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  • PMID
  • Then, in a second, "editing" step, the ligase itself rapidly hydrolyses only the valylated products [ PMID: 9554847 , PMID: 10446055 ] as shown from the crystal structures. (ebi.ac.uk)
  • The aminoacyl-tRNA synthetase (also known as aminoacyl-tRNA ligase) catalyse the attachment of an amino acid to its cognate transfer RNA molecule in a highly specific two-step reaction [ PMID: 10704480 , PMID: 12458790 ]. (ebi.ac.uk)
  • Lysine
  • These four Mur ligases are responsible for the successive additions of L-alanine, D-glutamate, meso- diaminopimelate or L-lysine, and D-alanyl-D-alanine to UDP- N-acetylmuramic acid . (wikipedia.org)
  • The co-factor ATP is cleaved to pyrophosphate and AMP, with the AMP being covalently joined to a highly conserved lysine residue in the active site of the ligase. (ebi.ac.uk)
  • Okazaki
  • Secara biologis, DNA ligase diperlukan untuk menggabungkan fragmen Okazaki saat proses replikasi, menyambung potongan-potongan DNA yang baru disintesis, serta berperan dalam proses reparasi DNA. (wikipedia.org)
  • domain
  • DNA ligase ini berasal dari bakteriofage T7, mempunyai struktur yang terdiri dari dua domain dengan sisi aktif ATP yang terbentuk oleh ujung-N domain yang lebih besar. (wikipedia.org)
  • forms
  • There are two forms of DNA ligase: one requires ATP ( EC:6.5.1.1 ), the other NAD ( EC:6.5.1.2 ). (ebi.ac.uk)