Light intermediate chain. Medical search. Frequent questions

Behavioral and other phenotypes in a cytoplasmic Dynein light intermediate chain 1 mutant mouse. (ox.ac.uk)
Neurofilament light chain (NfL) is a neuronal cytoplasmic protein highly expressed in large calibre myelinated axons. (bmj.com)
Mammalian cytoplasmic dynein-1 complexes contain two copies of the same intermediate chain (typically DYNC1I2 in most cells, DYNC1I1 in neurons) and same light intermediate chain. (embl.de)

Further evidence that neurofilament light chain gene mutations can cause Charcot-Marie-Tooth disease type 2E. (mda.org)
In CNS and peripheral nervous system diseases associated with axonal injury or degeneration, the concentration of neurofilament light chain (NfL) has been found to increase in cerebrospinal fluid (CSF) and blood. (bmj.com)

Here we have taken a genotype-driven approach in mouse (Mus musculus) to analyze the role of one subunit, the dynein light intermediate chain 1 (Dync1li1). (ox.ac.uk)

The DYNC1H1 gene mutations that cause SMA-LED replace single protein building blocks (amino acids) in the heavy chain subunit of the dynein complex. (medlineplus.gov)
DYNC1I1 and DYNC1I2 interact with the dynein light chains and the p150 subunit of dynactin at the N terminus and with the heavy chains through WD40 repeats at the intermediate chain C terminus. (embl.de)

In the Chlamydomonas reinhardtii flagellar axoneme, at least 11 dynein heavy chains (three outer arm and eight inner arm) exist, and each could play crucial and distinct roles in proper flagellar functions ( Kagami and Kamiya, 1992 ). (rupress.org)

In 1998, Aurora kinase B was identified in humans by a polymerase chain reaction screen for kinases that are overexpressed in cancers. (wikipedia.org)
Reverse transcriptase polymerase chain reaction. (cdc.gov)
Polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) analysis of the ribosomal RNA gene internal transcribed spacer-1 (ITS1) was used. (who.int)

Type III intermediate filaments are highly conserved and contain three domains: the head, rod and tail domains. (biolegend.com)

The protein produced from the DYNC1H1 gene is a heavy chain. (medlineplus.gov)
Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes and ependymal cells. (biolegend.com)

B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)

Abbreviations: Ch - chain DC - double crochet HDC - half double crochet Rnd - round SC - single crochet Sl St - slip stitch sp (sps) - space (spaces) St (Sts) - stitch (stitches) Skill Level: Intermediate Finished Size: About 5-3/4" x 5-3/4" Yarn: Medium weight #4 yarn. (favecrafts.com)

Two heavy chain proteins bind together to form the core of the dynein complex. (medlineplus.gov)
Applying the same criterium to the process of gene expression, which also involves many 'intermediate steps', would lead us to the conclusion that no genetic information is transmitted from genes to proteins, which is no less difficult to defend. (cyclingforums.com)

To achieve this, they have sought to attract foreign direct investment (FDI) - mostly efficiency- and resource-seeking - and to link their domestic sector to foreign markets through participation in global value chains (GVCs). (imd.org)
Clearly, global value chains are now the dominant framework for trade. (org.in)

The parts (subunits) of a dynein complex are classified by weight as heavy, intermediate, light intermediate, or light chains. (medlineplus.gov)

Sandia researchers are the first ever to directly measure a "QOOH" radical, a key reactive step in the chain of reactions in hydrocarbon oxidation. (sandia.gov)
The researchers found that under illumination, the decarboxylation of fatty acids could be easily induced by photo-generated holes on the semiconductor TiO 2 , subsequently generating alkyl radical intermediates. (greencarcongress.com)
Rationally controlling the conversion of radical intermediates for preferential hydrogen termination is the key to high selectivity in obtaining alkane products. (greencarcongress.com)
Silorane network is generated by cationic ringopening polymerization mechanism instead of free radical curing of methacrylate monomers 8 , and more light-curing time to form cations is required to initiate the polymerization reaction 5 . (bvsalud.org)

Depending on the immunoglobulin subtype, the rate of progression can vary from 0.3% per year in light-chain MGUS to 1.5% in IgM MGUS. (springermedizin.at)

This gene encodes an inner dynein arm heavy chain that provides structural support between the radial spokes and the outer doublet of the sperm tail. (nih.gov)
A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene. (mda.org)

Skill Level: Intermediate, must have wire working and jewelry making experience. (rockybeads.org)

Light entering the eye causes genes to be expressed in specific cells. (cyclingforums.com)
Synaptic transmitter binding to receptors on melatonin secreting cells in the pineal activate genes in the cell nucleus, but that involves a whole series of intermediate steps. (cyclingforums.com)
If I got it right, you argue that the fact that 'a whole series of intermediate steps' are involved in the signal cascade from the external stimulus to genes, this fact per se, excludes the possibility of any information being transmitted via the cascade. (cyclingforums.com)
Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)

Anna 16 by Yumco, 100% cotton, 100 g/530 m (3.53 Oz/579 yds) color beige, or any super fine, light fingering yarn or crochet thread for doilies. (ravelry.com)
Hakelgarn by Yumco, 100% cotton, 100 g/530 m, color salmon pink, or any super fine, light fingering yarn or crochet thread for doilies. (ravelry.com)
Light weight #3 cotton yarn. (favecrafts.com)

Is outer arm dynein intermediate chain 1 multifunctional? (embl.de)

The dynein f dimer is located close to the surface of the A-microtubule, whereas the other six heavy chain rings are roughly colinear at a larger distance to form three dyads. (rupress.org)

In this study, we analyzed bile canaliculi dynamics, Rho kinase (ROCK)/myosin light chain kinase (MLCK) pathway implication, efflux inhibition of taurocholate [a predominant bile salt export pump (BSEP) substrate], and expression of the major canalicular and basolateral bile acid transporters. (aspetjournals.org)
The cells of origin in most patients with CLL are clonal B cells arrested in the B-cell differentiation pathway, intermediate between pre-B cells and mature B cells. (medscape.com)

Unbound AE-labeled antibodies are then separated and removed, following which acid and base are added to initiate chemiluminescence and light emission is measured. (cdc.gov)

Amitychem Corporation manufacture and supply Side Chain For Meropenem with with high quality, low price and bulk supply. (guidechem.com)
Resorcinol is also used as a chemical intermediate in the manufacture of dyes and dyestuffs, pharmaceuticals, agricultural chemicals, plasticizers and polyurethane chain extenders. (adhesivesmag.com)
For example, as Meghnad Desai of the London School of Economics points out, "In the light of advances in technologies such as 3D printing and artificial intelligence, it is not far-fetched to imagine that businesses could manufacture domestically the intermediate products that they currently import. (org.in)

Neurofilaments are neuron-specific type IV intermediate filament heteropolymers composed of light, medium, and heavy chains (Petzold, 2005). (cdc.gov)
All the eight different heavy chains were identified in one 96-nm periodic repeat, as expected from previous biochemical studies. (rupress.org)
Based on mutants, we identified the positions of the AAA rings and the N-terminal tails of all the eight heavy chains. (rupress.org)
Each dyad consists of two heavy chains and has a corresponding radial spoke or a similar feature. (rupress.org)
In each of the six heavy chains (dynein a, b, c, d, e, and g), the N-terminal tail extends from the distal side of the ring. (rupress.org)
This chain grid catches fast and slow putts, heavy and light discs like no other target. (clintonmo.com)
Tetramer of two light chains and two heavy chains. (lu.se)

At present, LDC firms tend to perform low value-added and labor-intensive tasks in supply chains in primary industries (extractive and agro-based), low-tech industries (textiles and apparel), processing industries (food and beverage) and entry-level services. (imd.org)

1.61 High Index - Super Thin (for people who have moderate prescriptions and want a light lens). (glassesshop.com)
They require loose, rich, house plant potting mix, moderate intensity of light, temperatures ranging from cool to warm, plenty of water with a well drainage growing medium and infrequent light feeding. (herbs2000.com)
Gartner research finds that 82% of supply chains are making moderate to significant organizational structure changes over the next 12 months. (gartner.com)

However, there is no unanimous agreement, less especially about the nomenclature of the recessive and intermediate-conduction velocity subtypes. (medscape.com)

Intermediate CMT is an uncommon CMT variant characterized by a mixed axonal-demyelinating process. (mda.org)

Biotech Europe GmbH, Freiburg, Germa- cation of the virus in cells heterozygous for ny) was used to extract genomic DNA the mutation proceeded at an intermediate from white blood cells following the lysis rate [ 5 ]. (who.int)

Multiple sourcing and proximity sourcing are taking shape as long-term trends as global firms hardwire resilience and agility into their supply chains. (imd.org)
Design the supply chain organization to empower supply chain staff to act with agility, actively manage risk and opportunities, and enable a digital future. (gartner.com)

Species in the genus Lockhartia have a preference for a humid atmosphere, bright light and intermediate temperatures. (herbs2000.com)
The scientists discovered that when exposing the catalyst Pt/TiO 2 to H 2 atmosphere with light, the interaction between the catalyst and H 2 generated a hydrogen-rich surface, so photo-generated radicals could be rapidly terminated by surface hydrogen species, thus greatly inhibiting oligomerization. (greencarcongress.com)

Hangzhou Utanpharma Biology Co., Ltd.are involved in supplying of Active Pharmaceutical Ingredients and Intermediates.Established in the year 2012, we are involved in supplying and exporting of various Pharmaceutical industries based products like hormones, ca. (guidechem.com)
Since nature makes these long-chain acids by linking together acetate units, it is not surprising that the carbon atoms composing the natural products are multiples of two. (msu.edu)
In this case, trade would continue apace, "but the product mix would shift from intermediate to final products. (org.in)

Light in a rod or cone cell is translatedinto electrical potential, but that involves a whole series of intermediate steps. (cyclingforums.com)
Changes in electrical potential inrod and cone cells in the retina cause release of synaptic transmitter onto melatonin secreting cells in the pineal, but that involves a whole series of intermediate steps. (cyclingforums.com)
This conformational change involves movement of the hydrophobic side chain of Ile 288 towards the benzothiazole ring of DLSA. (rcsb.org)

Sandia scientists John Savee, left, and Eve Papajak (both 8353), are responsible for detection of QOOH intermediates, shown at Berkeley's Advanced Light Source , where the experiments were done. (sandia.gov)
As shown in the following table, these long-chain carboxylic acids are usually referred to by their common names, which in most cases reflect their sources. (msu.edu)

Business supply chain strategies are evolving, can poor countries benefit? (imd.org)
Home Research & Knowledge back to Home Supply Chain back to Research & Knowledge Business supply chain strategies are evolving, can poor countries benefit? (imd.org)
Many analysts and businesses are anticipating a period of transformation that will see a wide-ranging overhaul of supply chain configuration. (imd.org)
As the supply chain management decisions of multinationals and lead retailers adjust to this new environment, what are the implications for less developed countries? (imd.org)
As widely commented, the Covid-19 pandemic has exposed the fragility of supply chains. (imd.org)
Journey toward a more effective supply chain organization structure for the next-generation supply chain workforce. (gartner.com)
Follow three steps to maximize the ROI of supply chain restructuring. (gartner.com)
Supply chain leaders must map the drivers of reorganization, set clear objectives and customize design strategies. (gartner.com)
Download the Supply Chain Organization Redesign and Restructuring Guide to plan and manage your next transformation. (gartner.com)
Reorganizing without a clear business reason for doing so can lead to high supply chain costs and increased supply chain risk . (gartner.com)
Too often supply chain organization redesigns simply mask areas of friction, if not compound persistent challenges, around resource allocation, building and delivering expertise, and decision making. (gartner.com)
Supply chain leaders must first map the challenges driving the need for reorganization. (gartner.com)
For example, if the pace and cost of adding new staff (FTEs) is exceeding that of revenue and profit growth, you can set out to improve scalability of FTEs in the supply chain. (gartner.com)
Or, if the supply chain organization is too siloed, you can establish the need to align decision making with the commercial business. (gartner.com)
Supply chain issues, such as the shortage of computer chips and other raw materials, compound these price pressures and make it even harder to estimate whether inflation will peak in a few months or a few years. (bcg.com)
The WEF estimates that, "Reducing supply chain barriers to trade could increase [global] GDP up to six times more than removing tariffs. (org.in)
True, today's trade wars have disrupted international supply chains, and will continue to do so. (org.in)

Light Field cameras are a new type of 3D-cameras that capture a standard image together with the depth information of a scene. (jpeg.org)
Here we report the crystal structures of wild-type and red mutant (S286N) luciferases from the Japanese Genji-botaru (Luciola cruciata) in complex with a high-energy intermediate analogue, 5'-O-[N-(dehydroluciferyl)-sulfamoyl]adenosine (DLSA). (rcsb.org)

Since the development of the dental composite resin in the 1960s, numerous improvements in its composition and characteristics were made and with the increased demand by patients for esthetic restorations and simplification of the bonding procedures, light-cured composites have been widely used in the dental practice 1 . (bvsalud.org)

1.61 High Index - Super Thin (for people who have moderatepre-scriptions and want a light lens). (glassesshop.com)
Trifocal lens to see far, intermediate, and near. (glassesshop.com)
Metric 3D information can be captured with a single light field camera through a single lens in a single shot using just the available light. (jpeg.org)

Unlike light or sound, stimuli easily controlled by tweaking characteristics such as frequency and wavelength, it is difficult to probe how the brain builds neural representations of the small molecules that transmit odor. (harvard.edu)

The US producer price index for processed goods for intermediate demand rose by 24.4% in 2021, the index's largest calendar-year increase since 1974. (bcg.com)

Combinations of intermediate, light intermediate, and light chains make up the rest of the complex. (medlineplus.gov)

Participation in value chains has been a key plank of low-income country development strategies over the past generation. (imd.org)
These strategies may range from "light-touch" solutions (e.g., adding cross-functional teams, upskilling employees, redesigning the cadence and composition of team meetings) to major restructuring (e.g., installing a shared service organization, adding new roles, adding an intermediate management layer). (gartner.com)

Hypotheses include frequent zoonotic infections with limited subsequent human-to-human transmission chains and existence of a self-sustained epidemic in humans ( 4 ). (cdc.gov)

A sizeable share of LDC exports are now routed through such chains, which represent up to 40 percent of international trade. (imd.org)

In a manner similar to observations regarding severe acute respiratory syndrome CoV (SARS-CoV), an intermediate reservoir host might exist from which human infections are acquired. (cdc.gov)

Bruker's Dairy Analyzers based on MIR and NIR spectroscopy and light scattering technology set a new standard in routine QC for the analysis of liquid and solid samples. (bruker.com)

The molecular epidemiology of Huntington disease is related to intermediate allele frequency and haplotype in the general population. (cdc.gov)

After so many years of development, we have our own professional team, our own complete industrial chain from the design, material selection and production of glasses. (glassesshop.com)

Controlling and improving product quality to assure consumer health is of foremost importance to the milk and dairy producers, in all phases of the production chain. (bruker.com)
A raw material, intermediate or an API that is used in the production of an API and that is incorporated as a significant structural fragment into the structure of the API. (who.int)
In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. (lu.se)

An Auto-care Technician carries out a range of services and repairs to cars, car derived vans and light goods vehicles, working in an Auto-care or "Fast-Fit" Centre, which may be part of a national chain or operated by a regional/local independent group/owner. (wnc.ac.uk)
Subtypes with velocities within the intermediate range are called DI-CMT. (medscape.com)

In the attempt to reduce these problems some techniques were proposed to decrease the shrinkage stress effects, such as different incremental composite placement 10 , light-curing protocols and intermediate layer with hybrid glass ionomer or flowable composite 11 . (bvsalud.org)

Anatomy3

Organisms2

Chemicals and Drugs5

Phenomena and Processes2

Cytoplasmic3

Neurofilament light chain2

DYNC1LI11

Subunit2

Dynein heavy1

Polymerase chain re3

Filaments1

Protein2

Bone marrow1

Half Double Crochet1

Proteins2

Global value chains2

Subunits1

Radical4

Immunoglobulin1

Gene2

Skill Level1

Genes4

Yarn3

Outer arm1

Dimer1

Pathway2

Added to initiate1

Manufacture3

Heavy7

Level1

Moderate3

Nomenclature1

Axonal1

Mutation1

Agility2

Atmosphere2

Products3

Involves3

Shown2

Supply17

Type2

Widely1

Lens3

Characteristics1

Year1

Complex1

Strategies2

Humans1

Trade1

Human1

Analysis1

Molecular1

Design1

Production3

Range2

Layer1