• CD80, also known as B7-1, B7, and BB1, is a 60 kD single chain type I glycoprotein belonging to the immunoglobulin superfamily. (biolegend.com)
  • We marked of B7-1(CD80) and B7-2(CD86) costimulatory molecules. (annexpublishers.co)
  • The presence of CD80 and CD86 in NETs could influence the cell environment through the B7-1/B7-2:CD28/CTLA-4 pathway. (annexpublishers.co)
  • B7 molecules (B7-1/CD80 and B7-2/CD86) are integral membrane glycoproteins that are expressed on the surface of APCs. (annexpublishers.co)
  • Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) (also known as CD152) is a major negative regulator of T cell responses which interacts with the B7-1 (CD80) / B7-2 (CD86) ligands on the surface of an antigen-presenting cell. (scielo.br)
  • Our data revealed that at early times (30 min), both Antigen Presenting Cells (APCs) showed induction of important costimulatory molecules (CD80, CD86). (springeropen.com)
  • Ligation of MHC-I/peptide complexes presented by antigen-presenting cells (APCs), triggers the recruitment of lymphocyte-specific protein tyrosine kinase (Lck), which leads to lymphokine production, motility and cytotoxic T lymphocyte (CTL) activation. (thermofisher.com)
  • We aimed to clarify whether soluble CD40 ligand (sCD40L) activated B cells may be loaded with HBcAg18-27 peptide and served as antigen-producing cells (APCs) to induce HBV-specific cytolytic T lymphocytes (CTLs). (biomedcentral.com)
  • Efficient antigen presentation by antigen presenting cells (APCs) is critical for inducing T-cell mediated immunity in vivo [ 1 , 2 ]. (biomedcentral.com)
  • Polymorphonuclear neutrophils (PMNs) activated in vitro may express molecules normally associated with antigen presenting cells (APCs). (annexpublishers.co)
  • We have mapped the T cell recognition of MCPyV by use of a novel technology platform for T-cell enrichment and combinatorial encoding of histocompatibility antigen (HLA) class I multimers. (biomedcentral.com)
  • The heavy chain of human histocompatibility antigen HLA-B7 contains an immunoglobulin-like region. (expasy.org)
  • Decipher misregulations of the TGFß/BMP pathway induced by HLA-B27 in immune and intestine cells, in Drosophila and Human, to identify peptides and receptors involved in HLA-B27 non-canonical effects. (anr.fr)
  • 4 ] Interactions among subsets of immune cells through costimulatory ligands and their receptors are essential for the initiation of an immune response. (oncotarget.com)
  • Transcriptome analysis revealed a significant imbalance of ligands for activating and inhibitory NK-cell receptors in iPS-fibro. (biomedcentral.com)
  • Thus, the balance of ligands for NK-cell receptors should be considered prior to iPSC-based cell therapies. (biomedcentral.com)
  • A dysregulated immune system (including changes in the number and/or function of immune cells, cytokine levels, and the expression of inhibitory receptors or their ligands) plays a key role in the development of HCC. (wjgnet.com)
  • Jawed vertebrates (gnathostomes) generate a diverse repertoire of B and T cell antigen receptors through the rearrangement of immunoglobulin V, D, and J gene fragments, whereas jawless fish (agnathans) assemble diverse lymphocyte antigen receptor genes through the genomic rearrangement of leucine-rich repeat (LRR) - encoding molecules. (scielo.br)
  • Dendritic cells (DCs) are specialized antigen-presenting cells that have a notable role in the initiation and regulation of innate and adaptive immune responses. (mdpi.com)
  • West Nile virus T-cell ligand sequences shared with other flaviviruses: a multitude of variant sequences as potential altered peptide ligands. (ox.ac.uk)
  • H-2-deficient mice transgenic for either A2, A24, B7, DR2, DR3, or DR4 HLA alleles were immunized with overlapping peptides of the WNV proteome, and peptide-specific T-cell activation was measured by gamma interferon (IFN-γ) enzyme-linked immunosorbent spot (ELISpot) assays. (ox.ac.uk)
  • The multitude of WNV sequences shared with other flaviviruses as interspecies variants highlights the possible hazard of defective T-cell activation by altered peptide ligands in the event of dual exposure to WNV and other flaviviruses, by either infection or immunization. (ox.ac.uk)
  • The most restrictive step involved in antigen presentation is binding of the peptide to MHC class I. It is estimated that only 1 out of 200 peptides will bind a given MHC class I allele with sufficient strength to elicit a CTL response [ 9 ]. (biomedcentral.com)
  • CAP1-6D, an altered peptide ligand can help bypass tolerance. (bmj.com)
  • Methods Patients with a PS 0-1, HLA-A2+ and CEA-expressing, previously-treated PC were randomized to receive 10 μg (arm A), 100 μg (arm B) or 1000 μg (arm C) of CEA peptide emulsified in Montanide and GM-CSF, given every 2 weeks until disease progression. (bmj.com)
  • Importantly, we show for three different epitopes that MCC specific T cells are capable of killing target cells expressing Large T antigen, including HLA-matched MCC cell lines, indicating that these T cells could provide functional activity upon in vivo transfer, and thus be employed in adoptive T cell therapy for MCC. (biomedcentral.com)
  • KIR3DL2 binds to HLA-B27 dimers and free H chains more strongly than other HLA class I and promotes the expansion of T cells in ankylosing spondylitis. (ox.ac.uk)
  • B27(2) tetramers bound KIR3DL2-transfected cells more strongly than HLA-A3. (ox.ac.uk)
  • KIR3DL2Fc bound to HLA-B27-transfected cells more strongly than to cells transfected with other HLA-class I. KIR3DL2Fc pulled down multimeric, dimeric, and monomeric FHC from HLA-B27-expressing cell lines. (ox.ac.uk)
  • In vitro studies revealed that knockdown of B7-H3 on tumor cells enhanced T-cell growth and interferon-γ secretion when stimulated by anti-CD3 and anti-CD28 monoclonal antibodies. (oncotarget.com)
  • Interferon-γ reduced CXCR4 expression on cancer cells and inhibited the CXCL12-induced cell migration.B7-H1 and B7-H3 are independent predictors of poorer survival in patients with NSCLC. (oncotarget.com)
  • Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
  • Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
  • CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
  • HLA-identical sibling stem cells are used for the treatment of patients suffering from various hematologic malignant and nonmalignant diseases. (ashpublications.org)
  • Dendritic cells (DCs), activated macrophages, and activated B cells are all capable of presenting antigen peptides. (biomedcentral.com)
  • Antigen-specific CD40L-activated B cells may efficiently endocytose and present antigens, such as protein, RNA, and cDNA, to prime primary T cells and boost robust memory T-cell responses [ 9 ]. (biomedcentral.com)
  • However, little is known whether CD40L-activated B cells may present HBV antigen to T cells. (biomedcentral.com)
  • iPSC-derivatives with B2M knockout did not cause an additional increase in NK-cell activation, although they were devoid of HLA-I, the major inhibitory molecules for NK-cells. (biomedcentral.com)
  • In addition, we showed that pretreatment of iPS-fibro with proinflammatory cytokine IFNγ restored the ligand imbalance, thereby reducing the degranulation and cytotoxicity of NK-cells. (biomedcentral.com)
  • In summary, we showed that iPSC-derived cells can be sensitive to the cytotoxic potential of autologous NK-cells regardless of HLA-I status. (biomedcentral.com)
  • One is the ability to administer large numbers of highly selected cells with high avidity for tumor antigens that can recognize shared and patient-specific mutated (neo) antigens. (biomedcentral.com)
  • Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
  • The impacts of proinflammatory cytokines and antigen presentation by pleural mesothelial cells (PMCs) on Th22-cell differentiation were explored. (atsjournals.org)
  • In particular, PMCs were able to function as antigen-presenting cells to stimulate CD4 + T-cell proliferation and Th22-cell differentiation. (atsjournals.org)
  • Pleural mesothelial cells stimulate CD4 + T-cell proliferation and Th22 cell differentiation in response to tuberculosis antigen. (atsjournals.org)
  • Naive CD4 + T cells can develop into various helper T (Th) subsets with different cytokine profiles and play a discriminative role in translating antigen-specific immune responses into tissue functions or immunopathology. (atsjournals.org)
  • Specificity : The mouse monoclonal antibody 15-414 recognizes en extracellular epitope of CD172a (SIRP alpha), an approximately 90 kDa transmembrane glycoprotein expressed on cells of myeloid origin and neurons. (abeomics.com)
  • PMNs activated in vitro may express molecules normally associated with antigen presenting cells required for T cell activation. (annexpublishers.co)
  • The Compact disc11b+ Kupffer cells portrayed intracellular TNF and surface area Fas-ligand (FasL). (enmd-2076.com)
  • In a study of lung adenocarcinoma [ 4 ] , EMT markers were associated with enhanced tumor infiltration of CD4 + Foxp3 + Tregs and upregulation of inhibitory immune checkpoint molecules such as programmed cell death (PD)-ligand (L) 1, PD-L2, TIM-3, B7-H3, and CTLA-4. (encyclopedia.pub)
  • Recently, a novel class of small molecules was developed to inhibit the association of programmed cell death ligand 1 (PD-L1) with its receptor programmed cell death protein 1 (PD-1). (biomedcentral.com)
  • Within the last year the landscape for mUC has seismically shifted following the approval of five therapies targeting the programmed cell death protein (PD-1)/programmed cell death ligand 1 (PD-L1) axis. (biomedcentral.com)
  • For those who are ineligible for cisplatin-based regimens or experience progression of disease, in 2016-2017 the United States Food and Drug Administration approved five monoclonal antibodies that achieve immune checkpoint blockade by targeting the programmed cell death protein-1/programmed death-ligand 1 (PD-1/PD-L1) pathway. (iospress.com)
  • and to block HLA-I restricted responses anti-HLA-I antibody W6/32 ascites (ATCC) was added at a final dilution of 1 : 40 for 30 min before adding peptides in ELISPOT assays. (peptidesprice.com)
  • Approximately 30% (137) of the WNV proteome peptides were identified as HLA-restricted T-cell ligands. (ox.ac.uk)
  • In the large-scale benchmark calculation consisting of 216 known HIV epitopes covering all 12 recognized HLA supertypes, the NetCTL-1.2 method was shown to have a sensitivity among the 5% top-scoring peptides above 0.72. (biomedcentral.com)
  • T cell epitopes from Large T antigen of MCPyV display a large sequence variation with other polyomaviruses, but are highly conserved among different strains of MCPyV. (biomedcentral.com)
  • To identify antigenic M. tuberculosis CTL epitopes, a bioinformatics method (NetCTL) was employed to predict epitopes restricted to at least one of the 12 HLA-I supertypes.18 Based on the predictions, 206 potential CTL epitopes were synthesized. (peptidesprice.com)
  • There is also a need for rational combinations beyond interleukin (IL)-2 and programmed death (PD)-1/ cytotoxic T-lymphocyte-associated antigen (CTLA)-4 immune checkpoint blockade and to combat exhaustion and restore costimulatory functions, e.g., with gene-engineered or pharmacologic agent-treated TILs. (biomedcentral.com)
  • Sex, TNM stage, B7-H1, B7-H3, and T-cell intracellular antigen-1 expression remained significant prognostic factors after adjusting for other prognostic factors in a multivariate Cox proportional hazards regression model. (oncotarget.com)
  • Chimeric antigen receptor T (CART) cell therapy targeting the B cell specific differentiation antigen CD19 has shown clinical efficacy in a subset of relapsed/refractory (r/r) diffuse large B cell lymphoma (DLBCL) patients. (frontiersin.org)
  • Evidence has recently been obtained that two very different recombinatorial systems for lymphocyte antigen receptor diversification appeared at the beginning of vertebrate evolution approximately 500 million years ago. (scielo.br)
  • We investigated the T cell recognition of 398 in silico predicted HLA-ligands from Large T, Small T and VP1 and identified T-cell responses restricted to HLA-A1, A2, A3, A11 and B7. (biomedcentral.com)
  • Numerous T cell responses were detected against MCPyV in both healthy donors and MCC patients, with a striking observation that T cell responses against Large and Small T antigens were found exclusively in MCC patients, suggesting that these oncoproteins are only presented to the immune system in the tumor-bearing host and represent highly specific targets for cancer immunotherapy of MCC. (biomedcentral.com)
  • This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
  • We investigated the T cell recognition of both the oncogenic proteins, Large and Small T antigen and the capsid protein VP1 that is profoundly expressed also in the non-symptomatic MCPyV infected healthy individuals. (biomedcentral.com)
  • PD-L1 (also known as CD274 or B7-homolog 1 [B7-H1]) is a transmembrane protein involved in the immune system suppression. (studylib.net)
  • This study focused on the identification of human leukocyte antigen (HLA)-restricted West Nile virus (WNV) T-cell ligands and characterization of their distribution in reported sequence data of WNV and other flaviviruses. (ox.ac.uk)
  • The A*0301 bearing haplotype (HLA A3-B7-DR15-DQ6) is described as the longest known multgene haplotype in humans. (wikipedia.org)
  • HLA-B27 is the main genetic factor contributing to spondyloarthritis. (anr.fr)
  • HLA-A3, which is not associated with spondyloarthritis (SpA), is also a ligand for KIR3DL2. (ox.ac.uk)
  • B7-H1 and B7-H3, two members of the B7 family that are thought to regulate T-cell activation, are expressed in human non-small cell lung cancer (NSCLC). (oncotarget.com)
  • The field of Lymphocyte Surface Antigens and Activation Mechanisms is examined in two chapters. (scielo.br)
  • B7-H3 was identified as a negative prognostic marker for NSCLC. (encyclopedia.pub)
  • Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
  • Compared to parental fibroblasts, iPSC-derivatives had a reduced expression of HLA-I simultaneously with an increased gene expression of major activating ligands, such as MICA , NECTIN2 , and PVR . (biomedcentral.com)
  • antigen, while maintaining self-tolerance. (123dok.net)
  • Namely, recipients sharing one or more HLA Ags with their cord blood donor inherited paternal Ags had reduced relapse rates compared with those who did not. (ashpublications.org)
  • cutaneous exposure to antigen in atopic dermatitis may enhance the development of asthma. (cdc.gov)
  • However, the tumor microenvironment (TME) imposes different mechanisms that facilitate the impairment of DC functions, such as inefficient antigen presentation or polarization into immunosuppressive DCs. (mdpi.com)
  • Whereas there is little evidence to indicate whether self-antigens in SLE are aberrant in sequence or structure, there is evidence that the aberrant handling of self-antigens could facilitate lupus pathogenesis. (biomedcentral.com)
  • HLA B7-DR15-DQ6 is a multigene haplotype that covers a majority of the human major histocompatibility complex on chromosome 6. (wikipedia.org)
  • The human leukocyte Ag HLA-B27 (B27) is strongly associated with the spondyloarthritides. (ox.ac.uk)
  • Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. (expasy.org)
  • Figure B. PE conjugated Mouse anti Human CD11c ( MCA2087PE ) and Amethyst Orange conjugated Mouse anti Human HLA DP DQ DR ( MCA477AMO ). (bio-rad-antibodies.com)
  • In this study, we show that B27(2) and B27 FHC bind more strongly to KIR3DL2 than other HLA-class I, including HLA-A3. (ox.ac.uk)
  • HLA 1991: proceedings of the eleventh International Histocompatibility Workshop and Conference, held in Yokohama, Japan, 6-13 November 1991. (wikipedia.org)
  • Binding to B27(2) and B27 FHC stimulated greater KIR3DL2 phosphorylation than HLA-A3. (ox.ac.uk)
  • Binding of PD-1 to its ligand, PD-L1, leads to protection against self-reactivity. (studylib.net)
  • One B7-DR2-DQ6 derives from the fact that DR15 is a split antigen of the DR2 broad antigen serotype. (wikipedia.org)