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  • anterior limb-bud
  • These results are compared with results obtained in other reptiles and chick embryos, in the light of the theories on the role of the somites and of the apical crest in the development of the anterior limb-bud. (biologists.org)
  • tissue
  • To investigate the role of macrophages during scar-free tissue repair in an efficiently regenerating model, we dissected the inflammatory response to injury in regenerating limbs of the axolotl aquatic salamander ( Ambystoma mexicanum ) at the cellular and molecular level. (pnas.org)
  • Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales. (biologists.org)
  • These data implicate mIGF-1 as a powerful enhancer of the regeneration response, mediating the recruitment of bone marrow cells to sites of tissue damage and augmenting local repair mechanisms. (pnas.org)
  • Indeed, the transplantation of bone marrow-derived SCs into the mdx dystrophic mouse model had a limited impact on muscle cell replacement ( 10 ), suggesting that the poor recruitment of circulating SCs is one of the limiting factors for tissue repair ( 10 , 11 ). (pnas.org)
  • In addition, the question of whether salamander blastema tissue could induce regeneration and tumor regression in animals with a limited regeneration ability is discussed. (jcancer.org)
  • Previous studies suggest that the most abundant cells in the blastema are connective tissue fibroblasts that have undergone dedifferentiation [ 5 , 6 ]. (jcancer.org)
  • Of course animal cells are not able to be included in human tissue, but they can secrete factors for rejuvenating. (wikipedia.org)
  • A central question is whether the generation of progenitor cells during limb regeneration and mammalian tissue repair occur via separate or overlapping mechanisms. (rupress.org)
  • Thus, limb regeneration and mammalian tissue repair share common cellular and molecular programs. (rupress.org)
  • RNA interference of the H + ,K + -ATPase ion pump results in membrane hyperpolarization, which has no effect on the amount of new tissue (blastema) that is regenerated yet produces regenerates with tiny 'shrunken' heads and proportionally oversized pharynges. (biologists.org)
  • The notion of epithelial cell plasticity derives largely from early studies of tissue regeneration in primitive experimental models. (jci.org)
  • Plant cells have a remarkable plasticity that allows cellular reprogramming from differentiated cells and subsequent tissue regeneration. (bioportfolio.com)
  • Clonal analysis reveals nerve-dependent and independent roles on mammalian hind limb tissue maintenance and regeneration. (bio-protocol.org)
  • Enhancing stem cell survival in vivo for tissue repair. (bio-protocol.org)
  • We analysed expression levels of the most commonly used pluripotency associated factors in regenerating and non-regenerating tissue and compared them with levels in a pluripotent reference cell. (biomedcentral.com)
  • The recent introduction of in vivo lineage-tracing techniques using fluorescently labeled cells challenged the long-standing view that complete dedifferentiation is a major force driving vertebrate tissue regeneration. (biomedcentral.com)
  • extracellular matrix
  • Systemic macrophage depletion during this period resulted in wound closure but permanent failure of limb regeneration, associated with extensive fibrosis and disregulation of extracellular matrix component gene expression. (pnas.org)
  • Rachele Mariano started conducting research in Professor Gardiner's lab in Fall 2008, where she became involved in studying the effects of the extracellular matrix in axolotl limb regeneration. (uci.edu)
  • We used nerve deviations and extracellular matrix (ECM) grafting to test for interaction between limb components of differing positional values during the axolotl wound healing process. (uci.edu)
  • plasticity
  • Somatic cells that change from one mature phenotype to another exhibit the property of plasticity. (jci.org)
  • It is increasingly clear that epithelial and endothelial cells enjoy some of this plasticity, which is easily demonstrated by studying the process of epithelial-mesenchymal transition (EMT). (jci.org)
  • As we discuss in this Personal Perspective, we believe that context and various changes in plasticity biomarkers can help identify at least three types of EMT and that using a collection of criteria for EMT increases the likelihood that everyone is studying the same phenomenon - namely, the transition of epithelial and endothelial cells to a motile phenotype. (jci.org)
  • skeletal muscle
  • Although in lethally irradiated mice, bone marrow-derived SCs replenish the depleted satellite cell pool and subsequently incorporate effectively into exercised skeletal muscle ( 9 ), less is known about the ability of bone-marrow-derived SCs to ameliorate muscle damage under more clinically relevant conditions. (pnas.org)
  • We describe a multipotent Pax7 + satellite cell population located within the skeletal muscle of the salamander limb. (rupress.org)
  • cytokines
  • Macrophages are an important source of both inflammatory and anti-inflammatory signals, arriving in mammalian wounds 48-96 h after injury, where they clear dead cells, release proinflammatory cytokines, and subsequently produce factors that dampen inflammation and stimulate angiogenesis, fibroblast migration, and replication ( 17 ). (pnas.org)
  • Neural cells, for example, express growth-associated proteins, such as GAP-43 , tubulin , actin , an array of novel neuropeptides , and cytokines that induce a cellular physiological response to regenerate from the damage. (wikipedia.org)
  • The JNK signal transduction cascade is activated by exposure of cells to cytokines or environmental stress. (biomedcentral.com)
  • cellular
  • Swiss doctor Paul Niehans, who was one of the fathers of cellular therapy, developed in 1931-1949 years the so-called Fresh cell therapy. (wikipedia.org)
  • this is such a fundamental piece of cellular machinery that there is no expectation that cancer cells could find a way around it. (fightaging.org)
  • This unexpected phenotype might indicate that partial cellular dedifferentiation is sufficient to condition the muscle into a regeneration program, which might not just comprise the myofiber but also could include the activation of satellite cells. (biomedcentral.com)