndrome (MS) is used to describe a cluster of metabolic disorders: insulin resistance (IR) or hyperglycemia, abdominal obesity, dyslipidemia (high very-low-density lipoprotein-triglyceride [VLDL-TG] concentration and low plasma high-density lipoprotein cholesterol [HDL-C]), and essential hypertension (HTN). (basicmedicalkey.com)
  • Lee S, Bacha F, Gungor N, Arslanian S " Comparison of different definitions of pediatric metabolic syndrome: relation to abdominal adiposity, insulin resistance, adiponectin, and inflammatory biomarkers. . (bcm.edu)
  • A series of studies published in 2001 show that improving testosterone levels result in increased muscle strength and volume, improved hemoglobin levels and rising Insulin Like Growth Factor-1, the latter of which is an indirect measure of human growth hormone levels. (healthwithoutrisk.com)
  • Hemoglobin A1C levels measure blood sugar control over the previous 90 days with a level of 5.7% indicating insulin resistance and 6.5% or higher as Type 2 diabetes. (healthwithoutrisk.com)
  • We hope that AMRA's technology can help us in developing new drugs to treat diseases associated with lipid overload, such as non-alcoholic fatty liver disease, diabetic heart disease and insulin resistance syndromes. (drugtargetreview.com)
  • As for abdominal obesity group, there was the significant association between 25(OH)D and HbA1c, glucagon, HOMA-IR, baseline insulin and C-p. (researchsquare.com)
  • Basically all research about relationship between 25(OH)D and islet function in T2D has focused on the insulin-secreting β-cells. (researchsquare.com)
  • Too much abdominal fat is associated with a defect in the body's response to insulin. (wustl.edu)
  • However, even in the absence of the hyperglycaemic state which characterizes type 2 diabetic patients, non diabetic individuals with a specific form of obesity, named abdominal obesity, often show clustering metabolic abnormalities which include high triglyceride levels, increased apolipoprotein B, small dense low density lipoproteins and decreased high density lipoproteins-cholesterol levels, a hyperinsulinemic-insulin resistant state, alterations in coagulation factors as well as an inflammatory profile. (researchgate.net)
  • Polycystic ovary syndrome (PCOS) is strongly associated with abdominal obesity and insulin resistance and effective approaches to nutrition (e.g., omega-3 fatty acids intake) might improve the cardiometabolic risk profile. (frontiersin.org)
  • Fasting serum FGF21 and adiponectin levels as well as fasting insulin, glucose, transaminases, and lipid profiles were measured by enzyme-linked immunosorbent assays in 45 lean and 70 obese children aged 7-14 years. (jomes.org)
  • Clinical and investigational evidence suggests that the increased breast cancer risk associated with greater abdominal visceral obesity may be related to anomalous insulin signaling through the insulin receptor substrate 1 pathway, leading to insulin resistance, hyperinsulinemia, and increased concentrations of endogenous estrogen and androgen. (ijmpo.org)
  • Progress in understanding the pathogenesis of the syndrome has been hindered by the challenge of understanding the complex relationships among features of MS, IR or insulin sensitivity, pancreatic β-cell function, and host factors. (basicmedicalkey.com)
  • This new ability to measure both plasma glucose and insulin concentration allowed the development of oral glucose tolerance testing ( 7 ) and the glucose clamp techniques ( 8 ). (basicmedicalkey.com)
  • These methods have proved critical in dissecting the complex relationships between organ-specific IR and insulin secretion. (basicmedicalkey.com)
  • The relationship between IR and insulin secretion is complex. (basicmedicalkey.com)
  • Although a focus is often placed on insulin as a regulator of blood glucose, insulin plays a key role in the regulation of lipid and protein metabolism, in addition to cellular growth and development. (basicmedicalkey.com)
  • These and subsequent studies showed that more insulin-resistant subjects had greater plasma insulin concentration, VLDL-TG, and plasma glucose during the oral glucose tolerance test than did insulin-sensitive subjects, findings supporting the relationship between IR and MS ( 26 ). (basicmedicalkey.com)
  • Lee S, Bacha F, Hannon T, Kuk JL, Boesch C, Arslanian S " Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys: a randomized, controlled trial. . (bcm.edu)
  • Lee S, Bacha F, Gungor N, Arslanian SA " Cardiorespiratory fitness in youth: relationship to insulin sensitivity and beta-cell function. . (bcm.edu)
  • A number of studies have suggested that certain dietary factors as well as age, sex, weight, body mass index (BMI), waist to hip ratio (WHR), education and smoking may have an important link with CVD [6-8]. (who.int)
  • Hazard Ratios (HR) for incident AF was calculated in relation to quartiles of body mass index (BMI), waist circumference, waist hip ratio, waist height ratio, body fat. (lu.se)
  • Results: After adjustment for multiple risk factors, the risk of AF was significantly increased in the 4th versus 1st quartile of weight (HR for men/women = 2.02/1.93), BMI (HR = 1.62/1.52), waist circumference (HR = 1.67/1.63), waist to hip ratio (HR = 1.30/1.24), waist to height ratio (1.37/1.39) and body fat percentage (HR = 1.21/1.45) in men/women. (lu.se)
  • Measures of overall weight (BMI, weight) were slightly more predictive than measures of abdominal obesity (waist hip ratio and waist height ratio) both in men and women. (lu.se)
  • This has led to an increasing evidence for abdominal obesity indices such as waist circumference (WC), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) as predictors of CVD [ 16 , 17 ]. (hindawi.com)
  • Duration of diabetes influence the effect of 25(OH)D on the ratio of glucagon/C-p, on behalf of islet function homeostasis, in T2D patients with abdominal obesity. (researchsquare.com)
  • At eight weeks, waist circumference, waist to height ratio, hemoglobin A1c, total cholesterol, vascular cell adhesion molecule 1 (VCAM-1, an inflammatory cell that contributes to atherosclerosis), and urinary albumin to creatinine ratio (an early indicator of kidney disease) were lower at the end of the study among participants who received French maritime pine bark extract in comparison with the placebo. (lifeextension.com)
  • The present study indicated that daily supplementation with 100 mg of pine bark extract in patients with type 2 diabetes mellitus and microalbuminuria had favorable effects on glycemic control, serum VCAM-1, and urinary albumin to creatine ratio level, as well as total cholesterol concentrations and abdominal obesity which could be helpful in the control of diabetes complications," they concluded. (lifeextension.com)
  • While these and other studies have reported superior prediction of diabetes with waist circumference or waist-to-hip ratio compared with BMI, it is notable that this is far from a universal finding. (diabetesjournals.org)
  • Indeed, a recent meta-analysis of 32 studies concluded that BMI, waist circumference, and waist-to-hip ratio had similar associations with incident diabetes ( 6 ). (diabetesjournals.org)
  • This is the waist/hip ratio. (lightbearers.org)
  • We sought in this study to assess if LAP can outperform BMI, waist-to-height-ratio (WHtR), or waist-to-hip-ratio (WHpR) in identifying prevalent and predicting incident diabetes. (biomedcentral.com)
  • Fat oxidation can be assessed clinically by measuring respiratory quotient (RQ), which is the ratio of the carbon dioxide expired to the oxygen consumed during indirect calorimetry. (frontiersin.org)
  • BackgroundThe relationship between acute combat-related traumatic injury (CRTI) to coronary flow reserve (CFR) and subclinical cardiovascular risk have not been examined and was the primary aim of this study.Methods and resultsUK combat veterans from the ADVANCE cohort study (UK-Afghanistan War 2003-14) with traumatic limb amputations were compared to injured non-amputees and to a group of uninjured veterans from the same conflict. (imperial.ac.uk)
  • METHODS: In a prospective cohort study, we recruited 132 individuals newly diagnosed with IPF and measured 4MGS change over 6 months. (imperial.ac.uk)
  • Body composition was measured by both dual-energy X-ray absorptiometry (DXA) and bioelectrical impedance (BIA) methods. (frontiersin.org)
  • Methods: 1638 patients with abdominal obesity were selected. (scirp.org)
  • ABSTRACT We carried out a dietary intake assessment in 486 adults ≥ 20 from the Tehran Lipid and Glucose Study. (who.int)
  • Tehran Lipid and Glucose Study was initiated in 1998 to determine the risk factors of arteriosclerosis among the urban population of Tehran and to develop population-based measures to control the rising trend of diabetes mellitus and dyslipidaemia. (who.int)
  • Tehran Lipid and Glucose Study was initi- disease (CVD) since the mid-1970s, this ated in 1998 to determine the risk factors of is still the primary cause of morbidity and arteriosclerosis among the urban population mortality in many countries [ 1,2 ]. (who.int)
  • The results showed that the L_K56 group had significant decreases in percent body fat ( p = 0.004), visceral fat area ( p = 0.0007), total body fat mass ( p = 0.018), trunk body fat mass ( p = 0.003), waist circumference ( p = 0.003), glycosylated hemoglobin( p = 0.002) at the end of the study compared with baseline. (biomedcentral.com)
  • The primary outcomes of this study were changes in blood pressure and weight, and the secondary outcomes were changes in body composition, glycosylated hemoglobin A1c (HbA1c), and blood lipids. (researchgate.net)
  • The Nonalcoholic Fatty Liver Disease (NAFLD) is the most prevalent liver disease in adults, and can progress and be characterized as hepatic steatosis (HS) which is derived from the accumulation of lipids in hepatocytes, and histopathologic condition is more than 5% of the weight of liver. (scirp.org)
  • NAFLD can progress and be characterized as hepatic steatosis (HS) which is derived from the accumulation of lipids in hepatocytes, and histopathologic condition is more than 5% of the weight of liver. (scirp.org)
  • Post-mortem analyses of coronary arteries have indicated that obesity (associated with a high accumulation of abdominal fat measured at autopsy) was predictive of earlier and greater extent of large vessels atherosclerosis as well as increase of coronary fatty streaks. (researchgate.net)
  • Lipid accumulation product (LAP) is an alternative continuous index of lipid accumulation, which is computed from waist circumference (WC, cm) and triglycerides (TGs, mmol/l): (WC-65) ×TG (men) and (WC-58) ×TG (women). (biomedcentral.com)
  • Lipid accumulation should be defined and measured specifically in those contexts where accumulation may represent a physiologic danger [ 6 , 7 ]. (biomedcentral.com)
  • These contexts might be described as lipid over accumulation [ 8 ]. (biomedcentral.com)
  • Kahn described a simple index for estimating lipid over accumulation among adults - designated the "lipid accumulation product" (LAP) - based on a combination of two measurements that are safe and inexpensive to obtain. (biomedcentral.com)
  • If LAP is better correlated than BMI with cardiovascular risk factors, this finding would support the notion that the over accumulation of lipid carries worse cardiovascular consequences than the less specific over accumulation of weight [ 9 ]. (biomedcentral.com)
  • Back in 2004, Washington University investigators found that removing abdominal fat with liposuction did not provide the metabolic benefits normally associated with similar amounts of fat loss induced by dieting or exercising. (wustl.edu)
  • The OLS regression and quantile regression further showed that 25(OH)D was associated with glucagon and fasting C-p levels in T2D patients with abdominal obesity. (researchsquare.com)
  • 25(OH)D was negatively associated with glucagon and C-p in T2D patients with abdominal obesity. (researchsquare.com)
  • In the DIRECT-PLUS study, 294 participants with abdominal obesity/dyslipidemia were prospectively randomized to one of three intervention groups: healthy dietary guidelines (standard science-based nutritional counseling), MED, and Green-MED. (biomedcentral.com)
  • Recently, Ross and Katzmarzyk ( 7 ) reported that for a given BMI, individuals with high CRF had lower abdominal skinfold thickness and waist circumference compared with individuals with lower CRF, independent of sex. (diabetesjournals.org)
  • These clinical observations regarding the detrimental health effects of central or upper body obesity were subsequently reinforced by the results of large prospective epidemiological studies of diabetes incidence, in which fat patterning of subjects was estimated using body surface measurements, specifically waist and hip circumferences and skinfold thicknesses ( 2 - 5 ). (diabetesjournals.org)
  • A previous study in a sample of middle-aged men and women found that higher amounts of subcutaneous abdominal fat are associated with lower levels of subclinical atherosclerosis[ 9 ]. (biomedcentral.com)
  • Therefore, the aim of this study was to investigate and compare the relationships of SFT and VFT with carotid atherosclerosis and cardiovascular risk factors in patients with T2DM. (biomedcentral.com)
  • Among them, patients who had undergone thorough evaluations for carotid atherosclerosis and abdominal SFT and VFT were included in this study. (biomedcentral.com)
  • A study appearing in the October 2014 issue of Lipids in Health and Disease found that adherence to a two week Paleo diet resulted in a 9.1 mmHg drop in systolic and a 5.2 mmHg in diastolic blood pressure. (healthyfellow.com)
  • Anthropometric measurements, body composition assessment, and metabolic parameters were measured at baseline and after 60 days of intervention. (biomedcentral.com)
  • In this context, the relatively few large epidemiologic cohorts that have conducted detailed baseline assessments of abdominal fat distribution in combination with prospective evaluations of outcomes such as incident diabetes can provide novel insights into the natural history of the obesity-diabetes relationship. (diabetesjournals.org)
  • Further of Tehran and to develop population-based progress in prevention depends on identify- measures to control the rising trend of dia- ing the population at increased risk [ 1 ]. (who.int)
  • A subsidiary group of 743 people 20 ed between some dietary and non-dietary years from the Tehran Lipid and Glucose factors and risk factors for CVD. (who.int)
  • If these two risk factors have a synergistic relationship, rigorous lifestyle modification may contribute to greater reduction in cardiovascular burden than previously expected. (biomedcentral.com)
  • In various epidemiological studies, a strong positive relationship has been reported between some dietary and non-dietary factors and risk factors for CVD. (who.int)
  • However, it is less clear whether overall fat or abdominal fat distribution are most important for risk of developing AF. (lu.se)
  • This study investigates how different anthropometric measures correlate to the risk of developing clinical AF in the Malmö Diet and Cancer cohort (MDC-cohort). (lu.se)
  • Conclusion: All measures of obesity were associated with increased risk of developing AF. (lu.se)
  • It is well established that abdominal fat gain (the pot belly) increases the risk of cardiovascular disease, heart attack and type 2 diabetes. (healthwithoutrisk.com)
  • AMRA has entered into a unique international collaboration with Pfizer to investigate the relationship between fat and muscle distribution in the body and metabolic health, including risk factors for conditions such as obesity and diabetes. (drugtargetreview.com)
  • Relationship between childhood obesity and these risk factors has not been attested in the Iranian population before. (pharmapdf.com)
  • Although both abdominal fat and low CRF are significant predictors of health risk, the independent contribution of these two factors is not firmly established. (diabetesjournals.org)
  • There are few studies about the relationship between risk factors, NCDs and NAFLD. (scirp.org)
  • Nowadays the relationship between 25-hydroxyvitamin D (25(OH)D) level and the risk of T2D has become a hotspot of research. (researchsquare.com)
  • This lack of clarity in the epidemiologic literature regarding optimal measures of obesity for studies of diabetes risk is due at least in part to the nature of these proxy (surrogate) measurements. (diabetesjournals.org)
  • Katzmarzyk et al previously published sex-, age-, and race/ethnicity-specific body mass index (BMI) and waist circumference cutpoints to identify adolescents at risk for CVD risk factor clustering ( 8 ). (cdc.gov)
  • When waist circumference is equal to or greater than 40 inches in men it is a risk factor. (lightbearers.org)
  • For years, scientists have been aware of a relationship between disease risk and excess belly fat. (wustl.edu)
  • During medical exams, some physicians measure waist circumference to identify patients at increased risk for these problems. (wustl.edu)
  • 1 , 2 This has attracted interest to the use of biomarkers to identify persons who are at risk for the development of metabolic abnormalities and for whom preventive measures could be tailored. (jomes.org)
  • The results indicated that a combination of high waist circumference and elevated fasting blood glucose was associated with a 126% increased risk of CRC. (cannatelehealth.com.au)
  • A statistically significant relationship was found between RLF, the cumulative CMR score and all but one of the risk factors. (biomedcentral.com)
  • Obesity increases CVD risk due to its effect on blood lipid levels. (slideserve.com)
  • Stroke Abdominal obesity appears to predict the risk of stroke in men. (slideserve.com)
  • INT RODUCTIO N: Th e eld erly h ypert en si ve pa ti ent s of ten h aveincreased prevalence of cardiometabolic risk factors and their attendantco-morbidities. (bvsalud.org)
  • Anthropometric factors, glycemic parameters, lipids and factors related to inflammation and kidney function were assessed at the beginning and end of the study. (lifeextension.com)
  • It's the first evidence of a potential mechanistic link between abdominal fat and systemic inflammation. (wustl.edu)
  • At the same time, I am a classic example of a Yale study that indicated that non-overweight women might be more vulnerable to stress, more likely to have excess abdominal fat and higher stress hormone cortisol levels. (spavelous.com)
  • Having excess weight in your abdominal region can lead to fat accumulating in the liver and muscle cells. (healthline.com)
  • 25(OH)D level was associated with HbA1c, glucagon and HOMA-β in non-abdominal obesity group after adjustment. (researchsquare.com)
  • Although the prevalence of smoking in the Western world has progressively declined over the past forty years - due largely to effective and comprehensive tobacco control measures - tobacco consumption remains high in many countries across Asia where about 40-70% of men smoke [ 4 ]. (biomedcentral.com)
  • In another study, supplementation with Lactobacillus plantarum reduced fat mass and serum lipid profile concurrently with downregulation of lipogenic gene expression in the adipocytes, and modulated gut microbiota composition, resulting in reductions in the bodyweight of high fat diet (HFD) fed obese mice [ 13 ]. (biomedcentral.com)
  • Anthropometric indices, biochemical parameters, serum 25(OH)D, and islet function including C-peptide (C-p) and glucagon were measured. (researchsquare.com)
  • Serum omega-3 fatty acid levels were measured with the gas chromatography method. (frontiersin.org)
  • Waist circumference (WC) measurements were carried out in duplicate and the arithmetic mean was calculated. (bvsalud.org)
  • When the Fatty acid (FA) oxidation capacity in the muscle decreases, the intramyocellular lipid concentration increases ( 5 ). (frontiersin.org)
  • The enzyme aromatase can convert testosterone to estradiol so measuring estradiol levels is part of the protocol for monitoring men on testosterone replacement. (healthwithoutrisk.com)
  • The lipid panel will also show doctors the levels of high density lipoprotein (HDL) and low density lipoprotein (LDL) in your blood. (healthline.com)
  • For this study, Yuelong Ji, Ph.D., of the Johns Hopkins Bloomberg School of Public Health and colleagues measured the levels of acetaminophen in umbilical cord blood taken after childbirth from 996 women who were part of a study called the Boston Birth Cohort. (psychnews.org)
  • These factors were compared between obese and overweight children and their correlations with body mass index and other measures of obesity were tested. (pharmapdf.com)
  • This study sought to evaluate the relationship between FGF21 and metabolic parameters in obese Korean children and adolescents. (jomes.org)
  • One interesting finding is that fibroblast growth factor 21 (FGF21) plays a central role in the maintenance of glucose and lipid homeostasis. (jomes.org)
  • The aim of this master's thesis was to identify differences in the development and health of infants primarily fed with either milk-fat (MF) or vegetable-oil (VO) based formula, during the first year of life, and to elucidate the relativeness of lipid source and structure in currently commercially available formulas for infant growth and infectious morbidity. (helsinki.fi)
  • Many current techniques to measure intracellular lipid can be cumbersome and expensive, which can limit their use in population studies and clinical trials. (drugtargetreview.com)
  • However, mean changes in body fat mass, visceral fat area, weight, body mass index, waist circumference and hip circumference were not significantly different between groups. (biomedcentral.com)
  • The moderate analyses revealed significantly interaction effect of 25(OH)D and glucagon on C-p ( P =0.0124), as well as the effect of 25(OH)D and duration of diabetes on glucagon/C-p in abdominal obesity group. (researchsquare.com)
  • Independent t -test and multivariate correlation analysis were used to evaluate the relationship between FGF21 and metabolic parameters. (jomes.org)
  • RQ measured during fasting reflects a period of high dependency on endogenous FFAs for fuel. (frontiersin.org)
  • Both overall obesity and abdominal obesity were related to incidence of AF in this population-based study, although the relationship for overall obesity was stronger. (lu.se)
  • We chose the IDF definition of MS, instead of that of the ATP-III because the IDF abdominal perimeter cut-off point was one of the selection criteria used in the DESIRE study. (scirp.org)
  • In the present study we aimed to examine the relationship between colorectal cancer and metabolic syndromes. (cannatelehealth.com.au)
  • In a three-month study 17 , subjects given the same dose of green tea extract decreased their body weight 4.6 percent (-7.7 pounds) and waist circumference by 4.48 percent (-4.14 cm). (totalhealthmagazine.com)
  • The measures used to calculate CMR were collected via clinic visits from a population-based cohort study. (biomedcentral.com)