• Fortunately, hypoxia ischemia can be modeled in neonatal rats via carotid artery ligation, followed by a period of induced hypoxia. (uconn.edu)
  • The rats underwent left carotid ligation followed by hypoxic stress. (bvsalud.org)
  • The rats in the model group and the ligustrazine group were used to establish a neonatal rat model of HIE by ligation of the left common carotid artery followed by hypoxia treatment, and blood vessels were exposed without any other treatment for the rats in the sham-operation group. (bvsalud.org)
  • Indeed following carotid artery ligation. (techuniq.com)
  • At 48 h after the injections, hypoxic-ischemic (HI) injury was induced by unilateral carotid artery ligation followed by hypoxia for 65 min. (biomedcentral.com)
  • This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. (medsci.org)
  • Preterm Fetal Hypoxia-Ischemia Causes Hypertonia and Motor Deficits in the Neonatal Rabbit: A Model for Human Cerebral Palsy? (jneurosci.org)
  • Prenatal hypoxia-ischemia to the developing brain has been strongly implicated in the subsequent development of the hypertonic motor deficits of cerebral palsy (CP) in premature and full-term infants who present with neonatal encephalopathy. (jneurosci.org)
  • Hypoxia-ischemia (H-I) is also associated with subsequent cerebral injury in a disproportionately high percentage of the survivors of premature birth ( Volpe, 2001 ). (jneurosci.org)
  • Most previous studies have employed models of cerebral hypoxia-ischemia in postnatal animals. (jneurosci.org)
  • Examples of these studies include injection of bromodeoxyuridine for proliferation tracing, Apelin-13 for cerebral ischemia, and α-interferon for its antiviral and antibiotic properties. (wikipedia.org)
  • Cerebral ischemia/reperfusion (I/R) injury is the main pathophysiological process present in ischemic stroke. (wikipedia.org)
  • cerebral ischemia decreased the extent KU 0060648 of neutrophil emigration and macrophage/activated microglial infiltration 48 hours later and only in the ischemic hemisphere (41). (techuniq.com)
  • In adult rat melatonin given after focal cerebral ischemia improves short term evaluations of infarct size and neurobehavioral outcomes (41) suggesting that melatonin treatment may be applicable to global brain ischemia in the neonate. (techuniq.com)
  • Following induction of global ischemia in neonatal pigs melatonin combined with hypothermia decreased MR spectroscopic indices of impaired cerebral energy metabolism compared with hypothermia alone (45). (techuniq.com)
  • An UCCAO caused a slight cerebral ischemia (cerebral blood flow [CBF] 70%) without hypotension (MABP 85 mmHg), systemic inflammation, multiple organs injuries, or neurological injury. (medsci.org)
  • An HS caused a moderate cerebral ischemia (52% of the original CBF levels), a moderate hypotension (MABP downed to 22 mmHg), systemic inflammation, and peripheral organs injuries. (medsci.org)
  • However, combined an UCCAO and an HS caused a severe cerebral ischemia (18% of the original CBF levels), a moderate hypotension (MABP downed to 17 mmHg), systemic inflammation, peripheral organs damage, and neurological injury, which can be attenuated by whole body cooling. (medsci.org)
  • Global cerebral ischemia is associated with delayed neuronal death. (asahq.org)
  • Its effects were evaluated on neuronal cell death and outcome after global cerebral ischemia. (asahq.org)
  • Global cerebral ischemia was induced by cardiocirculatory arrest. (asahq.org)
  • The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. (hindawi.com)
  • In in vitro experiment, RSV prevented hypoxia-induced NRCM senescence and apoptosis. (hindawi.com)
  • The p53-associated signaling pathway has been demonstrated to regulate hypoxia-induced apoptosis and senescence [ 5 ]. (hindawi.com)
  • HPC protected neonatal rat cardiomyocytes against H/R injury by increasing cell viability, while reducing LDH release and cell apoptosis. (spandidos-publications.com)
  • Neuronal apoptosis is closely associated with brain damage induced by ischemia/reperfusion injury [ 3 - 5 ]. (einj.org)
  • SYVN1/GPX5 axis affects ischemia/reperfusion induced apoptosis of AC16 cells by regulating ROS generation. (e-century.us)
  • Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)
  • These findings provide a unique behavioral model to define mechanisms and sequelae of perinatal brain injury from antenatal hypoxia-ischemia. (jneurosci.org)
  • We investigated the effects of pentoxifylline, a methylxanthine derivative and type-4 phosphodiesterase inhibitor, on short-term memory and apoptotic neuronal cell death in the hippocampus following perinatal hypoxic-ischemia in newborn rats. (einj.org)
  • Pentoxifylline ameliorated perinatal hypoxic-ischemia in rat pups. (einj.org)
  • Perinatal hypoxic-ischemia is accompanied by neurodegeneration, including necrotic and apoptotic neuronal death [ 1 , 2 ]. (einj.org)
  • Persistent myocardial ischemia and hypoxia will cause malignant cardiac remodeling and subsequent heart failure. (hindawi.com)
  • Adult rats were subjected to myocardial ischemia/reperfusion (I/R) injury with or without ischemic preconditioning (IPC), and the level of miR‑133b‑5p in myocardium was measured. (spandidos-publications.com)
  • Reperfusion after cardiac ischemia increases cell death and infarct size (IS), called myocardial ischemia/reperfusion (I/R) injury, which is the main cause of myocardial injury during the cardiac surgery particularly in coronary artery bypass graft surgery ( 1 , 2 ). (spandidos-publications.com)
  • Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
  • After hypoxia and ischemia, the production of reactive oxygen species (ROS) rapidly accumulates and leads to mitochondrial dysfunction and delayed neuronal death. (frontiersin.org)
  • Mice were treated with RSV by gastric tube (320 mg/kg/day) or vehicle one week before left coronary artery ligation or sham surgery until the end of the experiments. (hindawi.com)
  • Male Wistar rats were subjected to coronary artery ligation, and primary neonatal rat ventricular myocytes were treated with hypoxia or hydrogen peroxide (H 2 O 2 ). (ijbs.com)
  • Hmox1 knockout (Hmox1 −/− ) and wild-type (WT, Hmox1 +/+ ) mice were subjected to a permanent ligation of the left anterior descending coronary artery. (springer.com)
  • These results indicate that UCBMC may promote NSC proliferation and alleviate brain injury in HI neonatal rats via Shh signaling. (bvsalud.org)
  • Additionally, we found that overexpression of miR-101a reversed the improved migration ability of CFs and further reduced CF proliferation caused by hypoxia. (cyberleninka.org)
  • Acute or chronic inflammation induced by ischemia has also been suggested to play an important role in the process of malignant cardiac remodeling [ 3 ]. (hindawi.com)
  • Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
  • On the other hand, the number of circulating hEPC is increased in hypoxia or acute myocardial infarction (AMI). (intechopen.com)
  • More encouragingly melatonin provided to neonatal mice before and after severe hypoxia significantly increased hippocampal neuronal survival at 3 7 and 14 days as well as functional motor outcomes two weeks following insult (43). (techuniq.com)
  • A microglia‑mediated inflammation model was induced by LPS in BV‑2 microglial cells in vitro , whilst a SAE‑related cognitive impairment model was established in mice using cecal ligation and perforation (CLP) surgery. (spandidos-publications.com)
  • Whilst vector administration in these studies was conducted with pharmacological interventions or in neonatal animals, rAAV8 vectors appear more efficient at crossing the blood vessel barrier and transducing heart and skeletal muscle of adult mice and hamsters (Wang et al. (justia.com)
  • In addition, inhaled hypoxic air preconditioning including intermittent hypoxia has been suggested a potential non-pharmacological therapeutic intervention to improve some cardiovascular diseases such as hypertension, myocardial infarction. (spandidos-publications.com)
  • This study aimed to investigate the potential relationship between hypoxia, miR-101a and TGF-p signaling pathway in CFs. (cyberleninka.org)
  • In the present study, a new neurobehavioral battery of tests was used to characterize the motor performance of newborn pups after sustained hypoxia-ischemia to the preterm rabbit fetus at 67-70% gestation. (jneurosci.org)
  • Uterine ischemia in the dams resulted in a distinct neurobehavioral phenotype in the newborn pups, which was characterized by an increase in forelimb tone that was significantly correlated with histological evidence of persistent injury to subcortical motor pathways involving the basal ganglia and anterior thalamus. (jneurosci.org)
  • Preterm fetuses (67-70% gestation) were subjected to sustained global hypoxia. (jneurosci.org)
  • Antenatal hypoxia-ischemia at preterm gestation results in hypertonia and abnormalities in motor control. (jneurosci.org)
  • In addition, neonatal rat cardiomyocytes (NRCMs), cardiac fibroblasts (CFs), and macrophages were isolated for in vitro experiments. (hindawi.com)
  • Neonatal rat cardiomyocytes were isolated and subjected to hypoxia/reoxygenation (H/R) injury, with or without HPC. (spandidos-publications.com)
  • METHODS@#Neonatal Sprague-Dawley rats, aged 7 days, were randomly divided into a sham-operation group with 8 rats, a model group with 12 rats, and a ligustrazine group with 12 rats. (bvsalud.org)
  • OBJECTIVE: To verify the potential of hypothermic hypoxic-ischemic encephalopathy (HIE) therapy in neonatal asphyxia, based on literature data, comparing the benefits between selective head cooling (SHC) and whole-body cooling (WBC), see that the use of TH as a standard treatment in newborns with moderate or severe HIE has been adopted. (bvsalud.org)
  • OBJECTIVES@#To study the effect of ligustrazine injection on mitophagy in neonatal rats with hypoxic-ischemic encephalopathy (HIE) and its molecular mechanism. (bvsalud.org)
  • Oxidative stress is an important mechanism of neonatal hypoxic-ischemic brain damage. (frontiersin.org)
  • Such HPC may enhance cellular tolerance to subsequent hypoxia-induced oxidative stress, simulating the protective effects of IPC, taking advantage of convenient and non-invasive intervention ( 3 , 4 ). (spandidos-publications.com)
  • Umbilical cord blood mononuclear cells (UCBMC) transplantation may improve hypoxia-induced brain injury in neonatal rats, but the mechanism is unclear. (bvsalud.org)
  • In fact in a randomized double blind placebo-controlled study of 53 pregnant women whose fetuses demonstrated evidence of hypoxia arterial cord blood from infants of allopurinol-treated mothers exhibited lower levels of S-100B a marker of brain injury KU 0060648 a very short-term outcome. (techuniq.com)
  • Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation. (hindawi.com)
  • Neonatal trials following HI brain injury have been limited. (techuniq.com)
  • Taken together, these results indicate the TLRs play an important role in ischemia-induced injury in the adult brain. (biomedcentral.com)
  • Hypoxia, viral infection, and traumatic injury are the most common environmental causes of DCMs, and are associated with the subsyndromes focal polymicrogyria and focal cortical dysplasia (FCD) Type IIId, both of which have a high incidence of epilepsy. (eneuro.org)
  • This is the first direct demonstration of α2δ-1's role in injury-induced cell death in the CNS, and suggests that α2δ-1 may be broadly involved in pathologic changes after neonatal brain insult. (eneuro.org)
  • However, the molecular pathway involved in myocardial neovascularisation after ischemia remains unknown. (elifesciences.org)
  • To better understand the molecular and cellular changes associated with early life insult-induced cortical network reorganization, we used the neonatal freeze-lesion (FL) model. (eneuro.org)
  • Advances in treatment, such as antenatal steroids, early use of CPAP, early administration of surfactant and availability of better neonatal care, have improved the survival of extremely premature newborns. (ogmagazine.org.au)
  • Hypoxic ischemia (HI) involves multiple mechanisms, but the detailed pathogenesis is still unclear. (frontiersin.org)
  • Therefore, prolonged hypoxia may play a critical role in aberrant cardiac remodeling in cardiovascular diseases [4-6]. (cyberleninka.org)
  • and (v) the role of hypoxia-inducible factor-1 in lung development. (stanford.edu)
  • The rats in the ligustrazine group were intraperitoneally injected with ligustrazine (20 mg/kg) daily after hypoxia-ischemia, and those in the sham-operation group and the model group were intraperitoneally injected with an equal volume of normal saline daily. (bvsalud.org)
  • Hypoxia/reoxygenation (H/R) as well as hypoxic preconditioning (HPC) is widely used for simulating in vivo myocardial I/R and ischemic preconditioning (IPC) in a cell culture model. (spandidos-publications.com)
  • The common neonatal complications in premature babies are described below. (ogmagazine.org.au)
  • Extremely premature babies are routinely monitored during neonatal intensive care unit stay and treated prophylactically with caffeine citrate (intravenously or orally) until 34 weeks. (ogmagazine.org.au)
  • A common player among these pathological stimuli is hypoxia, which may directly result from a lack of oxygen or indirectly from increased oxygen depletion caused by activated resident cells or infiltrated inflammatory cells. (cyberleninka.org)
  • Background/Aims: Hypoxia is a basic pathological challenge that is associated with numerous cardiovascular disorders including aberrant cardiac remodeling. (cyberleninka.org)