• The binding of a monoclonal antibody mAb806, which recognizes the dimer interface, to the truncated EGFR(1-501)-Fc fusion protein is reduced in the presence of ligand, consistent with a change in conformation. (edu.au)
  • The difference in basal activity correlates with the cellular localization of the two ligands. (embopress.org)
  • Metalloprotease inhibitors also reduced growth of EGF-responsive tumorigenic cell lines and were synergistic with the inhibitory effects of antagonistic EGFR antibodies. (pnas.org)
  • The Drosophilia EGF receptor (DER) pathway fulfills multiple roles during oogenesis, embryonic and post‐embryonic development. (embopress.org)
  • Infusion of decorin into experimental rodent spinal cord injuries has been shown to suppress scar formation and promote axon growth. (wikidoc.org)
  • Both estrogen (E2) and EGF regulate lactotrophs, and we recently demonstrated that EGF phosphorylates S118 on estrogen receptor- (ER) and requires ER to stimulate prolactin (PRL) release. (scialert.net)
  • MM cells stimulate OC differentiation mainly indirectly stimulating the production, by the surrounding cells, of soluble factors [ 5 ] such as the receptor activator of nuclear factor kappa-Β ligand (RANKL). (springer.com)
  • Arthritic mice were treated with RB200 alone or in combination with the TNF receptor fusion protein etanercept. (biomedcentral.com)
  • When the scientists kept these Tregs out of the brain, either by preventing their migration or by killing them in mice engineered to express diphtheria toxin receptor in Tregs, the mice recovered only half as well as littermates with healthy Treg numbers. (alzforum.org)
  • Tregs taken from the stroke model mice proliferated in response to serotonin, implying a functional receptor. (alzforum.org)
  • Although the identities of all of the proteases involved have not been definitively established, recent data suggests that the release of TGFα involves TACE, a member of the ADAM family of metalloproteases, which originally was identified as being responsible for the release of tumor necrosis factor α ( 8 - 10 ). (pnas.org)
  • Within the EGFRs there are four ECDs, with domains I and III being ligand-binding domains and domains II and IV mediating binding to each other and to other members of this receptor family. (biomedcentral.com)
  • Being part of this family will make you a ligand for the epidermal growth factor receptor. (prospecbio.com)
  • Epigen is the newest epidermal growth factor family member. (prospecbio.com)
  • The large body of structural data available for several members of the QS LuxR family complexed with different classes of ligands (AHLs and other compounds), has been exploited to dissect the cartography of their regulatory domains through structure-based multiple sequence alignments, structural superimposition and a comparative analysis of the contact residues involved in ligand binding. (mdpi.com)
  • It was also an independent, unfavorable prognostic factor for DFS (p=0.026) and OS (p=0.007). (e-crt.org)
  • 50% was an independent prognostic factor for longer PFS (hazard ratio (HR) 0.433, 95% confidence interval (CI) 0.250-0.751, P = 0.003). (cdc.gov)
  • Their constituent actin filaments have pointed ends oriented toward the interior of the cell and undergo growth and exchange by the concerted addition of monomers to the distal plus ends and depolymerization from the minus ends, a process denoted as treadmilling. (rupress.org)