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  • mutations
  • Our lab pioneered the concept, the mathematical foundations, as well as the implementation of utilizing somatic mutations naturally acquired by individual cells, to reconstruct cell lineage trees among cells of multi-cellular organisms and applied it to various questions of biological and medical importance. (weizmann.ac.il)
  • In particular, the reconstruction of a cell lineage tree, capturing the cell division history of organism cells, can be attempted by applying algorithms and techniques of population genetics to somatic mutations accumulated during cell division. (weizmann.ac.il)
  • We applied a method for reconstructing cell lineage trees from somatic mutations to MSCs and myogenic and non-myogenic cells from individual myofiber that were cultured at clonal density. (weizmann.ac.il)
  • We analyze acquired somatic mutations to reconstruct lineage trees of hundreds of oocytes and other cells, sampled from mismatch-repair deficient mice at various ages. (weizmann.ac.il)
  • In the current study, a high-throughput method that utilizes neutral somatic mutations accumulated in individual cells to reconstruct cell lineage trees was applied to hundreds of cells of human acute leukemia harvested from multiple patients at diagnosis and at relapse. (weizmann.ac.il)
  • It is often argued that a reduced ability to purge deleterious mutations condemns asexual lineages to an early extinction. (pnas.org)
  • genes
  • The Human Cell Lineage Identification RT² Profiler PCR Array profiles the expression of 84 key genes for cellular differentiation. (qiagen.com)
  • A genetic and developmental pathway from STAT 3 to the OCT 4 -NANOG circuit is essential for maintenance of ICM lineages in vivo," Genes and Development , vol. 27, no. 12, pp. 1378-1390, 2013. (hindawi.com)
  • RNAi knockdown of either Cbx3 or Med26 inhibits neural differentiation while up-regulating genes involved in mesodermal lineage decisions. (nih.gov)
  • Thus, Cbx3 and Med26 together ensure the fidelity of lineage specification by enhancing the expression of neural genes and down-regulating genes specific to alternative fates. (nih.gov)
  • species
  • Yet, despite this bleak theoretical forecast, some lineages, including the bdelloid rotifers ( 5 ), oribatid mites ( 6 ), and darwinulid ostracods ( 7 , 8 ), dispensed with sexual reproduction long ago, and the majority of animal phyla have some obligately asexual species ( 9 ). (pnas.org)
  • It argues that many of the tropics' species-rich lineages originated there and were slow in colonizing the temperate zones that have killer winters. (thefreedictionary.com)
  • These results provide a rare demonstration of a large-scale and probably driven trend occurring across multiple independent lineages and influencing both the form and number of species through deep time and in the present day. (pnas.org)
  • We present here an analysis of 45 orthologous gene sequences across the eight species that resolves the relationships of major Plasmodium lineages, and provides the first comprehensive dating of the age of those groups. (cambridge.org)
  • Although some 30 plant lineages have been classified as succulent, only a small subset of those are species-rich and ecologically important elements of arid and semiarid ecosystems worldwide. (pnas.org)
  • Early, diverse fossils - those currently recognized as coming from distinct species like Homo habilis, Homo erectus and others - may actually represent variation among members of a single, evolving lineage. (nytimes.com)
  • ancestors
  • Abundant data from the Ming dynasty onward enable Szonyi to survey the historical evolution of lineages through ancestral halls, where agnatic kinsmen perform rituals before the ancestors' spirit tablets. (thefreedictionary.com)
  • Lineage society for descendants of ancestors who were made Knights of the Bath. (cyndislist.com)
  • No studies have yet been done, however, to characterize the HCDR3-binder-class responses to immunization, nor have any bona fide unmutated common ancestors (UCAs) from full, patient-derived bnAb lineages been studied in the setting of a bnAb KI model. (nature.com)
  • vivo
  • Equating this information with the in vivo location of cells and their lineage history is a current challenge. (nature.com)
  • traces
  • The Nyingma lineage traces its origin to the Indian master, Guru Padmasambhava, also known as Guru Rinpoche, who came to Tibet in 817 C.E. at the invitation of the Tibetan King, Trisong Detsen (742-797). (nalandabodhi.org)
  • patterns
  • Methods for analyzing the patterns of nonsynonymous and synonymous substitutions usually rely on stochastic models in which the selection regime may vary across the sequence but remains constant across lineages for any amino acid position. (pnas.org)
  • gene
  • It has been suggested that the absence of meiosis in asexual lineages causes the two alleles at any given locus to become progressively more divergent given that within-individual recombination (gene conversion and/or crossing over) and chromosomal deletions occur at negligible levels ( 5 , 12 , 13 ). (pnas.org)
  • major
  • Here, we demonstrate a parallel increase in the morphological complexity of most of the deep lineages within a major clade. (pnas.org)
  • Here, we demonstrate a remarkable and pervasive trend for increasing morphological complexity in multiple parallel lineages of the Crustacea [the major arthropod group with the longest and most disparate fossil record ( 10 )] throughout the Phanerozoic. (pnas.org)
  • Phylogeny of babblers (Aves, Passeriformes): major lineages, fami. (ingentaconnect.com)
  • pathway
  • CH103, a prototype of the HCDR3-binder class of CD4-binding site bnAbs, is one of the only two bnAb lineages whose complete virus-Ab co-evolution pathway has been comprehensively characterized 6 , and whose co-evolved Env maturation pathway, from which sequential immunogens have been derived for this study, can now also be investigated in SHIV CH505-infected non-human primates 20 . (nature.com)
  • populations
  • The findings are a start to identifying the location of specific pieces of Neanderthal DNA in modern humans and a beginning to creating a collection of Neanderthal lineages surviving in present-day human populations. (eurekalert.org)
  • analysis
  • NEW YORK (GenomeWeb) - Different Salmonella Enteritidis lineages are behind the enterocolitis it causes in high-income areas and the invasive disease it causes in low-income areas, a new genomic analysis suggests. (genomeweb.com)
  • In addition, the analysis of surviving archaic lineages points to the possibility that there were fitness costs to the hybridization of Neanderthal and humans," Akey said. (eurekalert.org)
  • Data lineage enables you to trace data quality issues and other errors back to their root cause and perform impact analysis on proposed changes. (sas.com)
  • thus
  • They, together with the Tibetan-born teacher Vairochana, received the transmission of this lineage directly from the aforementioned lineage holders, and in turn transmitted and brought the lineage and teachings to Tibet, thus commencing in Tibet the lineage which continues to the present day. (nalandabodhi.org)
  • include
  • These lineages of revealed teachings include the Dzogchen, or Great Completion, teachings taught by Garab Dorje, Shri Simha, Padmasambhava, Jnanasutra, and Vimalamitra, and are known today in Tibet as the Nyingma lineage. (nalandabodhi.org)
  • addition
  • In addition, we confirmed the positive correlation between physical and lineage proximity of crypts, by showing that the colon is separated into small domains that share a common ancestor. (weizmann.ac.il)
  • In addition, private interests within the lineage also had their parts to play, and theft and embezzlement were not uncommon. (thefreedictionary.com)
  • individual cells
  • NEW YORK (GenomeWeb) - Using somatic base substitutions as a guide, researchers from the Wellcome Trust Sanger Centre and elsewhere developed a method to trace the lineages of individual cells back to the earliest divisions of the fertilized egg. (genomeweb.com)
  • details
  • That's a good analogy for data lineage, which details the journey data took to get from where it started to where it is now. (sas.com)
  • common
  • Phys.org) -- The most common lineages of fish found today in oceans, lakes, and rivers evolved about the same time as mammals and birds, a new Yale University-led study shows. (phys.org)
  • The first six of these nine yanas or vehicles are common to all schools of Tibetan Buddhism, whereas the last three are unique to the Nyingma lineage. (nalandabodhi.org)
  • Several
  • The lineage has a broad distribution, but is most prominent in semiarid and arid regions, with several main centers of diversity in arid Mexico and the southwestern United States, the central Andes of Peru and Bolivia, and eastern Brazil ( 2 ). (pnas.org)
  • Methods
  • The Lineage acetabular system with metal liners uses sophisticated manufacturing methods and materials to minimize wear debris generation. (bio-medicine.org)
  • back
  • Please enter your email so we can alert you when the LINEAGE PACK 29L BACKPACK in is back in stock. (thenorthface.com)
  • Shenhui was so successful in this endeavor that the vast majority of Chan lineages since that time have traced themselves back to Huineng rather than Faru, Shenxiu, or Xuanze. (thefreedictionary.com)
  • size
  • Proposed evolutionary trends, such as Cope's rule for evolutionary size increase within lineages, have generally turned out to be only weakly predictive, either resulting from passive diffusion away from some barrier ( 1 - 4 ) or applying only at local temporal and taxonomic scales ( 5 - 9 ). (pnas.org)
  • shows
  • Data lineage shows where and when data was created or captured, and where it is stored and maintained. (sas.com)
  • Direct
  • Direct experimental observations on the genomic stability of asexual lineages are necessary to shed light on this issue. (pnas.org)
  • The only national lineage society for female direct descendants of Union veterans of the Civil War. (cyndislist.com)
  • A lineage society to honor those who can prove they are direct descendants of Union soldiers who served in Indiana units in the Civil War, or who were residents of Indiana when they served in non-Indiana units. (cyndislist.com)
  • degree
  • With purely descriptive data, it is difficult to evaluate whether this pattern is a consequence of the rapid demise of asexual lineages, an unusual degree of mutational stability, or recombination. (pnas.org)
  • provides
  • Data lineage provides a complete audit trail for data, which is increasingly important for compliance with regulations such as the EU GDPR. (sas.com)