• The PGM3 enzyme is involved in a process called glycosylation, which attaches groups of sugar molecules (oligosaccharides) to proteins. (medlineplus.gov)
  • During this process, complex chains of sugar molecules (oligosaccharides) are added to proteins and fats (lipids). (medlineplus.gov)
  • Glycosylation modifies proteins and lipids so they can perform a wider variety of functions. (medlineplus.gov)
  • The wide variety of signs and symptoms in PGM3 -CDG are likely due to impaired glycosylation of proteins and lipids that are needed for the normal function of many organs and tissues. (medlineplus.gov)
  • Specifically, my research has investigated how human milk oligosaccharides and bioactive milk proteins and lipids impact neonatal gut development, microbiome composition and function, immune development and function and cognitive development, in collaboration with my colleague Ryan Dilger. (nutrition.org)
  • Extraction procedures are optimized to precipitate and remove proteins and nucleic acids while maximizing solubilization of GSLs along with other lipids. (springer.com)
  • Current Chemical Biology covers the following areas: Chemical Synthesis (Syntheses of biologically important macromolecules including proteins, polypeptides, oligonucleotides, oligosaccharides etc. (ingentaconnect.com)
  • CD57, also known as HNK-1, NK-1, and Leu-7 is a 100-115 kD oligosaccharide antigenic determinant expressed on a variety of proteins, lipids, and chondroitin sulfate proteoglycans. (biolegend.com)
  • Oligosaccharide antigenic determinant present on a variety of proteins, lipds, and chrondroitin sulfate proteoglycans, 100-115 kD. (biolegend.com)
  • A number of presentations were focused on the role of CD1 proteins, which present lipid antigens (e.g., from mycobacteria or Francisella tularensis , a potential weapon of bioterrorism) to T cells. (cdc.gov)
  • It serves the human nutrition and health industry through a portfolio of products including vitamins, nutritional lipids, minerals, carotenoids, nutraceuticals, digestive enzymes, probiotics and prebiotics including human milk oligosaccharides (HMOs) and active pharmaceutical ingredients (APIs). (hospitalmanagement.net)
  • Manipulation of the gut microbiota through the administration of prebiotics or probiotics may assist in weight loss and reduce plasma glucose and serum lipid levels, decreasing the incidence of cardiovascular diseases and type 2 diabetes mellitus. (biomedcentral.com)
  • Prebiotics are described by Gibson and Roberfroid as non-digestible poli- or oligosaccharides (OS) that beneficially affect the host by selectively stimulating the growth and/or activity of one or a limited number of beneficial bacteria in the colon [ 8 ]. (biomedcentral.com)
  • Here, we have reviewed recent studies concerning the role of the gut microbiota in metabolic syndrome and the effects of probiotic bacterial strains and prebiotics on the prevention or treatment of metabolic syndrome, such as their anti-obesity and anti-inflammatory effects and their ability to improve glycemic control and modulate serum lipids. (biomedcentral.com)
  • Patrick Adlercreutz researches enzyme technology, focusing on the use of enzymes for production of carbohydrate-based surfactants, oligosaccharides (prebiotics), lipids, and chiral building blocks (used for, e.g., pharmaceuticals). (lu.se)
  • 2018) "Marine Poly- and Oligosaccharides as Prebiotics", Journal of Agricultural and Food Chemistry. (lu.se)
  • Breast milk also contains other immunoglobulins, antibodies, oligosaccharides, lipids, bioactive peptides, among other components with unique mechanisms that besides the protection against these diseases, stimulate the development of infants' immune systems. (bvsalud.org)
  • Synthesis of lipid-linked oligosaccharides by a compartmentalized multi-enzyme cascade for the in vitro N-glycosylation of peptides. (mpg.de)
  • Essential nutrients like oat beta glucan, vitamin E, nutritional lipids and tomato concentrate can be used to develop new foods, beverages and dietary supplements that support whole health for diabetics and those susceptible to the disease. (dsm.com)
  • The oligosaccharide donor for the enzyme is the dolichol pyrophosphate linked oligosaccharide GlcNAc 2 Man 9 Glc 3 . (umassmed.edu)
  • Novel variant pathway in the synthesis of protein- and lipid-1inked, complex-type oligosaccharides. (or.jp)
  • Healthy microbiome is known to improve immunity, nutrient absorption, lipid transport and overall digestive and bowel health. (tatachemicals.com)
  • Specifically, by using lipid nanodiscs as cellular membrane mimics, we obtained yields of up to 440 µg/mL for the single-subunit OST enzyme, 'Protein glycosylation B' (PglB) from Campylobacter jejuni , as well as for three additional PglB homologs from Campylobacter coli, Campylobacter lari , and Desulfovibrio gigas . (biorxiv.org)
  • Being typically a minor component of the cell membrane, they are of utmost importance for biological functions that rely on lipid-lipid and lipid-protein interactions (Schnaar and Kinoshita 2015 ). (springer.com)
  • The results clearly highlight the influence of the different fatty acids of the Gb 3 sphingolipids on the phase behaviour and the binding properties of Shiga toxin B subunits, even though the membranes were only doped with 5 mol% of the receptor lipid. (springer.com)
  • In contrast, globosides are neutral lipid molecules. (springer.com)
  • Sequential mannose trimming of N -glycan, from M9 to M8B and then to oligosaccharides exposing the α1,6-linked mannosyl residue (M7A, M6, and M5), facilitates endoplasmic reticulum-associated degradation of misfolded glycoproteins (gpERAD). (elifesciences.org)
  • By modeling and simulating neuraminidase apo glycoproteins embedded in complex-mixture lipid bilayers, we show that the geometry and dynamics of the neuraminidase enzymatic pocket may differ depending on stalk length, with possible repercussions on the binding of the endogenous sialylated-oligosaccharide receptors. (nih.gov)
  • In enzymology, a glycolipid 3-alpha-mannosyltransferase (EC 2.4.1.132) is an enzyme that catalyzes the chemical reaction in which an alpha-D-mannosyl residue is transferred from GDP-mannose to a lipid-linked oligosaccharide, being attached by an alpha-1,3-D-mannosyl-D-mannose bond. (wikipedia.org)
  • Lipid modulation of glycolipid receptor function‐an approach to soluble mimics. (or.jp)
  • Of note, with these extraction procedures, GSLs are categorized by their glycan structure, whereas the lipid tails are not determined (Fahy et al. (springer.com)
  • These protocols are specific to each lipid category but can be also applied to several types of biological matrices. (lipidmaps.org)
  • Aiming to produce functional oligosaccharides such as di-D-fructose dianhydrides (DFAs) from inulin in subcritical water (the hot compressed water), the hydrolysis mechanism of inulin was investigated. (go.jp)
  • Other names in common use include mannosyltransferase II, guanosine diphosphomannose-oligosaccharide-lipid II, mannosyltransferase, and GDP-mannose-oligosaccharide-lipid mannosyltransferase II. (wikipedia.org)
  • The design of optimal vaccines against such pathogens should include lipid and peptide antigens. (cdc.gov)
  • In this case you would be targeting the O-antigen or core oligosaccharide. (stackexchange.com)
  • are the simplest lipids but they may be a part of or a source of many complex lipids. (flashcardmachine.com)
  • Oligosaccharyltransferase (OST) catalyzes the transfer of a preassembled high-mannose oligosaccharide onto N-X-T or N-X-S acceptor sites (seqons) as the nascent polypeptide is transported into the RER lumen through the Sec61 complex. (umassmed.edu)
  • This study aimed to determine the effects of fructo-oligosaccharides (FOS) on steatohepatitis and visceral adiposity in an obese mouse model of NASH. (biomedcentral.com)
  • The detoxification is important, as the lipid-A portion of the LPS contributes significantly to sepsis. (stackexchange.com)
  • Analytical methods were selected from special issues and review papers published by LIPID MAPS® Consortium members, maintaining some of the traditional and introducing new ones with the latest technology and instrumentation. (lipidmaps.org)