• In particular, mutations in DNA binding sites recognized by transcription factors can alter regulator binding affinities and, consequently, expression of target genes. (biomedcentral.com)
  • The transcription factor RBPJ forms a coactivator complex in the presence of a Notch signal, whereas it represses Notch target genes in the absence of a Notch stimulus. (uni-ulm.de)
  • In line with this, RBPJL is able to fully reconstitute transcriptional repression at Notch target genes in cells lacking RBPJ. (uni-ulm.de)
  • Enhancers promote transcription by providing a binding platform for transcription factors [ 12 ] that can act on (distal) target genes through three-dimensional chromatin looping [ 13 - 15 ]. (biomedcentral.com)
  • As a TF, USF1 has a bidirectional regulatory function, being able to regulate gene expression by activating or suppressing the promoter region of target genes ( 5 , 6 ). (spandidos-publications.com)
  • FOXP2 represents the first transcription factor whose expression consistently differentiates normal and abnormal plasma cells and FOXP2 target genes are implicated in MM pathogenesis. (ox.ac.uk)
  • To understand SARS-CoV-2 microevolution, this study explored the genome-wide frequency, gene-wise distribution, and molecular nature of all point-mutations detected across its 71,703 RNA-genomes deposited in the GISAID repository, till 21 August 2020. (preprints.org)
  • Phylogeny based on 4,618 spatiotemporally-representative genomes revealed that entities belonging to the early lineages are mostly spread over Asian countries (including India, the biggest hotspot of the pandemic) whereas the recently-derived lineages are more globally distributed. (preprints.org)
  • By comparing the genomes of species whose evolutionary lineages diverged at different times in the past, researchers can see when in evolutionary history a particular conserved sequence first appeared. (sciencedaily.com)
  • a , Maximum-likelihood tree using concatenated protein sequences of 100 genes randomly selected from 4,694 Fusarium orthologous genes that have clear 1:1:1:1 correlation among the Fusarium genomes and have unique matches in Magnaporthe grisea , Neurospora crassa and Aspergillus nidulans . (nature.com)
  • Both pufferfish genomes encode five tenascin genes: two tenascin-C paralogs, a tenascin-R with domain organization identical to mammalian and avian tenascin-R, a small tenascin-X with previously undescribed GK repeats, and a tenascin-W. Four tenascin genes corresponding to tenascin-C, tenascin-R, tenascin-X and tenascin-W were also identified in the X. tropicalis genome. (biomedcentral.com)
  • While the size of the introns, number of introns per gene and the number of intron-containing genes can vary greatly between sequenced eukaryotic genomes, the structure of a gene with reference to intron presence and positions is typically conserved in closely related species. (biomedcentral.com)
  • Evolution of genes and genomes on the Drosophila phylogeny. (kb.se)
  • In the first period of evolutionary innovation, in addition to changes affecting developmental genes, the study found a dramatic enrichment in conserved elements near genes for proteins known as "transcription factors," which bind to DNA and regulate whole groups of other genes. (sciencedaily.com)
  • In contrast to cytokines, transcription factors often are localized inside the nucleus and bound to DNA and other proteins. (bdbiosciences.com)
  • This buffer system can also be used to stain some transcription factors and other intracellular proteins. (bdbiosciences.com)
  • Close to 800 genes remain annotated as hypothetical proteins awaiting proper identification (1). (sjtu.edu.cn)
  • Previously, the genome of the cereal pathogen Fg was sequenced and shown to encode a larger number of proteins in pathogenicity related protein families compared to non-pathogenic fungi, including predicted transcription factors, hydrolytic enzymes, and transmembrane transporters 5 . (nature.com)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • These are frequently activated by fusion to other transcriptional proteins resulting in chimeric transcription factors. (stanford.edu)
  • Locally, a number of proteins called lineage-determining transcription factors can access their binding sites even if they are partially occluded by nucleosomes, recruiting chromatin-remodeling enzymes and exposing the underlying DNA. (vahedilab.com)
  • Promoter region motif analysis indicated that ETV5 has more binding motifs and genes than USF1 itself for USF1‑regulated DEGs, indicating that USF1 may indirectly modulate gene expression by regulating ETV5 expression in Huh7 cells. (spandidos-publications.com)
  • XCI leads to the transcriptional silencing of one of the X chromosomes in female cells, which results in expression of the genes that located on the other, remaining active X chromosome. (wikipedia.org)
  • Results: By live imaging of single-gene transcriptional events in individual cells, we have directly recorded the potential for mitotic inheritance of transcriptional states down cell lineages. (dundee.ac.uk)
  • Our data showed strong similarity in frequency of transcriptional firing between mother and daughter cells. (dundee.ac.uk)
  • Both transcriptional pulse length and pulsing rate contributed to overall inheritance, and memory was determined by lineage, not cell environment. (dundee.ac.uk)
  • Although methylated H3K4 is usually associated with active transcriptional units, the modification was not required for gene activity but stabilized transcriptional frequency between generations. (dundee.ac.uk)
  • The hierarchical levels of genome architecture exert transcriptional control by tuning the accessibility and proximity of genes and regulatory elements. (biomedcentral.com)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
  • Second, systematic examination of transcriptional regulation has yielded new understanding about transcription start sites, including their relationship to specific regulatory sequences and features of chromatin accessibility and histone modification. (kb.se)
  • Rapid genomic sequencing and phylogenetic analysis revealed 2 distinct introductions of the lineage. (cdc.gov)
  • Genomic sequencing and analysis during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic have led to identification of ≈800 distinct SARS-CoV-2 lineages worldwide. (cdc.gov)
  • data, https://virological.org/t/preliminary-genomic-characterisation-of-an-emergent-sars-cov-2-lineage-in-the-uk-defined-by-a-novel-set-of-spike-mutations/563 ). (cdc.gov)
  • Genomic profiling also identifies genes associated with poor outcome in cases without molecular aberrations and specific genes that may be new therapeutic targets in adult ALL. (aacrjournals.org)
  • Our analysis revealed lineage-specific (LS) genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome. (nature.com)
  • Evolutionary loss and gain of introns in genomic sequence data may provide a mechanism by which organisms diversify gene expression and gene function. (biomedcentral.com)
  • Many of these genes were homologous to eukaryotic genes that encode fundamental processes in replication, transcription, and translation, providing direct evidence for their importance in Archaea. (sjtu.edu.cn)
  • The presence of non-coding introns is a characteristic feature of most eukaryotic genes. (biomedcentral.com)
  • XCI is a chromosome-wide monoallelic expression, that includes expression of all genes that are located on X chromosome, in contrast to autosomal RME (aRME) that relates to single genes that are interspersed over the genome. (wikipedia.org)
  • Methods of MAE detection can be divided into single gene or whole genome MAE analysis. (wikipedia.org)
  • Single-gene analysis Genome-wide analysis Chess A (November 2016). (wikipedia.org)
  • DNA methylation is the most commonly studied epigenetic mark in humans, as it is well recognised as a stable, heritable mark that can affect genome function and influence gene expression. (frontiersin.org)
  • They classified the genes into broad categories, such as developmental genes or genes involved in communication between cells, using information on gene functions available through the UCSC Genome Browser. (sciencedaily.com)
  • A single tenascin gene was identified in the genome of C. intestinalis that encodes a polypeptide with domain features common to all vertebrate tenascins. (biomedcentral.com)
  • Using whole-genome sequencing of OS, we found features of TP53 intron 1 rearrangements suggesting a unique mechanism correlated with transcription. (oncotarget.com)
  • Entire-genome sequence (WGS) evaluation indicated that each one the strains carried mdfA, a drug resistance gene for macrolide antibiotics, and in addition pathogenicity-related genes much like these within the Sakai pressure. (cellgenetherapy.com)
  • A deletion anywhere in the mitochondrial genome may affect transcription or translation of genes that were not affected by the deletion. (medscape.com)
  • Analysis of transcription in chromatin mutants demonstrated that the histone H3K4 methylase Set1 and Ash2, a component of the methylase complex, are required for memory. (dundee.ac.uk)
  • Both genes had been shown to contend aswell as cooperate in repressing lineage-specific transcription elements in HSCs.23 encodes to get a chromatin-binding protein. (afl-journal.org)
  • Binding of sequence-specific transcription factors and associated chromatin-modifying enzymes can induce post-translational modification of histone tails and can facilitate nucleosome removal [ 3 - 5 ], which can turn functional sequences such as promoters and enhancers into active, nucleosome-depleted sites [ 2 ]. (biomedcentral.com)
  • 2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)
  • We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)
  • We demonstrated for the first time that a transcription factor called TCF-1, which has been known to be required for T cell development for two decades, has an exceptional property to unwrap DNA from nucleosomes and create open chromatin, establishing the epigenetic identity of T cells (Johnson et al. (vahedilab.com)
  • 2018). Strikingly, we found that the ectopic expression of TCF-1 in fibroblasts can unwrap DNA from nucleosomes even at stretches with the most refractory chromatin states, leading to gene expression. (vahedilab.com)
  • We aim to elucidate the precise epigenetic mechanisms through which TCF-1 interacts with chromatin remodeling enzymes to unwrap DNA from nucleosomes, thus leading to a highly orchestrated cascade of gene expression events that drive T cell development and function. (vahedilab.com)
  • A detailed molecular understanding of the interactions between transcription factors and chromatin remodelers in packaging of DNA into chromatin in T cells is a significant contribution since it forms the foundation for the development of highly selective and efficient strategies including epigenetic therapies that could alter T cell fate and function at will. (vahedilab.com)
  • Because mutations in genes that are likely to be essential or strongly advantageous for growth are lethal or rapidly lost from the library, they may be identified by their low frequency in the libraries. (sjtu.edu.cn)
  • Monoallelic gene expression (MAE) is the phenomenon of the gene expression, when only one of the two gene copies (alleles) is actively expressed (transcribed), while the other is silent. (wikipedia.org)
  • Diploid organisms bear two homologous copies of each chromosome (one from each parent), a gene can be expressed from both chromosomes (biallelic expression) or from only one (monoallelic expression). (wikipedia.org)
  • XCI is critical for balanced gene expression in female mammals. (wikipedia.org)
  • The allelic choice of XCI by individual cells takes place randomly in epiblasts of the preimplantation embryo, which leads to mosaic gene expression of the paternal and maternal X chromosome in female tissues. (wikipedia.org)
  • Another scenario is also possible due to limited time-window of low-probability initiation, that could lead to high frequencies of cells with single-allele expression. (wikipedia.org)
  • Allelic exclusion is a process of gene expression when one allele is expressed and the other one kept silent. (wikipedia.org)
  • Epigenetic marks are heritable DNA modifications that can influence gene expression without changing the DNA sequence. (frontiersin.org)
  • To characterize gene expression signatures in acute lymphocytic leukemia (ALL) cells associated with known genotypic abnormalities in adult patients. (aacrjournals.org)
  • Gene expression profiles from 128 adult patients with newly diagnosed ALL were characterized using high-density oligonucleotide microarrays. (aacrjournals.org)
  • T-lineage ALL was characterized by a homogeneous gene expression pattern, whereas several subgroups of B-lineage ALL were evident. (aacrjournals.org)
  • BCR/ABL + gene expression pattern was more heterogeneous and was most similar to ALL without known molecular rearrangements. (aacrjournals.org)
  • Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. (aacrjournals.org)
  • Moreover, a correlational analysis between GINS1 expression and CD8+ T immune cells and a the construction of gene-drug interaction network was performed using TIMER, CDT, and Cytoscape. (bvsalud.org)
  • Here, we show that HSC-like cells were efficiently induced from mouse ESCs by enforced expression of Lhx2, a LIM-homeobox transcription factor. (ebiotrade.com)
  • Hence, TADs are believed to represent structural chromosomal units that are of functional importance for the regulatory cross talk that determines gene expression programs. (biomedcentral.com)
  • These results are reinforced by data integration including single nucleotide polymorphism array and gene expression array. (kb.se)
  • Meanwhile, gene expression data suggest that the MYH16 gene isn't as dead as it looks. (johnhawks.net)
  • Targeted disruption of the gene encoding D4Rs reduces the amplitude of the contrast sensitivity rhythm by reducing daytime sensitivity and abolishes the rhythmic expression of Npas2 and Adcy1 mRNA in the ganglion cell layer (GCL) of the retina. (jneurosci.org)
  • Aberrant expression of the neuronal transcription factor FOXP2 in neoplastic plasma cells. (ox.ac.uk)
  • Regarding animal models in ASD, many studies focus on gene expression, cortical neuronal migration and cell maturation, and neural network deficits. (bvsalud.org)
  • However, very few studies directly link animal oral communication and gene expression in cortical areas of language. (bvsalud.org)
  • 3. Translational research - to identify predictive biomarkers for treatment decision - by immunohistochemistry, gene expression or sequencing. (lu.se)
  • FOXP2 mRNA and protein were absent in mononuclear cells from different anatomical sites, lineages and stages of differentiation. (ox.ac.uk)
  • This gene encodes a nuclear polyglutamine-binding protein that is involved with transcription activation. (nih.gov)
  • In addition, mitochondrial DNA (mtDNA) encodes 2 ribosomal RNA genes and 22 transfer RNA (tRNA) genes necessary for the intramitochondrial synthesis of these 13 polypeptides. (medscape.com)
  • Unexpectedly, the ABCB1 (ATP-Binding Cassette Subfamily B Member 1) gene which encodes a P-glycoprotein and underlies dwarfing traits in maize ( br2 ), sorghum ( dw3 ) and pearl millet ( d2 ) displayed considerable variation in intron composition. (biomedcentral.com)
  • Frequencies of synonymous and non-synonymous substitutions allow studying selection of cancer somatic mutations in protein-coding regions [ 11 ]. (biomedcentral.com)
  • Many previous studies have shown that important evolutionary changes in animals have resulted from the gain, loss, or modification of gene regulatory elements, rather than from the evolution of new protein-coding genes. (sciencedaily.com)
  • One of the few antigens against which mammals develop protective immunity is the highly polymorphic OspC protein, encoded by the ospC gene on the cp26 plasmid. (cdc.gov)
  • By means of DNA sequencing of a large sample collection of the pathogen from across the United States, we studied the gene for the bacterium's highly diverse OspC protein, protective immunity against which develops in animals. (cdc.gov)
  • Forkhead box protein M1 (FOXM1) is a key transcription factor (TF) that regulates a common set of genes related to the cell cycle in various cell types. (mdpi.com)
  • Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. (nih.gov)
  • For instance, the methanogen Methanococcus maripaludis S2 possesses 1,728 protein coding genes, only a few of which have been characterized and an even smaller portion has been studied in detail. (sjtu.edu.cn)
  • The upregulated DEGs were primarily protein‑coding genes enriched in immune and inflammation response pathways, while the downregulated DEGs were mainly coding long non‑coding (lnc)RNAs, indicating the regulatory function of USF1. (spandidos-publications.com)
  • In order to learn more about their origins and relationships to each other, as well as to clarify the nomenclature used to describe them, the tenascin genes of the urochordate Ciona intestinalis , the pufferfish Tetraodon nigroviridis and Takifugu rubripes and the frog Xenopus tropicalis were identified and their gene organization and predicted protein products compared with the previously characterized tenascins of amniotes. (biomedcentral.com)
  • As well as, in contrast to glial fibrillary acidic protein (GFAP)-positive glioblastomas generated utilizing the same methodology in a earlier mannequin, the vast majority of tumor cells have been constructive for oligodendrocyte lineage transcription issue 2, however destructive for GFAP and neurofilaments. (cellgenetherapy.com)
  • In twenty one CC sufferers, PCR amplified E6/E7 genes have been decoded by DNA sequencing to check phylogenetic relatedness, mutational adjustments and their in-silico impact on protein construction. (cellgenetherapy.com)
  • Despite remarkable similarities among these Drosophila species, we identified many putatively non-neutral changes in protein-coding genes, non-coding RNA genes, and cis-regulatory regions. (kb.se)
  • Furthermore, transplantation of Lhx2-transduced hematopoietic cells into lethally irradiated mice resulted in multi-lineage repopulation of hematopoietic cells over 4 months. (ebiotrade.com)
  • HSCs with mutated may actually possess a proliferative benefit comparted to wild-type HSCs and predispose HSCs to malignant transformaiton.20,21 Hydroxychloroquine Sulfate can be the mostly mutated gene identified in clonal hematopoiesis of indeterminate potential (CHIP).22 Additionally, there is apparently a primary link between TET2 and DNMT3A in hematopoietic cells. (afl-journal.org)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
  • They found three broad categories of evolutionary innovations in gene regulation that increased in frequency during different periods in vertebrate evolution. (sciencedaily.com)
  • So many new body plans evolved during this time, it makes sense that the strongest signal in our analysis is for changes affecting genes involved in the development of the body plan and the complex regulation of other genes," said David Haussler, a distinguished professor of biomolecular engineering in the Baskin School of Engineering at UC Santa Cruz and corresponding author of the paper. (sciencedaily.com)
  • The results reinforce the importance of gene regulation as a mechanism through which evolution occurs on the molecular level, he said. (sciencedaily.com)
  • We are interested in understanding the underlying molecular mechanisms of senescence regulation by these genes. (umassmed.edu)
  • Our study demonstrates a circadian rhythm of contrast sensitivity that peaks during the daytime, and that its regulation involves interactions of D4Rs, the clock gene Npas2 , and the clock-controlled gene adenylyl cyclase 1 ( Adcy1 ) in a subset of retinal ganglion cells (RGCs). (jneurosci.org)
  • A new phylogenetic cluster, B.1.1.7 lineage or variant of concern 202012/01, is characterized by 17 unique mutations and was first detected in southeastern England in late September 2020 (A. Rambaut et al. (cdc.gov)
  • E6/E7 nonsynonmous mutations have a spectrum of organic impact in development of CC. Phylogenetic evaluation revealed ten sequence belonged to Asian whereas eleven to European sublineage to indicate CC circumstances in Chhattisgarh are a mixture of Asian and European lineage. (cellgenetherapy.com)
  • Phylogenetic analysis of phenotypically similar h-GISA in our study also suggests that CF patients are colonized by polyclonal populations of MRSA that represents an incredible reservoir for lateral gene transfer. (biomedcentral.com)
  • Our analysis identified 26 genes that are mutated at significantly high frequencies and thus are probably involved in carcinogenesis. (kb.se)
  • DNA sequencing of 623 genes with known or potential relationships to cancer revealed more than 1,000 somatic mutations across the samples. (kb.se)
  • These data provide evidence of somatic mutations in primary lung adenocarcinoma for several tumour suppressor genes involved in other cancers--including NF1, APC, RB1 and ATM--and for sequence changes in PTPRD as well as the frequently deleted gene LRP1B. (kb.se)
  • The first period, for example, was dominated by regulatory innovations affecting genes involved in embryonic development. (sciencedaily.com)
  • Although definitive assignments of essentiality still require detailed analyses of each gene, the methodology generates hypotheses about the nature of specific genes and a great deal of insight into specific questions regarding methanogens as well as more general questions about the genetics, biochemistry and physiology of archaea. (sjtu.edu.cn)
  • As of January 17, 2021, this lineage had been confirmed in 38 countries ( https://cov-lineages.org/global_report_B.1.1.7.html ). (cdc.gov)
  • There is growing evidence that resident progenitor cell populations exist in murine lung tissues and differentiate into a mesenchymal cell lineage [1, 2]. (keio.ac.jp)
  • In birds and mammals, tenascin-R genes encode 4.5 EGF-like repeats and 9 FN type III domains. (biomedcentral.com)
  • This tenascin has 18.5 EGF-like repeats, and the tenascin-X genes of mouse and human encode 29 and 32 FN type III domains, respectively. (biomedcentral.com)
  • Identification of genes involved in in vitro differentiation induction of embryonic stem cells (ESCs) into hematopoietic stem cells (HSCs) has been challenged during last decade. (ebiotrade.com)
  • Transduction of Lhx2 into ESC-derived mesodermal cells resulted in robust differentiation of c-Kit+/Sca-1+/Lineage- (KSL) cells in vitro. (ebiotrade.com)
  • Conclusions: This study showed that an osteoblastic cell lineage may be obtained from human bone marrow derived from adherent cells, and that the presence of the rhBMP-4 seems to have an effect during the first stages of differentiation only. (bvsalud.org)
  • Within B-lineage ALL, distinct signatures were associated with ALL1/AF4 and E2A/PBX1 gene rearrangements. (aacrjournals.org)
  • LS regions are rich in transposons and genes with distinct evolutionary profiles but related to pathogenicity, indicative of horizontal acquisition. (nature.com)
  • Retrospective studies of the survivors of famines, such as those exposed to the Dutch Hunger Winter of 1944-45, have linked exposures around conception to later disease outcomes, some of which correlate with DNA methylation changes at certain genes. (frontiersin.org)
  • The object of our study aimed to review and to correlate genes involved in ASD and those related to ultrasonic communication in animal model studies of language-based social behavior at the PubMed database. (bvsalud.org)
  • So over time, both alleles have a probability to initiate transcription. (wikipedia.org)
  • Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy. (crossref.org)
  • Frequency and distribution of polyQ disease intermediate-length repeat alleles in healthy Italian population. (nih.gov)
  • The Association for Molecular Pathology PGx Working Group considered functional impact of the variant alleles, allele frequencies in multiethnic populations, the availability of reference materials, and other technical considerations for PGx testing when developing these recommendations. (cdc.gov)
  • We found that the distributions and frequencies of types of OspC genes differed between populations of B. burgdorferi in the Northeast, the Midwest, and California. (cdc.gov)
  • A deep understanding of molecular mechanisms relevant to gene-environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. (frontiersin.org)
  • Gene-environment interactions, sunlight and vitamin D, and T lymphocytes as autoimmune disease initiators and vitamin D targets are discussed to explain the rationale for reviewing vitamin D mechanisms in T cells. (frontiersin.org)
  • Two main mechanisms for intron loss have been proposed, that is reverse transcription (RT)-mediated intron loss and intron deletion triggered by repair of double strand breaks (DSBs) via non-homologous end joining (NHEJ). (biomedcentral.com)
  • For many transcription factors, including multiple members of FOX, HOX, and NR families, we show that human cancers accumulate fewer mutations than expected by chance that increase or decrease affinity of predicted binding sites. (biomedcentral.com)
  • Further analysis of transcription factors with conserved binding motifs can reveal cell regulatory pathways crucial for the survivability of various human cancers. (biomedcentral.com)
  • Cooperative activity of GR with other transcription factors and a plethora of coregulators contribute to the tissue- and context-specific response toward the endogenous and pharmacological glucocorticoids (GCs). (uni-ulm.de)
  • New regulatory elements affecting transcription factors peaked in our early vertebrate ancestors 500 million years ago, then declined steadily to background levels by the time mammals evolved. (sciencedaily.com)
  • For some cell types, such as Th17 and regulatory T cells (Tregs), definitive identification depends on the combined use of surface and intracellular markers such as cytokines or transcription factors. (bdbiosciences.com)
  • No. 562574 / 562725 ) is designed for the staining of transcription factors alone or in combination with cell surface markers and cytokines. (bdbiosciences.com)
  • The T-box family genes are evolutionarily conserved transcription factors. (keio.ac.jp)
  • We show that T-box transcription factors called TBX-37 and TBX-38 are essential for mesodermal induction, and that these factors are expressed in ABa, but not ABp, descendants. (silverchair.com)
  • Inflammaging is driven by several factors, such as single nucleotide polymorphisms in the promoter regions of pro- and anti-inflammatory genes, chronic stimulation of immune cells with pathogens, changes in the composition of the gut microbiota, and cellular senescence [ 8 ]. (biomedcentral.com)
  • While driving for work is common in this industry and risky driving behaviors have been identified as contributing factors to fatal crashes among OGE workers, limited information is available on the frequency of risky driving behaviors and employer policies to reduce these behaviors. (cdc.gov)
  • FOXP2 mutation causes a severe inherited speech and language defect, while the related transcription factors FOXP1, FOXP3 and FOXP4 are implicated in cancer. (ox.ac.uk)
  • A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment. (crossref.org)
  • occur in every subgroups of MDS, which holds true for additional gene mutations involving epigenetic modifiers also.1,2 mutations in hematologic malignancies could be solitary nucleotide variants (SNV) aswell as frameshift mutations in MDS. (afl-journal.org)
  • These defects include 1) reduced class switch recombination, responsible for the generation of a secondary response of class switched antibodies, 2) reduced de novo somatic hypermutation of the antibody variable region, 3) reduced binding and neutralization capacity, as well as binding specificity, of the secreted antibodies, 4) increased epigenetic modifications that are associated with lower antibody responses, 5) increased frequencies of inflammatory B cell subsets, and 6) shorter telomeres. (biomedcentral.com)
  • All introns in ABCB1 underwent either a one-time loss (single loss in one lineage/species) or multiple independent losses (parallel loss in two or more lineages/species) with the majority of losses occurring within the grass family. (biomedcentral.com)
  • Conserved sequences outside of known genes are likely to be gene regulatory elements. (sciencedaily.com)
  • In addition, we sequenced 99 ospC flanking sequences from different lineages and compared the complete cp26 sequences of 11 strains as well as the cp26 bbb02 loci of 56 samples. (cdc.gov)
  • Asian sequences exhibiting larger frequency of L83V mutations and unique presence of S71C and C140 Cease codon mutations could also be linked with larger oncogenicity. (cellgenetherapy.com)
  • The proposed Th1-Tr1 switch appears to bridge two stable, self-reinforcing immune states, pro- and anti-inflammatory, each with a characteristic gene regulatory network. (frontiersin.org)
  • By integrating these two datasets, 16 overlapped genes were detected, including downregulated lncRNA‑NEAT1 and upregulated TF‑ETV5. (spandidos-publications.com)
  • Transfer of LS chromosomes between otherwise genetically isolated strains explains the polyphyletic origin of host specificity and the emergence of new pathogenic lineages in F. oxysporum . (nature.com)
  • Similarly, the large ribosomal RNA gene clusters that reside on different chromosomes manage to find each other in almost every cell nucleus to form another easily discernable nuclear entity, the nucleolus [ 27 - 29 ]. (biomedcentral.com)
  • Our findings on the age of the inactivating mutation in the MYH16 gene raise the intriguing possibility that the decrement in masticatory muscle size removed an evolutionary constraint on encephalization, as suggested by the anatomy of the muscle attachments relative to the sutures. (johnhawks.net)
  • Some findings showed critical genes, which modulate several aspects of verbal communication. (bvsalud.org)
  • The study, led by scientists at the University of California, Santa Cruz, and published this week in Science, focused on regulatory elements that orchestrate the activity of genes. (sciencedaily.com)
  • Most of the changes that have happened during vertebrate evolution, as animals acquired new body plans and features like feathers and hair, were not the result of new genes but of new regulatory elements that turn genes on and off in different patterns," Haussler said. (sciencedaily.com)
  • Because regulatory elements are typically located near the genes they govern, the researchers assigned each conserved element to the closest gene. (sciencedaily.com)
  • The ABCB1 gene structure is highly dynamic, while the structure of ABCB19 remained largely conserved through evolution. (biomedcentral.com)
  • Acquisitions of OspC genes that are novel for the region confer to recipients unique identities to host immune systems and, presumably, selective advantage when immunity to existing types is widespread among hosts. (cdc.gov)
  • The innate immune system is mainly composed of myeloid lineage cells, such as macrophages, neutrophils, and mast cells [ 2 ]. (hindawi.com)
  • However, age-related defects in other components of the immune system also occur and contribute to the increased frequency and severity of infectious diseases in the elderly. (biomedcentral.com)
  • It was also demonstrated that USF1 directly binds to the promoter region of 2,492 genes, which may be involved in the viral progression and cell proliferation pathways. (spandidos-publications.com)
  • In summary, the results demonstrated that USF1 binds to the promoter region of thousands of genes and affects a large part of DEGs indirectly. (spandidos-publications.com)
  • For instance, a previous study by the authors validated that USF1 binds to the core promoter of APOBEC3G and increases its transcription level in hepatocytes ( 7 ). (spandidos-publications.com)
  • As transcription from the H1 Pol III promoter is more ef﫿cient and precise when a guanine ("G") or an adenosine ("A") base is found on the +1 site (Ma et al. (berterolab.com)
  • The KSL cell induction frequency was superior to the case of Hoxb4. (ebiotrade.com)
  • Dynamic transcription factor activity profiling in 2D and 3D cell cultures. (chicagobiomedicalconsortium.org)
  • While IAEMH is associated with severe anaemia due to intravascular haemolysis caused by red cell invasion, oxidative injury, auto-antibodies, and/or pathogen-haem interaction, IAIMH is associated with haemophagocytic tri-lineage destruction of haematopoietic precursors in the bone marrow. (bvsalud.org)
  • Upon culture in endothelial growth media, these cells expressed endothelial lineage markers, such as CD31, Tie2, and VEGF receptor 2 (VEGFR2), and incorporated into blood vessels in ischemic tissues. (hindawi.com)
  • Interestingly, P-Tex cells expressed CDK4 genes as high as cancer cells, which could be simultaneously inhibited by CDK4 inhibitors and might be a potential reason for the ineffectiveness of CDK4 inhibitors in treating HPV-positive HNSCC. (elifesciences.org)
  • An analysis of the ABCB1 gene structure in 80 angiosperms revealed that the number of introns ranged from one to nine. (biomedcentral.com)
  • ThermoFisher Scientific, https://www.thermofisher.com ) performed as previously described ( 1 ) indicated that patient 1 was positive for the open reading frame 1ab (cycle threshold [C t ] 25.8) and nucleoprotein (C t 24.5) gene targets and patient 2 was positive for open reading frame 1ab (C t 28.1) and nucleoprotein (C t 27.29), but both were negative for the spike gene target. (cdc.gov)
  • Upstream transcription factor 1 (USF1) is a canonical transcription factor (TF) and is associated with the pathogenesis of several cancers, but its biological functions and molecular targets in HCC remain unclear. (spandidos-publications.com)
  • Reverse transcription‑quantitative PCR was then used to validate the downstream targets. (spandidos-publications.com)
  • It was just a study of a single gene, but this work generated an outsized reaction. (johnhawks.net)
  • Lymphomas are malignant neoplasms of lymphoid lineage. (medscape.com)
  • Here we present analysis of transcription factor binding motifs co-localized with non-coding variants. (biomedcentral.com)
  • Semiquantitative PCR showed that the M. guttatus ABCB1 gene copy without intron 7 had significantly lower transcript levels than the gene copy with intron 7. (biomedcentral.com)
  • The proposed mechanism is based on the knowledge that transcription of mtDNA is polycistronic, which means that all genes encoded on the heavy and light strands are transcribed as 2 large precursor RNA strands. (medscape.com)
  • mtDNA is inherited almost exclusively through the maternal lineage, with only a single report of paternal inheritance. (medscape.com)
  • Stochastic models of gene transcription with upstream drives: exact solution and sample path characterization. (crossref.org)
  • Upstream transcription factor (USF) 1 belongs to the basic helix-loop-helix leucine zipper family and serves as a cellular transcription factor (TF). (spandidos-publications.com)
  • The glucocorticoid receptor (GR) is a bona fide ligand-regulated transcription factor. (uni-ulm.de)
  • To date, a homeobox transcription factor Hoxb4 has been only demonstrated to possess such an effect in mice. (ebiotrade.com)
  • Find the tools and techniques, including BD fluorochrome-conjugated antibodies, buffers, kits and protocols that support intracellular cytokine staining and phosphoprotein and transcription factor detection by intracellular flow cytometry. (bdbiosciences.com)
  • The BD Pharmingen™ Transcription Factor Buffer Set (Cat. (bdbiosciences.com)
  • TBX4 is an essential transcription factor for the development of the hindlimbs and lungs [3]. (keio.ac.jp)
  • From this small number of new changes, they estimated when the gene lost its function: 2.4 million years, to which they applied an error factor plus or minus 300,000 years. (johnhawks.net)
  • Furthermore, Smurf2-deficient mice spontaneously develop tumors at higher frequency as compared to wild-type mice, suggesting that Smurf2 is a tumor suppressor. (umassmed.edu)
  • Globally, nsp1 / nsp2 / nsp3 / nsp11 and orf7a / orf3a / S were the most mutation-ridden non-structural and structural genes respectively. (preprints.org)
  • Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017]. (thermofisher.com)
  • Over the past 530 million years, the vertebrate lineage branched out from a primitive jawless fish wriggling through Cambrian seas to encompass all the diverse forms of fish, birds, reptiles, amphibians, and mammals. (sciencedaily.com)
  • Con respecto a los modelos animales en TEA, muchos estudios se centran en la expresión génica, la migración y maduración neuronal cortical y los déficits de la red neuronal, pero muy pocos son los estudios que relacionen directamente la comunicación oral animal y la expresión génica en áreas corticales del lenguaje. (bvsalud.org)
  • Studies of fixed aRME require either expansion of monoclonal cultures or lineage-traced in vivo or in vitro cells that are mitotically. (wikipedia.org)
  • pendent of those associated with cretory ducts, columnar epithelia the KRAS gene is more frequent- other key mechanistic characteris- lining the gastrointestinal tract and ly mutated in human cancer, which tics of IARC Group 1 carcinogens. (who.int)
  • Our ongoing studies have found that LT-HSC population, which give rise to all lineages of blood cells, increases in Smurf2-deficient mice, suggesting a beneficial effect of Smurf2 deficiency. (umassmed.edu)
  • Lateral gene transfers resulted in different linkages between the ospC gene and loci of the chromosome or other plasmids. (cdc.gov)