• To gain insight into how ectoderm is specified, we looked for candidate ectoderm-specific genes that are ectopically expressed in VegT-depleted embryos, and examined the role of one of these, the LIM homeobox gene Xlim5, in ectoderm development. (mysciencework.com)
  • The biological consequences of disruption of LIM-HD transcription factors are severe, demonstrating the importance of these genes in development (for review, see Hobert and Westphal, 2000 ). (biologists.org)
  • Gene duplication events are thought to be responsible for the increase in the number of both the transcription factors and interacting Ldb proteins during the course of evolution ( Meyer and Schartl, 1999 ). (biologists.org)
  • In this paper, we report results strongly suggesting that Bx is a regulatory mutation in dLMO , encoding a Drosophila LIM-only protein ( 16 ) that most likely corresponds to the activity associated with hdp-a . (pnas.org)
  • It is suggested that Chip cooperates with different LIM domain proteins and other factors to structurally support remote enhancer-promoter interactions. (wikipedia.org)
  • The protein is encoded by the fhl2 gene being mapped in the region of human chromosome 2q12-q14. (wikipedia.org)
  • MEOX2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from the United States National Library of Medicine, which is in the public domain. (wikipedia.org)