Ligands high affinity leukemia inhibitory factor receptor alpha subunit. Medical search. Frequent questions

Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
Human derived T lymphocytes engineered to express chimeric antigen receptors, which are expanded in vitro culture and then infused into patients exerting robust cytotoxicity after tumor antigen recognition and subsequent activation. (biomedcentral.com)
We have also studied pre-and post- experimental combined sets of higher (10 µg/mL) and significantly lower antigen concentrations (attogram level). (openaccesspub.org)

Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)
These cells secrete immune inhibitory growth factors and cytokines, including vascular endothelial growth factor (VEGF), which is primarily produced by microglia, myeloid-derived suppressor cells (MDSCs) and tumour-associated macrophages (TAMs). (encyclopedia.pub)
The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
If this rise of anti-inflammatory cytokines is too high, it may lead to immune paralysis. (openaccesspub.org)
Furthermore, LPLI induces the synthesis or release of many molecules, like growth factors, interleukins, inflammatory cytokines and others, which are related to promotive effects of LPLI. (biomedcentral.com)

The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. (cancer-genetics.org)
The protein encoded by this gene represents the beta subunit and is a type I membrane protein. (cancer-genetics.org)
A low affinity interleukin-5 receptor subunit that combines with the CYTOKINE RECEPTOR COMMON BETA SUBUNIT to form a high affinity receptor for INTERLEUKIN-5. (harvard.edu)

CD20 is induced in the context of microenvironmental interactions by CXCR4/SDF1 (CXCL12) chemokine signaling and the molecular function of CD20 has been linked to the signaling propensity of B-cell receptor (BCR) in this context. (wikipedia.org)
Designer T and NK cells are a modality within immunotherapy that manipulates receptor-ligand interactions to enhance cells of the immune system to destroy cancer more effectively. (encyclopedia.pub)
The microenvironment of the cell and the interactions of many growth factors have a role in tumor development and survival [ 2 , 7 ]. (biomedcentral.com)
Taking advantage of the diverse γδ TCR repertoire or other ligand-receptor interactions, γδ T cells can recognize a broad spectrum of tumor-associated antigens (TAAs) in a major histocompatibility complex (MHC)-independent manner, thereby activating downstream pleiotropic effects. (explorationpub.com)
The plasma membrane can be envisioned as a central compartment in the cellular adaptation to diverse stress conditions as it shapes the interactions between cells and their environment by harboring an elaborate complement of transmembrane proteins, e.g. transporters, channels, receptors, or adhesion proteins. (cell-stress.com)

Interleukin 11 is a pleiotropic cytokine that was originally detected in the conditioned medium of an IL-1 alpha -stimulated primate bone marrow stromal cell line (PU-34) as a mitogen for the IL-6-responsive murine plasmacytoma cell line T1165. (rndsystems.com)
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. (cancer-genetics.org)
Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. (cancer-genetics.org)
Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor . (wikidoc.org)
Interleukin-5 Receptor alpha Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
Several isoforms of the interleukin-5 receptor alpha subunit exist due to multiple ALTERNATIVE SPLICING. (harvard.edu)
This graph shows the total number of publications written about "Interleukin-5 Receptor alpha Subunit" by people in Harvard Catalyst Profiles by year, and whether "Interleukin-5 Receptor alpha Subunit" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Interleukin-5 Receptor alpha Subunit" by people in Profiles. (harvard.edu)
In addition, activated T cells can express an inducible co-stimulator (iCOS), a surface receptor that is structurally and functionally similar to CD28 and enhances expression of Th2-related interleukin (IL)-10 rather than immune activating IL-2 [ 8 ] . (encyclopedia.pub)

IL-11 exerts its biological activities through binding to a specific high-affinity receptor having an apparent molecular mass of 150 kDa. (rndsystems.com)

PD-1 is an immunoinhibitory receptor that stymies lymphocyte proliferation and cytokine secretion when bound to its membrane-bound or secreted ligands, PD-L1 or PD-L2, expressed by both immune and tumour cells [ 7 ] . (encyclopedia.pub)
However, evidence is now accumulating for rapid corticosteroid actions 25 , 26 , and the existence of membrane-bound steroid receptors that may mediate these rapid actions 27 , 28 . (ersjournals.com)

PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
Neither affinity-purified Ab1 nor Ab2 binds to platelets. (jci.org)
The S1 subunit contains a receptor binding domain or RBD that binds with the specific receptors, while the S2 subunit helps membrane fusion. (openaccesspub.org)

Both BLM and A5 are hydrophilic molecules that depend on transporters or endocytosis receptors to get inside of cells. (lookformedical.com)

Desk 2 Overview of immunohistochemistry (IHC) evaluation for subunits of ATP-dependent chromatin redecorating complexes in PDAC individual examples. (morainetownshipdems.org)

This immunosuppressive helper T cell phenotype can be further induced by the zinc-finger transcription factor GATA3, which regulates Th2 cytokine expression [ 9 ] . (encyclopedia.pub)
First, γδ T cells exposed to complicated cytokine networks are potentially affected by multiple inhibitory mechanisms. (explorationpub.com)

IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)
A download Hanging Sam: A Military Biography of General Samuel T. Williams: From Pancho Villa to of residues are experienced regulated for the high 3-phosphate by which SP1 assemblies present to connected formation phagosome by UCP1 in transmembrane C1q-mediated fusion momenta, and preferentially by the intracellular genes as Once. (evakoch.com)

Congenital FXIII deficiency is due principally to defects in the catalytic A subunit of FXIII, with more than 100 mutations throughout the factor XIII A gene identified. (medscape.com)
SMARCA4 SMARCA4 may be the various other mutually exceptional catalytic subunit from the SWI/SNF complicated which has significant assignments in pancreas advancement. (morainetownshipdems.org)

The natural binding of coronaviruses' spike (S) glycoprotein occurs with various receptors - ACE2, APN, DPP4, CEACAM, Sia, and O-acSia of human cells. (openaccesspub.org)

Upon binding of IL-6 to the receptor (alpha subunit), gp130 is homodimerized and is subsequently involved in down-stream signal processes binding tyrosine kinases and activating STAT1 and STAT3 transcriptional factors. (sbhsciences.com)
Sorafenib (Sor) can block receptor tyrosine kinases, which are involved in the development of new blood vessels, as well as cell proliferation as a result [ 22 ]. (biomedcentral.com)

An additional inhibitory mechanism exploited by the tumor microenvironment is represented by the imbalance in immune checkpoint molecules, responsible for NK cell exhausted status. (encyclopedia.pub)

ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)
The plasma membrane is not only the first point of encounter for many types of environmental stress, but given the diversity of receptor proteins and their associated molecules also represents the site at which many cellular signal cascades originate. (cell-stress.com)
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
The download Hanging Sam: A Military Biography of General of Insulin like Growth Factor Binding Proteins( IGFBPs) phase 50 response pathway good research with reviewed N cell and C formation enzymes binding for conjugating Insulin like Growth Factors I and II( IGF I and IGF II). (evakoch.com)

Thrombin, generated by reactions initiated by activated tissue factor VII/factor IX pathways, leads to clot formation. (medscape.com)

Of note, among these influence factors, CAR T cells differentiation and exhaustion are identified as the central part due to the fact that almost all factors eventually alter the state of cells differentiation and exhaustion. (biomedcentral.com)

High-resolution structures, biophysical and in silico studies have led to tremendous progress in understanding the mechanism of drug transport by these ABC transporters, and several promising therapies, including irradiation-based immune and thermal therapies, and nanomedicine have been used to overcome ABC transporter-mediated cancer chemoresistance. (nature.com)

G2A is a G-protein-coupled receptor (GPCR) involved in immune regulation. (ashpublications.org)

NK cells express a heterogeneous repertoire of chemoattractant receptors that are distinct for each cell subset, and thus differentially regulate the recruitment of each population to the tumor bed. (encyclopedia.pub)

Soluble factors released by immune, tumor, and stromal cells, including transforming growth factor (TGF)-β, adenosine, and prostaglandin E 2 (PGE 2 ), not only inhibit NK cell functionality, but they additionally determine their conversion toward a non-cytolytic phenotype. (encyclopedia.pub)
A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease . (wikidoc.org)

In addition, due to the high tumor heterogeneity, even patients in the same IPI risk category exhibit different clinical outcomes [ 6 ]. (biomedcentral.com)
γδ T cells express unique T cell receptor (TCR) γ and TCR δ chains, with structural and functional heterogeneity. (explorationpub.com)

Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. (sabbiotech.cn)
OVERVIEW - Biologic therapies that can increase the risk of infectious diseases include antithymocyte globulin, monoclonal antibodies to T and B cells, anticytokine therapies, agents that disrupt T cell costimulation signals, and agents that interfere with T cell inhibitory (checkpoint) signals. (medilib.ir)

Gene landscape and correlation between B-cell infiltration and programmed death ligand 1 expression in lung adenocarcinoma patients from The Cancer Genome Atlas data set. (cancer-genetics.org)
Ciliary neurotrophic factor is a protein that in humans is encoded by the CNTF gene . (wikidoc.org)
The protein encoded by this gene is a polypeptide hormone and neurotrophic factor whose actions have mainly been studied in the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neural populations including astrocytes . (wikidoc.org)
Amy and Sor cotreatment resulted in the highest glutathione levels and induction of pro-autophagic genes AMPK, HGMB1, ATG5, Beclin 1, and LC3, suppressed the mTOR and BCL2 anti-apoptotic gene. (biomedcentral.com)
may be the second most regularly mutated gene from the SWI/SNF subunits in PDAC and is among the well-studied SWI/SNF subunits. (morainetownshipdems.org)
encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)

ARID1B encodes another DNA-binding subunit from the individual SWI/SNF complicated. (morainetownshipdems.org)

This discovery has opened the way to identification of the molecular action of various cannabinoids and the cannabinoid receptors. (oncotarget.com)
Many types of molecular controls regulate this process, but G-protein-coupled receptors are especially important. (ashpublications.org)

Moreover, in vitro quantitative real-time PCR (qPCR) results showed that the mRNA expression levels of CXCL2, LYZ, and PARVB were significantly higher in the DLBCL group. (biomedcentral.com)
Objective: To study the inhibitory effect of ezetimibe in an experimental model of human hepatoma cell line (HepaRG) infected with hepatitis B virus (HBV) positive human serum in vitro. (bvsalud.org)

Subsequently, binding of the CD28 co-stimulatory receptor to the DCs' CD80/86 receptor fully activates the cytotoxic T cells which then migrate to infiltrate the tumour and kill the cells by locally releasing perforin and granzymes [ 2 ] [ 3 ] . (encyclopedia.pub)
Surface receptors such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed cell death protein 1 (PD-1) and nuclear transcription factors attenuate T cell responses, where CTLA-4 competes with CD28 for binding to CD80/86, resulting in inhibitory downstream signalling [ 6 ] . (encyclopedia.pub)

NT-501 is a product being developed by Neurotech that consists of encapsulated human cells genetically modified to secrete ciliary neurotrophic factor (CNTF). (wikidoc.org)

Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. (sabbiotech.cn)

This latter effect was due to protein kinase C activation in that it was inhibited by sphingosine and was not seen with 4 alpha-PMA, an inactive analogue. (jci.org)
2 The mechanism of lysophospholipid-mediated cell migration recently has been shown to require the expression of specific GPCRs, such as the receptors for sphingosine 1-phosphate (S1P), lysophosphatidic acid (LPA), and LPC. (ashpublications.org)

Characterization of a functional thrombin receptor. (jci.org)
Coagulation reactions leading to thrombin generation and activation of factor XIII. (medscape.com)

Likewise, knockdown marketed the growth-factor unbiased growth in regular individual pancreatic duct epithelial (HPDE) cell series [20]. (morainetownshipdems.org)

Neutrophils not only act through degranulation and phagocytosis but also create neutrophil extracellular traps (NETs), which destroy bacterial virulence factors and kill bacteria [ 14 ]. (biomedcentral.com)

Regulation of myelopoiesis through syntenin-mediated modulation of IL-5 receptor output. (harvard.edu)

NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)

The soluble form of IL-6R can bind its ligand and induce cellular responses by association with gp130, thus acting as an IL-6 agonist. (sbhsciences.com)

Interestingly, the association of IL-6 with the soluble form of IL-6R alpha is capable of eliciting a biological response in cells that express only the membrane gp130. (sbhsciences.com)

Multiple mechanisms are implicated in such dysfunction, spanning from inhibition of recruitment to the tumor bed, activation of inhibitory processes, blowing up of activation signals, and deregulation of metabolism ( Figure 1 ). (encyclopedia.pub)

In this review article, we will focus on a broad range of cannabinoids, their receptor dependent and receptor independent functional roles against various cancer types with respect to growth, metastasis, energy metabolism, immune environment, stemness and future perspectives in exploring new possible therapeutic opportunities. (oncotarget.com)

A key active site of curcumin for biological reactions is the diketo group, which acts as the primary hydrogen affinity site at physiological pH [ 1 , 12 ]. (hindawi.com)

Description: A sandwich ELISA kit for detection of Serine Palmitoyltransferase, Long Chain Base Subunit 3 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (1elisakits.com)
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) in samples from tissue homogenates, cell lysates or other biological fluids. (1elisakits.com)

Programmed death ligand 1 (PD-L1), a mediator of the PD-1 receptor, plays an inhibitory role in cancer immune responses. (cancer-genetics.org)

[8] The application claims methods of designing CNTF analogues with lower immunogenicity than Axokine based on analysis of affinity of each modified epitope for each of 52 class II MHC alleles, and provides specific examples of such modifications. (wikidoc.org)
Cannabinoid is a family of complex chemicals (terpenophenolic compounds) that exert most of their actions by binding to and activating specific Gαi protein-coupled receptors named as cannabinoid receptor, CB1 (Central receptor) and CB2 (Peripheral receptor) respectively [ 4 - 5 ]. (oncotarget.com)
In addition, there are other patient-specific factors that contribute to the risk. (medilib.ir)

It is found on B-cell lymphomas, hairy cell leukemia, B-cell chronic lymphocytic leukemia, and melanoma cancer stem cells. (wikipedia.org)
The anti-CD20 mAB ofatumumab (Genmab) was approved by FDA in October 2009 for chronic lymphocytic leukemia. (wikipedia.org)
The anti-CD20 mAB obinutuzumab (Gazyva) was approved by FDA in November 2013 for chronic lymphocytic leukemia. (wikipedia.org)
BTK mutations in patients with chronic lymphocytic leukemia (CLL) receiving tirabrutinib. (le.ac.uk)

As subunits enzyme is, the E bacillus hormones tested by the G1 and S enzymes, are involved and the ions of the invalid visitors are. (evakoch.com)

3-5 The immunological importance of these lysophospholipid receptors is illustrated by the profound immunodeficiency observed in mice lacking expression of the S1P 1 receptor in hematopoietic cells. (ashpublications.org)

Store undiluted at 4°C. The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography. (bdbiosciences.com)
It is a hypothalamic neuropeptide that is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks . (wikidoc.org)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) in tissue homogenates, cell lysates and other biological fluids. (1elisakits.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Serine Palmitoyltransferase, Long Chain Base Subunit 3 (SPTLC3) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)

These lymphocytes successfully eliminate the genetically unstable tumour cells with intrinsically high immunogenicity [ 4 ] through a series of successive stages [ 5 ] . (encyclopedia.pub)
6 The novel immunosuppressive drug FTY720 has been shown to inhibit several S1P receptors, resulting in blocked egress of lymphocytes from lymph nodes and thymus. (ashpublications.org)

Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)

Dr. Cochran's translational interests span protein-based drug discovery and development for applications in oncology and regenerative medicine, and the development of new technologies for high-throughput protein analysis and engineering. (stanford.edu)

These cells may be a key factor ultimately mediating the deviation of the antagonistic response between tumor inhibition and tumor promotion. (explorationpub.com)
Unlike most GPCRs, including the chemokine receptors, coupling to G i is not required for LPC/G2A-mediated chemotaxis, but coupling to G q/11 and G 12/13 is necessary as judged by inhibition with dominant negative forms of these alpha subunits or with regulators of G-protein signaling (RGS) constructs. (ashpublications.org)

This type of activation, called "trans-signalling", renders virtually all cells capable of responding to IL-6/sIL-6R alpha complexes, making for a large new spectrum of IL-6 activities, ranging from the control of the immune response to involvement in pathological states. (sbhsciences.com)
The concept of NK cells as a tool for cancer therapy was formally proved when the infusion of NK cells was first employed in the treatment of leukemia patients, with promising efficacy [ 2 ] . (encyclopedia.pub)
CD56 bright NK cells are known to express CCR2, CCR5, CCR7, and CXCR3, while CD56 dim NK cells specifically express CXCR1, CXCR2, CX3CR1, S1P 5 , and Chemerin Receptor 23 (ChemR23) [ 3 ] . (encyclopedia.pub)
At higher doses, cells undergo mitochondrial destabilization due to calcium release from the endoplasmic reticulum, and die. (hindawi.com)
[6] Like CNTF it is a neurotrophic factor , and may stimulate nerve cells to survive. (wikidoc.org)
JNK1 shRNA expressing INS1 cells demonstrated elevated apoptosis and cleaved caspase 9 and 3 in comparison to nonsense shRNA expressing control INS1 cells when subjected to palmitate and high blood sugar associated with elevated CHOP appearance, ROS development and mRNA appearance. (cgp60474.com)
JNK2 shRNA expressing INS1 cells didn't influence palmitate and high blood sugar induced apoptosis or ER tension markers, but increased appearance in comparison to non-sense shRNA expressing INS1 cells mRNA. (cgp60474.com)
Finally, JNK3 shRNA expressing INS1 cells didn't induce apoptosis in comparison to nonsense shRNA expressing INS1 cells when subjected to palmitate and high blood sugar but showed elevated caspase 9 and 3 cleavage connected with elevated and mRNA appearance. (cgp60474.com)
Detection of elevated ER tension marker appearance including ATF3, Bip and CHOP in mouse islets subjected to raised lipids and high blood sugar and in -cells of type 2 diabetics supports the participation of ER tension in the pathogenesis of Type 2 diabetes [12]C[14]. (cgp60474.com)
Therefore, study on factors and mechanisms that limit the in vivo persistence of CAR T cells is crucial for developing strategies to overcome these limitations. (biomedcentral.com)
In this review, we summarize the rapidly developing knowledge regarding the factors that influence CAR T cells in vivo persistence and the underlying mechanisms. (biomedcentral.com)
However, ~ 30-50% of patients experienced leukemia relapse, the majority relapsed within 1 year after CAR T cells therapy [ 6 ], and with prolonged follow-up, the relapse rate may be much higher. (biomedcentral.com)
Relapses of CD19-expressing leukemia in patients who achieved initial remission after CD19 targeting CART cells treatment highly correlates with poor CAR T cells persistence [ 2 ]. (biomedcentral.com)
Therefore, study on factors and mechanisms that limit the in vivo persistence of CAR T cells is crucial for developing strategies to reduce the probability of tumor relapse and improve the long-term disease-free survival for patients who are treated with CAR T cells. (biomedcentral.com)
Various factors in the process contribute to impact the in vivo persistence and durable antitumor effects of CAR T cells. (biomedcentral.com)
In this review, we summarize the rapidly developing knowledge regarding the influence factors and mechanisms of poor CAR T cells persistence, and also the potential strategies to overcome these limitations. (biomedcentral.com)
Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
Higher cells of download Hanging Sam: A Military and mental Canadian initiation in the 5'-end novo depends the lipid protein directly than NALP1-mediated deafness to the chain. (evakoch.com)

alpha, beta, gamma and delta. (biomedcentral.com)
While alpha-tocopherol was the first vitamin E isomer to be recognized, eight chemically distinct isomers are now known, consisting of alpha (α), beta (β), gamma (γ) and delta (δ)-tocopherols and α, β, γ and δ-tocotrienols (T3), all of them are referred to as vitamin E. The tocopherols are saturated forms of vitamin E, whereas the tocotrienols are unsaturated and possess an isoprenoid side chain (Table 1 ). (biomedcentral.com)

GRs), which ultimately alter transcription through direct DNA binding 31 or transcription factor inactivation 32 . (ersjournals.com)

These data claim that JNK1 protects against palmitate and high glucose-induced -cell apoptosis connected with decreased ER and mitochondrial tension. (cgp60474.com)

Anatomy3

Diseases4

Chemicals and Drugs33

Phenomena and Processes9

Information Science4

Antigen3

Cytokines5

Beta subunit3

Interactions5

Interleukin9

Exerts its biological activities1

Membrane-bound2

Binds3

Endocytosis1

Immunohistochemistry1

Cytokine2

Transmembrane2

Catalytic2

Glycoprotein1

Tyrosine kinases2

Tumor microenvironment1

Proteins4

Pathways1

Differentiation1

Transporters1

GPCR1

Repertoire1

Phenotype2

Heterogeneity2

Antibodies2

Gene6

Encodes1

Molecular2

Vitro2

CD802

Secrete1

Epidermal1

Sphingosine2

Thrombin2

Epithelial1

Extracellular1

Modulation1

Cytotoxicity1

Bind1

Soluble1

Signals1

Functional1

Physiological1

ELISA2

Immune responses1

Specific3

Chronic4

Enzymes1

Expression1

Tissue4

Lymphocytes2

Transcription factors1

Oncology1

Inhibition2

Cells18

Gamma2

Ultimately1

Apoptosis1