• Professor Landis and co-workers developed a series of new ligands based on chiral 3,4‑diazaphospholane structures ( Figure 1 ). (sigmaaldrich.com)
  • Scientists from the University of York have developed a new synthetic route that delivers significant quantities of two very important sparteine-based chiral ligands that could help in future development of drug molecules. (york.ac.uk)
  • Sparteine and the sparteine surrogate, developed in York in 2002, are chiral ligands with the potential to synthesise mirror-image 'enantiomeric' compounds that have been widely used in metal-mediated reactions to tackle complex synthetic problems and generate drug molecules. (york.ac.uk)
  • Their route uses common feedstock chemicals to make these chiral ligands on an unprecedented scale, moving away from the precarious use of naturally occurring compounds, and hence allowing supply issues to be addressed. (york.ac.uk)
  • Dr James Firth, lead chemist on the project, said: "Our approach to the family of sparteine chiral ligands allows synthesis of either mirror-image form on a gram-scale for the first time. (york.ac.uk)
  • A Josiphos ligand is a type of chiral diphosphine which has been modified to be substrate specific and is widely used for enantioselective synthesis. (wikipedia.org)
  • The ligands carry chiral information and thus they are modified for individual substrates. (wikipedia.org)
  • The substituent on the Cp is written in front of the F and the R on the chiral center after the F. The general approach for preparation of Josiphos ligands is outlined in figure 4, starting from Ugi's amine. (wikipedia.org)
  • Privileged Chiral Ligands and Catalysts Qi-Lin Zhou 2011 H-U. Blaser, W. Brieden, B. Pugin, F. Spindler, M. Studer and A. Togni, Top. (wikipedia.org)
  • The Fas ligand or FasL is a type II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. (bionity.com)
  • Chemical reactions of a verdazyl radical-palladium complex reveal the verdazyl's functionality as a redox-active ligand and a "cooperative" (acido-basic) ligand. (rsc.org)
  • Ligands in a complex dictate the reactivity of the central atom, including ligand substitution rates, the reactivity of the ligands themselves, and redox . (wikipedia.org)
  • Professor Landis and coworkers developed a new family of ligands based on 2,5‑disubstituted phospholane addressing these issues. (sigmaaldrich.com)
  • Utilizing this newly developed ligand, Thomas and coworkers synthesized a series of oxazolines and imidazoles. (sigmaaldrich.com)
  • Building on their work with bulky trialkylphosphines, Fu and coworkers explored the Hiyama transformation using one of their most versatile ligands, P(t-Bu) 2 Me. (sigmaaldrich.com)
  • Another example for a successful ligand system based upon sp2-hybridized phosphorus centers are the diphosphinidenecyclobutenes 2 that are investigated by Ozawa, Yoshifuji and coworkers. (yorku.ca)
  • Ligand selection is a critical consideration in many practical areas, including bioinorganic and medicinal chemistry , homogeneous catalysis , and environmental chemistry . (wikipedia.org)
  • Only recently, have sp 2 -hybridized phosphorus compounds been utilized as ligands for transition metals in catalysis. (yorku.ca)
  • The ligand chosen for the reaction has showed outstanding results in a variety of cross-coupling transformations. (sigmaaldrich.com)
  • Since the late 1990s several research groups have shown the versatility and efficiency of trialkyl phosphine ligands for a variety of palladium-catalyzed transformations. (sigmaaldrich.com)
  • More subtly, one might ask how strongly the hits are biased toward chemotypes previously explored by the extensive medicinal chemistry efforts against this and related targets, or whether the structure is capable of recognizing new chemotypes not explored by ligand-driven approaches. (pnas.org)
  • The magnitude of Δ o is determined by the field-strength of the ligand: strong field ligands, by definition, increase Δ o more than weak field ligands. (wikipedia.org)
  • Diphosphine ligands were prepared with secondary phosphines, they are today known as Josiphos ligands family, which gets the name after Josi Puleo, the technician who prepared the first one. (wikipedia.org)
  • Various ligands in this family are known, differing in what substituents are on the imidazoles. (wikipedia.org)
  • For sparteine, these were then recombined to generate the complexity required in the target ligand. (york.ac.uk)
  • one ranking system focuses on ligand 'hardness' (see also hard/soft acid/base theory ). (wikipedia.org)
  • Despite the lack of crystal structures, adrenergic GPCRs have been successfully targeted for drug discovery by using ligand-based analoging. (pnas.org)
  • Guest editors Louise Berben, Bas de Bruin and Alan Heyduk introduce this web collection focusing on recent achievements within the field of non-innocent ligands. (rsc.org)
  • And how does that relate to ligand-gated channels in general? (bio.net)
  • An important aspect of simple Crystal Field Theory is the orientation of the d-orbital lobes with respect to the position of the surrounding ligands. (merlot.org)
  • Here we describe a new approach for the automated design of ligands against profiles of multiple drug targets. (nih.gov)
  • Twenty years ago Tanabe and Sugano published the first ligand field energy diagrarns which are applicable to dN electronic configurations. (springer.com)
  • The present volume is an attempt to fill the gap by providing a reasonable nurober of complete and accurate ligand field energy diagrarns for dN configurations in the most commonly encountered symmetries. (springer.com)
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  • The TmMe anion is a tridentate, tripodal ligand topologically similar to the more common Tp ligands, but the two classes of ligands differ in several ways. (wikipedia.org)