• One of our recent highlights has been the development of chiral calcium complexes for the asymmetric hydroamination of amino-olefins. (findaphd.com)
  • One of the major challenges associated with the coordination complexes of calcium is their propensity to undergo ligands redistribution, or "Schlenk" equilibria. (findaphd.com)
  • Traditionally, enzymes and metal complexes with chiral ligands served as the main type of enantioselective catalysts. (beilstein-journals.org)
  • SPO ,N-ligands bearing a PHOX type backbone were inactive in this transformation as they tend to form inactive palladium-bis-ligand complexes. (cuvillier.de)
  • Semiempirical PM6 calculations indicate that the higher ability of the unsubstituted ligand to form chelated titanium complexes could be related to its higher enantioselectivity. (ua.pt)
  • CAREER: Design and Application of 2-Metallated Benzimidazoles as Robust Bifunctional Complexes for Sustainable Catalysis at the ppm Level. (ncsu.edu)
  • This chiral relay effect is demonstrated by both highly diastereoselective palladation and application of the oxazoline complexes as ligands in asymmetric catalysis. (sciforum.net)
  • Mechanisms of the asymmetric catalysis are proposed based on computational calculations and X-ray analysis of STR1-ligand complexes. (elsevierpure.com)
  • Bernard Lucas Feringa (Dutch pronunciation: [ˈbɛrnɑrt ˈlykɑz ˈbɛɱ ˈfeːrɪŋɣaː], born 18 May 1951) is a Dutch synthetic organic chemist, specializing in molecular nanotechnology and homogeneous catalysis. (wikipedia.org)
  • His early career was focused on homogenous catalysis and oxidation catalysis, and especially on stereochemistry with major contributions in the field of enantioselective catalysis, including monophos ligand used in asymmetric hydrogenation, asymmetric conjugate additions of organometallic reagents, including the highly reactive organolithium reagents and organic photochemistry and stereochemistry. (wikipedia.org)
  • Bondarev, O. Chiral diphosphites and diphosphoramidites as cheap and efficient ligands in Rh-catalyzed asymmetric olefin hydrogenation. (mpg.de)
  • Feringa, B. L. PipPhos and MorfPhos: Privileged monodentate phosphoramidite ligands for rhodium-catalyzed asymmetric hydrogenation. (mpg.de)
  • Blackmond, D. G. Why are BINOL-based monophosphites such efficient ligands in Rh-catalyzed asymmetric olefin hydrogenation? (mpg.de)
  • Sell, T. Mixtures of chiral monodentate phosphites, phosphonites and phosphines as ligands in Rh-catalyzed hydrogenation of N-acyl enamines: extension of the combinatorial approach. (mpg.de)
  • Mehler, G. Mixtures of chiral and achiral monodentate ligands in asymmetric Rh-catalyzed olefin hydrogenation: reversal of enantioselectivity. (mpg.de)
  • His research with undergraduates at Central focuses on introducing students to catalysis and developing new organometallic catalysts for transfer hydrogenation reactions. (ionicviper.org)
  • In the second part new PHOX -type ligands were tested in the iridium-catalyzed asymmetric hydrogenation of different unsaturated compounds. (cuvillier.de)
  • Although low activities and selectivities were found in most cases, one ligand showed promising results in the hydrogenation of allylic alcohols and imines. (cuvillier.de)
  • During this work as well a new organo-catalyst, based on the structure of 2,3-dihydrobenzo[1,4]oxazine, was developed which allows for the asymmetric organo-catalyzed transfer-hydrogenation of α,β-unsaturated aldehydes. (cuvillier.de)
  • An enantioselective C-H arylation of phosphine oxides with o-quinone diazides catalyzed by an iridium(III) complex bearing an atropchiral cyclopentadienyl (Cpx) ligand and phthaloyl tert-leucine as co-catalyst is reported. (unboundmedicine.com)
  • Enantioselective catalysis. (rider.edu)
  • Chiral phosphine compounds are extremely useful ligands in catalysis. (thieme.de)
  • She subsequently worked as an industrial research chemist in the area of chiral phosphine ligand synthesis with Celtic Catalysts Ltd. She joined University College Cork as a NMR Spectroscopist at the Analytical and Biological Research Facility at University College Cork. (bruker.com)
  • Furthermore air- and moisture-stable secondary phosphine oxide ( SPO ) containing bidentate ligands were tested in the palladium-catalyzed asymmetric allylic alkylation reaction. (cuvillier.de)
  • 2021 Macrocylases as synthetic tools for ligand synthesis: enzymatic synthesis of cyclic peptides containing metal-binding amino acids. (ed.ac.uk)
  • N-heterocyclic carbenes (NHCs) are commonly used ligands in transition-metal catalysis. (chemistryviews.org)
  • Mehler, G. A new principle in combinatorial asymmetric transition-metal catalysis: Mixtures of chiral monodentate P ligands. (mpg.de)
  • My research interests include development of new multidentate, non-innocent, and/or chiral ligands for application in transition metal-based asymmetric catalysis, small molecule activation, and alternative energy processes. (hawaii.edu)
  • Improving the sustainability of synthesis is a major goal in green chemistry, which has been greatly aided by the development of asymmetric transition metal catalysis. (ed.ac.uk)
  • Enantiospecific reductions provide monodentate chiral phosphorus(III) compounds having structures and biaryl backbones with proven importance as ligands in asymmetric catalysis. (unboundmedicine.com)
  • However, phosphorus ( P )-chiral ligands have not been explored as extensively in catalytic reactions as axially chiral, carbon ( C )-chiral, or planar-chiral compounds such as binap, diop, or josiphos. (thieme.de)
  • Potential application of these phosphorus-bridged [1]FCPs as monodentate ligands for asymmetric catalysis will be studied in the future. (usask.ca)
  • 2018 ) Development of C-Symmetric Chiral Bifunctional Triamines: Synthesis and Application in Asymmetric Organocatalysis. (academictree.org)
  • 2018 ) Evaluating polymer-supported isothiourea catalysis in industrially-preferable solvents for the acylative kinetic resolution of secondary and tertiary heterocyclic alcohols in batch and flow Green Chemistry . (academictree.org)
  • 2018 ) Computationally Guided Design of a Readily Assembled Phosphite-Thioether Ligand for a Broad Range of Pd-Catalyzed Asymmetric Allylic Substitutions Acs Catalysis . (academictree.org)
  • citation needed] Towards the future discipline of Systems chemistry, the development of a multistage chiral catalysts which comprises an integrated supramolecular system that brings together molecular recognition, chirality transfer, catalysis, stereoelectronic control and enantio-selectivity while all these processes can be enabled or disabled via an internal motor function, moves the design and application of molecular motors to a whole new level of sophistication. (wikipedia.org)
  • This work was dedicated to the development and evaluation of new chiral catalysts for asymmetric C-C and C-H bond forming reactions. (cuvillier.de)
  • 2023 ) Development of Immobilized Carreira (Phosphoramidite, Olefin) Ligands and Application in Iridium-Catalyzed Asymmetric Allylic Amination. (academictree.org)
  • Since the report by Fürstner, the catalytic asymmetric Nozaki-Hiyama reactions have attracted attention because they would allow control over enantioselectivity, thereby further enhancing the versatility of Nozaki-Hiyama reactions. (elsevierpure.com)
  • The main objective of my research group is to understand organophosphorus chemistry, with its multitude of applications in biology and catalysis always at the forefront of our minds. (ncl.ac.uk)
  • 1. Direct enolization chemistry of amide via designed asymmetric cooperative catalytic system. (caltech.edu)
  • His research interests include the design, synthesis and application of novel ligands in asymmetric catalysis, natural product synthesis and medicinal chemistry. (ucd.ie)
  • In 2012, there has been a thematic issue of the Beilstein Journal of Organic Chemistry devoted to asymmetric organocatalysis edited by one of the pioneers Benjamin List. (beilstein-journals.org)
  • These are versatile platforms that offer multiple possibilities for the modulation of the steric and electronic properties of the carbene ligand and/or organocatalyst, and offer also diverse opportunities for the introduction of several types of chiralities. (us.es)
  • Indolizy Carbene Ligand. (univ-amu.fr)
  • A copper-catalyzed asymmetric conjugate borylation (ACB) reaction was used to investigate the applicability of the Cholest CAAC as a stereo-directing chiral ligand. (chemistryviews.org)
  • Axial-to-central transfer of chirality is shown to provide ready access to various classes of P-chirogenic compounds that are key to catalysis and drug development. (nature.com)
  • Asymmetric catalysis is undoubtedly the most efficient way to prepare chiral compounds that our society requires as medicines, materials, or crop protecting agents. (beilstein-journals.org)
  • The suitability of asymmetric organocatalytic methods to assemble biologically relevant compounds is highlighted by a review article devoted to the syntheses of coumarin derivatives [16] . (beilstein-journals.org)
  • As a recipient of an NIH Ruth L. Kirschstein postdoctoral fellowship, Matt spent several years at the University of Minnesota - Twin Cities studying nonheme iron systems with Professor Lawrence Que, Jr. His research interests include the design and synthesis of bio-mimetic/inspired inorganic compounds for catalysis. (ionicviper.org)
  • Asymmetric catalysis has the potential to provide a more direct and efficient synthetic route compared to traditional resolution methods of constructing P -chiral compounds. (thieme.de)
  • The last part of this work aimed for the asymmetric α -allylation of carbonyl compounds by a tandem-catalysis approach. (cuvillier.de)
  • He is currently focused on the detection and catalysis of crosslinked amino acids, such as Cys-Tyr in galactose oxidase and His-Tyr in cytochrome c oxidase, in iron and copper enzymes. (ionicviper.org)
  • This study shows that PCY1 can tolerate peptides containing amino acids with classic inorganic and organometallic ligands as side chains, opening the door to the streamlined and efficient development of cyclic peptides as metal ligands. (ed.ac.uk)
  • In this paper the different families of chiral ImPy and TriPy carbenes and their application in asymmetric catalysis will be discussed. (us.es)
  • In particular, the easy access to this route provides a variety of homochiral phosphines and opens up many avenues for metal-catalysed asymmetric transformations. (nature.com)
  • The majority of chiral phosphines currently used as ligands in asymmetric metal-catalysed transformations are axial-chiral, planar-chiral or C-stereogenic phosphines. (nature.com)
  • Without giving up too much information, we plan to target a largely unexplored class of C1-Symmetric, P-Stereogenic ligands, rationally designed multidentate ligands for dinitrogen reduction, and phosphaalkene-based ligands as redox active / non-innocent platforms for interesting chemical transformations. (hawaii.edu)
  • Organocatalysis outgrew its initial inspiration by enzymatic catalysis, but the analogy with nature can be seen within the area. (beilstein-journals.org)
  • Three review articles and nine research papers showcase the diversity and breadth into which asymmetric organocatalysis has grown since then. (beilstein-journals.org)
  • In the first part of the thesis an ESI -MS screening method is described, which allows the determination of a chiral catalyst´s selectivity in the palladium catalyzed asymmetric allylic alkylation by testing its racemic form. (cuvillier.de)
  • In this review, we describe the development of a tridentate bis(oxazolinyl)carbazole ligand for the catalytic asymmetric Nozaki-Hiyama allylation, methallylation, propargylation, and allenylation. (elsevierpure.com)
  • Despite this, cyclic peptides remain underexplored as chiral ligands for catalysis due to synthetic complications upon macrocyclization. (ed.ac.uk)
  • SPO ,P ligands however, were able to promote the desired reaction in a highly selective fashion although only low activities were found. (cuvillier.de)
  • An intensive screening of both the organo-catalyst and the palladium-ligand led to reaction conditions which allowed for the selective mono-allylation of ketones in high yields. (cuvillier.de)
  • Recent advances in asymmetric catalysis show that the ability to control the coordination sphere of substrates can lead to improvements in enantioselectivity and activity, in a manner resembling the operation of enzymes. (ed.ac.uk)
  • In order to achieve our aims in catalysis, a significant amount of effort is spent on the development of new chiral ligands: we have recently reported a general route to a class of N-functionalised ethylene diamines,[1] which can be employed either as ligands in their own right, or as precursors for preparing imidazoline ligands. (findaphd.com)
  • His research program investigates aspects of light-induced reactivity of metal-ligand multiple bonds, cooperative ligand designs that include proton coupled electron transfer relays, and main group element reactivity in catalysis. (ionicviper.org)
  • Continuing his northeast tour, he moved to MIT in January 2012 to work on the design of new TREN-based macrocyclic ligands for Mo-catalyzed N2 reduction with Dick Schrock. (hawaii.edu)
  • Our catalytic asymmetric C-P coupling methodology allows the formation of a variety of structures with a high tolerance of different functional groups in the products. (nature.com)
  • This is a significant problem in relation to their catalytic performance, and ligands need to be designed that are able to control or supress these processes. (findaphd.com)
  • The high mobility of hydration water ensures that all thermally activated processes at the protein-water interface, such as binding, recognition and catalysis, can proceed at high rates. (lu.se)
  • Reetz, M. T. Palladium-Catalysed Amination of Aryl- and Heteroaryl Halides Using tert-Butyl Tetraisopropylphosphorodiamidite as an Easily Accessible and Air-Stable Ligand. (mpg.de)
  • The value of this new method was demonstrated when different new aryl- PHOX -type ligands, which are not easily accessible in their enantiopure form, were evaluated. (cuvillier.de)
  • Her doctoral research was conducted in the area of chiral diamide ligand synthesis and asymmetric catalysis under the supervision of Dr. Simon W. Breeden and Dr. Patrick O'Leary. (bruker.com)
  • He subsequently obtained a PhD degree at the same university in 1978, with the thesis titled "Asymmetric oxidation of phenols. (wikipedia.org)