Lipid based formulations. Medical search. Frequent questions

Lipid nanoparticles (LNP) are the leading delivery system for mRNA-based therapeutics and vaccines. (chi-peptalk.com)
Development of Brain Targeting Peptide Based MMP-9 Inhibiting Nanoparticles for the Treatment of Brain Diseases with Elevated MMP-9 Activity. (ljmu.ac.uk)

SHANGHAI, Sept. 9, 2022- WuXi STA, a subsidiary of WuXi AppTec, today announced the opening of a new sterile lipid nanoparticle (LNP) formulation development and manufacturing facility at its Wuxi city campus. (microbiozindia.com)
His Ph.D. dissertation was on Catalysis in aqueous media and Lipid Nanoparticle-based siRNA delivery. (oldwestbury.edu)
In 2021, he moved to the University of Connecticut School of Pharmacy for his Postdoctoral Research where he worked on Lipid Nanoparticle formulation development and LNP-based siRNA delivery of therapeutic agents to target cells. (oldwestbury.edu)
A lipid nanoparticle (LNP) containing messenger RNA (mRNA) enters a cell through an endosome (right). (acs.org)
The development of lipid nanoparticle (LNP) based therapeutics for delivery of RNA has triggered the advance of new strategies for formulation, such as high throughput microfluidics for precise mixing of components into well-defined particles. (lu.se)
formulations and devise new nanoparticle architectures. (lu.se)

Croda Pharma and Avanti Polar Lipids will be highlighting our Small Molecule Delivery solutions , ranging from Super Refined™ high purity excipients through to our expertise in lipid formulation. (avantilipids.com)

This study aimed to develop Tmx-loaded span-based nano-vesicles for delivery to malignant tissues with maximum efficacy. (springer.com)
During the incubation period, the lipid film will swell and strip away from the Teflon surface to form small "clouds" of vesicles. (avantilipids.com)
Shapiro, B. A. Stealth oxime ether lipid vesicles promote delivery of functional DsiRNA in human lung cancer A549 tumor bearing mouse xenografts. (oldwestbury.edu)
In turn, only recently surface-sensitive techniques have explored the phase behaviour of lipid layers in contact with solid surfaces, such as supported lipid bilayers (SLBs) and supported layers of vesicles (SLVs). (hindawi.com)

Whether it's small or large molecule therapeutics, CD Formulation is capable of troubleshooting to step up efforts for customers toward a quicker drug formulation path. (selfgrowth.com)
In recent years, successful results have been obtained in the treatment of genetic diseases, cancer immunotherapy and against emerging infectious diseases with nucleic acid-based therapeutics, especially small interfering RNAs (siRNAs) and antisense oligonucleotides. (hamiltoncompany.com)
However, these new nucleic acid-based therapeutics face formulation and distribution challenges in delivering disease targets efficiently, and subsequent high-scale production challenges. (hamiltoncompany.com)
Hence, the Hamilton product grant will enable the production of different nanoparticular systems containing nucleic acid-based therapeutics using Hamilton gas tight syringes in microfluidic systems. (hamiltoncompany.com)

Contributor Cindy H. Dubin spoke with several contract research/manufacturing organizations on how they are successfully overcoming solubility/bioavailability challenges, such as matching APIs to formulations and choosing the best excipients. (drug-dev.com)
Using high purity compendial excipients would be beneficial due to the prone oxidation in excipients commonly used in ophthalmic formulation. (avantilipids.com)
Specializing in drug formulation, the highly specialized CRO service provider CD Formulation has accumulated abundant experience in the custom synthesis of increased bioavailability excipients. (selfgrowth.com)
Recently, adding increased bioavailability excipients in drug formulations has gained widespread attention because they can alter the pharmacokinetics of drugs, ultimately resulting in improved bioavailability. (selfgrowth.com)
third, increased bioavailability excipients can even co-work with the digestion and absorption of physiological lipids in the body to promote the absorption of drugs. (selfgrowth.com)
ABITEC is dedicated to developing high quality lipid excipients for use globally in a range of diversified pharmaceutical applications. (abiteccorp.com)

Lipid-based drug delivery systems are one of the emerging technologies designed to address challenges such as the solubility and bioavailability of poorly water-soluble drugs. (mdpi.com)
Surface Active Agent - Surfactants, for instance, polyethylene glycol glycerol can be used to prepare lipid-based formulations that significantly improve solubility and thus oral bioavailability through various self-emulsifying systems. (selfgrowth.com)
As a reliable partner in the drug formulation field, we are fully devoted to solving problems concerning solubility, bioavailability, and drug absorption. (selfgrowth.com)
Bioaccessibility, a precursor to eventual bioavailability, was determined after digestion using a curcumin:lipid content dependent and independent method. (umass.edu)

It can be administered either in the classic amphotericin B deoxycholate formulation or as a lipid formulation. (medscape.com)
Pentavalent antimony compounds have been the mainstay of antileishmanial therapy for half a century, but lipid formulations of amphotericin B (though expensive and administered parenterally) represent a major advance for treating visceral leishmaniasis. (unboundmedicine.com)
The standard formulation, amphotericin B deoxycholate, must always be given in 5% D/W because salts can precipitate the drug. (msdmanuals.com)
Several lipid vehicles reduce the toxicity of amphotericin B (particularly nephrotoxicity and infusion-related symptoms). (msdmanuals.com)
Lipid formulations are preferred over conventional amphotericin B because they cause fewer infusion-related symptoms and less nephrotoxicity. (msdmanuals.com)
Amphotericin B is less frequently used and, when used, is often given as a liposomal formulation to decrease toxicity. (medscape.com)

This work can be considered as a departure point for further investigations on more complex lipid mixtures displaying relevant phases such as the liquid-ordered phase and solid-lipid interfaces with biologically functional importance. (hindawi.com)

Created in response to the increasing demand for complex injection dosage forms, this new facility adds to the company's fast-growing parenteral formulation capabilities and is yet another opportunity to enable customers as they develop and deliver better medicines for patients. (microbiozindia.com)

It is a SMARTICLES liposomal formulation of MTL-501. (pharmaceutical-technology.com)

They are manufactured by microfluidic mixing of a lipid-containing-ethanol-phase and an mRNA-carrying-aqueous-phase. (chi-peptalk.com)
When the LNP is inside the acidic endosome (middle), the ionizable lipids become positively charged and help release the LNP and mRNA into the cell's cytoplasm. (acs.org)
On top of that, mRNA strands are large and negatively charged and can't simply waltz across the protective lipid membranes of cells. (acs.org)

iposome formulations can be broadly divided into cationic, anionic and neutral subtypes. (encapsula.com)
His siRNA delivery system uses cationic lipids as a delivery agent. (oldwestbury.edu)
In this work, Faisal demonstrated the use of a uniquely designed cationic lipid (vector) to deliver siRNA into human lung cancer cells which subsequently turns down the expression of the encoded protein. (oldwestbury.edu)
SMARTICLES are amphoteric liposomes composed of combinations of lipids having anionic and cationic groups that work together to enable cell uptake. (pharmaceutical-technology.com)

Liposomal doxorubicin (Doxil®) is a liposome formulation encapsulating the chemotherapeutic drug, doxorubicin, thereby decreasing its toxicity. (encapsula.com)

Doxil® also contains polyethylene glycol (PEG)-lipid resulting in pegylation of the liposome surface, which enables it to have a prolonged circulation and a reduced volume of distribution, thereby improving tumor uptake through the enhanced permeability and retention effect (EPR) and extending effective tumor therapy. (encapsula.com)

Benjamin Schwartz, Senior Personal Care Application Specialist, AAK USA Inc. highlights how the structure of fatty acids found in plant-based lipids, and more importantly the triglycerides and wax esters that contain them, determine the interdependent properties of oxidative stability, compatibility, solid fat content, and crystallization types of various oils, fats, and waxes. (aocs.org)
The colloidal stability of the final formulation was affected by the type of incorporated nucleic acids (NAs) and decreased with the degree of base-pairing, as polyU induced extensive particle aggregation. (lu.se)

Julien Meissonnier reviews the development of a broad range of advanced oral drug delivery technologies, including a toolkit of technologies based upon the broad application of lipid-based drug delivery systems for optimum solubility enhancement. (drug-dev.com)
How to improve the solubility, bio-availability and therapeutic performance of pharmaceutical ingredients has become the top concern for the majority of drug developers," said the Marketing Manager of CD Formulation. (selfgrowth.com)

Light sensitive mixtures that contain polyunsaturated lipids should be protected from light using aluminum foil. (avantilipids.com)
The phase transitions of binary lipid mixtures are studied by a combination of Peltier-element-based adiabatic scanning calorimetry (pASC) and quartz crystal microbalance with dissipation monitoring (QCM-D). pASC, a novel type of calorimeter, provides valuable and unambiguous information on the heat capacity and the enthalpy, whereas QCM-D is proposed as a genuine way of determining phase diagrams by analysing the temperature dependence of the viscosity. (hindawi.com)
Both techniques give consistent phase diagrams, which compare well with literature results, showing their capability to map the phase behaviour of pure lipids as well as lipid mixtures. (hindawi.com)
During the last decades, the approach to overcome the complexity of biological membranes is to use simplified biomimetic models mainly consisting of binary or ternary mixtures of lipids [ 1 , 2 ]. (hindawi.com)
This requires the knowledge of static and kinetic thermodynamic properties of pure lipids and lipid mixtures. (hindawi.com)
In silastic membranes, the complete mixture significantly reduced triazine absorption in MO-based mixtures, while in PEG-based mixtures triazine absorption and apparent permeability were significantly increased. (cdc.gov)
In porcine skin, triazine permeability was significantly increased for both MO- and PEG-based complete mixtures and the trend was for greater triazine absorption in more complex PEG-based mixtures. (cdc.gov)
Interestingly, SRA or TEA alone significantly reduced triazine absorption in MO-based mixtures, and this interaction appears to be more additive than synergistic. (cdc.gov)
Although the physiochemical experiments suggest otherwise, triazine readily permeates a homogenous lipid membrane such as the SC, while triazine permeability and absorption was significantly enhanced by the complete mixture especially in PEG-based mixtures. (cdc.gov)

Hostapon CGN is a very mild anionic surfactant based on a natural amino acid and coconut oil giving an excellent skin feel in shower gels and facial & body washes. (clariant.com)

It can be used as a carrying agent for essential oils, tocopherols, carotenes, and pigments in cosmetic formulations. (usda.gov)
This course provides a detailed look into the roles that plant-based lipids play in personal care and cosmetic formulations. (aocs.org)

The performance of orally administered lipid-based drug formulations is crucially dependent on digestion, and understanding the colloidal structures formed during digestion is necessary for rational formulation design. (rsc.org)
AmB colloidal dispersion (ABCD) and AmB lipid complex (ABLC). (cdc.gov)

Using a microfluidic device, the digestion of lipid systems may be monitored with far better control over the mixing of the components and the application of enzyme, thereby elucidating a finer understanding of the structural progression of these lipid systems. (rsc.org)
Both microfluidic devices were found to be suitable for in situ SAXS measurements in tracking the kinetics with improved time and signal sensitivity compared to other microfluidic devices studying similar lipid-based systems, and producing more consistent and controllable structural transformations. (rsc.org)
To address this issue, our research is planned to produce polymeric and lipid nanoparticular drug delivery systems with microfluidic technology. (hamiltoncompany.com)
In this study, we have characterised the structure of LNPs throughout the formulation process using in situ small angle x-ray scattering in the microfluidic chip, then by sampling in the subsequent dialysis process. (lu.se)

Ice crystals that form during freezing will rupture the lipid membrane of the liposomes and change the size the liposomes particles. (encapsula.com)
In spite of the relevance of lipid-protein interactions, the phase behaviour of the lipid components of the cell membrane is believed to be of major importance to uncover some underlying principles behind the membrane function. (hindawi.com)

Gel formulations containing liposomal dispersions are being developed for transdermal delivery of drugs [ 2 ]. (ispub.com)

Cells in the uppermost layer, the stratum corneum (SC), are cornified and embedded in a lipid matrix [ 5 6 ]. (ispub.com)
Triazine partitioning from the formulation into the stratum corneum (SC) was significantly reduced by LAS, while SRA significantly reduced the pH of the formulation. (cdc.gov)

The presentation will focus on characterization of particulate matter in LNP formulations. (chi-peptalk.com)

One of the most debated issues in the biophysics of lipids is lipid miscibility and its relevance to the function and organization of biological membranes. (hindawi.com)
In 1997, Simons and Ikonen renewed the interest in lipid phase studies, suggesting that lateral phase separation in biological membranes could be functionally important [ 3 ]. (hindawi.com)
Sphingolipids are key structural components of cellular membranes containing a backbone of sphingosine (aliphatic amino alcohol) as the base of their structures. (frontiersin.org)

León, I. E. Lipid, polymeric, inorganic-based drug delivery applications for platinum-based anticancer drugs. (beilstein-journals.org)

Lipid rafts or ordered lipid domains may play a role in the localization, transport, and function of different proteins. (hindawi.com)

From a fundamental viewpoint, the interest in lipid phase behaviour stems from the nature and the thermodynamics of phase transitions, the mechanisms behind lipid miscibility and lateral phase separation, and the existence of critical phenomena [ 8 ]. (hindawi.com)
Information about the phase behaviour of supported lipid layers is relevant for lipid-based nanobiotechnology applications such as inmunosensors and lipid nanodevices [ 22 , 23 ]. (hindawi.com)

As the Lipid Technology segment of the Croda Pharma business, Avanti is primarily focused on developing innovative lipid-based products to address specific medical challenges that are not resolved by current technology or drug products. (avantilipids.com)
For 2020, the meeting will address the formulation challenges of emerging modalities, new strategies for predictive analysis at this stage, exciting new analytical methodologies and accelerating and the best practices being employed to overcome formulation challenges. (chi-peptalk.com)
This presentation considers the fundamentals of these challenges and how they may be overcome, as well as differences between glass- and polymer-based systems. (chi-peptalk.com)
Combining robust expertise and years of experience, CD Formulation is undoubtedly a good partner for drug developers who urgently need to overcome drug formulation and delivery challenges. (selfgrowth.com)
Columbus, OH - [February 5, 2019] - ABITEC Corporation continues to add new innovative ingredients that solve the everyday challenges of drug delivery and formulation. (abiteccorp.com)
The challenges of drug formulation and delivery continue to drive the need for lipid-based formulation solutions. (abiteccorp.com)

He has held leadership positions in R&D at country and regional levels, from past few years and his key research contributions are especially generic product development, life cycle management of consumer healthcare drug products (OTC) and developing novel drug delivery dosages/systems (especially lipid based). (selectbiosciences.com)
He has formulation development experience in vivid dosage forms (especially including Soft gels and Metered dose nasal sprays), & has hands-on led key challenging projects working with different organizations. (selectbiosciences.com)
Dr. Matt Ling has over 20 years' experience in the pharmaceutical industry, much of this gained in big pharma, with roles in analytical, formulation development, advanced drug delivery and project leadership spanning all phases of discovery and development. (xtalks.com)
Cambridge Healthtech Institute's 12th Annual Optimizing Biologics Formulation Development conference is an essential yearly gathering of analytical and formulation scientists from leading industry companies that provides an exchange of scientific developments and emerging technologies in an environment that encourages discussion with colleagues. (chi-peptalk.com)
As a premier Contract Research Development and Manufacturing Organization (CRDMO), WuXi STA's integrated drug product platform offers a full spectrum of services, including solid-state development, pre-formulation, formulation development, and clinical to commercial drug product manufacturing with a variety of drug delivery technologies, including a broad range of oral and injectable dosage forms. (microbiozindia.com)
American Aires ( CSE: WIFI ) is an Ontario based technology company that is focused on the research, development and implementation of innovative technology solutions to allow consumers to safely engage with electronic products of the 21st century. (investorideas.com)
The Company's AquAdvantage fish program is based upon a single, specific molecular modification in fish that results in more rapid growth in early development. (investorideas.com)
GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. (pharmaceutical-technology.com)

The approval was based on data from the phase 3 Epanova for Lowering Very High Triglycerides (EVOLVE) trial, which examined the efficacy of the product in lowering triglycerides and other key lipid parameters in patients with very high triglycerides. (medscape.com)

This includes formulation, drug delivery, lymph and plasma pharmacokinetic analysis, immunology and metabolism focusses. (monash.edu)
Kouchakzadeh H, Shojaosadati SA, Shokri F. Efficient loading and entrapment of tamoxifen in human serum albumin based nanoparticulate delivery system by a modified desolvation technique. (springer.com)
This text book is a guide for pharmaceutical academics (students and teachers) as well as industry professionals learning about drug delivery and formulation. (benthamscience.com)
It is developed based on SMARTICLES delivery technology. (pharmaceutical-technology.com)

Cellsome® liposomes made from neutral PEGylated lipids provide certain benefits. (encapsula.com)
For more information on the lipid composition of the liposomes mentioned above click here . (encapsula.com)
Cellsome® liposomes made from neutral PEGylated lipids are unilamellar and sized to 100 nm. (encapsula.com)
By having the liposome diameter (nm) and lipid concentration (µM), you can calculate the total number of the lipids in one liposome and number of the liposomes in one milliliter of the liposome solution. (encapsula.com)
Cellsome® made from neutral PEGylated lipids is a white translucent liquid made of nano size unilamellar liposomes. (encapsula.com)

AREV's model is to toll process extraction of targeted essential and functional oils and license its formulations to Licensed Producers in Canada. (investorideas.com)

Because no official policy exists for visceral leishmaniasis therapy in Italy (physicians can prescribe any registered drug under their own responsibility) and information on drug regimens used is not included in visceral leishmaniasis case reports, we aimed to assess whether changes have occurred, and to what extent, in first-line drug regimens adopted in Italy after lipid-associated AmB was introduced into clinical practice. (cdc.gov)
Skill Checkups are wholly fictional or fictionalized clinical scenarios intended to provide evidence-based educational takeaways. (medscape.com)

Contains highly purified fractions of oatmeal, plant extracts, and lipids to help calm irritations, moisturize and restore the skin lipid content. (medi-vet.com)

Automated CFS 1500 C system enables safe filling and sealing of capsules containing lipid-based formulations or potent compounds. (thomasnet.com)

The purpose of this study was to investigate the impact of different lipid-based formulations of curcumin on in vitro solubilization and bioaccessibility. (umass.edu)

Therefore, these results demonstrated that conventional CBD oil formulation but not CBD-NE requires bile-mediated micelle formation. (karger.com)

We also validated this formulation technologically and tested its behavior in in vitro colorectal cancer (CRC) models, including CRC patient-derived tumor organoids (PDOs). (frontiersin.org)

The effect on structure was investigated for LNPs with a benchmark lipid composition and containing different cargos: calf thymus DNA (DNA) and two model mRNAs, polyadenylic acid (polyA) and polyuridylic acid (polyU). (lu.se)

Diagnosis still typically relies on classic microbiological methods, but molecular-based approaches are being tested. (unboundmedicine.com)

Cholesterol does not count since it inserts itself into the hydrophobic fatty acid chains of the lipid. (encapsula.com)
Epanova will be the third prescription formulation of an omega-3 polyunsaturated fatty-acid (PUFA) product approved in the United States for the treatment of hypertriglyceridemia. (medscape.com)

With aquaculture facilities located in Prince Edward Island, Canada, and Indiana, USA, AquaBounty is raising its disease-free, antibiotic-free salmon in land-based recirculating aquaculture systems, offering a reduced carbon footprint and no risk of pollution of marine ecosystems as compared to traditional sea-cage farming. (investorideas.com)
and (3) strengthen health care for people with noncommunicable diseases by developing evidence-based norms, standards and guidelines for cost-effective interventions and by orienting health systems to respond to the need for effective management of diseases of chronic nature. (who.int)

Chapters presents comprehensive information about self-emulsifying formulations by providing an in-depth understanding of the basic concepts and formulation mechanisms. (benthamscience.com)

Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem of major significance, the pharmaceutical industry has been slow to apply and further develop this technology. (pharmatext.co.in)
This title provides a comprehensive summary of the theoretical and practical aspects of oral lipid-based formulations for use in industry, and provides further insights into a developing technology expected to assume increasing prominence in years to come. (pharmatext.co.in)
Cecilia Van Cauwenberghe, MS, Technical Insights Senior Research Analyst, Frost & Sullivan, reports that the proliferation of lower cost microfluidics-based genomics tools offering improved capabilities and allowing more access to end-users is expected to drive this technology for pharmaceutical and biomedical research throughout the next 5 years. (drug-dev.com)
AquaBounty Technologies ( NasdaqGS:AQB ) is a leader in the field of land-based aquaculture and the use of technology for improving its productivity and sustainability. (investorideas.com)

DNA, following the expected extent of base-pairing. (lu.se)
Indeed, the agenda will also feature what are likely to be lively expert debates on the controversial topics of adrenal vein sampling in primary aldosteronism , the role of diet in weight loss, and the optimal extent of lipid lowering. (medscape.com)

Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. (pharmatext.co.in)
The novel NE formulation developed in this study successfully improved the absorption of CBD regardless of bile secretion. (karger.com)

Two others relate to reproductive health: recommendations on testosterone therapy in men with hypogonadism , and an international evidence-based guideline on assessment and management of polycystic ovary syndrome (PCOS). (medscape.com)

However, these studies did not elucidate the critical experimental parameters involved in leukosomes formulation. (frontiersin.org)

The aim of this study was to develop a novel lipolysis method incorporating a two-stage gastric-to-intestinal transition and an absorptive compartment to reliably predict in vivo performance of lipid-based formulations (LBFs). (ruc.dk)
Most treatment recommendations represent consensus guidelines based on the Mycosis Study Group trials and the experience of many investigators. (medscape.com)
Late-breaking adrenal abstracts on March 17 will include a randomized trial that compared phenoxybenzamine and doxazosin for the preoperative treatment of pheochromocytoma (PRESCRIPT trial), and a study on a new child-friendly granule formulation of hydrocortisone . (medscape.com)

In the same period, other lipid-associated AmB drugs were registered in Italy for the treatment of fungal infections, i.e. (cdc.gov)

Anatomy8

Organisms8

Diseases4

Chemicals and Drugs130

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Phenomena and Processes43

Disciplines and Occupations9

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture25

Information Science4

Health Care7

Nanoparticles2

Nanoparticle6

Avanti Polar Lipids1

Vesicles4

Therapeutics4

Excipients6

Bioavailability4

Amphotericin6

Solid-lipid1

Parenteral1

Liposomal formulation1

MRNA3

Cationic4

Toxicity1

Polyethylene glycol1

Stability2

Solubility2

Mixtures9

Anionic1

Cosmetic formulations2

Colloidal2

Microfluidic4

Membrane2

Dispersions1

Stratum corneum2

Characterization1

Membranes3

Polymeric1

Proteins1

Phase behaviour2

Challenges6

Development8

Triglycerides1

Delivery4

Liposomes5

Functional1

Clinical2

Extracts1

Capsules1

Solubilization1

Conventional1

Vitro1

Composition1

Methods1

Fatty acid2

Systems2

Mechanisms1

Technology4

Extent2

Absorption2

Assessment1

Parameters1

Study3

Drugs1