Ligands vascular activating transcription factor 6. Medical search. Frequent questions

Regulation of arteriovenous specification and differentiation in both endothelial cells and vascular smooth muscle cells are also involved in Notch signaling including regulation of blood vessel sprouting, branching during normal and pathological angiogenesis, and the physiological responses of vascular smooth muscle cells ( 4 , 6 , 7 , 21 - 23 ). (frontiersin.org)
7 Besides, new vascular endothelial cells can release a variety of cytokines to nourish nerve cells and induce neurogenesis, and communication between nerves could also be repaired. (cbinsights.com)

Induction of growth factors [interleukin 6 (IL-6), insulin-like growth factor-1, and vascular endothelial growth factor/platelet-derived growth factor) may indirectly activate the AR and/or its downstream signaling pathways (5, 6, 7) . (aacrjournals.org)
At the proliferation stage, proliferation related pathways and basic cellular and metabolic processes were inhibited, while regulatory factors that initiate differentiation enter the ready-to-activate state, which provides a precondition for initiating adipose differentiation. (biomedcentral.com)
According to weighted gene co-expression network analysis, pathways positively related to adipogenic differentiation are significantly activated at the differentiation stage, while WNT, FOXO and other pathways that inhibit preadipocyte differentiation are negatively regulated. (biomedcentral.com)
Like other TNF-family receptors and the IL-1 receptor, RANK mediates its signal transduction via TNF receptor-associated factor (TRAF) proteins, suggesting that the signaling pathways activated by RANK and other inflammatory cytokines involved in osteoclast differentiation and activation are interconnected. (umassmed.edu)
These modules were also enriched in synergistically co-regulated genes and pathways relevant to vascular inflammation. (biomedcentral.com)
Diesel exhaust particles and oxidized phospholipids synergistically affect the expression profile of several gene modules that correspond to pathways relevant to vascular inflammatory processes such as atherosclerosis. (biomedcentral.com)
Ginsenoside Rg1 composite nanoparticles were employed to induce the expression of several key epigenetic enzymes and then activate the VEGF and Notch pathways after the onset of ischemic brain lesions. (cbinsights.com)
What two pathways do PTKs activate? (flashcardmachine.com)
Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)

Interleukin-6 and other cytokines play an important role in the progression of COVID-19. (jomes.org)
The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
Release of pathogen-associated molecular patterns due to the viral infection and activation of transcription factors such as nuclear factor kappa B, NOD-like receptor protein 3 inflammasome via pattern recognition receptors and ongoing production of cytokines at the entry sites. (racgp.org.au)
These cells secrete immune inhibitory growth factors and cytokines, including vascular endothelial growth factor (VEGF), which is primarily produced by microglia, myeloid-derived suppressor cells (MDSCs) and tumour-associated macrophages (TAMs). (encyclopedia.pub)
Hyperglycemia contributes to glycosylation of proteins and lipids, increases the production of reactive oxygen species, stimulates the synthesis and secretion of pro-inflammatory cytokines and acute phase proteins in various tissues, promoting thus inflammation processes in the vascular wall [ 2 , 3 ]. (medsci.org)
In the past, numerous studies investigating WAT inflammation have shown that the release of pro-inflammatory cytokines, such as TNFα, IL-6 or gp130 cytokines, are implicated in insulin-resistance [ 9 , 10 ]. (springer.com)

Toll-like receptors (TLRs) enable innate immune cells, such as macrophages, to recognize a wide variety of microbial ligands, thereby promoting inflammation. (frontiersin.org)
Treatment of human alveolar macrophages (AMs) with the synthetic GC dexamethasone (Dex) did not alter the expression of TLRs −1, −4, and −6. (frontiersin.org)
early treatment with HP24, reduces the manifestation of NOS2, a pro-inflammatory mediator, and stimulates proangiogenic mediators (vascular endothelial development factor A, Compact disc31, and Arginase I) both in macrophages and in the center of infection is usually seen as a parasite invasion from the center along with other organs. (healthy-nutrition-plan.com)
Activation of the vascular innate immune system inducing recruitment of macrophages, monocytes and neutrophils to the alveoli. (racgp.org.au)
5 The damaged brain tissue could be restored by angiogenesis, which provides oxygen and nutrients to improve recovery in the penumbra area, 6 and allows macrophages to clear necrotic nerve cells or tissues. (cbinsights.com)
Macrophages primarily have three major vital roles, phagocytosis, presentation of antigens, and in immunomodulation by producing different cytokinesis and growth factors [ 1 ] . (encyclopedia.pub)
Interleukin 10 helps in the deactivation of activated macrophages [ 1 ] . (encyclopedia.pub)
Tumor-associated macrophages (TAM) are created by cancerous and stroma cells in the tumor and are enlisted by tumor growth factors and chemokines [ 4 ] . (encyclopedia.pub)
Macrophages contain antigen-presenting cells, immunomodulators, and phagocytosis that play a vital role in the initiation and maintenance of inflammatory functions [ 6 ] . (encyclopedia.pub)

The manifestation of pro-inflammatory mediators such as for example tumor necrosis factor-alpha (TNF-), IL-6, interleukin 1 beta (IL-1), and nitric oxide synthase 2 (NOS2) is usually associated with intensifying tissue damage, resulting in cardiac pathological circumstances (7C11). (healthy-nutrition-plan.com)
There was also evidence of down-regulation of serum interleukin 6, a downstream nuclear factor κB effector. (aacrjournals.org)
In addition, activated T cells can express an inducible co-stimulator (iCOS), a surface receptor that is structurally and functionally similar to CD28 and enhances expression of Th2-related interleukin (IL)-10 rather than immune activating IL-2 [ 8 ] . (encyclopedia.pub)

PPAR ligands enhance VEGF-A appearance in individual vascular smooth Neratinib muscle tissue cells and upregulate NOS3 appearance in myocardial infarction (18, 19). (healthy-nutrition-plan.com)
We investigated the influence of alpha6beta1 on vascular endothelial growth factor (VEGF) expression because autocrine VEGF is necessary for the survival of serum-deprived cells in hypoxia. (umassmed.edu)
The results obtained indicate that alpha6beta1 is necessary for VEGF expression because the ability of hypoxia to activate HIF-1 and to stimulate VEGF transcription in MDA-MB-435 cells is dependent on alpha6beta1 expression by a mechanism that involves protein kinase C-alpha. (umassmed.edu)
Resveratrol activated p300 acetyltransferase-mediated VEGF signaling in the affected ventral spinal cord, which may have thus contributed to the acceleration of nerve regeneration and motor repair. (vinomis.com)
For example proteoglycans sequester biomolecules such as growth factors (TGF-β, VEGF, FGF etc.) and MMPs (Matrix Metalloproteinases). (springer.com)

Genomic actions involve the regulation of target genes, and suppress most of the vascular elements of inflammation and angiogenesis in the airway. (ersjournals.com)
We hypothesize that these pro-oxidative chemicals could synergize with oxidized lipid components generated in low-density lipoprotein particles to enhance vascular inflammation and atherosclerosis. (biomedcentral.com)
Similar transcription factors are activated and remain so during the first months as oedema subsides, thus inducing chronic inflammation and suppressing immunological recovery. (racgp.org.au)
But Actos also improved several heart disease risk factors, including cholesterol and markers of inflammation, such as C-reactive protein. (natap.org)

How is a receptor-ligand binding curve determined? (flashcardmachine.com)
Describe the three lines on a receptor-ligand binding curve? (flashcardmachine.com)
Designer T and NK cells are a modality within immunotherapy that manipulates receptor-ligand interactions to enhance cells of the immune system to destroy cancer more effectively. (encyclopedia.pub)

Differentially expressed genes in the left atria of mitral regurgitation (MR) pigs have been linked to peroxisome proliferator-activated receptor (PPAR) signaling pathway in the KEGG pathway. (biomedcentral.com)
Interestingly, gene ontology and pathway enrichment analysis of the differentially expressed genes in that study showed that peroxisome proliferator-activated receptor (PPAR) signaling pathway was identified in the KEGG pathway. (biomedcentral.com)
Peroxisome proliferator-activated receptor gamma (PPAR) is really a ligand-dependent transcription aspect from the nuclear receptor superfamily, mixed up in legislation of lipid fat burning capacity, insulin awareness, and inflammatory response (16). (healthy-nutrition-plan.com)
2011). In developing rat lung, 1-(N-methyl-N-nitrosamino)-1-(3-pyridinyl)-4-butanal) (NNA), a constituent of THS, disrupted signaling mechanisms by decreasing the levels of peroxisome proliferator-activated receptor and up-regulating fibronectin (Rehan et al. (immune-source.com)

PPARα is expressed mainly in metabolically active tissues, such as heart, liver, and skeletal muscle [ 6 ], and plays important physiologic roles in fatty acid oxidation and fatty acid metabolism. (biomedcentral.com)
Subsequently, the PPARγ agonist RSG increased caveolin-1 expression and decreased TLR4 expression and inflammatory factor levels. (researchsquare.com)

The major structural and functional changes related to the airway circulation include the proliferation of blood vessels (angiogenesis) 2 - 4 , increased blood flow 5 , 6 , increased microvascular permeability 7 , 8 , and oedema formation in the airway wall 9 . (ersjournals.com)

8 Vascular endothelial growth factor and Notch signaling pathway have a crucial role in brain angiogenesis. (cbinsights.com)
Our findings revealed the mechanism by which m 6 A modification regulated the angiogenesis and might provide potential biomarkers to predict the outcome of treatment, as well as provide suitable pharmacological targets for preventing the formation and progression of cerebral AVM. (biomedcentral.com)

Toll-like receptors (TLRs) are the major pattern recognition receptors of the innate immune system that sense a wide range of "danger" signals or pathogen-associated molecular patterns (PAMPs) ( 6 - 8 ). (frontiersin.org)
In the context of cancer, appropriately activated DCs can induce anti-tumor immunity by activating innate immune cells and tumor-specific lymphocytes that target cancer cells. (mdpi.com)

D inset) The ICD binds onto the DNA as a transcription factor to transcribe downstream Notch genes such as Hes1, Hey1, and Nrg1. (frontiersin.org)
Surface receptors such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and nuclear transcription factors attenuate T cell responses, where CTLA-4 competes with CD28 for binding to CD80/86, resulting in inhibitory downstream signalling [ 6 ] . (encyclopedia.pub)

To understand the functional interactions between the TrkA and p75 nerve growth factor (NGF) receptors, we stably transfected LAN5 neuroblastoma cells with an expression vector for ET-R, a chimeric receptor with the extracellular domain of the epidermal growth factor receptor (EGFR), and the TrkA transmembrane and intracellular domains. (umassmed.edu)
This pathway plays a prominent role in inter- and intracellular communication and subversion can lead to cancer, fibrosis vascular disorders, and immune diseases. (lu.se)
Pediatric patients who survived had higher levels of the chemokine regulated on activation, normal T-cell expressed and secreted marker and lower levels of plasminogen activator inhibitor 1, soluble intracellular adhesion molecule, and soluble vascular cell adhesion molecule than did pediatric patients who died. (cdc.gov)

The PPARs are ligand activated transcription factors that regulate genes important in cell differentiation, various metabolic processes, especially lipid and glucose homeostasis, insulin sensitivity, control of inflammatory processes and vascular integrity [ 6 ]. (biomedcentral.com)
In humans, the MHC is called the human leukocyte antigen (HLA) system and is located on the short arm of chromosome 6, near the complement genes. (medscape.com)
Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)

The TAM receptors and their ligands are overexpressed or activated in multiple malignancies, including LMS. (nature.com)
They represent the first line of defense against pathogens in the lower airspace and recognize microbial ligands via pattern recognition receptors ( 4 , 5 ). (frontiersin.org)
COVID-19 is caused by SARS-CoV-2, which primarily targets angiotensin converting enzyme-2 (ACE2) receptors on cells of the respiratory system and induces an immediate immunological cascade of cytokine responses that affect the individual cells and vascular system. (racgp.org.au)

Atherosclerosis is a chronic vascular inflammatory process where lipid deposition and oxidation in the artery wall constitute a hallmark of the disease [ 12 - 17 ]. (biomedcentral.com)
In the case of vulnerable groups such as those with obesity, hypertension or atherosclerosis, and vulnerable older groups with already compromised vascular systems and maladaptive immune responses, a post-COVID-19 hyperimmune response is an expectation rather than the exception. (racgp.org.au)
Currently increasing importance is attributed to the inflammatory process as a crucial factor responsible for the progressive damage to vascular walls and progression of atherosclerosis in obese people. (medsci.org)

A/A cells exhibited defects in several steps of autophagic processes (such as autophagosome and autolysosome formation) that are regulated by the transcriptional activities of the autophagy master transcription factors TFEB and TFE3 under ER stress conditions. (bvsalud.org)
We explored 36 mRNA-seq libraries in order to study transcriptome dynamics during proliferation and differentiation processes at 6 time points. (biomedcentral.com)
The process is activated and deactivated by inflammatory processes such as activating signals i.e., cytokinesis and TNF-α are deactivated by removing mediators and inflammatory effector cells. (encyclopedia.pub)

TLR2 induction did not enhance TLR2 signaling, as indicated by reduced cytokine production after treatment with TLR2 ligands in Dex- and/or LPS-primed AMs. (frontiersin.org)
Further recruitment of intravascular neutrophils in the lungs and to microglia in the brain, activates proinflammatory cytokine production. (racgp.org.au)
PD-1 is an immunoinhibitory receptor that stymies lymphocyte proliferation and cytokine secretion when bound to its membrane-bound or secreted ligands, PD-L1 or PD-L2, expressed by both immune and tumour cells [ 7 ] . (encyclopedia.pub)
This immunosuppressive helper T cell phenotype can be further induced by the zinc-finger transcription factor GATA3, which regulates Th2 cytokine expression [ 9 ] . (encyclopedia.pub)
Studies using these samples found associations between fatal outcomes and elevated liver enzyme levels, renal dysfunction, cytokine dysregulation, and genetic factors ( 7 - 9 ). (cdc.gov)

Taken together, these features of RAGE allow the receptor to propagate cellular dysfunction in a number of pathophysiologically relevant situations, most often dictated by the formation and persistence of ligands in the tissues. (jci.org)

Moreover, we identified and classified more than 100 transcription factors that showed significant changes during differentiation, and found novel transcription factors that were not reported to be related to preadipoctye differentiation. (biomedcentral.com)
Studies in osteoclast biology have led to the identification of factors responsible for the differentiation and activation of osteoclasts, the most important of which is the receptor activator of NF-kappa B ligand/osteoclast differentiation factor (RANKL/ODF), a tumor necrosis factor (TNF)-like protein. (umassmed.edu)
EGF activated the ET-R kinase and induced partial differentiation. (umassmed.edu)

How is a tyrosine kinase receptor activated? (flashcardmachine.com)

Exposure of isolated human adipocytes to tumor necrosis factor-α (TNF-α) produced a marked and specific decrease in the mRNA encoding the SREBP1c isoform and completely blocked the insulin-induced cleavage of SREBP1 protein. (diabetesjournals.org)
Classically the fat mass expansion results with an increase in the volume (hypertrophy) and the number (hyperplasia) of adipocytes [ 5 , 6 ]. (springer.com)

Thereafter, we identified significant difference of infiltrated immune cells (effector memory CD8 T cell, activated B cell, memory B cell, natural killer cell, CD56 bright natural killer cell, natural killer T cell, plasmacytoid dendritic cell, and neutrophil) between AD and control samples. (nature.com)
In Trp53KO/C-MycOE mice and mice with tumors grown from Hepa1-6 cells, injection of the combination of anti-PD1 and anti-TIGIT significantly reduced tumor growth, increased the ratio of cytotoxic to regulatory T cells in tumors, and prolonged survival.PVRL1, which is up-regulated by HCC cells, stabilizes cell surface PVR, which interacts with TIGIT, an inhibitory molecule on CD8+ effector memory T cells. (stanford.edu)

SARS-CoV-2 enters human cells mainly by binding to the angiotensin-converting enzyme 2 (ACE2), 1 which is highly expressed in lung alveolar cells, cardiac myocytes, the vascular endothelium, and other cells. (jomes.org)
In endothelium, Delta-like ligand 4 (DLL4) is one of main ligands to send a signal to Notch in the adjacent cell ( 4 , 6 ) ( Figure 1A ). (frontiersin.org)

Exclusion factors include previous myocardial infarction, febrile disorder, infectious or inflammatory disease, autoimmune disease, malignancy, acute or chronic viral hepatitis or use of immunosuppressive drugs. (biomedcentral.com)
Schwartz and Dameshek, in 1959, showed that 6-mercaptopurine was immunosuppressive in rats, ushering in the era of immunosuppressive drug treatment. (medscape.com)

The T cells also effectively terminate their activation and proliferation as a means of avoiding autoimmunity, resulting in different phenotypes that either further activate Th1 immune responses or suppress via Th2-driven responses. (encyclopedia.pub)
In cholangiocytes, CCN1 activated NF-κB through integrin α v β 5 /α v β 3 , leading to Jag1 expression, JAG1/NOTCH signaling, and cholangiocyte proliferation. (jci.org)

Binding of these ligands to RAGE does not accelerate clearance or degradation but rather begins a sustained period of cellular activation mediated by receptor-dependent signaling. (jci.org)
One of the most promising techniques for treating severe peripheral artery disease is the use of cellular tissue-engineered vascular grafts (TEVGs). (bvsalud.org)
Recent advances in the understanding of the cellular mechanisms responsible for these vascular abnormalities may ultimately lead to new therapeutic approaches for the treatment of asthma. (ersjournals.com)
BTE aims to combine the cellular ( osteogenic cells), extracellular ( osteoconductive scaffolds) and/or molecular elements ( osteoinductive growth factors) required for bone healing [ 2 ]. (biomedcentral.com)

Flow cytometric analysis indicated that TLR2-containing EVs were able to bind the TLR2 ligand Pam 3 CSK 4 . (frontiersin.org)
Natural and synthetic glucocorticoids bind to GR, producing major conformational changes that result in nuclear translocation or transrepression of transcription factors, including nuclear factor κB. (ashpublications.org)
(A) Notch Receptor and DLL4 ligand bind together. (frontiersin.org)
What proteins does IRS-1 bind to in order to activate Raf-1? (flashcardmachine.com)

Tumors from mice given anti-PD1 had larger numbers of memory CD8+ T cells (CD44+CD62L-KLRG1int) and T cells that expressed PD1, lymphocyte activating 3 (LAG3), and TIGIT compared with mice not given the antibody. (stanford.edu)

Subsequently, binding of the CD28 co-stimulatory receptor to the DCs' CD80/86 receptor fully activates the cytotoxic T cells which then migrate to infiltrate the tumour and kill the cells by locally releasing perforin and granzymes [ 2 ] [ 3 ] . (encyclopedia.pub)

Notch signaling regulates cell-fate determination during activation by signal sending and receiving, affected through ligand-receptor crosstalk. (frontiersin.org)
Once Notch is activated, the NICD is cleaved by γ-secretase and translocated into the nucleus ( Figures 1B,C ). Here, the NICD binds directly to the DNA, physically moving corepressors and histones, recruiting coactivators, and activating gene transcription ( 2 , 4 , 6 ) ( Figure 1D ). (frontiersin.org)
Mechanistically, down-regulation of METTL3 reduced the level of heterodimeric Notch E3 ubiquitin ligase formed by DTX1 and DTX3L, thereby continuously activating the Notch signaling pathway. (biomedcentral.com)

Hyperglycemia induction worsened the loss of BBB integrity induced by oxygen and glucose deprivation (OGD) by increasing the release of inflammatory factors and decreasing the expression of tight junction-associated proteins. (researchsquare.com)
The telomeres consist of repeating sequences and a set of special proteins, which interact with these repeats and spatially organize them in a specific manner, resulting in the formation of the nucleoprotein complex known as telomeric heterochromatin [ 6 , 7 ]. (actanaturae.ru)
In the affected ventral spinal cord, resveratrol enhanced the expression of several vascular endothelial growth factor family proteins (VEGFs) and increased the phosphorylation of p300 through Akt signaling, indicating activation of p300 acetyltransferase. (vinomis.com)

The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily that encompasses, among others, estrogen receptor and peroxisome proliferators-activated receptor. (ashpublications.org)

Both, obesity which is a major risk factor for the insulin resistance development and type 2 diabetes (T2DM), and the chronic hyperglycemia itself play an important role in its pathogenesis. (medsci.org)

and attracting to nascent inflammatory sites and activating circulating neutrophils, monocytes, eosinophils, gamma delta T cells, and Natural killer T cells. (wikipedia.org)

In addition, loss of tumor suppressor activity or proapoptotic factors can contribute to androgen-independent growth (8) and has been reviewed (9) . (aacrjournals.org)
They express a high level of mannose receptor (CD206) and are the largest secretor of pro-fibrotic factors, such as TGF-β and GF (growth factors), etc. (encyclopedia.pub)
ECM also modulates the bioavailability of many growth factors. (springer.com)
[ 6 ] These events lead the cancer cell to escape normal cell growth and control mechanisms, to avoid system control mechanisms (ie, immunologic surveillance), and to establish a nutrient supply. (medscape.com)
Furthermore, such approaches allow for predicting the Transforming Growth Factor b (TGF-b) pathway in quantities not yet measured. (lu.se)

Lung tissue gene/protein response demonstrated distinct patterns that are better predicted by either particle dose/aerosol responses (IL-1, KC, TGF-) or particle reactivity (TSLP, IL13, IL-6). (cdc.gov)

Finally, M. BUSSLINGER focuses on the transcription factors that regulate early B-lymphopoiesis in the bone marrow. (scielo.br)

Upon myocardial infarction (MI) immune system becomes activated by extensive necrosis of cardiomyocytes and release of damage-associated molecular patterns [ 16 ]. (springer.com)

Hyperglycemia treatment aggravated neurological impairment and axonal injury, increased cell apoptosis and glial activation, and promoted the release of inflammatory factors, including TNF-α, IL-1β, and IL-6. (researchsquare.com)

In contrast, caveolin-1 siRNA abrogated the protective effects of RSG in the in vitro BBB model of hyperglycemia by increasing TLR4 and Myd88 expression and the levels of inflammatory factors, including TNF-α, IL-1β, and IL-6. (researchsquare.com)

In a very interesting review, P. MARRACK & J. KAPPLER focus on naïve, activated, and memory T cells survival separately, and discuss experiments done in vitro and in mice lacking or containing normal populations of lymphocytes. (scielo.br)
The CFR for pediatric patients in this outbreak was lower than for adults ( 6 ), but the reasons for this increased survival were unknown. (cdc.gov)
The relatively large number of pediatric cases in this outbreak enabled closer investigation of factors associated with increased survival of pediatric patients with EVD. (cdc.gov)

We have used conditional gene deletion of mouse β-catenin in Sox17-positive embryonic and extra-embryonic endoderm as well as vascular endothelial progenitors to address the function of canonical Wnt signalling in cell lineage formation and patterning. (biologists.com)

These vascular components seem to have significant clinical implications because of their correlations to asthma severity, including airflow limitation 10 - 13 and bronchial hyperresponsiveness 7 , 11 , 14 - 18 . (ersjournals.com)

Through hypoxia-inducible factor 1 (HIF-1) which elicits various molecular events, cells are able to overcome low O2. (stanford.edu)
Recently, it is well established that N6-methyladenosine (m 6 A) is the most common and abundant RNA molecular modification in eukaryotes [ 5 ]. (biomedcentral.com)

The heart, kidneys, and liver are highly vascular organs and transplantation leads to a vigorous cell-mediated response in the host. (medscape.com)

Eukaryotic translation initiation factor 2α (eIF2α) is a key mediator of the endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR). (bvsalud.org)
The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. (cancerindex.org)
Sterol regulatory element binding protein (SREBP)-1 is a transcription factor with important roles in the control of fatty acid metabolism and adipogenesis. (diabetesjournals.org)
Mathematical modeling of signal transduction networks has previously been used to map out thermodynamical using rate equations is increasingly attracting attention as a properties of protein-folding models (6,7). (lu.se)

Anatomy16

Organisms8

Chemicals and Drugs136

Analytical, Diagnostic and Therapeutic Techniques and Equipment26

Phenomena and Processes68

Disciplines and Occupations1

Information Science4

Endothelial cells2

Pathways9

Cytokines6

Macrophages9

Interleukin3

VEGF5

Inflammation4

Receptor ligand3

Peroxisome prolifer4

PPAR2

Permeability1

Angiogenesis2

Innate2

Downstream2

Intracellular3

Genes3

Receptors3

Atherosclerosis3

Processes3

Cytokine5

Tissues1

Differentiation3

Kinase1

Adipocytes2

Effector2

Endothelium2

Immunosuppressive2

Proliferation2

Cellular4

Bind4

Lymphocyte1

Infiltrate1

Notch3

Proteins3

Glucocorticoid1

Insulin1

Monocytes1

Growth5

Responses1

Regulate1

Myocardial infarction1

Apoptosis1

Hyperglycemia1

Survival3

Embryonic1

Components1

Molecular2

Liver1

Protein4