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  • Inhibitors
  • The bimolecular fluorescence complementation assay program utilized in this research will offer a useful technique to display for inhibitors of different proteins kinases. (researchhunt.com)
  • Small molecule kinase inhibitors, with potential application against tumour cell invasion and metastasis, were used as template for molecular docking (pdb id 3S95), obtaining reliable docking solution. (fu-berlin.de)
  • Axon length within the first 7 hours and process growth after 3 days of culture were assessed in isolated rod photoreceptors treated with inhibitors of upstream regulators ROCK and p21-activated kinase (Pak) (Y27632 and IPA-3) and a direct LIMK inhibitor (BMS-5). (arvojournals.org)
  • Ross-Macdonald et al (2008) Identification of a nonkinase target mediating cytotoxicity of novel kinase inhibitors. (tocris.com)
  • Genetically induced loss of RHO function impedes transformation by a number of oncogenic stimuli, leading to an interest in developing small-molecule inhibitors that either target RHO GTPases directly, or that target their downstream protein kinase effectors. (aacrjournals.org)
  • Although inhibitors of RHO GTPases and their downstream signaling kinases have not yet been widely adopted for clinical use, their potential value as cancer therapeutics continues to facilitate pharmaceutical research and development and is a promising therapeutic strategy. (aacrjournals.org)
  • For example, RAC and CDC42 share two protein serine-threonine kinase effectors in common, PAK and MLK, and inhibitors for both these kinases have been developed. (aacrjournals.org)
  • phosphatidylinositol 3-kina
  • Journal Article] Alteration of phosphatidylinositol 3-kinase cascade in multilobulated nuclear formation of adult T cell leukemia/lymphoma(ATLL). (nii.ac.jp)
  • Reelin signaling involves the lipoprotein receptors apolipoprotein E receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR), the adapter protein Disabled1 (Dab1), and phosphatidylinositol-3-kinase (PI3K). (jneurosci.org)
  • novel
  • The crystal structure of pseudokinase PEAK1 (Sugen kinase 269) reveals an unusual catalytic cleft and a novel mode of kinase fold dimerization. (nih.gov)
  • regulation
  • The first three-dimensional structure of the PI3KC3 complex I, which is involved in autophagy, provides a framework for understanding the allosteric regulation of lipid kinase activity. (elifesciences.org)
  • A dual-color TIRFM study reveals a new form of inflammatory regulation, in which a lipid kinase and ion channel reciprocally regulate each other to amplify the response to painful stimuli. (elifesciences.org)
  • induce
  • PubMed]Amano Capital t, Tanabe E, Eto Capital t, Narumiya H, Mizuno E. LIM-kinase 2 induce development of tension fibers, focal adhesions and membrane layer blebs, reliant on its service by Rho-associated kinase-catalysed phosphorylation at threonine-505. (researchhunt.com)
  • axonal
  • RhoA-Rho kinase (ROCK) activity 15 , 16 and Ca 2+ influx 17 , 18 have been reported to play a role in regulating axonal retraction by rod photoreceptors in both isolated tiger salamander rod cells and detached porcine retinas. (arvojournals.org)