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  • pathologic
  • Immunofluorescence is negative except for occasional complement deposition along with the pathologic heavy chain and electron microscopy shows fine, granular, punctate electron dense deposits that lack fibrillary structure (see Emily's great review of Organized Deposition Diseases for more on fibrillary deposits). (blogspot.com)
  • HCDD
  • They speculate that the reason for this is that the conformational abnormality of the monoclonal heavy chain in IgG disease is such that it has a very high avidity for renal parenchyma so that even small quantities produced by a clinically undetectable population of cells is enough to cause HCDD. (blogspot.com)
  • The predominant pattern seen on light microscopy in HCDD is nodular glomerulosclerosis and of note all the cases of IgA related disease additionally had crescents. (blogspot.com)
  • underwent native
  • Design, setting, participants, & measurements: The case notes of 1993 unselected patients from four teaching hospitals within the United Kingdom who underwent native or transplant renal biopsies between 1993 and 2008 were reviewed. (asnjournals.org)
  • organs
  • The disease can also affect other organs such as the heart, and the gastrointestinal tract and peripheral nervous system. (dovepress.com)
  • biopsies
  • Design, setting, participants, & measurements: All native renal biopsies ( n = 235 including 106 men, 129 women) performed in patients aged ≥80 yr over a 3.67-yr period were retrospectively identified. (asnjournals.org)
  • Several studies have focused on the findings in renal biopsies in elderly patients ( 4 - 13 ). (asnjournals.org)
  • There is, however, a theoretical risk of increased hemorrhagic complications from renal biopsies in this setting. (asnjournals.org)
  • Despite these advantages, many clinicians are reluctant to perform percutaneous renal biopsies in patients with paraproteins because of the theoretical risk of a higher rate of hemorrhagic complications ( 8 , 9 ). (asnjournals.org)
  • However, clear evidence that performing percutaneous renal biopsies in these patients is associated with an actual higher incidence of clinically significant hemorrhagic complications is not well reported. (asnjournals.org)
  • Kidney
  • Monoclonal gammopathy of renal significance (MGRS) represents a group of kidney disorders caused by a monoclonal immunoglobulin that is secreted by a nonmalignant or premalignant B cell or plasma cell clone [ 1,2 ]. (uptodate.com)
  • This lesion is almost always induced by the excess of kappa light chains, excreted through the kidney and reabsorbed in the proximal tubule cells, which manifests with moderate CKD, and, rarely, with acquired adult Fanconi syndrome. (oatext.com)
  • The aim of the present meeting will be to promote scientific networking among researchers working in the field of Systems Biology applied to immune mediated kidney diseases. (ndt-educational.org)
  • Despite treatment with plasmapheresis, bortezomib and steroids, advanced chronic kidney disease developed. (biomedcentral.com)
  • There is a paucity of data on paediatric kidney disease in developing countries such as Malawi. (readbyqxmd.com)
  • Descriptive research on kidney disease is essential to improving patient outcomes. (readbyqxmd.com)
  • Children under 14 years with proteinuric kidney disease were enrolled from paediatric wards and outpatient clinics at Queen Elizabeth Central Hospital (QECH). (readbyqxmd.com)
  • The Role of Lipoprotein(a) in Chronic Kidney Disease. (readbyqxmd.com)
  • Studies suggest that the kidney has a role in Lp(a) catabolism, and that Lp(a) levels are increased in association with kidney disease only for people with large apo(a) isoforms. (readbyqxmd.com)
  • A case of a 12-year-old girl with chronic kidney disease, bilateral optic nerve colobomas and an exceptional PAX-2 gene mutation is presented. (readbyqxmd.com)
  • acute
  • As life expectancy increases, more elderly patients are surviving longer with acute and chronic diseases. (asnjournals.org)
  • Both acute & chronic renal failure could occur with this condition giving symptoms like reduced urine out put, generalized body swelling, haematuria and uremic features ( nausea, vomiting, loss of appetite, confusion/ drowsiness). (explainmedicine.com)
  • urine
  • Measure and follow the amount of M-protein light chains excreted in the urine over 24 hours. (cigna.com)
  • Correlation between changes in serum and urine FLCs during disease evolution in 71 patients with LCMM. (wikilite.com)
  • Two LCMM case studies in whom sFLC remained abnormal, indicating residual disease while urine tests normalised during follow-up. (wikilite.com)
  • Patients
  • role="button" tabindex="1" data-trigger="focus" data-html="true" data-placement="top" data-toggle="popover" data-content="Nasr SH, Valeri AM, Cornell LD, Fidler ME, Sethi S, D'Agati VD, Leung N. Renal monoclonal immunoglobulin deposition disease: a report of 64 patients from a single institution. (wikilite.com)
  • The goal was to differentiate patients with MGUS, who have no evidence of end-organ damage, from those with MGRS, who are at risk of developing progressive renal disease. (uptodate.com)
  • Paraproteins are frequently detected in patients with renal disease, both as an incidental finding and as the underlying cause of the renal injury. (asnjournals.org)
  • Comparing the results derived from OMICS technologies applied to patients and animal models, the scientific sessions will provide an unique overview on immune-mediated renal diseases, shedding light on genomic and environmental factors influencing gene expression signatures, cellular signalling, metabolic pathways, hormonal and cytokine imbalance, new targets for treatment. (ndt-educational.org)
  • After cycle 4 of therapy 9/21 patients with negative uIFE had an abnormal sFLC ratio, indicating residual disease. (wikilite.com)
  • proximal
  • Our cases demonstrate some peculiarities, making them rare even in the setting of light-chain proximal tubulopathy, which is rare itself. (oatext.com)