• Granulocyte Colony Stimulating Factor (G-CSF) is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. (rndsystems.com)
  • After two days of culture in HSM, the expression levels of α-fetoprotein (AFP) and albumin, which are hepatocyte markers, were upregulated, suggesting that hepatocyte differentiation was initiated ( 19 ). (spandidos-publications.com)
  • NPC markers are also useful in establishing and monitoring in vitro NPC culture differentiation. (sanbio.nl)
  • Second, altering the MSC state by inducing differentiation into multiple lineages did not affect the exosomal properties or endocytosis but triggered the expression of lineage-specific genes and proteins in vitro and in vivo respectively. (frontiersin.org)
  • Many existing tissue-engineering approaches focus on delivery of selected proteins (growth factors, transcription factors etc.) or nucleic acids to host or implanted stem cells to achieve lineage specific differentiation. (frontiersin.org)
  • Differentiation of distinct cell types at specific locations within a developing organism depends largely on the ability of cells to communicate. (biologists.com)
  • Differentiation was compared to mesenchymal stem cells derived from human bone marrow, which is known to differentiate into adipocyte, osteocyte, and chondrocyte lineages. (jove.com)
  • Stem and progenitor cell populations are often heterogeneous, which may reflect stem cell subsets that express subtly different properties, including different propensities for lineage selection upon differentiation, yet remain able to interconvert. (lu.se)
  • Most of the lineage differentiation SNPs are related to cell wall biosynthetic pathways. (biomedcentral.com)
  • Cell markers, or surface antigens, are molecules located on a cell's membrane used to identify specific cell types, their lineage, and their stage in the differentiation process according to the presence or absence of the expression of defined markers. (stemcell.com)
  • Objective: To establish cultures of cells from the pulp of permanent teeth by the explant method assessing parameters usually presented by stem cells, such as the expression of certain markers and the differentiation ability into osteogenic, adipogenic, and chondrogenic lineages. (bvsalud.org)
  • Similarly, the cells showed differentiation ability into all three lineages of cells tested. (bvsalud.org)
  • The isolated cells may be considered stem cells, based on the current criteria for their characterization, such as plastic adherence, expression of certain markers, and the absence of others, as well as multi-differentiation potential, which showed to be promising for the application in tissue regeneration. (bvsalud.org)
  • In the past years, I have been involved in several studies that contrast levels of population differentiation in putatively neutral marker genes with the corresponding data for potentially adaptive phenotypic traits to examine whether past selection pressures have been diversifying, unifying, or too weak to have any influence on the phenotypic variation. (lu.se)
  • Depending on the goal of a particular study, one can use neural stem cells markers, neural progenitor cell markers, neuron markers or PNS neuronal markers. (wikipedia.org)
  • Figure 3) or PSA-NCAM are markers frequently used for intermediate progenitor cells and early immature neurons (PMID: 29625071). (sanbio.nl)
  • The goal of this protocol is to test the ability of progenitor cells derived from human perivascular adipose tissue to differentiate into multiple cell lineages. (jove.com)
  • In fetal liver and adult bone marrow, Tie-2 is expressed by a subpopulation of hematopoietic progenitor cells characterized as Lineage markers^-, c-Kit^+, Sca1^+ cells. (thermofisher.com)
  • Also making up a part of the hematopoietic system are short-term repopulating progenitor cells, which give rise to lineage-specific cell types. (stemcell.com)
  • CD34 is the most commonly used cell surface marker to identify human HSPCs as it is expressed on HSCs, in addition to both multipotent and more differentiated progenitor cells of individual blood cell lineages. (stemcell.com)
  • 2004. Bayesian phylogenetic model selection using reversible jump Markov chain Monte Carlo. (berkeley.edu)
  • Activation of the VEGFA/VEGFR2 signaling and expression of blood vascular endothelial cell (BEC) markers, such as NRP1 and EphrinB2, further differentiate these precursor cells into BECs, which then form the hierarchical network of blood vessels 4 . (nature.com)
  • Under these conditions, iPS cells begin to differentiate into a hepatocyte lineage. (spandidos-publications.com)
  • First, it was tested whether patient‑derived ADSCs could differentiate into chondrogenic and osteogenic lineages. (spandidos-publications.com)
  • Adipose tissue-derived stem cells (ADSCs) have been characterized as having the ability to self-renew and differentiate into different connective tissue cells, including osteoblasts, adipocytes, chondrocytes and myocytes, under specific inductive stimuli ( 4 ). (spandidos-publications.com)
  • The distinct MAS phenotype that arises with hypercytokinaemia can be explained by activation of macrophages that are closely juxtaposed to sinusoids that permit direct phagocytic access to haematopoietic lineage cells. (nature.com)
  • Four distinct mt 16S rDNA lineages are evident. (usgs.gov)
  • Follicular dendritic cells are a distinct lineage (a different cell type than conventional dendritic cells), do not express class II MHC molecules, and therefore do not present antigen to Th cells. (msdmanuals.com)
  • On the contrary, "horizontal" transmission occurs between genomes of organisms of different lineages, involving one or few genes. (biomedcentral.com)
  • Singleton genes are present only in one genome and represent some genome-specific functionality. (biomedcentral.com)
  • Barrier markers are linked to putative genes involved in (processes of) reproductive isolation, and, when observed over two transects, indicate species-wide processes. (lu.se)
  • Twenty-six barrier markers were shared across both transects, of which some are clustered in the same chromosomal region, suggesting that their associated genes are involved in reduced gene flow across the entire hybrid zone. (lu.se)
  • Screening for lineage-defining BTB-ZF genes led to the discovery of a subset of T cells that expressed Zbtb20. (bvsalud.org)
  • The discovery of various proteins specific to certain cells led to the production of cell-type-specific antibodies that have been used to identify cells. (wikipedia.org)
  • A neuronal lineage marker can be a neuronal antigen that is recognized by an autoantibody for example Hu, which is highly restricted to neuronal nuclei. (wikipedia.org)
  • We have identified neuron-glia antigen 2 (NG2) as a unique molecular marker of S100β+ PSCs in skeletal muscle. (elifesciences.org)
  • In this work, we evaluated CAR-T cells specific for Siglec-6, an antigen expressed in CLL, as a novel CAR-T cell treatment for CLL. (bvsalud.org)
  • Pineal parenchymal cell tumor markers are less well characterized than their germ cell counterparts and include melatonin and the S antigen. (medscape.com)
  • mRNA vaccination further induced antigen-specific CD4+ and CD8+ T cells, and early CD4+ T cell responses correlated with long-term humoral immunity. (cdc.gov)
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
  • The stage-specific embryonic antigen 4 (SSEA4) is brain. (lu.se)
  • Here we use the dense genomic surveillance generated by the COVID-19 Genomics UK Consortium to reconstruct the dynamics of 71 different lineages in each of 315 English local authorities between September 2020 and June 2021. (cdc.gov)
  • A third more stringent national lockdown suppressed Alpha and eliminated nearly all other lineages in early 2021. (cdc.gov)
  • Our analysis will unequivocally determine the in vitro and in vivo fates of hES cell-derived cells with the neural crest cell markers present in our cultures. (ca.gov)
  • We have developed a rapid and sensitive loop-mediated isothermal amplification (LAMP) assay that distinguishes Zika viruses of Asian and African lineages. (nih.gov)
  • We will specifically assay the subsets of cells using specific NC-associated markers to enrich for candidate NC lineages. (ca.gov)
  • A growing number of molecular markers that recognize subsets of glial cells throughout the nervous system have been identified ( Jäkel and Dimou, 2017 ). (elifesciences.org)
  • Additional markers can be used to distinguish HSPC subsets within the CD34+ population and isolate HSPCs with different engraftment abilities and capacities to expand or generate mature blood cells in culture. (stemcell.com)
  • 2004. Modeling the site-specific variation of selection patterns along lineages. (berkeley.edu)
  • As males are the heterogametic sex in mammals, such sex-specific patterns can be indirectly observed when Y chromosome polymorphism is combined with mitochondrial sequence information. (uzh.ch)
  • Although the type of tumor cannot be determined reliably from the radiographic characteristics alone, some patterns are associated with specific tumors. (medscape.com)
  • We analyzed the geographic distribution of Tubifex tubifex from various river drainages in central Colorado by genetic screening with specific mitochondrial 16S ribosomal DNA (mt 16S rDNA) markers. (usgs.gov)
  • A neuronal lineage marker can be either DNA, mRNA or RNA expressed in a cell of interest. (wikipedia.org)
  • To localize mRNA in brain tissue, one can use a fragment of DNA or RNA as a neuronal lineage marker, a hybridization probe that detects the presence of nucleotide sequences that are complementary to the sequence in the probe. (wikipedia.org)
  • Although immunohistochemistry is the staple methodology for identifying neuronal cell types, since it is relatively low in cost and a wide range of immunohistochemical markers are available to help distinguish the phenotype of cells in the brain, sometimes it is time-consuming to produce a good antibody. (wikipedia.org)
  • Restriction endonuclease markers were developed to distinguish among the species at all life history stages, allowing rapid identification in areas of sympatric distribution. (unboundmedicine.com)
  • Therefore, we explored the possibility that a unique combination of glial cell markers could be used to distinguish PSCs. (elifesciences.org)
  • It is suggested that strains from the ancestors of modern Beijing lineage is circulating in Guangxi. (biomedcentral.com)
  • Strains of modern Beijing lineage (OR=2.04) were more likely to acquire drug resistances than Lineage 4. (biomedcentral.com)
  • Our findings also support the hypothesis that Modern Beijing lineage originated in South China. (biomedcentral.com)
  • Classic CD4 + Tregs are identified by the intracellular marker Foxp3 [ 11 ]. (hindawi.com)
  • Targeting classic Tregs is limited by the detection of Foxp3 and surface Treg markers on activated cells. (hindawi.com)
  • About half of Zbtb20+ T cells expressed FoxP3, the lineage-defining transcription factor for regulatory T cells (Tregs). (bvsalud.org)
  • All these cell lines express specific T-cell lineage markers (CD8, CD5 and XT-1 pan T-cell), and immature thymocytes CTX marker. (rochester.edu)
  • The DCGM4 antibody stains exclusively immature DCs of the LC lineage. (beckman.com)
  • Although macrophage activation syndrome (MAS) is often termed autoinflammatory in both loss and gain of function phenotypes, adaptive lineage cells, especially T cells, are clearly important in both settings. (nature.com)
  • The Shopsin Lab at NYU Langone studies genetic markers reflecting methicillin-resistant Staphylococcus aureus (MRSA) adaptation. (nyu.edu)
  • This deficit can be attributed to the difficulty of developing Y-specific genetic markers in non-model organisms and the general low levels of polymorphisms observed on the Y chromosome. (uzh.ch)
  • It happens among genomes in the same lineage and involves most of the genetic contents. (biomedcentral.com)
  • We designed the "spider‐specific" probe set using three spider genomes (Loxosceles, Parasteatoda and Stegodyphus) and ensured that the newly designed probe‐set include UCEs from the previously designed Arachnida probe set. (researchgate.net)
  • Using this technique, it is possible to locate gene expression to specific cell types in specific regions and observe how changes in this distribution occur throughout the development and correlate with the behavioral manipulations. (wikipedia.org)
  • Recent studies have revealed the importance of long noncoding RNAs (lncRNAs) as tissue-specific regulators of gene expression. (nature.com)
  • To identify a nuclear marker pathognomonic of astrocytic phenotype, we assessed differential RNA expression by FACS-purified adult astrocytes and, on that basis, evaluated the expression of the transcription factor SOX9 in both mouse and human brain. (jneurosci.org)
  • Its expression, restricted to the Langerhans cell lineage, is demonstrated at both the surface membrane and in the cytoplasm. (beckman.com)
  • At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. (karger.com)
  • Similarly, GATA-1 has been shown to induce lineage switching expression values even if, for simplicity, we assume only ``on'' of committed cells in hematopoiesis, first in cell lines (Kulessa and ``off'' states for each gene. (lu.se)
  • Significant variability in expression of tumor markers is such that the absence of AFP or bhCG does not rule out a mixed germ cell tumor. (medscape.com)
  • Cells were tested for the expression of surface markers and for ALDH1 enzyme activity, by flow cytometry. (bvsalud.org)
  • Cell markers are very valuable tools for examining the function of cells in normal conditions as well as during disease. (wikipedia.org)
  • We determine a comprehensive map of lineage-specific lncRNAs in human dermal lymphatic and blood vascular endothelial cells (LECs and BECs), combining RNA-Seq and CAGE-Seq. (nature.com)
  • Considering the boundaries of immunodeficiency and immune hypersensitivity in MAS related to systemic juvenile idiopathic arthritis and adult-onset Still disease, and the role of lymphoid cells, severe COVID-19 is generally a distinctive lung-specific immunopathology. (nature.com)
  • NG2 is expressed in Schwann cells already associated with the NMJ, indicating that it is a marker of differentiated PSCs. (elifesciences.org)
  • Intriguingly, our preliminary data show that many markers associated with NC cells are upregulated in hES-NPCs or during their derivation process. (ca.gov)
  • NPCs can additionally be obtained by direct reprogramming of somatic cells from different cell lineage (PMID: 22445518). (sanbio.nl)
  • 2008). Historically, this concept is highlighted by the experi- factors are key intrinsic regulators of these fate decisions and mental phenomenon of lineage reprogramming, for example, that fate choice involves modulating networks of transcription by the conversion of fibroblasts to muscles cells following trans- factors. (lu.se)
  • NK effector cells expressing a CAR construct may be used to target T-lineage markers. (bvsalud.org)
  • In this work, we compared the activity of a NK-specific CAR-NK and a CAR-T framework when expressed on NK effector cells to target CD3 and CD5 in T-cell malignancies. (bvsalud.org)
  • Contrary to the results of marker-gene analyses, our results for rare, threatened plants in Sweden and other areas provide little evidence for loss of adaptive potential in ecologically relevant characters with a polygenic basis. (lu.se)
  • In this review, we will present current data on lung aging and lung regeneration, with specific attention paid to stem cell-driven regeneration within the context of aging. (karger.com)
  • The nature of the stem cell substates and their relationship to commitment to differ- entiate and lineage selection can be elucidated in terms of a landscape picture in which stable states can be defined mathematically as attractors. (lu.se)
  • CD133+), but are rarely codetected with the neural stem dents, very few human-specific NSC markers have been cell (NSC) marker CD15. (lu.se)
  • We used genomic and geographic cline analyses to identify barrier markers based on their restricted introgression, and found that some markers are transect-specific, while others are shared. (lu.se)
  • Identify specific faculty members who are conducting research in your specific area of interest. (ubc.ca)
  • Since its initiation in 2003, the goal of the Hadley Y-DNA project has been to identify the various Hadley ancestral lineages and establish whether or not they descend from a common immigrant ancestor to the United States or separate origins in another country. (familytreedna.com)
  • Our current efforts are focused on identifying the generations at which specific mutations seen in STR results and SNP testing might have occurred so that we can identify where individual members' ancestral line connect to the Hadley subgroup ancestral line. (familytreedna.com)
  • Speciation entails a reduction in gene flow between lineages. (lu.se)
  • Although much attention has focused on the selective advantage of self-pollination, there have been few attempts to explore the selective and genetic mechanisms underlying the floral reduction so prevalent in selfing lineages. (lu.se)
  • Together, our study provides several lines of evidence supporting the intriguing concept that every cell type expresses precise lncRNA signatures to control lineage-specific regulatory programs. (nature.com)
  • The study of PSCs has relied on an anatomy-based approach, as the identities of cell-specific PSC molecular markers have remained elusive. (elifesciences.org)
  • This has been due to the absence of a cell-specific molecular marker with which PSCs can be identified, isolated, and genetically manipulated. (elifesciences.org)
  • In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)
  • In addition to their histologic characteristics, germ cell tumors retain molecular characteristics of their primordial lineage. (medscape.com)
  • Tests were conducted for gender-specific mitochondrial lineages, which occur in some other bivalves. (unboundmedicine.com)
  • Measurements of serum and CSF tumor markers are a valuable component of the preoperative evaluation. (medscape.com)
  • Although recent studies suggest a less favorable prognosis for patients with germinomas secreting bhCG, no established prognostic significance of tumor markers exists. (medscape.com)
  • Many of these lineages are only represented by single testers and require recruiting efforts and additional testing to determine this specific DNA signatures. (familytreedna.com)
  • however, in the broadest sense, the term refers to high cytokine concentrations in specific clinical contexts. (nature.com)
  • In contrast, at sites less affected by whirling disease, T. tubifex of lineages V and VI that are more resistant to M. cerebralis infections were more abundant. (usgs.gov)
  • In contrast, transect-specific putative barrier markers suggest local processes. (lu.se)
  • 2000). In *Correspondence to: Perrine Barraud, Department of Veterinary Medi- contrast, several cell surface markers have been used to cine, Neurosciences, Madingley Road, Cambridge CB3 OES, United enrich for NSCs in the rodent CNS. (lu.se)
  • The predominance of resistant T. tubifex worms (lineages V and VI) at low-impact sites supports the conclusion that when these genotypes are in greater abundance, the potential for more severe effects of whirling disease on wild rainbow trout populations may be diminished. (usgs.gov)
  • Tracing maternal and paternal lineages independently to explore breeding systems and dispersal strategies in natural populations has been high on the wish-list of evolutionary biologists. (uzh.ch)
  • Over the past decade, Y-chromosomal markers applied to human populations have revealed remarkable differences in the demographic history and behaviour between the sexes. (uzh.ch)
  • Data from artificially bottlenecked populations of Nigella degenii and wild populations of Brassica cretica show that genetic drift causes idiosyncratic, trait-specific changes in the genetic variation rather than a consistent, proportional decline in all measures of variation. (lu.se)
  • All three morning spu- showed elevated white cell count, elevated inflammatory tum smears also came back positive for acid fast bacil i markers, hyperlipidaemia and hyperglycaemia. (who.int)
  • With the advent of expanded STR, deeper subclade, and Big Y testing, we now have the ability to assign specific DNA markers to specific lines of descent from common ancestors. (familytreedna.com)
  • Across arachnids, transcriptomic approaches may generate thousands of loci, and target‐capture methods, using the previously designed arachnid‐specific probe‐set, can target a maximum of about 1,000 loci. (researchgate.net)
  • A key focus for the UCLA center will be creating and testing cloud-based tools for integrating and analyzing data about protein markers linked to cardiovascular disease. (feedburner.com)
  • The notion that an individual can discover their tribal affiliation through a DNA test reinforces the white supremacist notion of "race" as a biological trait tied to a specific gene, discoverable from saliva. (huffpost.com)