• Professor Lindhorst's research interests include the biological chemistry of carbohydrates and glycoconjugates, the synthesis of carbohydrates, peptides, and dendrimers, as well as ligand-receptor interactions and conformational switches. (chemistryviews.org)
  • Recent advances in click chemistry applied to dendrimer synthesis. (innovareacademics.in)
  • Efficient synthesis of carbazole core diblock dendrimer by double click chemistry. (innovareacademics.in)
  • Soto Castro D, Magana Vergara NE, Farfan N, Santillan R. Synthesis of steroidal dendrimers modified by 'click chemistry with PAMAM dendrons as unimolecular micelles. (innovareacademics.in)
  • Both flexible and stiff repeat units that have been employed previously in the synthesis of dendrimers were considered. (ncsu.edu)
  • In this paper we report the first catalytic Cu(II)-PAMAM dendrimer complexes that catalyze aerobic oxidative polymerization of DMP in water with significantly high catalytic efficiency ([monomer]/[catalyst]=2000). (lwgsw.com)
  • First, it is the first example that Cu(II)-PAMAM dendrimer complexes are used as catalysts. (lwgsw.com)
  • The generation of PAMAM strongly influences the catalytic efficiency of Cu(II)-PAMAM dendrimer catalyst. (lwgsw.com)
  • Dendrimers, an established polymeric nanocarrier system of the time, can deliver both drugs and genetic material and are being extensively studied to target the brain. (innovareacademics.in)
  • The dendrigraft polylysine (DGL) with its uniform size and multifunctional groups was employed as the polymeric core and conjugated with platinum-based compounds as therapeutics and WKYMVm peptide (Wpep) as a targeting ligand to construct the novel delivery platform Wpep-DGL/Pt. (thno.org)
  • These data suggest that the studied compounds, especially dendrimers, could be considered as novel molecules in the design of research projects aimed at the development of efficacious anti-biofilm disinfection treatments of water systems in order to minimize legionellosis outbreaks. (frontiersin.org)
  • Lamm is studying how dendrimers (large polymers with many branches) bind to ligands (smaller molecules that bind with other molecules to form larger complexes). (acm.org)
  • Further consideration of these data indicated that, while the dendrimers containing rigid ligands had better encapsulated redox cores for a given molecular weight, these molecules had higher electron-transfer rates for a given molecular radius. (ncsu.edu)
  • VPC-1 exhibits reversible colour changes upon uptake/release of water molecules due to the charge transfer character of the constituent dendrimer. (nature.com)
  • Therefore, multivalent carbohydrate systems are required to interact in an efficient manner with this receptor and compete with the natural ligands. (unimi.it)
  • In this work, we show that multivalent presentations of these glycomimetics based on polyester dendrons and dendrimers lead to very potent inhibitors (in the nanomolar range) of cell infection by Ebola pseudotyped viral particles by blocking DC-SIGN receptor. (unimi.it)
  • Furthermore, SPR model experiments confirm that the described multivalent glycomimetic compounds compete in a very efficient manner with polymannosylated ligands for binding to DC-SIGN. (unimi.it)
  • The newly synthesized multivalent galactoclusters proved to be significantly better ligands than simple d-galactose for lectin PA-IL and as a result, two representatives of the dendrimers were able to decrease adhesion of P. aeruginosa to bronchial cells to approximately 32% and 42%, respectively. (dissem.in)
  • Structural database of experimentally measured effects of missense mutations on protein-ligand complexes. (edu.au)
  • Two series of redox-active, ironāˆ’sulfur core dendrimers of the general structure (nBu4N)2[Fe4S4(S-Dend)4] (Dend = dendrons of generations 1 through 4) were prepared. (ncsu.edu)
  • The VDW porous crystal VPC-1 is formed from a novel aromatic dendrimer having a dibenzophenazine core and multibranched carbazole dendrons. (nature.com)
  • Fedeli E, Lancelot A, Serrano JL, Calvo P, Sierra T. Self-assembling amphiphilic Janus dendrimers: mesomorphic properties and aggregation in water. (innovareacademics.in)
  • The efficient reversible functionalization of the periphery of urea adamantyl poly(propylene imine) dendrimers with catalytic sites using noncovalent interactions is described. (tue.nl)
  • The PPI dendrimer encapsulated Cu ions in the internal nanovoids to form adjacent Cu species, which exhibited significantly high catalytic activity for the regioselective coupling reaction of DMP compared to previously reported enzyme and metal complex catalysts. (mdpi.com)
  • Another important factor on catalytic efficiency is the ratio of copper ion to ligand. (lwgsw.com)
  • Then I will talk about ligand-receptor interactions. (hstalks.com)
  • As a recognized ligand for proteins, understanding their mutual interactions provides solid ground to tune hyaluronan's gel properties using biocompatible peptides. (bvsalud.org)
  • Two high-performance Cu catalysts were successfully developed by immobilization of Cu ions in the nanospaces of poly(propylene imine) (PPI) dendrimer and magadiite for the selective C-C coupling of 2,6-dimethylphenol (DMP) to 3,3',5,5'-tetramethyldiphenoquinone (DPQ) with O 2 as a green oxidant. (mdpi.com)
  • Ligands of interest are aromatic Schiff's bases, crown ethers, phthalamates and alkylamine dendrimers and their derivatives. (edu.jm)
  • Active targeting involves use of targeting ligands such as antibodies, peptides (e.g cell penetrating peptides) which bind specifically to receptors, epitopes over-expressed on target site. (trialx.com)
  • Vinylnaphthalene-bearing hexaoxazole as a fluorescence turn-on type G-quadruplex ligand. (tmd.ac.jp)
  • While Macrophen and Double Macrophen were the most active substances among polyamino-phenolic ligands, dendrimers were overall twofold more effective than all other compounds with a reduction up to 85 and 73% of legionella and multi-species biofilms, respectively. (frontiersin.org)
  • Molecular structure-property relationships for electron-transfer rate attenuation in redox-active core dendrimers. (ncsu.edu)
  • Heterogeneous electron-transfer rate constants indicated that the rigid series of dendrimers were more effective at attenuating the rate of electron transfer than were the flexible series of dendrimers. (ncsu.edu)
  • In serial passaging cultures of mouse embryonic stem (ES) cells, we employed a dendrimer-immobilized substrate that displayed D-glucose as a terminal ligand. (sharif.edu)
  • In addition, by comparing T1 values of protons at two slightly different temperatures, the terminal groups in both sets of dendrimers were concluded to be, on average, more mobile than the other generations within the dendrimers. (ncsu.edu)
  • The cluster was soluble in CH 2 Cl 2 , CHCl 3 , MeOH, acetone and H 2 O. 1 H NMR spectra indicated the terminal bpy ligand is fixed at the surface of the Pd cluster. (matthey.com)
  • Smart aptamers forming G-quadruplex: Structural and functional change of aptamers forming G-quadruplex in response to surrounding conditions and its regulation with the ligands Abstracts of Papers of The American Chemical Society. (tmd.ac.jp)
  • The surface modification of dendrimers can reduce their innate toxicity problems and increase the therapeutic efficacy of brain disorders. (innovareacademics.in)
  • Use of a paramagnetic core to affect longitudinal nuclear relaxation in dendrimers - A tool for probing dendrimer conformation. (ncsu.edu)
  • The T1 values of the phenyl and benzyl protons in the paramagnetic core dendrimers were attenuated compared to those of analogous protons in the diamagnetic core dendrimers. (ncsu.edu)
  • This observation indicated that protons in each set of topologically different repeat units (generation) of the dendrimer approach the core of the molecule closely in space. (ncsu.edu)
  • Our system consists of an inorganic cluster surrounded by dendritic ligands which act as an organic coating. (ncsu.edu)
  • Within the BIOCEV project, this programme supervised by Jakubek PhD involves studies aimed at developing multifunctional ligands (MTDLs) intervening in the exchange of information between cancer cells and other cells of the ecosystem with the objective to influence the biological properties of the tumour (growth and migration). (cuni.cz)
  • The resulting supramolecular complex has been used as a multidentate ligand system in the palladium-catalyzed allylic amination reaction in a batch process and in a continuous-flow membrane reactor. (tue.nl)
  • Some examples of targeting ligands used in nanoscale drug delivery systems include folate, transferrin. (trialx.com)
  • This review article is an attempt to update on the potential of dendrimers explored in the past five years as a drug delivery avenue that can be considered as a promising solution in the management of a wide range of disorders affecting the central nervous system, including neoplastic, degenerative, and ischemic conditions. (innovareacademics.in)
  • Smuggling drugs into the brain: an overview of ligands targeting transcytosis for drug delivery across the blood-brain barrier. (innovareacademics.in)
  • This unique electronic properties of M NCs are potently depended on their size, morphology, metal oxidation state, and surrounding ligands [ 22 , 23 ]. (hindawi.com)
  • Effects of G-Quadruplex Ligands on the Topology, Stability, and Immunostimulatory Properties of G-Quadruplex-Based CpG Oligodeoxynucleotides. (tmd.ac.jp)
  • The D-glucose-displaying dendrimer (GLU/D) surface caused the ES cells to form loosely attached spherical colonies, while those on a gelatin-coated surface formed flatter colonies that were firmly attached to the surface. (sharif.edu)
  • One approach uses monoclonal antibodies (mAbs) to target the extracellular domain of the EGFR to block natural ligand binding. (wisc.edu)
  • The effect of repeat unit structure on the shape and internal organization of various dendrimers was probed using atomistic molecular dynamics simulations. (ncsu.edu)
  • Among the various nanocarriers, dendrimers owing to their unique physical and chemical characteristics, represent a potential therapeutic tool in biomedical and pharmaceutical science. (innovareacademics.in)
  • In this study, the anti-biofilm activity of previously fabricated polyamino-phenolic ligands and polyamidoamine dendrimers was investigated against legionella mono-species and multi-species biofilms formed by L. pneumophila in association with other bacteria that can be found in tap water ( Aeromonas hydrophila , Pseudomonas aeruginosa , Escherichia coli , Klebsiella pneumoniae ). (frontiersin.org)
  • We have previously demonstrated that linear pseudodi- and pseudotrisaccharides are adequate ligands for DC-SIGN. (unimi.it)
  • Phosphine ligands equipped with urea acetic groups, a binding motive complementary to that of the dendrimer host, have been prepared and assembled to the dendrimer support. (tue.nl)
  • The longitudinal relaxation time constants (T1) of the protons in a series of dendrimers that alternatively had paramagnetic ([Fe4S4(SR)4]2-, R = dendron) and diamagnetic (tetraphenylmethane) cores were compared. (ncsu.edu)
  • Target identification of a macrocyclic hexaoxazole G-quadruplex ligand using post-target-binding visualization. (tmd.ac.jp)
  • The concentration of the chemicals tested as anti-biofilm agents was chosen based on cytotoxicity assays: the highest non-cytotoxic chemical concentration was used for biofilm inhibition assays, with dendrimer concentration 10-fold higher than polyamino-phenolic ligands. (frontiersin.org)
  • Topologies of G-quadruplex: Biological functions and regulation by ligands. (tmd.ac.jp)