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  • lung
  • Changes in the lung density revealed by micro-CT suggested protection against BLM-induced lung injury by DRDE-30, which correlated well with changes in lung morphology and histopathology. (frontiersin.org)
  • DRDE-30 decreased the BLM-induced augmentation in BALF TGF-β and lung hydroxyproline levels, as well as reduced the expression of the mesenchymal marker α-smooth muscle actin (α-SMA), suggesting the suppression of epithelial to mesenchymal transition (EMT) as one of its anti-fibrotic effects. (frontiersin.org)
  • The results demonstrate that the Amifostine analog, DRDE-30, ameliorates the oxidative injury and lung fibrosis induced by BLM and strengthen its potential use as an adjuvant in alleviating the side effects of BLM. (frontiersin.org)
  • induction
  • Moreover, this type of stimulation increased the levels of the antiapoptotic protein myeloid cell leukemia-1 (Mcl-1) and protected from chemotherapy-induced apoptosis, whereas induction of apoptosis and down-regulation of Mcl-1 was observed following stimulation with sol-IgM. (bloodjournal.org)
  • The study will enroll 5 patients who are not on enzyme inducing anti-epileptic drugs (EIAEDs) and are scheduled to undergo salvage surgical resection for preoperative treatment with AC480 at 300 mg orally twice daily (BID) for 14 (plus or minus 2) days before surgery (Part I- Induction Therapy). (clinicaltrials.gov)
  • The importance of this step is highlighted by the association of defects in the 3′-end processing enzyme tyrosyl DNA phosphodiesterase 1 (TDP1) and neurodegeneration and by the cytotoxic induction of protein-linked DNA breaks (PDBs) and oxidized nucleic acid intermediates during chemotherapy and radiotherapy. (sciencemag.org)
  • tumor-cell
  • These findings are consistent with studies showing that THC and other cannabinoids can induce apoptosis in a variety of tumor cell lines, thereby raising the possibility of the use of cannabinoids as novel anticancer agents ( 11 ). (aacrjournals.org)
  • triggers
  • What triggers stress-induced premature senescence (SIPS) and how similar this mechanism is to replicative senescence are not well understood. (jove.com)
  • pharmacological
  • Given its radioprotective efficacy as described here, UA as an antioxidant and NF-κB pathway blocker, may function as an important pharmacological agent in protecting against gamma irradiation-induced injury. (frontiersin.org)
  • survival
  • MCL tumors respond to chemotherapy, but the remissions are short and the median survival is only 3 years. (aspetjournals.org)
  • Furthermore, its usefulness alone or combined with chemotherapy is considered as first-line therapeutic option for other types of hematologic malignancies ( 9 - 11 ) improving patient survival. (aacrjournals.org)
  • radiation
  • Lipid peroxidation, together with DNA damage, constitutes the key events involved in radiation induced cell death. (frontiersin.org)
  • Although Amifostine has been found to protect lungs from the toxic effects of radiation and BLM, its application is limited due to associated toxicity and unfavorable route of administration. (frontiersin.org)
  • responses
  • In addition, UA also reversed gamma irradiation induced inflammatory responses, as indicated by the decreased production of TNF-α, IL-6, and IL-1β. (frontiersin.org)
  • combination
  • the more untimely the infant, the greater the risk Fashion, a proposition not after all explored in this surround is activation of the adenosinergic combination induced nearby exercise This is when a "cracked jackpot" aspect is heard during percussion and can indicate dividing line of the sutures order kamagra 50 mg. (barbara-laufenistleben.de)
  • 1-3 Combination chemotherapy offers initial response rates of 40% to 70% in MM patients, 4 but refractoriness to these regimens eventually develops. (bloodjournal.org)