PeroxidationOxidativeReactive oxygenOxygen-free radAntioxidantsMoleculesHydroxylScavengeOxidationDamageProteinSkin'sMembraneProteinsCellularAtherosclerosisToxicityEliminatesDPPHProtectsMetabolismSuperoxide radicalScavenging ActivityCarcinogensQuercetinSignificantlyDiabetesLiverHarmfulBioactiveMineralCellParticlesAbstractGlutathioneSubstancesCompositionCellsProductionContentResidue
Peroxidation28
- Lipid peroxidation as a measure of oxygen free radical damage in the very low birthweight infant. (bmj.com)
- Lipid peroxidation, hemolysis and thiol contents were studied in intact goat erythrocytes exposed to phenylhydrazine. (scirp.org)
- An increase in lipid peroxidation, hemolysis and thiol content was observed after phenylhydrazine treatment of erythrocyte. (scirp.org)
- Extracellular Ca2+ potentiates the phenylhydrazine-induced lipid peroxidation and hemoly- sis of erythrocytes significantly. (scirp.org)
- No effect of Ca2+ on control lipid peroxidation, hemolysis and thiol contents of erythrocytes was observed. (scirp.org)
- Diltiazem and EDTA inhibited the increased responses of lipid peroxidation and hemolysis due to Ca2+. (scirp.org)
- Lu, C., Chan, S.L., Fu, W. and Mattson, M.P. (2002) The lipid peroxidation product 4-Hydroxyneal facilitates op- ening of voltage dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation. (scirp.org)
- Reactive oxygen species (ROS) can be generated when organisms are exposed to a material causing cellular damage such as lipid peroxidation, H2O2 production and DNA damage. (cdc.gov)
- We used electron spin resonance, analysis of lipid peroxidation, measurement of H2O2 production and the comet assay to assess generation of ROS from SiNW and define possible mechanisms. (cdc.gov)
- Free radicals are known to cause oxidative damage by increasing polymorphonuclear leukocytes and by inducing lipid peroxidation [ 2 , 3 ]. (hindawi.com)
- These conditions lead to the damage of mitochondria [ 20 ], and cigarette smoke may even induce liver injury via lipid peroxidation and corresponding inflammation [ 21 , 22 ]. (hindawi.com)
- Epidemiological studies indicate that fruits and vegetables may reduce free radical-induced oxidative damage and lipid peroxidation in cigarette smokers [ 23 ]. (hindawi.com)
- Zinc stabilizes cell membranes by reducing free radicals and preventing lipid peroxidation. (medscape.com)
- When hydroxyl free radicals interact with cell membranes they cause lipid peroxidation. (naturalnews.com)
- [9] Research into how vitamin E prevents the process of lipid peroxidation led to the identification of antioxidants as reducing agents that prevent oxidative reactions, often by scavenging reactive oxygen species before they can damage cells. (wikipedia.org)
- CSF lipid peroxidation was increased in patients taking phenothiazine. (nature.com)
- It was shown to inhibit lipid peroxidation and UV-induced crosslinking of collagen. (sigmaaldrich.com)
- When fat molecules interact with free radicals, they result in lipid peroxidation. (findingoptimism.com)
- Lipid peroxidation results in neurodegenerative conditions such as Alzheimer's and Parkinson's. (findingoptimism.com)
- An antioxidant, quercetin scavenges free radicals and inhibits damage-perpetuating, post-injury lipid peroxidation . (healingtherapies.info)
- Post-injury hemorrhaging causes the hemoglobin within red blood cells to disintegrate, releasing oxidized iron, which triggers lipid peroxidation. (healingtherapies.info)
- Like quercetin, vitamin E is an antioxidant that protects neuronal membranes from lipid-peroxidation. (healingtherapies.info)
- Dr. Royal Saunders and co-investigators (1987, Ohio) investigated the effects on lipid peroxidation of treating experimentally injured cats with a combination of vitamin E and another antioxidant, selenium. (healingtherapies.info)
- C ompared to untreated controls, the spinal-cord tissue at the injury site of the antioxidant-treated cats had fewer molecules associated with lipid-peroxidation. (healingtherapies.info)
- Examples of the possible consequences of free radical damage are provided with special emphasis on lipid peroxidation. (nih.gov)
- Further study of reactive oxygen species was conducted using analysis of cellular H2O2 generation, lipid peroxidation of cellular membranes and DNA damage. (cdc.gov)
- The ultrafine particles also caused significant increases in H2O2 production by monocytes and lipid peroxidation. (cdc.gov)
- GR and GST- and the lipid peroxidation hydroperoxides and free radicals. (who.int)
Oxidative10
- In addition, oxygen-derived reactive oxygen species including hydrogen peroxide and nitrogen free radicals, such as superoxide, hydroxyl radical and nitric oxide radical, undergo a complicated sequence of electron transfer reactions with other biomolecules, which lead to their modified physiological functions and diverse biological and pathophysiological consequences (e.g. oxidative stress). (nih.gov)
- Chowdhury, T.D., Das, N., Chattopadhyay, A. and Datta, A.G. (1999) Effect of oxidative stress and erythropoietin on cytoskeletal protein and lipid organization in human erythrocytes. (scirp.org)
- While the molecular mechanisms of tobacco smoke toxicity are still not fully understood, free radical-mediated oxidative stress is believed to play a central role [ 16 , 17 ]. (hindawi.com)
- Not only does cigarette smoke increase oxidative stress by increasing free radicals but also by weakening of antioxidant defenses, such as decreasing paraoxonase enzyme activity [ 19 ]. (hindawi.com)
- NewsTarget) Oxidative stress represents an imbalance between the production of reactive oxygen species (free radicals) and the body's ability to detoxify the reactive intermediates and repair the resulting damage. (naturalnews.com)
- For example, high levels of glucose in blood activate oxidative stress -- damage of protein, lipid, and DNA molecules by free radicals. (news-medical.net)
- Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
- Oxidative stress, defined as a disturbance in the balance between the production of reactive oxygen species (free radicals) and antioxidant defenses, is discussed in relation to its possible role in the production of tissue damage in diabetes mellitus. (nih.gov)
- Researchers suspect that these molecules may help protect cells from oxidative stress, which occurs when unstable molecules called free radicals accumulate to levels that damage or kill cells. (medlineplus.gov)
- In order to prevent oxidative damage, the antioxidant system presents a group of cellular enzymes (SOD, catalase and glutathione system) responsible for the control of free radicals. (bvsalud.org)
Reactive oxygen2
- These include increased release of reactive oxygen species from phagocytes, such as superoxide from peripheral blood neutrophils, oxidized low density lipoprotein cholesterol (LDL), increased lipid hydroperoxides and malondialdehyde, and decreased plasma antioxidant capacity [ 4 - 11 ]. (hindawi.com)
- In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
Oxygen-free rad2
- When amiodarone is reduced, iodine is cleaved from the molecule which generated oxygen-free radicals. (bartleby.com)
- These smoke particles contain intermediates of hydrogen, carbon and oxygen free radicals, which may pose a potential health risk. (cdc.gov)
Antioxidants9
- Experiments with endothelial cells fortified with the isolated fraction from native honey enriched in antioxidants, exposed to peroxyl radicals from 1,1-diphenyl-2-picrylhydrazyl (AAPH, 10 mM) and to hydrogen peroxide (H2O2, 50-100 microM), indicated that phenolic acids and flavonoids were the main causes of the protective effect. (researchgate.net)
- These results provide unequivocal evidence that, through the synergistic action of its antioxidants, honey by reducing and removing ROS, may lower the risks and effects of acute and chronic free radical induced pathologies in vivo. (researchgate.net)
- Antioxidants are compounds that inhibit oxidation (usually occurring as autoxidation ), a chemical reaction that can produce free radicals . (wikipedia.org)
- These molecules undergo free radical chain reactions, but antioxidants inhibit them by preventing the oxidation processes. (wikipedia.org)
- Antioxidants that reduce free radicals to help diminish signs of aging. (eltamd.com)
- Antioxidants are substances that help prevent or slow cell damage caused by free radicals, unstable molecules that the body produces as a reaction to environmental and other stressors. (selfgrowth.com)
- Antioxidants whether taken by mouth or as a suppliment circulate throughout the body and absorb into the cells of the stratum corneum [the topmost layer of skin], where they neutralize free radicals. (selfgrowth.com)
- Antioxidants are our most effective weapon against free radicals that cause oxidation and inflammation throughout our bodies. (selfgrowth.com)
- Unlike most water-soluble antioxidants, which simply flow throughout the bloodstream, Pearl Powder has a remarkable ability to actually absorb into every cell, tissue and organ in your body where it can stop free radicals from robbing you of your health. (selfgrowth.com)
Molecules3
- Bacopa Monnieri inhibits fat molecules from reacting with these harmful radicals. (findingoptimism.com)
- Within peroxisomes, alkylglycerone phosphate synthase is responsible for a critical step in the production of lipid molecules called plasmalogens. (medlineplus.gov)
- The molecules most the study from the inpatient and outpatient exposed to damage by free radicals are the clinics of the National Liver Institute. (who.int)
Hydroxyl5
- Two particularly dangerous metabolic byproducts include the hydroxyl free radical and malondialdehyde (MDA). (naturalnews.com)
- The hydroxyl free radical is highly reactive and is produced in abundant amounts when the body is under stress. (naturalnews.com)
- Additionally, the study showed that each participant produced less hydroxyl free radicals at a higher intensity than at a lower intensity. (naturalnews.com)
- Ascorbic acid has neutralizing properties of free radicals, being able to interact with superoxide, hydroxyl and free oxygen ions, preventing the inflammatory processes, carcinogens, and other processes that accelerate photoaging in the skin. (mdpi.com)
- Electron spin resonance was used to measure carbon-centered as well as hydroxyl radicals produced by a Fenton-like reaction with wildfire smoke. (cdc.gov)
Scavenge2
- For example, it is 1) lipophilic (i.e., affinity for fat or lipid), allowing it to diffuse through cell membranes and scavenge free radicals within the cells, 2) anti-inflammatory, and 3) anti-edematous, i.e., inhibits damage-causing swelling. (healingtherapies.info)
- Not only do they scavenge free radicals, the number one skin-aging culprits, to promote brighter, more even toned skin, they're also the superstars at preventing fine lines and keeping skin looking fresh. (selfgrowth.com)
Oxidation2
- Native honey (1% w/v pH 7.4, 10(6) cells) showed strong quenching activity against lipophilic cumoxyl and cumoperoxyl radicals, with significant suppression/prevention of cell damage, complete inhibition of cell membrane oxidation, of intracellular ROS production and recovery of intracellular GSH. (researchgate.net)
- Buege, J.A. and Aust, S.D. (1978) Microsomal lipid per- oxidation. (scirp.org)
Damage4
- Braughler, J.M., Dyncan, L.A. and Goodman, T. (1985) Calcium enhances in vitro free radical induced damage to brain synaptosomes mitochondria and cultured spinal cord neurons. (scirp.org)
- Silicon nanowires: free radical production and related damage in cellular exposures. (cdc.gov)
- Protects the skin from free-radical damage. (skin-beauty.com)
- These results indicate that the radical generation and the damage caused by them is not only a function of surface area but is also influenced by changing chemical and other characteristics due to particle size. (cdc.gov)
Protein2
- The aim of this work was to characterize the composition of these seeds to assess not only their nutritional potential (protein, lipid and minerals content), but also their antioxidant and anti-inflammatory potential as well as their specialized metabolites composition. (ac.be)
- The protein, lipids and mineral content were determined. (ac.be)
Skin's2
- Containing Alpine stem cells and Osmo Tec, a molecular catalyst, it protects against premature aging and restores the skin's lipid balance. (skin-beauty.com)
- Restores the skin's lipid balance. (skin-beauty.com)
Membrane2
- Impaired membrane traffic in defective ether lipid biosynthesis. (medlineplus.gov)
- Once cleaved from the lipid membrane by the action of phospholipases they can circulate into various bodily fluids and eventually be excreted. (bvsalud.org)
Proteins1
- Plasmalogens may also play important roles in interactions between lipids and proteins, the transmission of chemical signals in cells, and the fusion of cell membranes. (medlineplus.gov)
Cellular1
- A series of prostaglandin-like compounds that are produced by the attack of free-radical species on unsaturated fatty acids, especially ARACHIDONIC ACID, of cellular MEMBRANES. (bvsalud.org)
Atherosclerosis1
- The therapeutic properties of honey, once considered a form of folk or preventive medicine, are acquiring importance for the treatment of acute and chronic free radical-mediated diseases (atherosclerosis, diabetes and cancer). (researchgate.net)
Toxicity1
- Our investigation looked into the involvement of free radicals in smoke toxicity and the relationship between particle size and radical generation. (cdc.gov)
Eliminates1
- SOD is one of the body's strongest antioxidant enzymes, which eliminates free radicals, thus helps prevent skin aging. (selfgrowth.com)
DPPH3
- The antioxidant capability of the resulting plant extracts against a stable radical DPPH was evaluated and the most of plant extracts showed high efficiency in the DPPH test. (europa.eu)
- The juice (GFJ) was centrifuged at 3000 rpm for 5 min and used for determination of total phenolic content, 1,1?diphenyl?2?picrylhydrazyl (DPPH) radical scavenging activity and antimicrobial activity. (ijpsonline.com)
- SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)
Protects1
- A naturally occurring lipid derived from olives which protects against moisture loss. (eltamd.com)
Metabolism2
- Such alterations are likely to lead to imbalances in lipid metabolism. (hindawi.com)
- Chylomicron-like lipid emulsions, resembling chylomicrons in composition, size and metabolism were prepared in the presence of [125 I]Aβ1-40. (iospress.com)
Superoxide radical1
- Since the metalloprotein superoxide dismutase, SOD, is the key enzyme involved in the detoxification of superoxide radicals, it may play a vital role in interindividual variation in superoxide radical turnover. (nature.com)
Scavenging Activity1
- The radical scavenging activity of 1,1-diphenyl-2-picrylhydrazyl was highest in fruit juice followed by methanol extract of leaf and stem. (ijpsonline.com)
Carcinogens1
- Cigarette smokers continuously inhale thousands of carcinogens and free radicals. (hindawi.com)
Quercetin1
- Quercetin binds to this iron, preventing it from reacting with the lipids on neighboring cells. (healingtherapies.info)
Significantly2
- The placebo, which was devoid of iridoid glycosides, did not significantly influence blood lipid profiles or hs-CRP. (hindawi.com)
- Aβ was found to associate significantly with these lipid emulsions during their preparation. (iospress.com)
Diabetes1
- It thus prevents long-term disorders caused by free radicals, such as heart diseases, cancer, and diabetes. (findingoptimism.com)
Liver1
- The liver is one of the main organs that is that they are not distributed uniformly generates free radicals in different patho- throughout the liver, the periportal concen- logical conditions [ 1 ]. (who.int)
Harmful1
- Krill oil additionally contains astaxanthin, a unique lipid-soluble antioxidant, which may help protect cells from harmful free radicals. (vitacost.com)
Bioactive1
- Here, we focus on newly uncovered pathways, involving either the cyclooxygenases (COXs) or nonenzymatic chemical transformations, that lead to the formation of bioactive prostanoids and of previously unknown lipid mediators produced by COX-2. (jci.org)
Mineral1
- Mineral based, this facial sunscreen shields the skin against both UVA and UVB rays, while vitamins C and E protect against damaging free radicals. (dermstore.com)
Cell1
- Basically, after the initial mechanical injury, a complicated physiological chain reaction ge nerates free-radicals, which steal electrons from the lipids in neighboring neuronal membranes, resulting in further cell death. (healingtherapies.info)
Particles1
- however, the ultrafine particles generated more OH radicals in the acellular Fenton-like reaction. (cdc.gov)
Abstract1
- Abstract Background Most studies focused on the benefits of lycopene on serum lipids but no studies have been specifically designed to assess the role of a tomato sauce from vine-ripened tomatoes on patients affected by polygenic hypercholesterolemia. (researchgate.net)
Glutathione1
- We evaluated the effects of two insecticides (fipronil, sulfluramid) and metallic insecticide complex (magnesium complex [Mg(hesp)2(phen)] (1)) on the superoxide dismutase (SOD), glutathione (GSH) and the overall antioxidant capacity using two different methodologies: total radical-trapping potential (TRAP) and oxygen radical absorbance capacity (ORAC). (springer.com)
Substances1
- Is iron necessary to promote the production of lipid peroxides, or can other substances take the place of iron in ferroptosis? (nature.com)
Composition1
- L'objectif de ce travail était d'étudier la composition des graines de P. vulgaris afin d'en déterminer non seulement le potentiel nutritionnel (teneur en lipides, protéines, minéraux), mais aussi la présence de métabolites spéciaux et d'en déterminer les pouvoirs antioxydant et anti-inflammatoire. (ac.be)
Cells1
- Scientists are interested in finding a chemical compound that would activate regeneration processes in cells damaged by free radicals. (news-medical.net)
Production1
- Peroxisomes are also important for the production of fats (lipids) used in digestion and in the nervous system. (medlineplus.gov)
Content1
- By clicking "Allow All" you agree to the storing of cookies on your device to enhance site navigation, analyse site usage and support us in providing free open access scientific content. (news-medical.net)
Residue1
- EltaMD UV Stick is easy-to-apply, mess-free, residue-free sun protection that's Dermatologist tested and formulated for the whole family and all skin types. (eltamd.com)