Maternal single nucleotide polymorphisms in the fatty acid desaturase 1 and 2 coding regions modify the impact of prenatal supplementation with DHA on birth weight. (ouhsc.edu)
A fatty acid desaturase that is a rate-limiting enzyme for the conversion from dihomo-gamma-linolenic acid and EICOSATETRAENOATE (ETA) in the synthesis of ARACHIDONIC ACID and EICOSAPENTAENOATE (EPA). (bvsalud.org)
Delta1
In enzymology, a linoleoyl-CoA desaturase (also Delta 6 desaturase, EC 1.14.19.3) is an enzyme that converts between types of fatty acids, which are essential nutrients in the human body. (wikipedia.org)
MeSH1
Fatty Acid Desaturases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
Enzymes1
Early investigations were focused on the 10-kDa ACBPs from mammals and yeast, and from these studies the 10-kDa ACBP has been implicated in biological roles ranging from acyl-CoA transport, maintenance of acyl-CoA pools within the cell and in the protection of acyl-CoAs in the cytosol from enzymes including acyl-CoA hydrolase, acetyl-CoA carboxylase and acyl-CoA synthetase [reviewed in 3]. (aocs.org)
Regulation1
Regulation of hepatic fatty acid elongase and desaturase expression in diabetes and obesity. (ouhsc.edu)
Function1
The function of the acyl-CoA-binding domain in recombinant Arabidopsis ACBPs expressed in the bacterium Escherichia coli was established using site-directed mutagenesis followed by in vitro binding assays. (aocs.org)
1.14.19.32
In enzymology, a linoleoyl-CoA desaturase (also Delta 6 desaturase, EC 1.14.19.3) is an enzyme that converts between types of fatty acids, which are essential nutrients in the human body. (wikipedia.org)
The reaction is catalyzed by delta-6 desaturase (EC 1.14.19.3). (tuscany-diet.net)
Linoleic acid3
The elongases and desaturases that catalyze the conversion of linoleic acid to arachidonic acid and beyond, up to 22:5n6, are shared with the pathways leading to the synthesis of omega-3, omega-7 and omega-9 polyunsaturated fatty acids. (tuscany-diet.net)
Omega-3 polyunsaturated fatty acids seem to be the preferred substrates for desaturases, although the synthesis of omega-6 polyunsaturated fatty acids is prevalent due to the high dietary intake of linoleic acid. (tuscany-diet.net)
In the first step of the metabolic pathway, linoleic acid is activated by being joined to coenzyme A (CoA-SH). (tuscany-diet.net)
FADS3
Dietary essential polyunsaturated fatty acids (PUFAs) require fatty acid desaturases (FADS) for conversion to long-chain PUFAs (LCPUFAs), which are critical for many aspects of human health. (nih.gov)
From NCBI Gene: The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. (nih.gov)
FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. (nih.gov)
Substrates1
The enzyme mainly catalyzes the chemical reaction linoleoyl-CoA + AH2 + O2 ⇌ {\displaystyle \rightleftharpoons } gamma-linolenoyl-CoA + A + 2 H2O The 3 substrates of this enzyme are linoleoyl-CoA, an electron acceptor AH2, and O2, whereas its 3 products are gamma-linolenoyl-CoA, the reduction product A, and H2O. (wikipedia.org)
2.201
In the last step, the thioester bond of arachidonoyl-CoA is hydrolyzed with the release of arachidonic acid and coenzyme A. The reaction is catalyzed by an acyl-CoA hydrolase (EC 3.1.2.20). (tuscany-diet.net)
Acyl6
Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. (nih.gov)
9/3/2005) TOTAL DESCRIPTORS = 935 MH - 1-Acylglycerol-3-Phosphate O-Acyltransferase UI - D051103 MN - D8.811.913.50.173 MS - An enzyme that catalyzes the acyl group transfer of ACYL COA to 1-acyl-sn-glycerol 3-phosphate to generate 1,2-diacyl-sn-glycerol 3-phosphate. (nih.gov)
The reaction is catalyzed by a long-chain acyl-CoA synthetase (EC 6.2.1.3), at the expense of one molecule of ATP. (tuscany-diet.net)
Diacylglycerol acyltransferase (DGAT) catalyzes the last and committed step of TAG biosynthesis in the acyl-CoA-dependent pathway. (biomedcentral.com)
In higher plants, TAG biosynthesis has been documented and is believed to be mediated mainly via two pathways, acyl-CoA independent pathway and acyl-CoA-dependent Kennedy pathway [ 12 ]. (biomedcentral.com)
The latter pathway starts from glycerol-3-phosphate with three sequential acylation steps, with the last step being mediated by a diacylglycerol acyltransferase (DGAT), which employs an acyl-CoA as the acyl donor and transfers the acyl moiety to the sn -3 position of DAG for TAG assembly [ 13 ]. (biomedcentral.com)
Fatty acids2
D6D is a desaturase enzyme, i.e. introduces a double bond in a specific position of long-chain fatty acids. (wikipedia.org)
The reaction is catalyzed by elongase 5 or elongation of very long chain fatty acids protein 5 (EC 2.3.1.199), and malonyl-CoA is the donor of the acetyl group. (tuscany-diet.net)
Donor1
The systematic name of this enzyme class is linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase. (wikipedia.org)
Enzyme that catalyzes2
An enzyme that catalyzes the syn-dehydrogenation of linoleol-CoA gamma-linolenoyl-CoA. (bvsalud.org)
HN - 2006(1983) MH - 2-Oxoisovalerate Dehydrogenase (Acylating) UI - D050645 MN - D8.811.682.657.350.825 MS - An NAD+ dependent enzyme that catalyzes the oxidation 3-methyl-2-oxobutanoate to 2-methylpropanoyl-CoA. (nih.gov)