Lipid. Medical search. Frequent questions

Early studies that compared germ-free mice and conventionally raised mice suggested that the gut microbiota may play a role in host lipid metabolism. (news-medical.net)
Given that there is a link between lipid levels and obesity, it is possible that the effect of certain bacterial taxa on host lipid metabolism is the same species that affect the host's weight. (news-medical.net)
When we started this work, LDs had been identified, but their roles in regulating lipid metabolism were unclear. (asbmb.org)
We knew little about the intracellular architecture of neutral lipid metabolism and the nature and localization of the proteins that regulate LD assembly and maintenance. (asbmb.org)
We wanted to study these fundamental processes and identify the adipocyte proteins that regulate neutral lipid metabolism in response to fasting and feeding. (asbmb.org)
Because sex differences drive hepatic gene expression and overall lipid metabolism, we sought to determine whether sex differences were also apparent in these endpoints in response to bariatric surgery. (nih.gov)
Microarray and follow-up qPCR on liver revealed striking sex differences in gene expression after VSG that reflected a down-regulation of hepatic lipid metabolism and an up-regulation of hepatic inflammatory pathways in females vs. males after VSG. (nih.gov)
Taken together, although both males and females lose weight and improve plasma lipids, there are large-scale sex differences in hepatic gene expression and consequently hepatic lipid metabolism after VSG. (nih.gov)
The abnormal lipid metabolism is considered to be an important hallmark in the etiopathogenesis of psoriasis [ 21 - 23 ]. (hindawi.com)
Lipid metabolism in the epidermis may be regulated by the expression of apolipoprotein E (APOE), a glycoprotein which is synthesized in a wide variety of extrahepatic tissues including skin [ 27 - 29 ]. (hindawi.com)
The research in Fedorova's group is focused on development and implementation of lipidomics and bioinformatics solutions to address complexity and plasticity of lipid metabolism in variety of biological systems. (tu-dresden.de)
By using modern, state-of-the-art high resolution mass spectrometry in combination with a wide range of separation methods we explore the complexity and dynamics of natural lipidomes to integrate these data for a holistic understanding of lipid metabolism. (tu-dresden.de)
The liver X-receptors (LXRs) act as cholesterol sensors and participate in the regulation of lipid and cholesterol metabolism. (scirp.org)
Lxr ligand activation affected the expression of genes involved in lipid metabolism in zebrafish adult brain and eye as well as in zebrafish embryos. (scirp.org)
The expression of genes involved in lipid and cholesterol metabolism was also changed in the lxr morphants. (scirp.org)
Thus, various disorders of lipid metabolism have characteristic patterns of organ involvement and clinical history, depending on the particular substrate that is stored. (medscape.com)

Lipids also encompass molecules such as fatty acids and their derivatives (including tri-, di-, monoglycerides, and phospholipids), as well as other sterol-containing metabolites such as cholesterol. (wikipedia.org)
Lipids have been classified into eight categories by the Lipid MAPS consortium as follows: Fatty acyls, a generic term for describing fatty acids, their conjugates and derivatives, are a diverse group of molecules synthesized by chain-elongation of an acetyl-CoA primer with malonyl-CoA or methylmalonyl-CoA groups in a process called fatty acid synthesis. (wikipedia.org)
A lipid bilayer is a very thin layer that is in between lipid molecules. (answers.com)
Scientists at Tufts University and the Broad Institute of Harvard and MIT have developed unique nanoparticles comprised of lipids -- fat molecules -- that can package and deliver gene editing machinery specifically to the liver. (eurekalert.org)
With this new technology known as "Membrane coated-FET (lipid-FET)," molecules suspended in highly ionic concentrated solution, to a level of human blood, can be detected with higher sensitivity compared to that of the existing sensor, and dilution of the solution up to 100,000-fold is not required. (eurekalert.org)
One might think that they simply result from lipid molecules separating out within the aqueous intracellular environment. (asbmb.org)
As reported earlier, the helical arrangement of the protein component of the vesicles facilitates image averaging and enables us to determine how cholesterol and phospho-lipid molecules are distributed in the surrounding matrix, using headgroup size as a means to discriminate between the two kinds of lipid. (iucr.org)
A lipid bilayer or bilayer lipid membrane (BLM) is a membrane or zone of a membrane composed of lipid molecules (usually phospholipids ). (wikidoc.org)
They concluded, correctly, that the membrane is two lipid molecules thick and proposed it is made of a bilayer. (wikidoc.org)
Lipids are amphiphilic molecules since they consist of polar head groups and non-polar fatty acid tails. (wikidoc.org)
These are small balloons of lipid bilayer which can entrap polar molecules inside them. (wikidoc.org)
The interfacial regions of model phospholipid bilayers have a thickness of 8 to 10 Å, although they can be wider in biological membranes that include lipid molecules whose head groups have complex carbohydrates, found in the gangliosides or lipopolysaccharides [1] . (wikidoc.org)
They also can be described as having an internal lateral pressure or "the sponaneous radius of curvature", which defines the tendency of the lipid molecules to form curved rather than planar surfaces. (wikidoc.org)
Bile salts aid in forming lipid micelles, which create a hydrophilic surface with a hydrophobic core of lipid molecules, including FFA. (medscape.com)

cells contain a lipid bilayer with proteins embeded in this. (answers.com)
The Lipid Metabolites and Pathways Strategy (LIPID MAPS) consortium is actively involved in an integrated approach for the detection, quantitation and pathway reconstruction of lipids and related genes and proteins at a systems-biology level. (nih.gov)
Tiny bodies within cells called lysosomes regularly convert, or metabolize, the lipids and proteins into smaller components to provide energy for the body. (nih.gov)
However, LDs are well-organized organelles surrounded by proteins that act as gatekeepers that tightly control lipid entry and exit. (asbmb.org)
PLIN1 mainly acts as a dynamic scaffold for proteins involved in the storage and hydrolysis of neutral lipids in LDs. (asbmb.org)
In the past years, several proteins were suggested to transport lipids between the leaflets of a membrane, and to potentially influence transverse lipid asymmetry and related cell properties. (hu-berlin.de)
Figure 1: Biological membranes are often depicted as a sea of homogenous lipid in which membrane proteins reside and cytosolic proteins translocate. (nature.com)
In summary, the person is trying to get their head around the basic structure, formulas and meanings of carbohydrates, proteins, amino acids and lipids. (physicsforums.com)
I have been trying to get my head around the basics for these four (Carbohydrates, Proteins, Amino Acids and Lipids) for about a week and I just don't understand the basic structure, formulas and such. (physicsforums.com)
In this project, we investigate interactions between aggregating amyloid proteins and lipid membranes, and we explore the basic principles of the amyloid-lipid coaggregation. (lu.se)
Encapsulation in self-assembled lipid structures has been shown to increase the stability of large biomolecules, including proteins and nucleic acids (NAs), which has many potential applications in the food and pharmaceutical industries. (lu.se)
In the first part of my thesis, the encapsulation of different proteins in a lipid sponge phase (L3) system composed of food grade lipids was studied. (lu.se)
Comparison between the effect on the L3 phase of encapsulated beta-galactosidase (238 kDa), aspartic protease (34 kDa), myoglobin (17.6 kDa) and phytoglobin BvPgb 1.2 (38.4 kDa) demonstrated the importance of specific lipid-protein interactions on the L3 structure both in bulk and dispersions, as well as the stability of the encapsulated proteins. (lu.se)

In a study published today in the Proceedings of the National Academy of Sciences , they have shown that they can use the lipid nanoparticles (LNPs) to efficiently deliver the CRISPR machinery into the liver of mice, resulting in specific genome editing and the reduction of blood cholesterol levels by as much as 57% -- a reduction that can last for at least several months with just one shot. (eurekalert.org)
After a single injection of lipid nanoparticles packed with mRNA coding for CRISPR-Cas9 and a single-guide RNA targeting Angptl3, they observed a profound reduction in LDL cholesterol by as much as 57% and triglyceride levels by about 29 %, both of which remained at those lowered levels for at least 100 days. (eurekalert.org)
Also present are polyethylene glycol, and yes, even some cholesterol - which has a normal role in lipid membranes to make them less leaky - to hold their contents better. (eurekalert.org)
The AAP recommends lipid screening for young people with a family history of high blood cholesterol or premature cardiovascular disease, or the presence of at least one major risk factor for heart disease, such as smoking, high blood pressure, diabetes, or overweight/obesity. (cdc.gov)
A new study significantly refines the association between prostate cancer and blood lipids, highlighting genetic risk factors associated with low density lipoprotein (LDL) cholesterol and triglycerides as key players and identifying 17 related gene loci that make risk contributions to levels of these blood lipids and to prostate cancer. (sciencedaily.com)
High blood cholesterol is diagnosed by a blood test called a lipoprotein profile or lipid panel. (nationaljewish.org)
If it is not possible to get a lipoprotein profile or lipid panel done, knowing your total cholesterol and HDL cholesterol can give you a general idea about your cholesterol levels. (nationaljewish.org)
Medicines to lower your cholesterol level may be used if you are at high risk for heart disease or if your lipid levels don't drop after you have eaten a low-fat diet for a couple of months. (aafp.org)
It is shown that cholesterol segregates preferentially around the receptors in both leaflets of the lipid bilayer, interacting robustly with specific transmembrane sites and creating a network of bridging microdomains. (iucr.org)
Cholesterol interactions with the receptor are apparently essential for stabilizing and maintaining its physiological architecture, since the transmembrane structure contracts, involving displacements of the helices at the outer membrane surface by ∼2 Å (1-3 Å), when this lipid is extracted. (iucr.org)
Elevated lipids, particularly cholesterol , put young people at risk for heart disease later in life. (chop.edu)
Through the Lipid Heart Clinic, your family will receive information on ways to improve your child's cholesterol levels, mainly with dietary and lifestyle changes. (chop.edu)
Alterations in plasma lipid and lipoprotein composition including a tendency toward an increase in total cholesterol (TC) and triglyceride (TG) and decrease in high-density lipoprotein cholesterol (HDL-C) levels suggest that psoriasis may associate with the disorders of lipid metabolism [ 25 , 26 ]. (hindawi.com)
Morpholino knock down of lxr resulted in an overall impaired lipid deposition as determined by oil red O staining particularly in the head and around the eyes, and to significantly elevated levels of both total and free cholesterol in the yolk of lxr morphant embryos. (scirp.org)
While the measurement and management of cholesterol forms an integral part of cardiovascular risk management, it has been suggested that risk assessment could be improved by the assessment of various additional lipid-related markers either to supplement or replace traditional cholesterol measurements. (bmj.com)
The objective of the study was to test the hypothesis that levels of the various lipid components (total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides) are differentially associated with concentrations of total PCBs and total pesticides, and further that different congeners, congener groups and different pesticides do not have identical associations in serum samples obtained from Anniston residents in a cross-sectional study. (cdc.gov)
Fasting serum samples were obtained from 575 residents of Anniston who were not on any lipid-lowering medication and were analyzed for 35 PCB congeners, nine chlorinated pesticides, total cholesterol, LDL and HDL cholesterol and triglyceride concentrations. (cdc.gov)

Another study showed that 34 bacterial taxa were associated with BMI and blood lipids. (news-medical.net)
The parameters evaluated were body composition (body fat and lean mass), blood lipids, functional fitness, self-image, and self-esteem. (lww.com)

In the second part of my thesis, the structure of lipid nanoparticles (LNPs) for NA delivery was investigated using scattering methods and cryogenic transmission electron microscopy (cryoTEM). (lu.se)

Enforcing cancer cell SCD expression or raising circulating lipid levels through a higher-fat CR diet confers resistance to the effects of CR. (nature.com)

Fast Five Quiz: Lipids Management - Medscape - Jun 12, 2023. (medscape.com)

Although the term "lipid" is sometimes used as a synonym for fats, fats are a subgroup of lipids called triglycerides. (wikipedia.org)
For a century, chemists regarded "fats" as only simple lipids made of fatty acids and glycerol (glycerides), but new forms were described later. (wikipedia.org)
Up to 99% of the lipids in plant and animal material consist of such esters, known as fats and oils. (springer.com)
Some possible effects on lipid biochemistry of differences in the distribution on glycerol of long-chain n-3 fatty acids in the fats of marine fish and marine mammals. (springer.com)
Lipid Nutrition is more than a book which teaches current understandings of the role of fats and oils in health and disease. (wysong.net)
Lipids are fats that are important constituents of cells and sources of energy. (labtestsonline.org.uk)
Fats in the blood are called lipids. (aafp.org)
The Cardiac Center's Lipid Heart Clinic evaluates and treats children and adolescents up to 18 years of age who have high levels of lipids (fats) in their blood. (chop.edu)

Drastic enhancement of molecular detectability over potentiometric sensor surface via ion-impermeation across the lipid membrane. (eurekalert.org)
The Korean team of researchers successfully developed a proprietary biosensor technology with significantly enhanced molecular sensitivity using the artificial lipid membrane that mimics cellular membrane. (eurekalert.org)
In eukaryotic cells, the lipid species are frequently distributed asymmetrically between the plasma membrane leaflets. (hu-berlin.de)
Xiao Yi Li and Leif A. Eriksson "Photoreaction of Skin-sensitizing Trimethyl Psoralen with Lipid Membrane Models," Photochemistry and Photobiology 81(5), 1153-1160, (1 September 2005). (bioone.org)
Here, cryo-EM is used to examine the protein-lipid architecture of this membrane in tubular vesicles obtained from the (muscle-derived) electric organ of the Torpedo ray. (iucr.org)
Here, we analyse by cryo-EM the architecture of this membrane in vesicles isolated from the (muscle-derived) electric organ of the Torpedo ray, with view to defining the protein-lipid interplay required to achieve an optimal neurotransmitter response. (iucr.org)
The bilayer is composed of two layers of lipids arranged so that their hydrocarbon tails face one another to form an oily core held together by Van der Waals interactions, while their charged heads face the aqueous solutions on either side of the membrane. (wikidoc.org)
The properties of the bilayer are influenced by a variety of factors, including the lipid composition, temperature and membrane pressure. (wikidoc.org)
Moreover, we present the first nanomechanical characterization of a cubic phase lipid membrane, through AFM-based Force Spectroscopy (AFM-FS). (lu.se)
Absorption of lipid compounds into the enterocyte for biochemical usage occurs through diffusion across the cellular membrane and also through lipid transporters that are located on the luminal side of the enterocyte. (medscape.com)
For several of the amyloid disorders, protein aggregation has also been associated with membrane disruption in cells and in model lipid systems. (lu.se)
We study protein-lipid co-aggregation, membrane assoication and the consequences of protein-lipid interaction on aggregation kinetics and membrane intergrety. (lu.se)

Triglycerides are lipid compounds composed of a glycerol esterified to 3 fatty acid chains of varying length and composition. (medscape.com)
[ 4 ] If pancreatitis is likely or potentially threatening and levels of triglycerides are found to be 1000 mg/dL or greater, immediate institution of lipid lowering therapy should begin. (medscape.com)

The functions of lipids include storing energy, signaling, and acting as structural components of cell membranes. (wikipedia.org)
The lipid bilayer is a critical component of all biological membranes , including cell membranes , and so is absolutely essential for all life on Earth. (wikidoc.org)
Support for the existence of a lipid bilayer in cell membranes came with the discovery by Alec Bangham in 1965 that phospholipids , when introduced into an aqueous environment, spontaneously form liposomes . (wikidoc.org)

the amphiphilic nature of some lipids allows them to form structures such as vesicles, multilamellar/unilamellar liposomes, or membranes in an aqueous environment. (wikipedia.org)
Lipids are fat-like substances that are important parts of the membranes found within and between cells and in the myelin sheath that coats and protects the nerves. (nih.gov)
In this project, we study interactions between α-synuclein and lipid membranes. (lu.se)
We use model membranes with varying lipid compositions, and biological membranes in isolated exosomes. (lu.se)

Lipid storage diseases (also known as lipidoses) are a group of inherited metabolic disorders in which harmful amounts of fatty materials (lipids) accumulate in various cells and tissues in the body. (nih.gov)
People with these disorders either do not produce enough of one of the enzymes needed to break down (metabolize) lipids or they produce enzymes that do not work. (nih.gov)
Physicians at the Lipid Heart Clinic are specially trained to treat children with lipid disorders. (chop.edu)
Lipid storage disorders are a family of diverse diseases related by their molecular pathology. (medscape.com)
The biochemical basis of lipid storage disorders is well characterized and includes determining properties of enzymatic activities and various storage products. (medscape.com)
Lipid storage disorders are rare disorders, although some have an ethnic predilection with more appreciable frequency. (medscape.com)

The left column lists the lipids known as phospholipids. (springer.com)

A total of 758 Anniston residents had multiple measurements of blood pressure, provided information on demographic factors, medications, smoking, and exercise and provided blood samples for determination of PCBs and total serum lipids. (cdc.gov)
Hypertension also increased with body mass index (BMI), but was not related to total serum lipids levels, gender, smoking or exercise. (cdc.gov)

Although humans and other mammals use various biosynthetic pathways both to break down and to synthesize lipids, some essential lipids cannot be made this way and must be obtained from the diet. (wikipedia.org)

By contrast, although KD also impairs tumour SCD activity, KD-driven increases in lipid availability maintain the unsaturated to saturated fatty acid ratios in tumours, and changing the KD fat composition to increase tumour saturated fatty acid levels cooperates with decreased tumour SCD activity to slow tumour growth. (nature.com)
Properties of lipid formulations can vary depending on the composition (cationic, anionic, neutral lipid species), however, the same preparation method can be used for all lipid vesicles regardless of composition. (sigmaaldrich.com)
When preparing liposomes with mixed lipid composition, the lipids must first be dissolved and mixed in an organic solvent to assure a homogeneous mixture of lipids. (sigmaaldrich.com)
Furthermore, its protein-lipid composition, organization and size are subject to modification by physiological events, making it an important mediator of neuronal plasticity. (iucr.org)
Using a combination of small angle x-ray and neutron scattering (SAX/NS), dynamic light scattering (DLS) and cryoTEM, the colloidal stability, LNP morphology, lipid composition of the LNP core-shell structure and structure of the core were determined. (lu.se)

Liposomes (lipid vesicles) are formed when thin lipid films or lipid cakes are hydrated and stacks of liquid crystalline bilayers become fluid and swell. (sigmaaldrich.com)
The hydrated lipid sheets detach during agitation and self-close to form large, multilamellar vesicles (LMV) which prevents interaction of water with the hydrocarbon core of the bilayer at the edges. (sigmaaldrich.com)
The general elements of the procedure involve preparation of the lipid for hydration, hydration with agitation, and sizing to a homogeneous distribution of vesicles. (sigmaaldrich.com)
The hydration medium is generally determined by the application of the lipid vesicles. (sigmaaldrich.com)
The paper, titled "Hypoxic Induction of Exosome Uptake through Proteoglycan-Dependent Endocytosis Fuels the Lipid Droplet Phenotype in Glioma" and published at Molecular Cancer Research, shows that exosome-like extracellular vesicles (EVs) may serve anabolic functions by transforming hypoxic, patient-derived human glioblastoma cell lines into a lipid loaded phenotype. (lu.se)

How large can a lipid bilayer sheet be? (answers.com)
This fluid lipid bilayer cross section is made up entirely of phosphatidyl choline . (wikidoc.org)
The thickness of the hydrocarbon core region is about 27 Å for the model bilayer formed by DOPC lipid whose acyl chains have eighteen carbon atoms and a single double bond (di(C18:1)PC) [2] . (wikidoc.org)
The thickness of a lipid bilayer increases by 0.8 Å per each additional carbon atom of the lipid tail in the liquid crystalline state, or by 1.1 Å in the gel state (these numbers should be multiplied by 2 because the bilayer has two leaflets). (wikidoc.org)

High lipid levels may also be caused by medical conditions such as diabetes, hypothyroidism, alcoholism, kidney disease, liver disease and stress. (aafp.org)
In some people, certain medicines, such as birth control pills, steroids and blood pressure medicines, can cause high lipid levels. (aafp.org)
Some people with high lipid levels have yellowish, fatty bumps on their skin. (aafp.org)
What is the treatment for high lipid levels? (aafp.org)
We are committed to helping your family adopt a healthy lifestyle, to ensure a healthier future for your child with high lipid levels, and everyone else in your family. (chop.edu)

Hydration of the dry lipid film/cake is accomplished simply by adding an aqueous medium to the container of dry lipid and agitating. (sigmaaldrich.com)

In immunocytochemical studies in differentiated adipocytes, we saw anti-perilipin immunoreactivity in well-defined ringlike patterns around both large and small intracellular lipid droplets. (asbmb.org)
Lipid droplet hijacking by intracellular pathogens. (bvsalud.org)
Various intracellular pathogens, including viruses , bacteria , and parasites , specifically target host lipid droplets during their life cycle . (bvsalud.org)
The possible use of lipid droplets by intracellular pathogens, as part of an anti- immunity strategy, is an intriguing question meriting further investigation in the near future . (bvsalud.org)

I'm very happy to be here today to discuss clinical research in lipid-lowering therapies and lipoprotein-lowering therapies with my colleagues, Drs Budoff and Shubrook. (medscape.com)
The aim of this paper was to determine whether cardiovascular risk prediction could be improved by adding information on other lipid-related markers, including: apolipoprotein B and apolipoprotein A-I, lipoprotein(a), or lipoprotein-associated phospholipase A2. (bmj.com)
In conclusion, smoking is clearly associated with increase serum lipid and lipoprotein values with exception HDL which significantly decreased in smoker compared to non-smokers students. (who.int)

The major force driving the formation of lipid bilayers is the hydrophobic interaction between the tails and their repusion by water. (wikidoc.org)

A key component of this approach is a bioinformatics infrastructure involving a clearly defined classification of lipids, a state-of-the-art database system for molecular species and experimental data and a suite of user-friendly tools to assist lipidomics researchers. (nih.gov)
In addition, decreased accumulation of analogs of diacylglycerol and ceramide suggest MDR1 Pgp mediated transport of these lipid species. (hu-berlin.de)
At the heart of a renaissance in lipid biochemistry, systems biology is being used to define the cellular lipome, build a comprehensive picture of metabolic interconnections, discover new molecular species and determine how lipids modulate biological functions. (nature.com)
Hydration time may differ slightly among lipid species and structure, however, a hydration time of 1 hour with vigorousshaking, mixing, or stirring is highly recommended. (sigmaaldrich.com)
Nutritional stress like nitrogen deprivation, phosphorus starvation, and iron supplementation can enhance the lipid content in many microalgae species [ 8 - 11 ]. (hindawi.com)
Advances in lipidomics allow identification of hundreds of lipid species from biological samples. (mdpi.com)

ABSTRACT Studies have shown that cardiovascular risk factors, such as obesity, blood lipid levels, start early in childhood and some are on the rise in children. (who.int)

For example, monoglycerides of the short-chain fatty acids are undoubtedly lipids, but they would not fit the definition on the basis of solubility because they are more soluble in water than in organic solvents. (springer.com)
The basic components of lipids are listed in the central column with the fatty acids occupying the prominent position. (springer.com)
Upregulation of stearoyl-CoA desaturase (SCD), which synthesises monounsaturated fatty acids, is required for cancer cells to proliferate in a lipid-depleted environment, and CR also impairs tumour SCD activity to cause an imbalance between unsaturated and saturated fatty acids to slow tumour growth. (nature.com)
In the mouth, dietary fat constituents such as mono- and diunsaturated fatty acids give rise to taste signals that stimulate food intake, in part by enhancing the production of lipid-derived endocannabinoid messengers in the gut. (jci.org)

Aging is not recommended for high transition lipids as lipid hydrolysis increases with elevated temperatures. (sigmaaldrich.com)

Elevated plasma lipid levels are associated with increased cardiovascular risk. (natap.org)

Nitrogen stress increases lipids content in microalgae, the main feedstock for algal biodiesel. (hindawi.com)

The LNPs are made up of long chain lipids that have a charged or polar head that is attracted to water, a carbon chain tail that points toward the middle of the bubble containing the payload, and a chemical linker between them. (eurekalert.org)

This study, part of the Tehran Lipid and Glucose Study, determined and compared the prevalence of overweight and its associated risk factors in 2 555, 1 329 and 1 158 Tehran children and adolescents in 2000, 2003 and 2006 respectively. (who.int)
Overall the prevalence of obesity in Tehran children and adolescents increased significantly from 2000 to 2006 while blood pressure and serum lipid concentrations decreased. (who.int)
Due to the importance in determining lipid levels, in addition to the anthropometric measurements of children and adolescents, it was planned to determine the prevalence of overweight and dyslipidaemia in children of six to nine years enrolled in public elementary schools in the city of Vitória, Espírito Santo, Brazil. (bvsalud.org)

It has been suggested that continuous separation of psoriatic scales caused the permanent loss of lipids which adversely affects lipid homeostasis. (hindawi.com)
Our data show that lxr is an important component of the regulatory network governing the lipid homeostasis during zebrafish development, which in turn may support a role of lxr for normal development of the central nervous sytem, including the retina. (scirp.org)
L. Wang, G. U. Schuster, K. Hultenby, Q. Zhang, S. Andersson and J. A. Gustafsson, "Liver X Receptors in the Central Nervous System: From Lipid Homeostasis to Neuronal Degeneration," Proceedings of the National Acadamy of Sciences of the USA, 15 October 2002, pp. 13878-13883. (scirp.org)

As a field, lipidomics is in its infancy, yet it has already begun to influence lipid biochemistry in myriad ways. (nature.com)

On this new paper released on March 2021, Myriam Cerezo-Magaña and collaborators explore the interplay between hypoxia, lipid scavenging, proteoglycans and lipid storage. (lu.se)

But its risk factors, such as abnormal lipid levels and overweight/obesity often emerge during childhood and adolescence. (cdc.gov)

The guidelines that cover the screening of patients for elevated serum lipid levels, and the treatment of patients with lipid abnormalities, rest on calculations of individual patients' risk for a future cardiovascular event. (medscape.com)
Proportions of other taxa were shown to affect only lipid levels, such as Eggerthella , Pasteurellaeceae, and Butyricimonas . (news-medical.net)
A study looked at the association of blood lipid levels and the microbiota of 145 European women. (news-medical.net)
A change in nutrient availability observed with CR, but not with KD, is lower lipid levels in the plasma and tumours. (nature.com)
Abnormal lipid levels are major risk factors for heart disease, the leading cause of death among adults in the United States. (cdc.gov)
The report, "Prevalence of Abnormal Lipid Levels among Youths -United States, 1999-2006," was published today in CDC's Morbidity and Mortality Weekly Report (MMWR). (cdc.gov)
The researchers found that young people who were overweight or obese were more likely to have one or more abnormal lipid levels compared to normal weight youth. (cdc.gov)
Fourteen percent of normal weight, 22 percent of overweight, and 43 percent of obese youth had one or more abnormal lipid levels. (cdc.gov)
Reviewing health indicators for 3,125 youths, researchers found that differences in lipid levels were associated with sex, age, and race/ethnicity. (cdc.gov)
Overweight and obese young people are at far greater risk of having abnormal lipid levels than are youths with normal weights," said Ashleigh May, Ph.D., Epidemic Intelligence Service Officer in CDC's Division for Heart Disease and Stroke Prevention, and lead author of the report. (cdc.gov)
The findings, published in the April 30, 2014 online issue of the International Journal of Epidemiology , provide new insights into the pathobiology of prostate cancer and may point to novel therapies to lower blood lipid levels that might help prevent prostate cancer -- the second most common cause of cancer death among American men. (sciencedaily.com)
And they might, ultimately, help shape "genetically stratified dietary or chemoprevention studies repurposing clinically approved drugs that regulate blood lipid levels" to alter the risk of developing prostate cancer, he said. (sciencedaily.com)
The first ways to reduce your lipid levels are (1) eat less fat, (2) exercise regularly and (3) lose weight if you weigh too much. (aafp.org)
We believe combining the expertise of medical doctors and licensed dietitians offers your child the best possible treatment for lowering lipid levels. (chop.edu)
We are examining the role of modified lipids specifically in signalling processes, regulating physiological and pathological events at the cellular and organismal levels. (tu-dresden.de)
This suggests that the potential long-term health effects of high- and low-carbohydrate weight loss diets remain a concern, and that blood lipid levels should be monitored in obese subjects with the metabolic syndrome. (proteinpower.com)
In my opinion (and the opinion of many others) the lipid parameters of most value in determining risk for heart disease are triglyceride levels and HDL levels. (proteinpower.com)
The percentages of patients remaining on the comparator PI with normal lipid levels by NCEP Guidelines did not change from baseline to week 12. (natap.org)
The high levels of HDL-C are protective factors for coronary heart disease, although the lipid profile had been changed. (bvsalud.org)
For this cross-sectional study, data were analyzed from randomly selected adults (n=774) who completed the Anniston Community Health Survey and underwent measurements of height, weight, fasting glucose, lipid and PCB levels and verification of medications. (cdc.gov)

Chemical structures and molecular targets of lipid-derived mediators involved in the monitoring of dietary fat. (jci.org)

In this study, evidence shows that EVs can fuel hypoxic glioma cells to acquire a lipid droplet (LD+) phenotype and such effect is associated with increased EV internalization through a hypoxia-sensitive mechanism dependent on heparan sulfate proteoglycan (HSPG) receptor and lipid raft-mediated endocytosis. (lu.se)
The authors found that the hypoxia-mediated HSPG-dependent EV uptake could be further evidenced by the reversal of EV-mediated lipid droplet loading by targeting of HSPG receptor function. (lu.se)

Lipid droplets, or LDs, are key lipid storage structures in cells. (asbmb.org)
Lipid droplets were long considered to be simple storage structures, but they have recently been shown to be dynamic organelles involved in diverse biological processes , including emerging roles in innate immunity . (bvsalud.org)

Typically lipid solutions are prepared at 10-20mg lipid/ml organic solvent, although higher concentrations may be used if the lipid solubility and mixing are acceptable. (sigmaaldrich.com)

Some locks should be lifted starting by the improvement of growth rate and lipid content which are the key parameters of lipid productivity. (hindawi.com)
So, we've got a situation here where the lipid parameters improved more on the low-carb diet as compared to the low-fat diet, yet we've got the authors of the article, the generators of this data, telling us that the HCLF diet had "more favorable effects on the blood lipid profile. (proteinpower.com)
This study was designed to examine the effect on lipid parameters of a switch to ATV 400 mg QD from another PI (boosted or not) in a virologically suppressed, treatment-experienced patient population. (natap.org)
See table below showing changes in all lipid parameters followed in this study. (natap.org)

Lipid-based drug delivery systems are one of the emerging technologies designed to address challenges such as the solubility and bioavailability of poorly water-soluble drugs. (mdpi.com)

What do you know about the safety and tolerability of lipid-lowering therapies? (medscape.com)

It is difficult to provide a clear and comprehensive definition for the class of substances called lipids. (springer.com)

Daunorubicin lipid complex is used to treat advanced Kaposi's sarcoma (a type of cancer that causes abnormal tissue to grow on different parts of the body) related to acquired immunodeficiency syndrome (AIDS). (medlineplus.gov)
Twenty percent of young people aged 12-19 years in the United States have at least one abnormal lipid level, according to a study from the Centers for Disease Control and Prevention. (cdc.gov)
More boys (24 percent) than girls (16 percent) had at least one abnormal lipid level. (cdc.gov)

The study also found that 32 percent of these young people would be candidates for lipid screening based on American Academy of Pediatrics (AAP) guidelines. (cdc.gov)
In light of this, the study's authors suggested that clinicians should be aware of guidelines for lipid screening and treatment among youths. (cdc.gov)
Fast Five Quiz: Do You Know Current Guidelines for Lipid Management? (medscape.com)
Are you up-to-date on the latest guidelines for lipid management in adults? (medscape.com)
for the lipid profile the Atherosclerosis Prevention Guidelines in Childhood were used. (bvsalud.org)

During hydration some lipids form complexes unique to their structure. (sigmaaldrich.com)

mRNA adsorption with pH and proportion of the cationic ionisable lipid (CIL) DLin-MC3-DMA was first studied in a model system for two model mRNAs and human erythropoietin mRNA. (lu.se)

One way an amino acid differs from a lipid is that the amino acids contain? (answers.com)

Daunorubicin lipid complex injection must be given under the supervision of a doctor who is experienced in giving chemotherapy medications for cancer. (medlineplus.gov)
You may experience a reaction while you receive a dose of daunorubicin lipid complex injection, usually within 5 minutes after your infusion starts. (medlineplus.gov)

Both studies showed significantly improved lipids after switching. (natap.org)

Biological lipids originate entirely or in part from two distinct types of biochemical subunits or "building-blocks": ketoacyl and isoprene groups. (wikipedia.org)
Figure 2: Known initial biochemical steps responsible for the synthesis of all lipids. (nature.com)

Results of lipid profile support that psoriasis is one of the independent risk factors for hyperlipidemia and emphasize the need of screening cardiovascular diseases in psoriatic patients. (hindawi.com)
In particular, the group is studying the role of modified lipids in ferroptosis, a newly described type of cell death implicated in degenerative diseases and cancer. (tu-dresden.de)
In amyloid plaques associated with several amyloidogenic diseases, tightly associated lipids have been identified. (lu.se)

So we hypothesized that LDs serve as active centers for the storage and breakdown of neutral lipids. (asbmb.org)
however, two-stage culture raised lipids to 50% in which neutral lipids were enhanced 2.14 times. (hindawi.com)
This enables microalgae to accumulate a significant amount of neutral lipids under stress conditions. (hindawi.com)

Anthropometric measurements and laboratory analysis for lipid profile were assessed using standard techniques. (who.int)

In 1947, T. P. Hilditch defined "simple lipids" as greases and waxes (true waxes, sterols, alcohols). (wikipedia.org)

although both diets had similar improvements for a number of metabolic risk markers, the HCLF diet had more favorable effects on the blood lipid profile. (proteinpower.com)

Anatomy20

Organisms11

Diseases10

Chemicals and Drugs133

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Psychiatry and Psychology1

Phenomena and Processes54

Disciplines and Occupations1

Technology, Industry, Agriculture11

Information Science2

Health Care2

Metabolism16

Molecules14

Proteins13

Cholesterol17

Blood lipids2

Nanoparticles1

Circulating lipid levels1

20231

Fats8

Membrane12

Triglycerides2

Cell membranes3

Membranes4

Disorders6

Phospholipids1

Serum lipids2

Essential lipids1

Composition5

Vesicles5

Bilayer4

High lipid levels5

Aqueous1

Intracellular4

Lipoprotein3

Hydrophobic1

Species6

Abstract1

Fatty acids4

Hydrolysis1

Plasma lipid1

Increases1

LNPs1

Children and adolescents3

Homeostasis3

Biochemistry1

Interplay1

Obesity1

Levels20

Molecular1

Droplet2

Structures2

Typically1

Parameters4

Solubility1

Therapies1

Substances1

Abnormal3

Guidelines5

Hydration1

Cationic1

Amino acids1

Complex injection2

Significantly1

Biochemical2

Diseases3

Neutral3

Measurements1

Waxes1

Metabolic1