• MBS019114 is a ready-to-use microwell, strip plate Sandwich ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand 3 (TRAIL-R3) ELISA Kit target analytes in biological samples. (mybiosource.com)
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (mybiosource.com)
  • Recent results indicated that the plasma Flt3 ligand concentration was increased in patients suffering from either acquired or induced aplasia, suggesting that Flt3 ligand might be useful as a biological indicator of bone marrow status. (irsn.fr)
  • We thus followed in a mouse model as well as in several clinical situations the variations in plasma Flt3 ligand concentration, after either homogeneous or heterogeneous irradiations. (irsn.fr)
  • The results indicated that the concentration of Flt3 ligand in the blood reflects the bone marrow status, and that the follow-up of plasma Flt3 ligand concentration could give predictive information about the bone marrow function and the duration and severity of pancytopenia and thrombocytopenia. (irsn.fr)
  • Nevertheless, the clinical use of Flt3 ligand as a biological indicator of bone marrow damage require the knowledge of the mechanisms regulating the variations in plasma Flt3 ligand concentration. (irsn.fr)
  • The results indicated that the variations in plasma Flt3 ligand variations were not solely due to a balance between its production by lymphoid cells and its consumption by hematopoietic cells. (irsn.fr)
  • Moreover, we showed that T lymphocytes are not the main regulator of plasma Flt3 ligand concentration as previously suggested, and that other cell types, possibly including bone marrow stromal cells, might be strongly implicated. (irsn.fr)
  • These results also suggest that the Flt3 ligand is a main systemic regulator of hematopoiesis, especially during induced bone marrow aplasia. (irsn.fr)
  • Serum Levels of Soluble FLT3 Ligand in Patients with Active Multiple Myeloma Constitute Marker of Bone Marrow Plasma Cell Proliferative Activity. (nih.gov)
  • Human bone marrow stromal cells simultaneously support B and T/NK lineage development from human haematopoietic progenitors: a principal role for flt3 ligand in lymphopoiesis. (nih.gov)
  • FLT3 ligand impedes the efficacy of FLT3 inhibitors in vitro and in vivo. (nih.gov)
  • Title: Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo. (nih.gov)
  • In synergy with other growth factors, Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. (wikipedia.org)
  • however, tris-pyridylphosphines have been thoroughly investigated as ligands in transition metal complexes used for catalysis. (wikipedia.org)
  • In octahedral complexes, reductive elimination can be very slow from the coordinatively saturated center, and often, reductive elimination only proceeds via a dissociative mechanism, where a ligand must initially dissociate to make a five-coordinate complex. (wikipedia.org)
  • Similar to octahedral complexes, a dissociative mechanism for square planar complexes initiates with loss of a ligand, generating a three-coordinate intermediate that undergoes reductive elimination to produce a one-coordinate metal complex. (wikipedia.org)
  • In an associative mechanism, a ligand must initially associate with the four-coordinate metal complex to generate a five-coordinate complex that undergoes reductive elimination synonymous to the dissociation mechanism for octahedral complexes. (wikipedia.org)
  • This is due to bond strength, with metal-ligand bonds in first-row complexes being weaker than metal-ligand bonds in third-row complexes. (wikipedia.org)
  • For IGFs to reach the tissues from the bloodstream, the circulating complexes are believed to partly dissociate, possibly enhanced by limited proteolysis of IGFBP-3. (wikipedia.org)
  • Because it is stabilized in human serum by forming complexes with IGF-1 and ALS, which are both GH-dependent, serum IGFBP-3 also appears regulated by GH. (wikipedia.org)
  • Trizolate is a tridentate ligand, and can form complexes with metals via the three nitrogen atoms. (wikipedia.org)
  • Important complexes containing P(Cy)3 ligands include the 2005 Nobel Prize-winning Grubbs' catalyst and the homogeneous hydrogenation catalyst Crabtree's catalyst. (wikipedia.org)
  • It is used as a ligand in coordination chemistry, it forms strong complexes with most metal ions. (wikipedia.org)
  • Since cyanide is both a good σ-donor and π-acceptor its presence accelerates the rate of substitution of ligands trans from itself, the trans effect.1 A key step in hydrocyanation is the oxidative addition of hydrogen cyanide to low-valent metal complexes. (wikipedia.org)
  • Industrially, hydrocyanation is commonly performed on alkenes catalyzed by nickel complexes of phosphite (P(OR)3) ligands. (wikipedia.org)
  • For asymmetric hydrocyanation, popular chiral ligands are chelating aryl diphosphite complexes. (wikipedia.org)
  • citation needed] 14-3-3 proteins can be considered evolved members of the Tetratrico Peptide Repeat (TPR) superfamily, generally have 9 or 10 alpha helices, and usually form homo- and/or hetero-dimer interactions along their amino-termini helices. (wikipedia.org)
  • To prevent premature ligand binding during its synthesis, the precursor protein of sortilin contains a 44-amino acid pro-peptide that serves as a chaperone for the Vps10p domain. (wikipedia.org)
  • 5FP6: Structure of cyclin-dependent kinase 2 with small-molecule ligand 3-(4,7-dichloro-1H-indol-3-yl)prop-2-yn-1-ol (AT17833) in an alternate binding site. (rcsb.org)
  • Serum concentrations of Flt-3 ligand in rheumatic diseases. (nih.gov)
  • for example, serum IGFBP-3 is increased in acromegaly and low in GH-deficient children. (wikipedia.org)
  • Immunoassays for serum IGFBP-3 are often used as part of the diagnosis of childhood GH-deficiency. (wikipedia.org)
  • Synthetic galectin-3 ligands were obtained by decorating lactose and galactose cores with various moieties or by creating branched structures such as glycodendrimers (reviewed in refs. (aacrjournals.org)
  • The structures revealed a conserved ligand-binding interface in D2 and a unique mechanism for VEGFR dimerization and activation, with homotypic interactions in D5. (uzh.ch)
  • A structural model of the VEGF-C/VEGFR-3 D1-7 complex derived from small-angle X-ray scattering data is consistent with the homotypic interactions in D5 and D7. (uzh.ch)
  • Taken together, our data show that ligand-dependent homotypic interactions in D5 and D7 are essential for VEGFR activation, opening promising possibilities for the design of VEGFR-specific drugs. (uzh.ch)
  • Title: Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis. (nih.gov)
  • The most widely studied IGFBP3 polymorphism, at nucleotide-202 in the promoter region, is significantly associated with circulating IGFBP-3 levels, although the mechanism is unclear. (wikipedia.org)
  • To assess the linearity of the assay, five samples were spiked with high concentrations of Flt-3 Ligand in various matrices and diluted with the appropriate Calibrator Diluent to produce samples with values within the dynamic range of the assay. (rndsystems.com)
  • 3. The compound of claim 1, wherein R.sub.1 is heteroaryl. (patents.com)