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Amino Acid MotifsSequence Analysis, ProteinProtein Interaction Domains and MotifsDatabases, ProteinProteinsSoftwareAmino Acid SequenceMolecular Sequence DataProtein Interaction MappingComputational BiologyInternetConserved SequenceSequence AlignmentProtein Structure, TertiaryUser-Computer InterfaceBinding SitesProtein BindingSequence Homology, Amino AcidModels, MolecularEvolution, MolecularAlgorithmsNucleotide MotifsBase SequenceHelix-Turn-Helix MotifsTranscription FactorsMutagenesis, Site-DirectedMutationDNA-Binding ProteinsConsensus SequenceCloning, MolecularCell LineRecombinant Fusion ProteinsPromoter Regions, GeneticDNAProtein Structure, SecondaryTranscription, GeneticProtein ConformationSequence Analysis, DNARecombinant ProteinsHelix-Loop-Helix MotifsStructure-Activity RelationshipTransfectionNucleic Acid ConformationHeLa CellsNuclear ProteinsEF Hand MotifsPeptidesSequence DeletionCOS CellsDNA PrimersRNA-Binding ProteinsBacterial ProteinsCarrier ProteinsEscherichia coliCrystallography, X-RayPhylogenySequence Homology, Nucleic AcidRegulatory Elements, TranscriptionalRegulatory Sequences, Nucleic AcidProtein TransportAmino Acid SubstitutionGene Expression RegulationSaccharomyces cerevisiaeMembrane ProteinsTwo-Hybrid System TechniquesMutagenesisPhosphorylationSignal TransductionSubstrate SpecificityRNA, MessengerDimerizationSaccharomyces cerevisiae ProteinsRepressor ProteinsPlasmidsLeucine ZippersOligodeoxyribonucleotidesRNARepetitive Sequences, Amino AcidPeptide FragmentsAT-Hook MotifsMultigene FamilyPoint MutationCercopithecus aethiopsEnhancer Elements, GeneticRepetitive Sequences, Nucleic AcidCytoplasmKineticsCysteineProtein Sorting Signals
SLiMsProteinsLace motifsAnimal motifsCurvilinear linesHerringboneGeometricSubstrateMediateBodiceResiduesInteractionsProtein interactionSLiMPatternsSequenceTulleConsensusDelicateEmbroideryAntibodiesGeneDetectionAncientDiscoveryHighlyResearchDataMembraneComplexMeansColorApproachDesignLifeEasyArrayQualityBlackTypeSimpleNature
SLiMs5
  • In molecular biology short linear motifs (SLiMs), linear motifs or minimotifs are short stretches of protein sequence that mediate protein-protein interaction. (wikipedia.org)
  • Complex formation - Ligand SLiMs often function as simple interfaces that recruit proteins to multi-protein complexes (e.g. the Retinoblastoma-binding LxCxE motif) or act as aggregators in scaffold proteins (e.g. (wikipedia.org)
  • Short linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them difficult to identify. (nih.gov)
  • During my second postdoc, I coined the term "Short Linear Motif" (SLiM) for a specific type of protein interaction motif and was instrumental in developing SLiMDisc and SLiMFinder, two of the first algorithms for successfully predicting SLiMs from protein sequences. (edu.au)
  • 2) intrinsically disordered protein-protein interactions and short linear motifs (SLiMs). (edu.au)
Proteins7
  • The first definition was given by Tim Hunt: "The sequences of many proteins contain short, conserved motifs that are involved in recognition and targeting activities, often separate from other functional properties of the molecule in which they occur. (wikipedia.org)
  • MDM2 binds a subset of peptide motifs corresponding to real proteins with a range of allosteric responses to MDM2 ligands. (ed.ac.uk)
  • These data invoke two modes of peptide binding at the MDM2 N-terminus that rely on a consensus core motif to control the equilibrium between MDM2 binding proteins. (ed.ac.uk)
  • This approach stratifies MDM2 interacting proteins based on the linear motif feature and provides a new biomarker assay to define clinically relevant Nutlin-3 responsive MDM2 interactors. (ed.ac.uk)
  • Known as "destabilising motifs", these sequences attract the attention of a group of proteins called Ccr4-Not. (elifesciences.org)
  • CST uses peptide libraries as immunogens to produce antibodies reactive against short linear phosphorylated motifs present in many different proteins. (cellsignal.com)
  • Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. (bvsalud.org)
Lace motifs1
  • Quintessentially romantic, the Beatrix Dress is a bohemian gown featuring a high neckline and full-length sleeves, decorated with an embroidery inspired by Victorian lace motifs. (temperleylondon.com)
Animal motifs2
  • Among painted animal motifs are the deer, bull and duck. (indianetzone.com)
  • the latter describes this red-and-cream wool and cotton example with its floral and animal motifs. (cooperhewitt.org)
Curvilinear lines2
  • Though Figured and Fancy varieties do maintain regularity and often a linear quality, the inclusion of curvilinear lines, natural or architectural elements, etc. distinguishes. (cooperhewitt.org)
  • Art Nouveau can be characterized by floral motifs, curvilinear lines, bold linear shapes, and feminine silhouettes. (newel.com)
Herringbone1
  • GLASS MOSAIC Description Charisma™ captures the modern mosaic with picket, linear, and herringbone motifs. (emser.com)
Geometric3
  • The designs are mostly linear and geometric. (indianetzone.com)
  • Forms and decorative motifs, while thoroughly integrated, often were treated in a linear or geometric manner that rendered their relation to nature almost unrecognizable. (metmuseum.org)
  • Named after the Tabwa culture from Central Africa, the collection's inspiration comes from their fondness for linear geometric motifs. (designpublic.com)
Substrate3
  • In vitro proteome-wide detection of CN-binding peptides, in vivo SLiM-dependent proximity labeling, and in silico modeling of motif determinants uncovered unanticipated CN interactors, including NOTCH1, which we establish as a CN substrate. (nih.gov)
  • Rapid determination of multiple linear kinase substrate motifs by mass spectrometry. (kettenbachlab.org)
  • This novel method is broadly applicable to any protein kinase for which a substrate consensus motif has been identified and can also be used to produce antibodies highly reactive against acetylation, methylation and proteolytic cleavage containing motifs. (cellsignal.com)
Mediate2
  • Also, regions of high functional density can mediate molecular switching by means of overlapping motifs (e.g. the C-terminal tails of integrin beta subunits), or they can allow high avidity interactions by multiple low affinity motifs (e.g. multiple AP2-binding motifs in Eps15). (wikipedia.org)
  • Linear motifs mediate protein-protein interactions (PPI) that allow expansion of a target protein interactome at a systems level. (ed.ac.uk)
Bodice1
  • Hand-stitched botanical motifs and detailed hearts are embroidered onto the tulle bodice, and scattered with crystal stones. (temperleylondon.com)
Residues3
  • However, only few hotspot residues (on average 1 hotspot for each 3 residues in the motif) contribute the majority of the free energy of binding and determine most of the affinity and specificity of the interaction. (wikipedia.org)
  • First, only few or even a single mutation can result in the generation of a functional motif, with further mutations of flanking residues allowing tuning affinity and specificity. (wikipedia.org)
  • We propose that procentriole assembly requires PLK4 to phosphorylate STIL in two different regions: phosphorylation of residues in the STAN motif allow STIL to bind SAS6 and initiate cartwheel assembly, while phosphorylation of S428 promotes the binding of STIL to CPAP, linking the cartwheel to microtubules of the centriole wall. (elifesciences.org)
Interactions3
  • In addition, this means that these interactions can be easily modulated by post-translational modifications that change the structural and physicochemical properties of the motif. (wikipedia.org)
  • We use Statecharts for modeling small and recurring patterns of interactions in gene regulatory networks, called motifs . (biomedcentral.com)
  • My main focus are protein structure and intrinsic disorder, their interactions mediated by linear motifs and their evolution as modeled by substitution matrices. (about.me)
Protein interaction1
  • The biological activity of these short peptides got me interested in short protein-protein interaction motifs, which have been the subsequent focus of my research. (edu.au)
SLiM1
  • We harnessed unbiased systematic approaches for SLiM discovery to elucidate the regulatory network of calcineurin (CN)/PP2B, the Ca 2+ -activated phosphatase that recognizes LxVP and PxIxIT motifs. (nih.gov)
Patterns1
  • Patterns range from zigzags and stripes to linear Greek key motifs. (toryburch.com)
Sequence3
  • To further improve acquisition speed, we introduce concatenated, periodic DNA sequence motifs, yielding up to 100-fold-faster sampling in comparison to traditional DNA-PAINT. (nature.com)
  • We extend this approach to six orthogonal sequence motifs, now enabling speed-optimized multiplexed imaging. (nature.com)
  • Fig. 1: Faster DNA-PAINT through overlapping sequence motifs. (nature.com)
Tulle1
  • Linear embroidery, framed by a delicate scalloped edge Chantilly lace trim, run down the skirt and flow into voluminous dotty tulle godets. (temperleylondon.com)
Consensus2
  • A new linear motif based on a MDM2 interaction consensus is used to select novel MDM2 interactors based on Nutlin-3 responsiveness in a cell-based proteomics screen. (ed.ac.uk)
  • We validate cyclophilin B as a novel protein with a consensus MDM2 binding motif that is stabilised by Nutlin-3 in vivo, thus identifying one of the few known interactors of MDM2 that is stabilised by Nutlin-3. (ed.ac.uk)
Delicate1
  • The Gunda Gunde style is characterized by bold blocks of color defined by detailed, and often delicate, linear motifs. (loc.gov)
Embroidery1
  • The selection of motifs features a typology of couples, thoughtfully and continuously through an unyielding linear thread, from drawing to embroidery. (cd-cc.si)
Antibodies3
  • Beverly, MA-October 22, 2002 Business Wire - Cell Signaling Technology (CST) announced today the issuance of its U.S. Patent No. 6,441,140, directed to the production of a novel class of motif-specific, context-independent antibodies, highly useful for the identification of subclasses of protein kinase substrates. (cellsignal.com)
  • CONCLUSIONS: Overall, our results showed that antibodies elicited by specific linear epitopes of SARS-CoV-2 proteome are age dependent and related to COVID-19 clinical severity. (bvsalud.org)
  • Moreover, humoral immunity induced by primary vaccination with AZ displayed differences in linear spike peptide epitope coverage and a lack of anti-S2 IgG antibodies. (bvsalud.org)
Gene3
  • We present an improved method for modeling gene regulatory network motifs using Statecharts and we describe the successful modeling of several motifs, including those which could not be modeled or whose models could not be distinguished using the method of a previous proposal. (biomedcentral.com)
  • Our modeling approach is able to simulate some interesting temporal properties of gene regulatory network motifs: the delay in the activation and the deactivation of the "output" gene in the coherent type-1 feedforward loop, the pulse in the incoherent type-1 feedforward loop, the bistability nature of double positive and double negative feedback loops, the oscillatory behavior of the negative feedback loop, and the "lock-in" effect of positive autoregulation. (biomedcentral.com)
  • We present a Statecharts-based approach for the modeling of gene regulatory network motifs in biological systems. (biomedcentral.com)
Detection1
  • The detection of repeated subsequences, time series motifs, is a problem which has been shown to have great utility for several higher-level data mining algorithms, including classification, clustering, segmentation, forecasting, and rule discovery. (videolectures.net)
Ancient1
  • To be more specific, self destruction as well as the mutability of human fate is a main motif of ancient Greek tragedies. (lu.se)
Discovery2
  • However, for many domains, the inherent streaming nature of time series demands online discovery and maintenance of time series motifs. (videolectures.net)
  • In this paper, we develop the first online motif discovery algorithm which monitors and maintains motifs exactly in real time over the most recent history of a stream. (videolectures.net)
Highly1
  • The conservation of these motifs varies: some are highly conserved while others, for example, allow substitutions that retain only a certain pattern of charge across the motif. (wikipedia.org)
Research1
  • In recent years there has been significant research effort spent on efficiently discovering these motifs in static offline databases. (videolectures.net)
Data1
  • Our core ideas allow useful extensions of our algorithm to deal with arbitrary data rates and discovering multidimensional motifs. (videolectures.net)
Membrane1
  • Serum samples were analyzed by a peptide microarray containing 5828 overlapping 15-mer synthetic peptides corresponding to the full SARS-CoV-2 proteome and selected linear epitopes of spike (S), envelope (E) and membrane (M) glycoproteins as well as nucleoprotein (N) of MERS, SARS and coronaviruses 229E, OC43, NL63 and HKU1 (isolates 1, 2 and 5). (bvsalud.org)
Complex2
  • The basic motifs used to build more complex networks (that is, simple regulation, reciprocal regulation, feedback loop, feedforward loop, and autoregulation) can be faithfully described and their temporal dynamics can be analyzed. (biomedcentral.com)
  • Our algorithm has a worst-case update time which is linear to the window size and is extendible to maintain more complex pattern structures. (videolectures.net)
Means1
  • This means that when groups of mRNAs all carry the same motif, the cell can destroy them all together. (elifesciences.org)
Color1
  • From the start, his works were instead vibrant and rich in linear and color motifs and were informed by the surrounding culture, one of the oldest, largest, and most influential in Africa, with a long tradition of sculpture, wood and metal carving, textiles, and beadwork. (cdc.gov)
Approach1
  • This study uses a proteomics approach and linear motif sub-stratifications to expand on PPIs of MDM2. (ed.ac.uk)
Design1
  • Hex, linear, and wood inspired motifs act as a design springboa. (emser.com)
Life1
Easy1
  • We model motifs in an easy and intuitive way by taking advantage of the visual features of Statecharts. (biomedcentral.com)
Array1
  • We aimed to evaluate the immunoglobulin G (IgG) response towards linear peptides on a peptide array containing sequences from SARS-CoV-2, Middle East respiratory syndrome-related coronavirus (MERS) and common-cold coronaviruses 229E, OC43, NL63 and HKU1 antigens, in order to identify immunological indicators of disease outcome in SARS-CoV-2 infected patients. (bvsalud.org)
Quality1
  • Consequently, motif quality is a major determinant of mRNA stability for Puf3 targets in vivo and can be used for the prediction of mRNA targets. (elifesciences.org)
Black1
  • Experience the best cup of coffee with these Matte Black Linear Mugs. (kirklands.com)
Type1
  • Ces vingt dernières années, on assiste à une augmentation spectaculaire du nombre de cas de diabète de type 1 avec une mortalité plus élevée en Afrique Noire en lien avec les difficultés d'accès aux soins, à la rupture de suivi engendrant un nombre élevé de perdus de vue. (bvsalud.org)
Simple1
  • We will use this simple demo file showing a Linear Sketch Pattern. (javelin-tech.com)
Nature1
  • each 'minute' will feature a pair of garments-the primary work representing the linear nature of fashion and the secondary work its cyclical character. (designboom.com)