• A reaction with unsaturated fatty acid leads to lipid peroxidation products. (eaglebio.com)
  • For example, monoglycerides of the short-chain fatty acids are undoubtedly lipids, but they would not fit the definition on the basis of solubility because they are more soluble in water than in organic solvents. (springer.com)
  • The basic components of lipids are listed in the central column with the fatty acids occupying the prominent position. (springer.com)
  • Some possible effects on lipid biochemistry of differences in the distribution on glycerol of long-chain n-3 fatty acids in the fats of marine fish and marine mammals. (springer.com)
  • Fatty foods are sensitive to photooxidation, [16] which forms hydroperoxides by oxidizing unsaturated fatty acids and ester . (wikipedia.org)
  • Ozone reacts with the unsaturated fatty acids of the lipid layer in cellular membranes, forming hydro peroxides. (silvermedicine.org)
  • Lipid oxidation, particularly oxidation of unsaturated fatty acids such as omega-3 fatty acids, has posed a serious challenge to the food industry trying to incorporate heart-healthy oil products into their lines of healthful foods and beverages. (usda.gov)
  • Benzofuranes (WSSA Group 16), chlorocarbonic acids (Group 26), phosphorodithioates (Group 8), and thiocarbamates (Group 8) are examples of herbicides that are known inhibitors of several plant processes including: 1) biosynthesis of fatty acids and lipids which may account for reported reductions in cuticular wax deposition, 2) biosynthesis of proteins, isoprenoids (including gibberellins), and flavonoids (including anthocyanins), and 3) gibberellin synthesis inhibition which may result from the inhibition of kaurene synthesis. (weedscience.org)
  • The lipid oxidation was measured as lipid hydroperoxide concentration and the significant reduction of lipid oxidation was observed under shelf-life stress tests at both 40 oC and 70 oC. (usda.gov)
  • As consumers are increasingly drawn to fresh meat displays in supermarkets, it becomes essential to understand the science behind the deterioration of these products due to factors like photo lipid oxidation. (wspa.com)
  • Promolux recognizes the intricate science behind meat preservation and has developed proprietary LED lighting technologies that specifically combat the effects of photo and lipid oxidation. (wspa.com)
  • Conventional LED lighting sources often emit visible wavelengths of radiation that affect photo and lipid oxidation, accelerating the deterioration of meat quality and increasing the risk of bacterial growth and spoilage. (wspa.com)
  • The enzyme hydroperoxide dehydratase (EC 4.2.1.92) catalyzes the chemical reaction (9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate ⇌ {\displaystyle \rightleftharpoons } (9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate + H2O This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. (wikipedia.org)
  • Alternatively, indirect methods for assessing oxidative stress have been applied and focus mainly on the oxidative damage ROS cause in biomolecules, such are lipids, proteins, and DNA. (molvis.org)
  • Lipids and proteins are attacked and oxidized, resulting in loss of chlorophyll and carotenoids and in leaky membranes which allow cells and cell organelles to dry and disintegrate rapidly. (weedscience.org)
  • This report aims to establish values for plasma lipid hydroperoxides (LOOH) and total antioxidant status (TAS) in healthy cows and its relationship with milk yield. (copernicus.org)
  • Ladner, C., Ehninger, G., Gey, K.F. and Clemens, M.R. (1989) Effect of etoposide (VP16-213) on lipid peroxi- dation and antioxidant status in a highdose radiochemo- therapy regimen. (scirp.org)
  • Existing studies have confirmed that ferroptosis involves the metabolisms of the Fe, lipids, amino acid, each mechanism is mutually independent but interrelated, and they are formed a complex regulatory network. (frontiersin.org)
  • Sensitizers like myoglobin or hemoglobin, coupled with light, lead to the formation of hydroperoxides, an alternative pathway for hydroperoxide formation compared to the free radical mechanism in autoxidation This process can compromise both the appearance and nutritional quality of meat products. (wspa.com)
  • The Total Lipid Hydroperoxide ELISA Assay Kit is intended for the quantitative determination of peroxides in EDTA-plasma, serum and cell culture supernatants. (eaglebio.com)
  • The Total Lipid Hydroperoxide ELISA Assay kit allows an easy, rapid and precise quantitative determination of the total peroxides in biological samples. (eaglebio.com)
  • When LDL was variably oxidized by dialysis against FeSO4 or CuSO4, or by UV irradiation, the inhibitory activity correlated with TBA reactivity and total lipid peroxides, but not with electrophoretic mobility or fluorescence (360 ex/430 em). (rupress.org)
  • Instead, may protect sperm from premature acrosome reaction in the epididymis by binding to lipid peroxides, which might otherwise interact with phospholipase A2 and induce the acrosome reaction. (joplink.net)
  • The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
  • Further potential but not confirmed hydrolysis products are acetic acid and tert-butyl hydroperoxide. (europa.eu)
  • The lung toxicity was measured using lactate dehydrogenase (LDH) activity assay, lipid hydroperoxide (LPO) assay, histology, and immunohistology analysis. (news-medical.net)
  • Comparative study on the toxicity of methyl linoleate-9,10-ozonide and cumene hydroperoxide to alveolar macrophages. (wur.nl)
  • Silymarin protects against its toxic principle α-amanitin by preventing its uptake through hepatocyte membranes and inhibiting the effects of tumour necrosis factor-α, which exacerbates lipid peroxidation. (springer.com)
  • Anti-obesity and lipid lowering effects of Cymodocea nodosa sulphated polysaccharide on high cholesterol-fed-rats. (szn.it)
  • Instead of trying to find a definition that would include all lipids, it is better to provide a scheme describing the lipids and their components, as illustrated in Fig. 2.1 shows. (springer.com)
  • Up to 99% of the lipids in plant and animal material consist of such esters, known as fats and oils. (springer.com)
  • Biochemical changes of lipids in plant foods and feeds. (csic.es)
  • The Total Lipid Hydroperoxide ELISA Assay kit is for research use only and not to be used in diagnostic procedures. (eaglebio.com)
  • This study aimed to determine whether aerobic training could reduce lipid peroxidation and inflammation at rest and after maximal exhaustive exercise in overweight/obese adolescent girls. (humankinetics.com)
  • Brain regions were analyzed for PQ levels, amount of lipid peroxidation, and functional activity of the 20S proteasome. (nih.gov)
  • When isolated rat hepatocytes were exposed to cumene hydroperoxide (50-200 µM), enhanced lipid peroxidation, decreased glucose-6-phosphatase activity, decreased cytochrome P450 content, and stimulation of aminopyrene demethylation were seen. (nih.gov)
  • In one study, the presence of cumene hydroperoxide accelerated the activation of cytochrome P450scc and inhibited NADPH-dependent lipid peroxidation. (nih.gov)
  • Assays measuring H2O2 production, oxygen consumption, DNA damage and lipid peroxidation were used to assess possible cellular injury following RAW cell incubation with tungstate nanoparticles. (cdc.gov)
  • Mechanism of lipid peroxidation in meat and meat products - a review. (scielo.br)
  • Hypertensive rats presented signs of cardiac oxidative stress, depicted by increased lipid peroxidation. (hindawi.com)
  • However, these changes were not followed by accumulation of lipid peroxidation-generated reactive aldehydes and damaged proteins. (hindawi.com)
  • Surprisingly, lysosomal proteostasis impairment by lipid dysregulation is independent of lipid peroxidation or changes in lysosomal stability, nor is it caused by effects on many other aspects of lysosomal or proteasomal function. (elifesciences.org)
  • Thermal oxidation boosts lipid peroxidation and causes chemical changes in cooking oil. (pitco.com)
  • 3 This acquired dependence on a pathway protecting against lethal lipid peroxidation renders the therapy-resistant high-mesenchymal state particularly sensitive to ferroptosis, thus opening a new window for therapeutic intervention. (nature.com)
  • Free radicals, lipid peroxidation and sperm function. (thieme-connect.com)
  • We have also found that lipofuscin-photosensitized aerobic reactions lead to enhanced lipid peroxidation as measured by accumulation of lipid hydroperoxides and malondialdehyde in illuminated pigment granules. (nih.gov)
  • 1994 The effects of lipid peroxidation on rabbit aortic endothelial cell phospholipid turnover was studied using linoleic acid hydroperoxide (LOOH). (usc.edu)
  • These cell responses indicate that induction of lipid peroxidation produces rapid fatty acid release and phospholipid turnover involving repair as well as de novo synthesis. (usc.edu)
  • Linoleic acid hydroperoxide-induced peroxidation of endothelial cell phospholipids and cytotoxicity. (usc.edu)
  • 1994 Peroxidation of endothelial cell phospholipids was examined following treatments with linoleic acid hydroperoxide. (usc.edu)
  • Over the concentration ranges where lipid peroxidation was evident (20-40 microM treatments in complete medium), significant cytotoxicity was apparent after 1 h of exposure. (usc.edu)
  • GR and GST- and the lipid peroxidation hydroperoxides and free radicals. (who.int)
  • Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (By similarity). (nih.gov)
  • Since ferroptosis is executed by lipid peroxidation, oxygen, polyunsaturated fatty acids (PUFA), and iron are necessary constraints. (unipd.it)
  • Furthermore, since phospholipid hydroperoxides (PL-OOH) have a key role in membrane lipid peroxidation -i.e. their decomposition generates radicals in the membranes- GPx4-mediated regulation of ferroptosis is consistent with both, the mechanisms of lipid peroxidation and protection which have been finely elucidated in vitro in the last forty years of the XX century. (unipd.it)
  • An activatable system has been developed that enables tumor-specific singlet oxygen ( 1 O 2 ) generation for cancer therapy, based on a Fenton-like reaction between linoleic acid hydroperoxide (LAHP) tethered on iron oxide nanoparticles (IO NPs) and the released iron(II) ions from IO NPs under acidic-pH condition. (nih.gov)
  • We subsequently showed that increased lipid uptake and/or disrupted lipid metabolism led to increased lysosomal protein aggregation and, concomitantly, accumulation of sphingolipids and cholesterol esters. (elifesciences.org)
  • Accumulation of phospholipid hydroperoxides is generally prevented by the activity of the main ferroptosis suppressor, glutathione peroxidase 4 (GPX4), that catalyzes the glutathione (GSH)-dependent reduction of lipid hydroperoxides to their corresponding alcohols. (nature.com)
  • Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (PubMed:24439385). (nih.gov)
  • It is a form of death characterized by abnormal intracellular iron metabolism, dysfunction of the glutathione-dependent antioxidant system, and massive accumulation of lipid hydroperoxides. (biomedcentral.com)
  • We have now determined that vit C induces lipid hydroperoxide decomposition to the DNA-reactive bifunctional electrophiles 4-oxo-2-nonenal, 4,5-epoxy-2(E)-decenal, and 4-hydroxy-2-nonenal. (nih.gov)
  • Lipase decomposition produces esters/lipids, which act as emulsifiers to increase the softness of bread. (selfgrowth.com)
  • Furthermore, we proved that this method can be applied to determine the hydroperoxyl group position of esterified lipids (e.g., phospholipids and cholesterol esters ) as well as polyunsaturated fatty acids (PUFAs) including n-3, n-6, and n-9 FA. (bvsalud.org)
  • Lipase will partially break down these added fats into esters/lipids and free fatty acids. (selfgrowth.com)
  • Most enzymes in this family help add an oxygen molecule to certain fatty acids to produce substances called fatty acid hydroperoxides. (medlineplus.gov)
  • show that unlike in blood vessels, the lymph is a more efficient route for tumor metastasis due to a more favorable redox environment, whereby disseminating cancer cells acquire additional protection against ferroptosis via incorporation of monosaturated fatty acids into their lipid bilayers. (nature.com)
  • Combined actions of three enzymes: lipase, lipoxygenase (LOX) and hydroperoxide lyase (HPL) convert lipidic substrates such as C 18:2 and C 18:3 fatty acids into short chain volatiles. (ac.be)
  • Following treatments with 20-40 microM LOOH, cells prelabeled with either arachidonic acid (20:4) or oleic acid (18:1) showed a movement of these fatty acids out of the phospholipids and into neutral lipid and free fatty acid pools. (usc.edu)
  • Cumene hydroperoxide is reduced by glutathione (GSH) to cumenol. (nih.gov)
  • The review further examines the main toxic effects of ROS on lipid, protein, glutathione metabolism, catalase, superoxide dismutases, and antioxidant capacity of plasma. (hindawi.com)
  • The selenium-dependent glutathione peroxidase 4 (GPX4) inhibits ferroptosis, converting unstable ferroptotic lipid hydroperoxides to nontoxic lipid alcohols in a tissue-specific manner. (nih.gov)
  • GPx4 catalyzes a glutathione (GSH)-dependent reduction of membrane hydroperoxides to corresponding alcohols. (unipd.it)
  • These results suggest that lipid dysregulation may have primary effects on the stability of endogenous proteins, potentially through direct biophysical mechanisms. (elifesciences.org)
  • Both ROS and RNS are highly reactive, and can damage proteins, lipids and DNA. (anti-agingfirewalls.com)
  • Interestingly, cells that spontaneously metastasized through the blood also exhibited increased lipid peroxide formation. (nature.com)
  • These screens recovered components of the known proteostasis network, and uncovered a link between protein and lipid homeostasis. (elifesciences.org)
  • Protein and lipid homeostasis are important for maintaining cellular functions but their crosstalk remains largely unknown. (elifesciences.org)
  • However, in our view the experimental evidence in support of the paper's stated conclusions remains incomplete and measures that (i) go beyond reliance on the ProteoStat stain as the sole metric for aggregation and proteostatic challenge, (ii) biochemically back up the results and provide plausible mechanistic insights into the connection of lysosomal lipid handling and protein aggregation are needed. (elifesciences.org)
  • Botanical products can improve glucose metabolism and the overall condition of individuals with diabetes not only by hypoglycemic effects but also by improving lipid metabolism, antioxidant status and capillary function ( Bailey and Day, 1989 ). (scialert.net)
  • 17. Aldose reductase inhibitor, epalrestat, reduces lipid hydroperoxides in type 2 diabetes. (nih.gov)
  • 2010). Selenoprotein P reduces lipid hydroperoxides in human embryonic kidney cells following exposure to 15-hydroperoxyeicosatetraenoic acid. (utah.edu)
  • Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). (nih.gov)
  • When the hydroperoxides decompose, they negatively affect the flavor and decreases the oil quality. (pitco.com)
  • Cumene can react with alkylperoxy radicals and oxygen in natural waters to form cumene hydroperoxide which is readily decomposed by UV light. (nih.gov)
  • At concentrations in excess of 0.5 mM (76 µg/mL), cumene hydroperoxide was cytotoxic to human adenocarcinoma (A549) cells. (nih.gov)
  • The composition of human diet plays an important role in the management of lipid and lipoprotein concentrations in the blood. (scialert.net)
  • Au sein de celle-ci, les actions combinées de trois enzymes, lipase, lipoxygénase (LOX) et hydroperoxyde lyase (HPL), convertissent un substrat lipidique (acides C 18:2 et C 18:3 ) en molécules volatiles à courte chaine. (ac.be)
  • Hydroperoxide and lipid peroxide generation was correlated with an increase in mitochondrial hydrogen peroxide generation and with a reduced functioning of mitochondrial complex I in response to cocaine. (erowid.org)
  • Effect of temperature on lipid composition. (jcadonline.com)
  • An increase in ambient temperature effectuates changes in composition of skin surface lipids (SSL). (jcadonline.com)
  • Oxidized lipids, such as 13-hydroperoxyoctadecadienoic acid (13-HPODE), have been implicated in the pathogenesis of atherosclerosis. (elsevierpure.com)
  • Instead, it is involved in the step following the creation of fatty acid hydroperoxides. (medlineplus.gov)
  • Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). (nih.gov)
  • Cumene hydroperoxide was also shown to inhibit lipoprotein secretion in the Golgi apparatus of rat hepatocytes. (nih.gov)
  • 2010). Selenoprotein P protects cells from lipid hydroperoxides generated by 15-LOX-1. (utah.edu)
  • Human exposure to cumene hydroperoxide can occur in the workplace through contact with emissions produced during its use in acetone and phenol production. (nih.gov)
  • Vitamin C-mediated formation of genotoxins from lipid hydroperoxides in the absence of transition metal ions could help explain its lack of efficacy as a cancer chemoprevention agent. (nih.gov)
  • play an important role in lipid hydroperoxide-induced smooth muscle cytotoxicity. (elsevierpure.com)
  • Of oxidized lipid structures, the hydroperoxyl group position of lipid hydroperoxides (LOOHs) is a critical factor in determining their biological roles . (bvsalud.org)
  • Lipids are important components of all types of meat and are responsible for many desirable characteristics of meats. (scielo.br)
  • At the same time, polar lipids have an effect on increasing the volume of baked products. (selfgrowth.com)
  • In addition, lipids are the main ingredients to manufacture various products, such as soups, butter, ready to eat food, among others for the food industry and other products, such as lipstick, creams, etc, for the cosmetic and pharmaceutical industries. (intechopen.com)
  • This reaction is quite complex and depends on the lipid type used and the processing conditions. (intechopen.com)
  • Lipids contribute very significantly to the quality of almost all kinds of foods. (ijert.org)