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  • obesity
  • We examined the combined effects of different types of dietary carbohydrates and fats on the etiology of obesity and its complications in the Zucker fatty (fa/fa) rat, a model of obesity. (biomedsearch.com)
  • In addition, cytochrome P450 2C (CYP2C) expression is decreased and sEH expression is increased in obese Zucker rats, a commonly used animal model of obesity and insulin resistance ( 18 ). (pnas.org)
  • Leptin, a neuroendocrine hormone released by adipose tissue, is important in modulating obesity by signaling satiety and increasing metabolism. (physiology.org)
  • Mutations in the gene encoding leptin ( 46 ) and the leptin receptor lead to profound obesity in mice and rats ( 4 , 5 , 13 , 26 , 44 ) and in humans ( 32 ). (physiology.org)
  • Hepatic
  • RESULTS: Both 0.03% and 0.05% SSC treatment alleviated hepatic steatosis and reduced serum TG and TC concentration significantly in OA fed rats. (biomedsearch.com)
  • Cumulatively, this study provides support for coordinate roles for glucokinase and PFK2 in the elevated hepatic glycolysis in fa/fa rats. (physiology.org)
  • PPAR
  • To understand the molecular basis of the biological effects of KRP-297, we examined the effect on peroxisome proliferator-activated receptor (PPAR) isoforms, which may play key roles in lipid metabolism. (diabetesjournals.org)
  • I. Szatmari, E. Rajnavolgyi, and L. Nagy, "PPAR γ , a lipid-activated transcription factor as a regulator of dendritic cell function," Annals of the New York Academy of Sciences , vol. 1088, pp. 207-218, 2006. (hindawi.com)
  • inflammatory
  • Peripheral tissue insulin resistance involves cellular inflammatory responses thought to be invoked by excess lipid. (physiology.org)
  • The discrepancies in lipid parameters, nutritional and inflammatory markers, blood oxidative indexes, antioxidant micronutrients or trace elements (selenium, zinc, vitamin E) related to polyunsaturated fatty acids were checked in these populations. (unboundmedicine.com)
  • humans
  • However, minimal information exists on effect of SM on cholesterol absorption and metabolism in humans. (biomedcentral.com)
  • In humans, 1 g/day of dietary SM does not alter the blood lipid profile except for an increased HDL-cholesterol concentration and has no effect on cholesterol absorption, synthesis and intraluminal solubilization compared to control. (biomedcentral.com)
  • markers
  • The increase in the C18:1/C18:0 delta9 desaturase activity and enhanced lipid peroxidation without any essential fatty acid deficiency could be early markers of protein-calorie malnutrition. (unboundmedicine.com)
  • adiposity
  • These data suggest that the structural adiposity and functional decline in reproductive tract condition of the dbldb mutants are related to the enhanced cellular lipid deposition observed in this species. (docme.ru)
  • model
  • The obese Zucker rat is a model of hyperinsulinemia and type 2 diabetes. (ahajournals.org)
  • Kimoto N, Hirose M, Futakuchi M, Iwata T, Kasai M, Shirai T. Site-dependent modulating effects of conjugated fatty acids from safflower oil in a rat two-stage carcinogenesis model in female Sprague-Dawley rats. (mercola.com)