Lineage progenitors. Medical search. Frequent questions

While such pre-leukemic stem cells (pre-LSCs) are capable of giving rise to healthy blood and immune cells, additional mutations can cause a complete block in differentiation and thereby result in the malignant expansion of aberrant progenitor cells 8 . (nature.com)
The cAMP-PKA-CREB signaling cascade cross talks with the Notch pathway, acting synergistically by reducing progenitor markers and inducing astrocytic differentiation. (intechopen.com)
Specifically, its goal is to interrogate the capacity of cells residing in the postnatal DOC tissues to acquire developmental plasticity to undergo lineage reprogramming (trans-differentiation) in vivo in response to injury and other types of environmental stress, and to generate functionally-competent cells of alternative lineage(s). (nih.gov)
The major goal of the Laboratory of Katia Georgopoulos, PhD, at Massachusetts General Hospital is to understand how multipotent progenitors of the hematopoietic and epithelial systems utilize diverse programs in gene expression to achieve distinct fates in cellular differentiation. (massgeneral.org)
3. PML is a key component for the differentiation of myeloid progenitor cells to macrophages. (nih.gov)
This interaction inhibits PU.1 induced transcription from the MCSFR promoter and its induction of macrophage differentiation from hematopoietic progenitor cells. (hindawi.com)
Bone marrow-derived stem cells (BMSCs) and chondrocytes have been reported to present "dedifferentiation" and "phenotypic loss" during the chondrogenic differentiation process in cartilage tissue engineering, and cartilage progenitor cells (CPCs) are novel seeding cells for cartilage tissue engineering. (biomedcentral.com)
miR-762 regulates the proliferation and differentiation of retinal progenitor cells by targeting NPDC1. (stembook.org)
Fate-specific differentiation of neural progenitors attracts keen interest in modern medicine due to its application in cell replacement therapy. (amrita.edu)
Though various signaling pathways are involved in maintenance and differentiation of neural progenitors, the mechanism of development of lineage-restricted progenitors from embryonic stem (ES) cells is not clearly understood. (amrita.edu)
Here, we have demonstrated that neuronal vs. glial differentiation potential of ES cell-derived neural progenitors (ES-NPs) are governed by the growth factors, exposed during their proliferation/expansion phase and cannot be significantly altered during differentiation phase. (amrita.edu)
Upon serum-induced differentiation of infected progenitor cells to astrocytes, JCV commenced early gene expression, followed by DNA replication and late gene expression. (nih.gov)
We have used Affymetrix microarrays to determine the expression of over 25,000 genes at multiple times during astrocyte differentiation from neural progenitor cells. (nih.gov)
Both culture systems are capable of supporting the isolation of a population cells capable of self-renewal and multi-lineage differentiation. (stemcell.com)
GM-CSF is a hematopoietic growth factor which stimulates proliferation and differentiation of hematopoietic progenitor cells. (nih.gov)
GM-CSF belongs to a group of growth factors termed colony stimulating factors which support survival, clonal expansion, and differentiation of hematopoietic progenitor cells. (nih.gov)
ATCC also offers a complete system of normal and Parkinson's disease tri-lineage-capable neural progenitor cells (NPCs), lineage marker-labeled NPCs, and expansion and differentiation media. (atcc.org)

Diverse and heritable lineage imprinting of early haematopoietic progenitors. (edu.au)
6. Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis. (nih.gov)
We have previously established that haematopoietic progenitors with very similar phenotypes often exhibit highly heterogeneous fates. (edu.au)

Neural stem and progenitor cells (NSPCs) are a mixture of stem cells and more specialized cells termed progenitors that form the final cells of the brain and spinal cord - neurons, astrocytes and oligodendrocytes. (ca.gov)
Accurately identifying and characterizing the different progenitor cells in this lineage has continued to be a challenge for the field. (ca.gov)
Inherent cell membrane properties are thus sufficient to define progenitor cells that form neurons and astrocytes in the nervous system, can be used to specifically isolate these cells, and are linked to patterns of sugar molecules on the cell surface. (ca.gov)
Neural stem and progenitor cells (NSPCs) are heterogeneous populations of self-renewing stem cells and more committed progenitors that differentiate into neurons, astrocytes and oligodendrocytes. (ca.gov)
Inherent plasma membrane biophysical properties are thus sufficient to define progenitor cells of differing fate potential in the neural lineage, can be used to specifically isolate these cells, and are linked to patterns of glycosylation on the cell surface. (ca.gov)
A research team has announced a new and better way to culture mouse lung progenitor cells so that they can differentiate in vitro and in vivo along all epithelial lineages. (jax.org)
Currently, the two adult lung epithelial compartments (airways and alveoli) are separately maintained by distinct lineage-restricted stem cells. (jax.org)
Whereas conventional dendritic cells (cDCs) originate mostly from a common dendritic cell progenitor (CDP), pDCs have been shown to develop from both CDPs and common lymphoid progenitors. (nih.gov)
Here, we found that pDCs developed predominantly from IL-7R + lymphoid progenitor cells. (nih.gov)
A range of tissues from skeletally mature mice were then stained to examine any leakage of the promoter or any significant contribution of MyoD-lineage cells to non-muscle tissues. (medscape.com)
From 2 weeks onwards, no labeled cells were observed (Figure 2B-C). These results indicate that MyoD-lineage cells make a minimal contribution to closed fracture healing. (medscape.com)
In contrast to the closed fracture model, a major contribution by MyoD-lineage cells was observed at all stages of the fracture repair process. (medscape.com)
Megakaryocyte-erythroid progenitor cells, among other blood cells, are generated as a result of hematopoiesis, which occurs in the bone marrow. (wikipedia.org)
Hematopoietic stem cells can differentiate into one of two progenitor cells: the common lymphoid progenitor and the common myeloid progenitor. (wikipedia.org)
Megakaryocyte/erythrocyte progenitor cells must commit to becoming either platelet-producing megakaryocytes via megakaryopoiesis or erythrocyte-producing erythroblasts via erythropoiesis. (wikipedia.org)
Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte/erythrocyte progenitor cells. (wikipedia.org)
We show that, during development, AT1 and AT2 cells arise directly from a bipotent progenitor, whereas after birth new AT1 cells derive from rare, self-renewing, long-lived, mature AT2 cells that produce slowly expanding clonal foci of alveolar renewal. (nih.gov)
Chromosomal Analysis in Lineage-Specific Mouse Hematopoietic Stem Cells and Progenitors. (bvsalud.org)
Hematopoiesis is maintained throughout life from the hematopoietic stem cell niche in which hematopoietic stem cells and lineage-specific hematopoietic progenitors (HSPCs) reside and regulate hematopoiesis . (bvsalud.org)
Thus, this chapter focuses on the structural (clastogenicity) and numerical (aneugenicity) form of CA analysis in lineage-specific HSPCs comprised of myeloid, erythroid and lymphoid lineages.In this protocol, we describe how to perform CA analysis in lineage-specific HSPCs derived from freshly isolated mouse bone marrow cells (MBMCs) using the combined techniques of colony-forming unit (CFU) and karyotyping . (bvsalud.org)
Oligodendrocyte progenitor cells (OPCs) receive synaptic innervation from glutamatergic and GABAergic axons and can be dynamically regulated by neural activity, resulting in activity-dependent changes in patterns of axon myelination. (nih.gov)
Here, we provide evidence implicating midbrain dopamine neurons in the innervation of oligodendrocyte lineage cells in the anterior corpus callosum and nearby white matter tracts of male and female adult mice. (nih.gov)
These results suggest that oligodendrocyte lineage cells may respond to dopamine released from midbrain dopamine axons, which could affect myelination. (nih.gov)
Together, this work broadens our understanding of neuron-glia interactions with important implications for myelin plasticity by identifying midbrain dopamine axons as a potential regulator of corpus callosal oligodendrocyte lineage cells. (nih.gov)
Oligodendrocyte progenitor cells. (nih.gov)
Here, we demonstrate that LSCs, HSCs, and pre-leukemic stem cells can be identified and molecularly profiled by combining single-cell transcriptomics with lineage tracing using both nuclear and mitochondrial somatic variants. (nature.com)
While mutational status discriminates between healthy and cancerous cells, gene expression distinguishes stem cells and progenitor cell populations. (nature.com)
Existence of auditory and vestibular progenitor cells. (nih.gov)
Identification of stem or progenitor cells that give rise to hair cells/supporting cells in embryos and adults (human). (nih.gov)
Investigation of the otic placode as one possible beginning source to identify progenitors, although cells are already developmentally biased. (nih.gov)
potential progenitors, supporting cells, etc. (nih.gov)
Identification of new cell surface markers for progenitor cells using non-traditional probe generating techniques. (nih.gov)
We previously reported that Piezo1 activation is a key mediator of mechanosensitive lineage choice in human neural stem/progenitor cells (hNSPCs), and that activation of Piezo1 in this system required cell-generated traction forces 7 . (nature.com)
Other suggested cells of origin include the neural crest‒derived cell of amine precursor uptake and decarboxylation (APUD) system, dermal fibroblasts, pre or pro B cells, residual epidermal stem cells, and epithelial, non-Merkel cell progenitors. (medscape.com)
Identification of Nepro, a gene required for the maintenance of neocortex neural progenitor cells downstream of Notch. (nih.gov)
Sathe P, Metcalf D, Vremec D, Naik SH, Langdon WY, Huntington ND, Wu L, Shortman K. Lymphoid tissue and plasmacytoid dendritic cells and macrophages do not share a common macrophage-dendritic cell-restricted progenitor. (edu.au)
While there have been promising developments in this area, many challenges remain, including insufficient characterization of stem/progenitor cell sources as to their capacity to generate functional differentiated cell progeny, which results in insufficient numbers of cells available for building new tissues and poor survival and integration of injected cells with the host tissues. (nih.gov)
While mechanisms of differential regenerative capacity of tissues are complex and still poorly understood, it is recognized that the availability of stem/progenitor cells to generate new tissue is one of the key factors needed for successful regeneration. (nih.gov)
Traditionally, in mammals the developmental progression from stem/progenitor cells to fully-differentiated cells have been viewed as a unidirectional and terminal process, but recent advances beginning with the discovery of cellular reprogramming and derivation of induced pluripotent stem cells, put the universality of this simple paradigm into question. (nih.gov)
In fact, multiple examples of naturally-occurring in vivo reprogramming of differentiated cells into stem/progenitor state following injury and/or inflammatory stress have been described. (nih.gov)
Alternatively, and/or in addition, lineage reprogramming in vivo can be induced by targeted gene transfer to deliver to cells genes coding for master tissue-specific genetic and epigenetic regulators via viral vectors or other gene transfer technologies. (nih.gov)
and none have labeled the large pool of adult SGZ stem and progenitor cells. (jneurosci.org)
Olfactory bulb neural progenitor cells transferred to pancreas express β cell genes and produce insulin. (genengnews.com)
Scientists say adult neural progenitor cells taken from the brains of diabetic mice are capable of producing insulin when transplanted back into the pancreas of diabetic animals. (genengnews.com)
Antagonistic interactions between transcription factors contribute to cell fate decisions made by multipotent hematopoietic progenitor cells. (hindawi.com)
These lines all have the striking phenotype that besides being unable to differentiate into mature B cells they can be induced to differentiate into other hematopoietic lineages in vitro and in vivo [ 5 - 7 ]. (hindawi.com)
Mice lacking PU.1 do not make lymphocytes, myeloid cells, or the progenitors for these cells (CMPs, GMPs, or CLPs) [ 10 , 11 ]. (hindawi.com)
In our previous study, cartilage progenitor cells from different subtypes of cartilage tissue were isolated and identified in vitro, but the study on in vivo chondrogenic characteristics of cartilage progenitor cells remained rarely. (biomedcentral.com)
In the current study, we explored the feasibility of combining cartilage progenitor cells with poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) to produce tissue-engineered cartilage and compared the proliferation ability and chondrogenic characteristics of cartilage progenitor cells with those of bone marrow-derived stem cells and chondrocytes. (biomedcentral.com)
Cartilage progenitor cells may undergo chondrogenesis without chondrogenic induction and are better at chondrogenesis than BMSCs but worse than chondrocytes in the application of cartilage tissue engineering. (biomedcentral.com)
Recently, chondrogenic stem/progenitor stem cells derived from cartilage tissue were isolated and identified. (biomedcentral.com)
Human Primordial Germ Cells Are Specified from Lineage-Primed Progenitors. (stembook.org)
Additionally, we advance the concept that fibrosis progression occurs in a fibrogenic niche that is composed of a fibrogenic ECM that nurtures fibrogenic mesenchymal progenitor cells and their fibrogenic progeny. (jci.org)
During embryonic development, a wide variety of cells, tissues, and organs originate from a handful of progenitor cells. (nih.gov)
These progenitor cells undergo precise programming to become a specific cell type-a process known as a cell fate or lineage decision. (nih.gov)
For example, progenitor cells in the early mouse embryo, as early as three days after conception, express transcription factors that predispose them to divergent cell fates later in development-NANOG leads to epiblast cells whereas GATA6 induces primitive endoderm cells. (nih.gov)
A few hours after this co-expression progenitor cell state, cells decide to restrict their expression to either NANOG or GATA6 by a yet unknown process. (nih.gov)
Stem cells are the progenitors of specialized cell types in the body and have the ability to self-renew. (cshlpress.com)
Stem and progenitor cells make 'decisions' in order to generate our various tissues and organs. (edu.au)
Each progenitor is tagged with a unique DNA 'stamp' such that it is inherited by daughter cells and detected in progeny using DNA sequencing and computational analysis. (edu.au)
Our data detail the underlying pathways that cause progenitor cells and early osteoblasts to create fat cells instead of bone-producing cells," Li says. (nih.gov)
JC Virus (JCV), the etiological agent of the human brain demyelinating disease progressive multifocal leukoencephalopathy, can non-productively infect multipotential human neural progenitor cells. (nih.gov)
Researchers at the Max Planck Institute of Molecular Cell Biology and Genetics succeeded in mimicking the sustained expression of the transcription factor Pax6 as seen in the developing human brain, in mouse cortical progenitor cells. (mpg.de)
This altered the behavior of these cells to one that is akin to that of progenitors in the developing primate neocortex. (mpg.de)
These animals have more Pax6-positive progenitor cells and a higher Pax6 expression level in the germinal layer close to the ventricle in the right hemisphere. (mpg.de)
The developing neocortex contains different types of neural stem and progenitor cells, but one particular class, the basal progenitors, behave differently in small-brained animals such as mice than in large-brained animals such as humans. (mpg.de)
The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. (ny.gov)
Neural stem and progenitor cells (NSCs) have traditionally been cultured using the neurosphere system. (stemcell.com)
GM-CSF induces partially committed progenitor cells to divide and differentiate in the granulocyte-macrophage pathways which include neutrophils, monocytes/macrophages and myeloid-derived dendritic cells. (nih.gov)
In vitro exposure of human bone marrow cells to LEUKINE at concentrations ranging from 1-100 ng/mL results in the proliferation of hematopoietic progenitors and in the formation of pure granulocyte, pure macrophage and mixed granulocytemacrophage colonies. (nih.gov)

In the November 6 Nature Methods , the team led by Bing Lim and Massimo Nichane of the Genome Institute of Singapore and Kyle M. Loh of Stanford University School of Medicine, and including Siva V, Ph.D., of The Jackson Laboratory's Single Cell Biology Lab, showed that mouse Sox9+ multipotent embryonic lung progenitors can be isolated and expanded long-term in 3D culture. (jax.org)
Isolation and 3D expansion of multipotent Sox9 + mouse lung progenitors. (jax.org)
Currently available methods often rely on injection into tissues of in vitro expanded heterogeneous multipotent stem and progenitor cell populations or of in vitro differentiated progeny of pluripotent cell lines. (nih.gov)
Our study suggests that E2A association with PU.1 may contribute to E2A's promotion of B lymphoid cell fate from multipotent hematopoietic progenitors. (hindawi.com)

Expression of SiglecH and Ly6D defined pDC lineage commitment along the lymphoid branch. (nih.gov)
14. Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors. (nih.gov)
The B cell transcription factors, E2A and EBF, are necessary for commitment of multipotential progenitors and lymphoid primed multipotential progenitors to lymphocytes. (hindawi.com)
The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways. (stembook.org)
INTRODUCTION: Commitment of osteoclast progenitors to the osteoclast lineage requires RANKL/RANK-mediated intercellular signals. (nih.gov)
Cbfβ governs osteoblast-adipocyte lineage commitment through enhancing β-catenin signaling and suppressing adipogenesis gene expression. (nih.gov)

Cultured Sox9+ progenitors transcriptionally resemble their in vivo counterparts and generate both airway and alveolar cell types in vitro . (jax.org)
12. In Vivo Deletion of the Cebpa +37 kb Enhancer Markedly Reduces Cebpa mRNA in Myeloid Progenitors but Not in Non-Hematopoietic Tissues to Impair Granulopoiesis. (nih.gov)
He carried out his postdoctoral work in George Church's group at Harvard Medical School and the Wyss Institute for Biologically Inspired Engineering at Harvard University, where he developed in vivo barcoding strategies to record lineages during mouse development. (sfari.org)
By building upon the previously developed mouse barcoding and in situ sequencing technologies, Kalhor plans to create a mouse model for in vivo barcoding of the brain and to integrate this model with cutting-edge single-cell sequencing technologies to obtain whole-brain lineage maps in neurotypical and autism mouse models. (sfari.org)

We found previously that populations of NSPCs with more neuron progenitors (NPs) can be distinguished from those with more astrocyte progenitors (APs) by their inherent cell membrane properties, without the need for specific cell markers or labels. (ca.gov)
We found previously that populations of NSPCs with more neurogenic progenitors (NPs) can be distinguished from those with more astrogenic progenitors (APs) by their inherent biophysical properties, specifically the electrophysiological property of whole cell membrane capacitance, which we characterized with dielectrophoresis (DEP). (ca.gov)
[ 5 , 6 ] Furthermore, experiments have demonstrated that epidermal progenitors in the touch domes are capable of producing Merkel cell lines and that epithelial progenitor populations in adults have the capacity to give rise to both neuroendocrine and squamous lineages. (medscape.com)
Persistence of poor quality bone matrix post-irradiation highlights the importance of retaining functional osteoclast and osteoclast progenitor cell populations long-term. (upstate.edu)

Researchers from the Rocha Lab conducted a series of experiments using mouse embryos to determine how plasticity is maintained in the progenitor state but also rapidly lost. (nih.gov)

9. Single-cell RNA sequencing reveals developmental heterogeneity among early lymphoid progenitors. (nih.gov)
However, Pax5 has a very limited ability to commit multipotential progenitors (MPPs) to early lymphoid progenitors, suggesting that, unlike GATA1, Pax5 does not repress PU.1 to promote B cell fate. (hindawi.com)

Combined, we anticipate this suite of tools will allow us to gain a high-resolution understanding into the principles and molecular mechanism governing development and the establishment of lineage fate in normal and cancerous tissues, with view to therapeutic interventions. (edu.au)
In many developmental systems, nuclear regulators have been implicated in coupling key events in gene expression with specific cell fate and lineage decisions. (massgeneral.org)
1. Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. (nih.gov)
2. Creating Lineage Trajectory Maps Via Integration of Single-Cell RNA-Sequencing and Lineage Tracing: Integrating transgenic lineage tracing and single-cell RNA-sequencing is a robust approach for mapping developmental lineage trajectories and cell fate changes. (nih.gov)
PU.1 activity is also critical for determining cell fate acquisition of uncommitted progenitors. (hindawi.com)
Quantitative fate mapping: Reconstructing progenitor field dynamics via retrospective lineage barcoding. (sfari.org)
Before a progenitor cell commits to a specific fate or lineage, the cell is considered plastic, meaning it still has the potential to become more than one type of cell. (nih.gov)
We have used the technique to decipher the complexity of their individual fate and to reconstruct single cell lineage decisions in haematopoiesis (Naik, Nature, 2013). (edu.au)

Additionally, mutated immature myeloid progenitors showed a megakaryocytic-erythroid lineage bias, also as previous mouse studies have found. (genomeweb.com)

Siva V comments, "This work, primarily driven by Massimo Nichane and team, demonstrated that a single respiratory cell type - Sox9 + progenitors of lung - can be used to regenerate the lungs and can be propagated in vitro using defined culture conditions. (jax.org)

GM-CSF is a multilineage factor and, in addition to dose-dependent effects on the myelomonocytic lineage, can promote the proliferation of megakaryocytic and erythroid progenitors. (nih.gov)

Our current work focuses on the ability of Ikaros proteins to partition in these functionally distinct higher order molecular complexes and the way that these distinct complexes alter chromatin structure and expression of lineage-specific genes. (massgeneral.org)
Such diverse functional roles for organelles that were once thought to be simple may be attributed to their distinct heteroplasmic genome, exclusive maternal lineage of inheritance, and ability to generate signals to communicate with other cellular organelles. (jci.org)

13. Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement. (nih.gov)
Most importantly, CRISPR/Cas9-mediated ablation of the entire Id (Id1-4) family in mouse embryos leads to failure of anterior cardiac progenitor specification and the development of heartless embryos. (xenbase.org)

This indicates a need for a laboratory technique that allows the study of CA in specific HSPCs subpopulations comprising differential hematopoietic lineages. (bvsalud.org)

In humans, basal progenitors can undergo multiple rounds of cell division, thereby substantially increasing neuron number and ultimately the size of the neocortex. (mpg.de)
In mice, these progenitors typically undergo only one round of cell division, thus limiting the number of neurons produced. (mpg.de)
Strikingly, sustaining Pax6 expression in mouse basal progenitors increased their capacity to undergo multiple rounds of cell division, as typically observed in primates. (mpg.de)

In mouse hematopoiesis, eosinophils originate from the eosinophil lineage-committed progenitor (EoP) that has been purified downstream of the granulocyte/macrophage progenitor (GMP). (elsevierpure.com)

Using this mouse, we explore whether adult-generated neurons are derived from the nestin lineage. (jneurosci.org)
Consequently, the mouse progenitors generated more neurons - a prerequisite for a bigger brain. (mpg.de)

Membrane biophysics define neuron and astrocyte progenitors in the neural lineage. (ca.gov)
also called glioblastoma) develop from the astrocyte lineage. (anatomywarehouse.com)

Here we use molecular markers, lineage tracing and clonal analysis to map alveolar progenitors throughout the mouse lifespan. (nih.gov)
8. Gene expression analysis of myeloid and lymphoid lineage markers during mouse haematopoiesis. (nih.gov)

4. Epigenetic control of early dendritic cell lineage specification by the transcription factor IRF8 in mice. (nih.gov)
18. Dicer1 deletion in myeloid-committed progenitors causes neutrophil dysplasia and blocks macrophage/dendritic cell development in mice. (nih.gov)

Elimination of Ikaros function in the early hematopoietic system prevents the generation of an adaptive immune system, whereas loss of Ikaros after specification into the lymphoid lineage leads to the development of aggressive lymphoid leukemias. (massgeneral.org)

In addition, the authors consider the potential of stem-cell-based therapies in the clinic (e.g., for treating retinal diseases and skin disorders) and the innovations that are facilitating the development of those therapies, including various lineage reprogramming strategies and new biomaterials that modulate stem cell properties. (cshlpress.com)

Early B cell progenitors cell lines can be grown out from the fetal liver or bone marrow isolated from mice deficient in each of these factors. (hindawi.com)

The contributors describe how the first cell lineages arise in the mammalian embryo, stem cell dynamics during the development and homeostasis of specific tissues (e.g., epithelia and brain), and what happens when stem cell integrity is compromised (e.g., by DNA mutations). (cshlpress.com)

This H1 av N1 lineage is now enzootic and has also undergone reassortment resulting in emergence of multiple genotypes and 2 main enzootic subtypes, H1N2 (H1 hu N2), also designated lineage IB ( 3 ), and H3N2, through acquisition of human seasonal influenza virus-origin hemagglutinin (HA) or neuraminidase (NA) gene segments ( 1 ). (cdc.gov)

Many chapters illustrate how single-cell profiling, stem-cell-derived organoids, intravital microscopy, lineage tracing, quantitative modeling, and other modern approaches have offered important insights. (cshlpress.com)

This line provided the basis for altering the expression of Pax6 in the cortical stem cell lineage such that it would be sustained in basal progenitors. (mpg.de)

1 However, other factors are required to induce complete maturation in these two lineages. (nih.gov)

B ) Comparative immunohistology for control (top row) and CKO eyes (bottom row) showing tissue organization with DAPI, the RPC marker and progenitor maintenance factor Hes1, the RPC marker Cyclin D1, the RGC marker Pou4f2, and the photoreceptor precursor marker Otx2. (elifesciences.org)

This progenitor viral genome has three bases that differ from the Wuhan strains. (news-medical.net)

Their paper is titled "Insulin biosynthesis in neuronal progenitors derived from adult hippocampus and the olfactory bulb. (genengnews.com)

They arise from a progenitor cell that differentiates down one of the cell lines. (anatomywarehouse.com)

Sub-network A includes species native to China, western North America, as well as M. x domestica and its four primary progenitor species, M. sieversii (Ledeb. (usda.gov)
However, in the early 1980s, the classical swine H1N1 strain was displaced by a new European enzootic swine IAV strain, the Eurasian, avian-like H1N1 (H1 av N1) lineage 1C ( 3 ), probably after cross-species transmission directly from birds to mammals ( 1 ). (cdc.gov)
A potential cause underlying this difference in the proliferative capacity of basal progenitors could be the differential expression of Pax6 between species. (mpg.de)

Anatomy44

Organisms9

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes37

Disciplines and Occupations1

Information Science4

Differentiation17

Haematopoietic progenitors3

Cells70

Multipotent4

Commitment6

Vivo4

Populations4

Plasticity1

Early lymphoid progenitors2

Fate8

Myeloid Progenitors1

Vitro1

Erythroid progenitors1

Distinct2

Cardiac progenitor2

Hematopoietic lineages1

Undergo3

Hematopoiesis1

Neurons2

Astrocyte2

Markers2

Dendritic cell2

Lymphoid lineage1

Retinal1

Bone marrow1

Tissues1

Gene1

Tracing1

Cortical1

Maturation1

Tissue1

Genome1

Adult1

Arise1

Species3