Linear iga dermatosis. Medical search. Frequent questions

Linear immunoglobulin A (IgA) dermatosis (LAD) is an autoimmune subepidermal vesiculobullous disease that may be idiopathic or drug-induced. (medscape.com)
Bullous lesions of the palmar surface in an elderly man with vancomycin-induced linear immunoglobulin A (IgA) dermatosis. (medscape.com)
Initially used as an antibiotic for leprosy, dapsone has been subsequently adapted to treat several skin diseases that are pathologically characterized by tissue deposition of immunoglobulin A (IgA) and infiltration of one type of white blood cells termed neutrophils. (scirp.org)
This article discusses the oral manifestations of several well-characterized autoimmune blistering diseases, including pemphigus vulgaris, bullous pemphigoid, linear immunoglobulin A (IgA) bullous dermatosis, and paraneoplastic pemphigus (PNP). (medscape.com)
A linear pattern of immunoglobulin and/or complement deposition at the cutaneous basement membrane zone is a characteristic feature in a number of acquired bullous diseases and is occasionally observed in systemic lupus erythematosus. (iacdworld.org)
Abstract: Childhood linear immunoglobulin A dermatosis is a rare autoimmune vesiculobullous disease. (investigacaoemdermatologia.com.br)
It results in linear deposition of autoantibodies (immunoglobulin A) against antigens in the basal membrane zone, leading to subepidermal cleavage. (investigacaoemdermatologia.com.br)
Linear immunoglobulin (Ig) A dermatosis is an immune-mediated bullous disease characterized by linear deposits of IgA along the basal membrane. (actasdermo.org)

Differentials include erythema multiforme, Stevens Johnson syndrome, and other autoimmune blistering diseases such as pemphigus vulgaris, bullous pemphigoid, epidermolysis bullosa acquisita, and linear IgA bullous dermatosis. (bauersmiles.com)

Linear IgA bullous dermatosis (LABD) is an autoimmune, subepidermal vesiculobullous dermatosis. (comu.edu.tr)
Autoimmune vesiculobullous conditions, drug-induced vulvar dermatoses and many such, which occur as part of generalized disease, are not discussed here. (jsstd.org)

Linear IgA dermatosis is an autoimmune disease histopathologically characterized by the linear deposition of IgA at the basement membrane zone (BMZ). (medscape.com)
The pathogenesis involves the deposition of IgA immune complexes in the papillary dermis. (logicalimages.com)

[ 5 ] linear IgA bullous dermatosis (dogs), epidermolysis bullosa acquisita (dogs), and bullous systemic lupus erythematosus (1 dog). (medscape.com)

587 Adult linear IgA disease is an acquired, autoimmune blistering disease that may present with a clinical pattern of vesicles indistinguishable from dermatitis herpetiformis, or with vesicles and bullae in a bullous pemphigoid-like appearance. (wikipedia.org)
The authors suggest that an IgA-specific immune response may occur against bullous pemphigoid antigens in linear IgA dermatosis. (medscape.com)
It is likely that some cases initially described were of bullous pemphigoid or linear IgA dermatosis bullosa, given the unavailability of better diagnostic tools at that period. (scielo.br)
The differential diagnosis includes bullous pemphigoid, cicatricial pemphigoid, linear IgA disease, a bullous drug eruption and a severe arthropod bite reaction. (lynniezulu.com)
Bullous pemphigoid is the most common autoimmune dermatosis presenting with crops of tense pruritic blisters, often in older adults. (lynniezulu.com)

The etiology underlying drug-induced linear IgA dermatosis remains elusive but is speculated to be caused by an immune response towards a drug-derived hapten-protein antigen. (medscape.com)
[ 37 ] Particularly severe cases of drug-induced linear IgA dermatosis respond to a short course of oral corticosteroids. (medscape.com)
Drug-induced linear IgA bullous dermatosis demonstrating the isomorphic phenomenon. (nih.gov)
Linear IgA bullous dermatitis can be idiopathic or drug-induced. (dermnetnz.org)
Drug-induced IgA disease usually resolves on withdrawal of the offending drug. (dermnetnz.org)

The differential diagnosis for SJS/TEN includes erythema multiforme (EM), autoimmune bullous diseases (including linear IgA dermatosis), autoimmune disease (including bullous lupus erythematosus), staphylococcal scalded skin syndrome (SSSS), graft-vs-host disease (GVHD), generalized fixed bullous drug eruption, and acute generalized exanthematous pustulosis (AGEP). (clinicaladvisor.com)

Unlike dermatitis herpetiformis , where the deposits of IgA on direct immunofluorescence are granular , there is no association with gluten sensitive enteropathy . (dermnetnz.org)
Dermatitis herpetiformis, an intensively itching and blistering skin disease related to gluten-sensitive enteropathy, is such an excellent example of IgA-mediated neutrophil-directed skin disease highly responsive to dapsone treatment [1]. (scirp.org)

Since dapsone is effective in treating IgA-mediated skin diseases by blocking the binding of neutrophils to the tissue site, it could also be an effective treatment for severe cases of COVID-19 lung injury, which has a similar pathological mechanism. (scirp.org)
In fact, dapsone is considered a first-line medication for these IgA-mediated skin diseases [1] [2]. (scirp.org)
The medical community recognized not only the clinical usefulness of dapsone for the treatment of IgA-mediated neutrophil-directed skin diseases, but also delineated the mechanism of how dapsone stops the destructive effects of neutrophils. (scirp.org)
Research conducted in our laboratory and in others has demonstrated that dapsone inhibits the binding of neutrophils to IgA. (scirp.org)
This IgA complex model system allowed us to examine the effects of neutrophil chemokine GM-CSF and dapsone on the binding of neutrophils to the IgA complex. (scirp.org)
In IgA-mediated pathogenesis, dapsone can be successfully used. (uni-luebeck.de)

Transient acantholytic dermatosis (Grover disease) is a pruritic papular eruption in the seborrheic regions of older men. (logicalimages.com)

In 1969 Van der Meer, in turn, revealed the occurrence of granular IgA deposits in those same locations, which constituted a major milestone for the understanding of this disease and permitted for the first time its differentiation from linear IgA dermatosis bullosa. (scielo.br)
The major diagnostic criterion for diagnosis is the presence of granular IgA deposits in the dermal papillae of uninvolved perilesional skin as shown by direct immunofluorescence, and the diagnosis should not be made unless this has been confirmed. (patient.info)

Childhood linear IgA disease (also known as "Chronic bullous disease of childhood") is an acquired, self-limited bullous disease that may begin by the time the patient is age 2 to 3 and usually remits by age 13. (wikipedia.org)
Children and adults are affected, with disease of the former historically referred to as chronic bullous dermatosis of childhood. (medscape.com)
It is also called linear IgA bullous dermatosis and in children, it may be known as linear IgA dermatosis of childhood or chronic bullous disease of childhood. (dermnetnz.org)
Also known as linear IgA bullous dermatosis or chronic bullous disease of childhood, LAD causes blisters on the skin and mucous membranes. (autoimmuneinstitute.org)

Bullous lesions on the genital area in a child with linear IgA dermatosis. (medscape.com)
In cases of linear IgA dermatosis induced by vancomycin, new lesions stop forming within approximately 2 weeks of withdrawal. (medscape.com)
Extremely rarely, severe IgA bullous disease develops in the neonatal period, and may progress to produce severe mucosal , aerodigestive lesions , and corneal scarring. (dermnetnz.org)

The best-characterized antigen is a 97-kd protein extracted from human epidermis that binds IgA antibodies from sera of patients with linear IgA dermatosis. (medscape.com)
this antigen is recognized by circulating antibodies in some patients with linear IgA dermatosis, but it has not been further characterized. (medscape.com)
Some patients possess IgA and IgG antibodies toward laminin 332 in what Zone et al described as linear IgA/IgG bullous dermatosis. (medscape.com)
IgA anti-tissue transglutaminase or IgA endomysial antibodies are highly specific and sensitive for untreated coeliac disease. (patient.info)
Typically, the skin blisters form in a line, and a corresponding line of IgA antibodies is found below the epidermis during skin biopsies. (autoimmuneinstitute.org)

LABD is an autoimmune blistering disorder characterized by the presence of linear IgA deposits along the basement membrane zone of the skin and mucous membranes. (bldgactive.com)
Skin Biopsy: A biopsy of a blister is often performed to examine the linear IgA deposits. (bldgactive.com)
Direct Immunofluorescence: This test helps in visualizing IgA deposits along the basement membrane. (bldgactive.com)
A few cases have been described in which direct immunofluorescence has revealed characteristic linear deposits of IgA. (dermnetnz.org)
DH is characterized by the presence of IgA deposits on top of the dermal papillae and manifests itself mainly on the extensor surface of the limbs, buttocks and scapular area. (scielo.br)

Linear IgA bullous disease may present as toxic epidermal necrolysis (TEN) - a severe cutaneous adverse drug reaction with widespread blistering and painful loss of skin. (dermnetnz.org)

Welcome to the definitive guide on Linear IgA Bullous Dermatosis (LABD), a complex skin disorder that can be challenging to diagnose and manage. (bldgactive.com)
Linear IgA Bullous Dermatosis, often abbreviated as LABD, is a rare autoimmune skin disorder. (bldgactive.com)

We designed an IgA complex model with IgA binding to skin basement membrane zone (BMZ) antigen. (scirp.org)
linear epidermal basement membrane zone deposit of IgA is found in involved and in normal skin . (en-academic.com)

We aim to delineate the similarities between IgA-mediated neutrophil-directed blistering skin diseases and the severe pulmonary COVID-19 infection by reviewing the relevant medical literatures, in order to compare the pathological mechanisms of these two different clinical situations. (scirp.org)
High incidence of autoimmune diseases and potential complications, including the development of lymphoma have been demonstrated in this dermatosis. (scielo.br)
We review the pathogenesis, clinical features, diagnosis, differential diagnosis, and therapy of autoimmune bullous skin diseases of childhood, especially of the most common linear IgA dermatosis. (uni-luebeck.de)
The course will finally focus on occupational dermatoses, skin cancer, and venereology (sexual transmitted diseases). (unict.it)

We report the case of a 60-year-old woman with rheumatoid arthritis being treated with sulfasalazine who developed linear IgA dermatosis and drug rash with eosinophilia and systemic symptoms (DRESS). (actasdermo.org)
The dermatosis and associated symptoms resolved following withdrawal of the drug and treatment with systemic corticosteroids for 2 months. (actasdermo.org)
Describimos el caso de una mujer de 60 años con artritis reumatoide en tratamiento con sulfasalazina, que desarrolló un cuadro de dermatosis IgA lineal con clínica de DRESS (drug-rash with eosinophilia and systemic symptoms) el cual respondió al suspender el fármaco causal más tratamiento con corticoides sistémicos durante dos meses. (actasdermo.org)

Drug eruptions can mimic a wide range of dermatoses. (medscape.com)

Patients with DH and CD may have the same association with histocompatibility antigens (HLA), the presence of circulating IgA against transglutaminase autoantigens and clinical remission on gluten-free diet. (scielo.br)

Linear IgA bullous dermatosis is a rare immune-mediated blistering skin disease frequently associated with medication exposure, especially vancomycin, with men and women being equally affected. (wikipedia.org)
Who gets linear IgA bullous disease? (dermnetnz.org)
What are the clinical features of linear IgA bullous disease? (dermnetnz.org)
How is linear IgA bullous disease diagnosed? (dermnetnz.org)
Gourgiotou K., Papathanasi K., Karalexis A., Katsambas A. Subcorneal pustular dermatosis and thyroid disease. (dermahair.gr)

Large, randomized, placebo-controlled, double-blind studies have not been performed for the treatment of linear IgA dermatosis in children or adults. (medscape.com)

ISSVD classification of inflammatory vulvar dermatoses. (jsstd.org)

Linear IgA Bullous Dermatosis: The Diagnostic Compass has guided us through the intricate landscape of this rare skin disorder. (bldgactive.com)
In juvenile plantar dermatosis , which affects children up to the age of 14, the skin on the front of the sole becomes red, glazed, and symmetrically cracked. (en-academic.com)

Analysis of published reports reveals strong evidence pointing to the involvement of IgA and neutrophils in both clinical situations. (scirp.org)

Diseases13

Chemicals and Drugs4

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Immunoglobulin8

Pemphigus vulgaris1

Vesiculobullous2

Deposition2

Epidermolysis bullosa acquisita1

Pemphigoid5

Drug-induced5

Bullous drug1

Dermatitis Herpetiformis2

Dapsone6

Acantholytic dermatosis1

Granular2

Chronic4

Lesions3

Antibodies5

Deposits5

Cutaneous1

LABD2

Basement2

Diseases4

Systemic3

Eruptions1

Antigens1

Disease5

Adults1

Inflammatory1

Skin2

Involvement1