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  • Enigma
  • ZASP belongs to the Enigma subfamily of proteins and stabilizes the sarcomere (the basic units of muscles) during contraction, through interactions with actin in cardiac and skeletal muscles. (wikipedia.org)
  • kinase
  • ZASP functions to maintain structural integrity of sarcomeres during contraction, and has been shown to be involved in protein kinase A signaling. (wikipedia.org)
  • cellular
  • We then assembled a cellular 'snapshot' of the LIM proteins known to be expressed in the heart that helps explain how mutations in these proteins may play a role in the development of heart failure. (sigmaaldrich.com)
  • amino
  • The LIM domains, represented by white ovals, are predominately localized at the amino terminus (left), however, some can be found at the carboxyl terminus (right). (sigmaaldrich.com)
  • bind
  • We are the first to examine 33 LIM proteins (including three that bind to but do not themselves contain LIM domains) that are implicated in either the development of the heart, heart disorders and failure or both. (sigmaaldrich.com)