GlycosphingolipidsBiosynthesisMoleculesSphingolipidsMetabolismAntibodiesBilayerDropletTriglyceridesPhospholipidsCarbohydrateAcidicNeu5GcGlycoproteinsSphingosineSialicPathwaysCholesterolBioGlycoVesiclesSugarsAcylBiological functionsExamplesInteractionStructuralExpressionStructureStudyCellsMajorSpecific
Glycosphingolipids2
- The right concentrating on of GALC to the lysosome is important for the degradation of glycosphingolipids together with the first lipid part of myelin. (aetox.com)
- Is key in the biosynthesis of glycosphingolipids and gangliosides. (foodb.ca)
Biosynthesis1
- So the study of glycan structures is also complicated by the lack of a proper and direct template for their biosynthesis, contrary to the case with amino acids and proteins. (biochemistryconferences.com)
Molecules3
- In contrast, globosides are neutral lipid molecules. (springer.com)
- The main biological functions of lipids include energy storage, acting as structural components of cell membranes , and participating as important signaling molecules . (wikidoc.org)
- Lipids also encompass molecules such as fatty acids and their derivatives (including tri- , di- , and monoglycerides and phospholipids ), as well as other sterol -containing metabolites such as cholesterol . (wikidoc.org)
Sphingolipids2
- The results clearly highlight the influence of the different fatty acids of the Gb 3 sphingolipids on the phase behaviour and the binding properties of Shiga toxin B subunits, even though the membranes were only doped with 5 mol% of the receptor lipid. (springer.com)
- Sphingolipids attached to a glycan (or a carbohydrate) is referred to as glycosphingolipid. (brainwritings.com)
Metabolism6
- cAMP is associated with kinases function in several biochemical processes, including the regulation of glycogen , sugar , and lipid metabolism . (wikipedia.org)
- Perilipin 5 S155 phosphorylation by PKA is required for the control of hepatic lipid metabolism and glycemic control. (uci.edu)
- Perilipin 5 (PLIN5) is a lipid-droplet-associated protein that coordinates intracellular lipolysis in highly oxidative tissues and is thought to regulate lipid metabolism in response to phosphorylation by protein kinase A (PKA). (uci.edu)
- We detected phosphorylation on S155 and identified S155 as a functionally important site for lipid metabolism. (uci.edu)
- Re-expression of PLIN5 S155A in the liver of Plin5 liver-specific null mice reduced lipolysis compared with wild-type PLIN5 re-expression, but was not associated with other changes in hepatic lipid metabolism. (uci.edu)
- Glycerophospholipids , also referred to as phospholipids , are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling. (wikidoc.org)
Antibodies2
- IgG antibodies in opposition to gangliosides GM1 and GD1a are strongly related to motor axonal variants of Guillain-Barré syndrome, and anti-GQ1b with Miller Fisher syndrome. (aetox.com)
- GBS cluster sufferers have been characterised by a extra extreme medical phenotype with extra sufferers requiring mechanical air flow and better frequencies of auto antibodies in opposition to sulfatide, GalC and sure ganglioside epitopes (54 %) as in comparison with sporadic GBS circumstances. (aetox.com)
Bilayer2
- These EV contain a lipid bilayer associated to membrane proteins. (frontiersin.org)
- The exosome vesicles are a type of extracellular vesicles (EV), which are defined as lipid-bilayer spheroid structures, without replicating capacity, that are released from cells, including both prokaryotes and eukaryotes. (frontiersin.org)
Droplet2
- BSCL2 lipid droplet biogenesi. (gsea-msigdb.org)
- FLIM-FRET analysis of protein-protein interactions showed that PLIN5 S155 phosphorylation regulates PLIN5 interaction with adipose triglyceride lipase at the lipid droplet, but not with α-β hydrolase domain-containing 5. (uci.edu)
Triglycerides3
- Triglycerides (fats) Fat is just one type of lipid and an abbreviation for fatty acids. (brainwritings.com)
- Sterols are lipids and triglycerides are lipids, but cholesterol is not a fat. (brainwritings.com)
- Although the term lipid is sometimes used as a synonym for fats , fats are a subgroup of lipids called triglycerides and should not be confused with the term fatty acid . (wikidoc.org)
Phospholipids2
- How are phospholipids different from other lipids? (brainwritings.com)
- Short answer: Phospholipids have several distinct features, but two major differences from other lipids are that they are amphiphilic - i.e., they are both hydrophilic (head end: attracts water) and hydrophobic (tail end: repels water) - with the polar head end including a phosphate group. (brainwritings.com)
Carbohydrate1
- Discovering carbohydrate and glycan antigens as cancer biomarkers or even abnormal glycation pathways in metabolic disorders such as diabetes inhibited the importance of the expansion of glycoscience in a future, as a way of representing new biomarkers and therapeutic targets in disease. (biochemistryconferences.com)
Acidic1
- Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. (affbiotech.cn)
Neu5Gc1
- The Structural Complexity and Animal Tissue Distribution of N-Glycolylneuraminic Acid (Neu5Gc)-Terminated Glycans. (gu.se)
Glycoproteins3
- immune-mediated nerve problems that concentrate on glycans borne by glycolipids and glycoproteins enriched within the peripheral nerves. (aetox.com)
- Expression of cell-surface glycoproteins was evaluated by SNA lectin blot analysis, as described (5), by using the DIG Glycan Differentiation Kit (Roche Molecular Biochemical), exactly as per the manufacturer's recommendations. (biomedigs.org)
- Sialic acid is a generic term for the N- or O-substituted derivatives of neuraminic acid, a monosaccharide with a nine-carbon backbone and are found widely distributed in animal tissues and to a lesser extent in some other organisms, ranging from fungi,plants,yeasts and bacteria, mostly in glycoproteins and gangliosides. (biochemistryconferences.com)
Sphingosine2
- A molecule comprised of a lipid attached to sphingosine. (cdghub.com)
- This leads to the formation of sphingosine-1-phosphate, a potent signaling lipid. (foodb.ca)
Sialic2
- Based on the ganglio GSL series, gangliosides are synthesized, where sialic acids are linked to the glycan structure to produce negatively charged GSLs. (springer.com)
- Normally, transferrin has two N-glycans each with two sialic acid sugars (tetrasialotransferrin). (cdghub.com)
Pathways1
- Lipids are a diverse group of compounds that have many key biological functions, such as acting as structural components of cell membranes, serving as energy storage sources and participating in signaling pathways. (wikidoc.org)
Cholesterol2
- We found endosomal escape does not play a role for the enhancer effect of MIC while the effect of MIC on MAP30 is cholesterol dependent and that ganglioside GM1, a lipid raft marker, can competitively inhibit cytotoxicity of MAP30 enhanced by MIC. (bvsalud.org)
- As a component of the cell membrane, cholesterol plays an important role in regulating cell membrane fluidity, phase change and permeability, forming lipid rafts and micro-domains on the membrane. (bioglyco.com)
BioGlyco1
- CD BioGlyco has diversified Lipid Analysis services. (bioglyco.com)
Vesicles1
- Extracellular vesicles (EV) are lipid bound products secreted by cells. (biaseparations.com)
Sugars1
- As proteo refers to protein, while glycan represents sugar or a group of sugars, so proteoglycan is a long polysaccharide chain covalently attached to a protein. (biochemistryconferences.com)
Acyl2
- [3] [4] The fatty acyl structure represents the major lipid building block of complex lipids and therefore is one of the most fundamental categories of biological lipids. (wikidoc.org)
- Other major lipid classes in the fatty acyl category are the fatty esters and fatty amides. (wikidoc.org)
Biological functions1
- Being typically a minor component of the cell membrane, they are of utmost importance for biological functions that rely on lipid-lipid and lipid-protein interactions (Schnaar and Kinoshita 2015 ). (springer.com)
Examples2
- Examples are cerebrosides and gangliosides. (brainwritings.com)
- Examples of some lipids from various categories. (wikidoc.org)
Interaction1
- Although the causes leading to α-synuclein aggregation are not clear, the GM1 gangliosideM1interaction is recognized to prevent this process. (bvsalud.org)
Structural2
- UVPD based LC-MS separations of gangliosides shed light on the ceramide lipid bases, glycan moieties, and their isobaric structural variants. (showboat-alkmaar.nl)
- MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
Expression1
- Compared with controls, a marked reduction in adhesion to fibronectin (20C40%) and increase (40C60%) in adhesion to laminin was observed in the two clones (S8 and S25) demonstrating comparatively high levels of ST6GalNAcV mRNA expression and cell surface 2,6-linked gangliosides (Fig. 4). (biomedigs.org)
Structure2
- Of note, with these extraction procedures, GSLs are categorized by their glycan structure, whereas the lipid tails are not determined (Fahy et al. (springer.com)
- Glycolipid entries from the LIPID MAPS Structure Database (LMSD) . (glycosmos.org)
Study1
- The ASD rat model was developed in this study to demonstrate the role and mechanism of ganglioside GM1 (GM1). (bvsalud.org)
Cells1
- It is caused by mutation in the alpha subunit of the HEXOSAMINIDASE A resulting in lipid-laden ganglion cells. (curehunter.com)
Major1
- In this context, major effort has been put in developing synthetic strategies towards gangliosides and the interested reader is referred to an excellent review of Hunter et al. (springer.com)
Specific1
- Lipid-specific oligomerization of the Marburg virus matrix protein VP40 is regulated by two distinct interfaces for virion assembly. (uci.edu)