Light chains gene rearrangement b lymphocyte light chain. Medical search. Frequent questions

Genes, Immunoglobulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
The heavy and light immunoglobulin genes are present as gene segments in the germline cells. (uchicago.edu)
This graph shows the total number of publications written about "Genes, Immunoglobulin" by people in this website by year, and whether "Genes, Immunoglobulin" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Genes, Immunoglobulin" by people in Profiles. (uchicago.edu)
B-cell transcription factor expression and immunoglobulin gene rearrangement frequency in acute myeloid leukemia with t(8;21)(q22;q22). (uchicago.edu)
Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development. (uchicago.edu)
Jawed vertebrates (gnathostomes) generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish (agnathans) assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding molecules. (scielo.br)
They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. (lookformedical.com)
Therapies for these disorders (eg, intravenous immunoglobulin [IVIG], bone marrow transplantation, gene therapy) are very costly and require highly advanced facilities. (medscape.com)
Immunoglobulin gene rearrangement begins with heavy-chain gene rearrangement followed by light-chain gene rearrangement. (medscape.com)
The five corresponding immunoglobulin classes are designated as IgM, IgD, IgG, IgA, or IgE, depending on which type of heavy chain they use. (healthtipsdesk.com)
Flow cytometric evaluation of these cells showed a 10-fold excess of B cells expressing λ immunoglobulin (Ig) light chain compared with B cells expressing κ Ig light chain. (basicmedicalkey.com)

T lymphocytes recognize and respond to foreign antigens by means of specific T cell receptors (TcR). (clinlabnavigator.com)
Sometimes T cell clonality can be inferred when the lymphocytes express a predominance of CD4 or CD8 antigens. (clinlabnavigator.com)
The field of Lymphocyte Surface Antigens and Activation Mechanisms is examined in two chapters. (scielo.br)
A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes. (lookformedical.com)
VDJ rearrangement is a process by which the genes responsible for encoding the variable region of the B-cell receptor and T-cell receptor are rearranged to create a diverse repertoire of receptors capable of recognizing a wide variety of antigens. (osmosis.org)
Such binding of antibodies to antigens initiates a chain of events that helps our immune system to destroy or remove the foreign pathogens from our body. (e-adventure.net)

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) (also known as CD152) is a major negative regulator of T cell responses which interacts with the B7-1 (CD80) / B7-2 (CD86) ligands on the surface of an antigen-presenting cell. (scielo.br)
Evidence has recently been obtained that two very different recombinatorial systems for lymphocyte antigen receptor diversification appeared at the beginning of vertebrate evolution approximately 500 million years ago. (scielo.br)
And the antigen receptors for T cells and B cells have a lot of things in common, one of which is that they share the same mechanism - called VDJ rearrangement - to generate a massively diverse set of receptors. (osmosis.org)
VDJ stands for variability, diversity, and joining, respectively, and VDJ rearrangement has 4 key characteristics that help ensure that each antigen receptor is unique. (osmosis.org)
Lymphocytes are a type of white blood cell that can remember and recognize an antigen it has encountered before and initiate an immune response against it. (e-adventure.net)
The immune system is comprised of various continuously circulating cells (T and B lymphocytes, and antigen-presenting cells present in various tissues). (healthtipsdesk.com)

The production of antibodies by B-cells is a complex multistep process that involves extensive genetic rearrangement and recombination before the final product is produced. (e-adventure.net)
The diversity of T-cell receptors is also achieved by means of genetic rearrangement of V, D, and J segments. (healthtipsdesk.com)

Antibodies are Y-shaped proteins that have a unique structure with two heavy chains and two light chains joined together by disulfide bonds. (e-adventure.net)
two identical heavy chains and two identical light chains connected by disulfide bonds . (wikipedia.org)
Disulfide interchange enzyme -- An enzyme that catalyzes the rearrangement of disulfide bonds within proteins during folding. (nih.gov)

The process is mediated by recombination-activating genes (RAG1 and RAG2) and involves the introduction of double-strand breaks at specific recombination signal sequences (RSS) flanking the V, D, and J segments, followed by joining of the broken ends. (osmosis.org)
The three gene segments (variable, diversity, joining) which encode the variable domain (the VDJ region for the H chain, and the VJ region for the L chain) are capable of undergoing a process called recombination. (healthtipsdesk.com)

B lymphocytes, named after their site of origin in the bursa of Fabricius in birds or in the bone marrow in humans, form the basis for humoral immunity by their production of immunoglobulins. (medscape.com)

To overcome this limitation, TcR genes undergo a complex series of DNA rearrangements to produce more than one billion unique receptors. (clinlabnavigator.com)

The nodules resemble to some extent the GERMINAL CENTER of lymph node follicles and most likely represent neoplastic proliferation of lymph node-derived follicular center B-LYMPHOCYTES. (lookformedical.com)

Out of all the types of leukocytes, lymphocytes are the key player responsible for antibody production. (e-adventure.net)
Upon BCR activation, the cell integrates various signaling pathways that lead to the expression of essential genes, including genes involved in antibody production. (e-adventure.net)
Schematic structure of an antibody: two heavy chains (blue, yellow) and the two light chains (green, pink). (wikipedia.org)
The specificity of an antibody is determined by the amino acid sequence of the variable domains of the H and L chains, and this sequence is unique for each corresponding cell clone. (healthtipsdesk.com)

TcR gene rearrangements are useful in the diagnosis of T cell malignancies such as T cell ALL and lymphoblastic lymphoma, mycosis fungoides, Sezary syndrome, T cell PLL/CLL, and adult T cell leukemia. (clinlabnavigator.com)
Malignant lymphoma composed of large B lymphoid cells whose nuclear size can exceed normal macrophage nuclei, or more than twice the size of a normal lymphocyte. (lookformedical.com)
A form of non-Hodgkin lymphoma having a usually diffuse pattern with both small and medium lymphocytes and small cleaved cells. (lookformedical.com)
Because of the suspicion of B cell lymphoma, a malignant tumor of cells of the B lymphocyte lineage, the surgeon elected to remove the entire lymph node. (basicmedicalkey.com)

A group of lymphomas exhibiting clonal expansion of malignant T-lymphocytes arrested at varying stages of differentiation as well as malignant infiltration of the skin. (lookformedical.com)

Most of these lymphomas represent the malignant counterpart of B-lymphocytes at midstage in the process of differentiation. (lookformedical.com)

In a very interesting chapter, Z. PANCER and M. D. COOPER first consider the emergence of lymphocytes as a novel circulatory cell type in vertebrates and then discuss phylogenetic aspects of the superfamily of LRR - containing proteins and their role in immunity. (scielo.br)
containing a basic amino group, an acidic carboxyl group, and a side chain attached to an alpha carbon atom, and that link together by peptide bonds to form proteins, or that function as chemical messengers and as intermediates in metabolism. (nih.gov)

All malignant cells contain an identical gene rearrangement pattern that is easily identifiable by Southern blot analysis. (clinlabnavigator.com)
A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes. (lookformedical.com)
A group of malignant lymphomas thought to derive from peripheral T-lymphocytes in lymph nodes and other nonlymphoid sites. (lookformedical.com)

The completed genes are created when the segments are shuffled and assembled (B-LYMPHOCYTE GENE REARRANGEMENT) during B-LYMPHOCYTE maturation. (uchicago.edu)
The gene segments of the human light and heavy chain germline genes are symbolized V (variable), J (joining) and C (constant). (uchicago.edu)
During VDJ rearrangement, DNA segments called V (variable), D (diversity), and J (joining) are rearranged to form the coding sequence for the receptor variable region. (osmosis.org)

Flow cytometric analysis of these cells showed a predominant population of B cells expressing IgM, λ light chain, CD10, and CD20, and immunohistochemical stains performed on slides showed strong cytoplasmic staining for BCL-2. (basicmedicalkey.com)

In contrast, a polyclonal proliferation of lymphocytes is due to division of millions of different B and T cells, each containing a different set of gene rearrangements. (clinlabnavigator.com)

The key cells of the adaptive immune response are the lymphocytes- the B and T cells . (osmosis.org)

A clone must comprise at least 5% of the total number of lymphocytes to be detected. (clinlabnavigator.com)
These lymphocytes comprise two major types: T-cells and B-cells. (e-adventure.net)

T lineage disorders lack a phenotypic marker of clonality like the kappa and lambda light chain restriction in B lineage disorders. (clinlabnavigator.com)

and fourth, there's random reassortment of two chains - meaning that this process involves two different chains that come together to make the receptor. (osmosis.org)

Molecular analysis of the beta TcR gene rearrangements provides the most definitive assessment of T cell clonality. (clinlabnavigator.com)

Some eight years later it was discovered that triplets of the base pairs specified each amino acid in the polypeptide chain of each protein [ 11 , 12 ]. (biomedcentral.com)
Cistron -- A basic unit of hereditary material, it is the smallest genetic unit that must be intact to function as a transmitter of genetic information, i.e., to determine the sequence of amino acids of one polypeptide chain. (nih.gov)

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance. (uchicago.edu)
In 1944 it was realized that genetic transformation in bacteria was due to DNA and not protein and that DNA was the molecule responsible for heredity in genes and chromosomes [ 8 ]. (biomedcentral.com)

The heavy chain germline genes have an additional segment D (diversity). (uchicago.edu)
Clathrin light chain diversity regulates membrane deformation in vitro and synaptic vesicle formation in vivo. (academictree.org)

Through this process, Anfinsen could analyze the fragments of the three-dimensional amino acid chain. (nih.gov)

Detection of a TcR gene rearrangement indicates that a monoclonal population of T cells is present. (clinlabnavigator.com)
A classification of B-lymphocytes based on structurally or functionally different populations of cells. (lookformedical.com)
Out of the two types of lymphocytes, B-cells are the ones responsible for producing antibodies. (e-adventure.net)
Examination of smears prepared from aspirated cells revealed mainly small, irregular lymphocytes. (basicmedicalkey.com)
Why does the presence of a B cell population in which a large majority of the cells express λ light chain indicate a neoplasm rather than a response to an infection? (basicmedicalkey.com)
If the lymph node cells were analyzed by polymerase chain reaction (PCR) to assess Ig heavy-chain rearrangements, what abnormal finding would you expect? (basicmedicalkey.com)
During the maturation of B cells, the cells first express a rearranged μ heavy chain gene, which associates with the surrogate light chain to produce the pre-B cell receptor (see Chapter 4 ). (basicmedicalkey.com)

By one definition, it is synonymous with 'gene. (nih.gov)

It is selective for peptide bonds with aromatic or large hydrophobic side chains on the carboxyl side of this bond. (nih.gov)
Located predominantly in cell nuclei, it is composed of two chains of nucleotides--deoxyribose and phosphate backbones with side chains of purine (adenine or guanine) or pyrimidine (cytosine and thymine) bases projecting inward. (nih.gov)

The majority of mantle-cell lymphomas are associated with a t(11;14) translocation resulting in overexpression of the CYCLIN D1 gene (GENES, BCL-1). (lookformedical.com)

X-linked agammaglobulinemia (XLA), also known as Bruton agammaglobulinemia, results from a mutation of the BTK gene, which encodes the pre-B-cell receptor (Pre-BCR) and BCR. (medscape.com)

Just like antibodies, the B cell receptor has a heavy chain and a light chain. (osmosis.org)

Beta genes rearrange in the early thymocyte of stage of T cell development. (clinlabnavigator.com)

Mechanical stimulation led to a significant increase in chondrogenic gene expression, while histological analysis detected sulphated glycosaminoglycans and collagen II only in loaded specimens, confirming MC hydrogel suitability to support load induced MSCs chondrogenesis. (nature.com)

B cell receptor light chain repertoires show signs of selection with differences between groups of healthy individuals and SLE patients. (uchicago.edu)
Both rearrangements occur before the CD3-TcR complex is expressed on the cell surface. (clinlabnavigator.com)
A maturing T cell undergoes VDJ rearrangement . (osmosis.org)
Genotype -- The specific allelic composition of a cell, either of the entire cell or more commonly for a certain gene or a set of genes. (nih.gov)

At the same time further rearrangement is stopped. (healthtipsdesk.com)
amylase removes two glucose residues at a time, leaving the starch chain shorter. (nih.gov)

Alpha chains rearrange a little later during the common thymocyte stage. (clinlabnavigator.com)

Anatomy10

Organisms4

Diseases7

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes32

Information Science3

Immunoglobulin12

Antigens6

Antigen6

Genetic rearrangement2

Disulfide bonds3

Recombination2

IMMUNOGLOBULINS1

Receptors1

Follicular1

Antibody4

Lymphoma4

Clonal expansion1

Differentiation1

Proteins2

Malignant3

Segments3

Predominant1

Proliferation1

Immune1

Comprise2

Lineage1

Involves1

Clonality1

Polypeptide chain2

Molecule2

Diversity2

Fragments1

Cells7

Definition1

Side chains2

Translocation1

Mutation1

Antibodies1

Development1

Stimulation1

Cell4

Time2

Stage1