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  • Mapping
  • Genetic maps in linkage disequilibrium (LD) units play the same role for association mapping as maps in centimorgans provide at much lower resolution for linkage mapping. (pnas.org)
  • Tested measures of relative efficiency, support intervals, and localization error determine the operating characteristics of LD maps that are applicable to every sexually reproducing species, with implications for association mapping, high-resolution linkage maps, evolutionary inference, and identification of recombinogenic sequences. (pnas.org)
  • The high levels of nucleotide polymorphism and low linkage disequilibrium suggest that it may be possible to map functional variation to very fine scales in P. tremula using association-mapping approaches. (genetics.org)
  • Association analysis, or linkage disequilibrium (LD) mapping, has been used extensively to dissect traits in species where traditional QTL-mapping approaches are not feasible, such as in humans ( R afalski and M organte 2004 ). (genetics.org)
  • finite
  • Taking subpopulation structure into account with a hierarchical model, we estimate the magnitude of genetic differentiation and linkage disequilibrium in a metapopulation on the basis of geographical samples, rather than decompose a population into a finite number of random-mating subpopulations. (genetics.org)
  • reliable
  • Most geneticists are familiar with subsequent refinements and use of linkage, which was introduced to human genetics by Bernstein ( 3 ) and subsequently evolved into current maps reliable to a resolution of ≈1 cM or ≈1 Mb ( 4 , 5 ). (pnas.org)
  • order
  • Linkage maps specifying order were introduced by Sturtevant ( 1 ), and the distances were made approximately additive by Haldane ( 2 ). (pnas.org)