Ligand superfamily member. Medical search. Frequent questions

Denosumab is an inhibitor of RANKL (receptor activator of nuclear factor kappa-Β ligand), which works by decreasing the development of osteoclasts, which are cells that break down bone. (wikipedia.org)
Precursors to osteoclasts, called pre-osteoclasts, express surface receptors called RANK (receptor activator of nuclear factor-kappa B). RANK is a member of the tumor necrosis factor receptor (TNFR) superfamily. (wikipedia.org)
Homeostatic osteoclastogenesis is effectively induced by RANKL (Receptor activator of nuclear factor kappa-B ligand). (frontiersin.org)
These receptors are members of the nuclear receptor superfamily of ligand-dependent transcription factors. (sanevax.org)
Cloned in the 80s, the GR has become one of the best-studied and clinically most relevant members of the nuclear receptor superfamily. (uni-ulm.de)
isoforms and the 6 major RXRα, β and γ isoforms that belong to the nuclear receptor (NR) superfamily, and act as ligand-dependent transcriptional regulators. (degruyter.com)
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. (cancerindex.org)
Peroxisome proliferator activated receptors (PPARs) are members of the nuclear hormone receptor superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid hormone receptors. (sigmaaldrich.com)
A greater understanding of the mechanism of transcriptional regulation by nuclear receptors has lead to the identification of multiple accessory proteins that bind to the nuclear receptors in a ligand-dependent manner. (sigmaaldrich.com)

NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2. (spandidos-publications.com)
Small‑molecule γ‑secretase inhibitors (AL101, MRK‑560, nirogacestat and others) and antibody‑based biologics targeting Notch ligands or receptors [ABT‑165, AMG 119, rovalpituzumab tesirine (Rova‑T) and others] have been developed as investigational drugs. (spandidos-publications.com)
Key players in the controlled induction of cell death are the Death Receptors (DR). CD95 is a prototypic DR activated by its cognate ligand CD95L triggering programmed cell death. (researchgate.net)
The exogenous pathway mediated by death receptors and death ligands is a very important pathway for cell apoptosis. (bvsalud.org)
The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. (lu.se)

Characterization of the receptor for the transmembrane activator and calcium-modulator and cyclophilin ligand interactor (TACI), encoded by the gene TNFRSF13B ( tumor necrosis factor receptor superfamily member 13B), suggests that people with the C104, A181E, and ins204A variants may be at risk for IgAD that progresses to CVID. (medscape.com)

Death ligands are mainly members of the tumour necrosis factor (TNF) family, of which FasL is an important member. (bvsalud.org)
BACKGROUND: Fas ligand (FasL) is expressed by activated T cells and induces death in target cells upon binding to Fas. (bvsalud.org)

inflammatory bowel disease: …mutation of a gene called TNFSF15 (tumour necrosis factor ligand superfamily member 15), which is involved in suppressing inflammation, has been identified as an ethnic-specific IBD susceptibility gene. (britannica.com)

A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS . (online-medical-dictionary.org)
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. (fishersci.com)
TL1A is a type II transmembrane protein belonging to the TNF superfamily and has been designated TNF superfamily member 15 (TNFSF15). (novusbio.com)
CD30 ligand (CD30L)/TNFSF8 is a type II membrane protein belonging to the TNF superfamily. (rndsystems.com)
Epidermal growth factor receptor (EGFR) is a transmembrane glycoprotein and member of the protein kinase superfamily that regulates cell growth and differentiation. (biolegend.com)
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN . (nih.gov)
Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. (cancerindex.org)
2sigma(F). The protein belongs to the papain superfamily of cysteine proteases and has some unique properties compared to other members of the family. (rcsb.org)

Ligand binding induces EGFR dimerization and autophosphorylation, initiating the MAPK, Akt, and JNK signaling pathways. (biolegend.com)
Stimulation of CD95 by its physiological ligand CD95L induces its oligomerization leading in turn to the transduction of either apoptotic or non‐apoptotic signals. (researchgate.net)

RANK is activated by RANKL (the RANK-Ligand), which exists as cell surface molecules on osteoblasts. (wikipedia.org)
TNF and RANKL are members of the TNF superfamily. (frontiersin.org)

NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.FAS ligand and other ligands are binding to the receptor for signaling pathways for example in apoptosis or JNK signaling. (il-12p40.com)

Th17 cell proliferation is promoted by tumor necrosis factor (TNF)-like ligand 1A (TL1A), which binds to death receptor 3 (DR3) expressed on Th17 cells. (nih.gov)
The extracellular region of CD95 binds to CD178 (Fas ligand). (biolegend.com)

Description: A sandwich quantitative ELISA assay kit for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates or other biological fluids. (1elisakits.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in serum, plasma, tissue homogenates and other biological fluids. (1elisakits.com)
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 9 (TNFSF9) in samples from serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (1elisakits.com)

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. (nih.gov)

Son principal ligand, le CD154, appartient à la famille des TNFs (Tumor necrosis factor). (umontreal.ca)
Its main ligand, the CD154, belongs to the Tumor necrosis factors (TNFs) superfamily. (umontreal.ca)
In addition, several studies have demonstrated the beneficial effect of blocking the binding of CD40 to its major ligand CD154, in various diseases. (umontreal.ca)

The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. (cancerindex.org)

Detects human CD30 ligand/TNFSF8 in direct ELISAs. (rndsystems.com)
Mouse myeloma cell line NS0-derived human CD30 Ligand/TNFSF8. (rndsystems.com)
The specific receptor for CD30L is CD30/TNFRSF8, a type I transmembrane glycoprotein belonging to the TNF receptor superfamily. (rndsystems.com)
Human and mouse CD30 ligand cDNAs share 70% sequence homology. (rndsystems.com)

X-ray crystallography of human PPAR isoforms has revealed important residues responsible for ligand binding, heterodimerisation and co-factor interactions. (sigmaaldrich.com)

Honorary Life member of The Australian Physiological and Pharmacological Society. (edu.au)

Some isoforms dominantly inhibit the activity of other estrogen receptor family members. (cancerindex.org)

With the involvement of PPARs in many diverse metabolic pathways there is great clinical interest in the potential utility of PPAR ligands for the treatment of cancer, inflammation, psoriasis, atherosclerosis, dyslipidaemia, neurological disorders, obesity and diabetes. (sigmaaldrich.com)

Inadequate efficacy similarly halted the development of agents impinging on the activity of the activin receptor-like kinase (ALK)1, a member of the transforming growth factor-β superfamily. (lu.se)

We find that the electrophysiological and structural properties of these proteins indicate that they are new members of the ligand-gated ion channel superfamily. (nih.gov)

Some patients with IgAD later develop CVID, and family members of patients with CVID may have only selective IgAD. (medscape.com)
The CD40 is a member of the TNF receptor family. (umontreal.ca)

PPARs have a highly conserved DNA binding domain (region C) and a diverse ligand-independent activation domain (region A/B) which can confer constitutive activity on the receptor. (sigmaaldrich.com)

The C-terminal ligand-binding domain (regions E/F) is the site of ligand docking and has the most diversity between the pharmacologically distinct subtypes. (sigmaaldrich.com)

Precursors to osteoclasts, called pre-osteoclasts, express surface receptors called RANK (receptor activator of nuclear factor-kappa B). RANK is a member of the tumor necrosis factor receptor (TNFR) superfamily. (wikipedia.org)
The corresponding endoglin and ALK-1 proteins are specific endothelial receptors of the transforming growth factor β superfamily essential for maintaining vascular integrity. (bmj.com)
Nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that include muscle and neuronal nAChRs and receptors for GABA A , glycine, and serotonin. (jneurosci.org)
G-protein coupled receptors (GPCRs) represent one of the most evolutionarily diverse superfamilies of the human genome. (nih.gov)
Serotonin 5-HT 3 receptors (5-HT 3 R) are members of the Cys loop receptor superfamily of ligand-gated ion channels ( Reeves and Lummis, 2002 ) that includes the GABA A , glycine, and nicotinic acetylcholine receptors (AChR). (jneurosci.org)
The retinoic acid-related orphan receptors (ROR α-γ or NR1F1-3) and the orphan receptor TAK1 (TR4 or NR2C2) are members of the nuclear receptor superfamily of ligand-dependent transcription factors. (nih.gov)
The androgen receptor (AR) is a member of the steroid-hormone receptor superfamily of nuclear receptors. (thermofisher.com)
Nuclear hormone receptors, their ligands, and relevant accessory proteins play important roles in development and aging, metabolism, and disease, and comprise a large superfamily of receptors for a multitude of hormones, xenobiotics, lipids, and other known and unknown ligands. (nih.gov)
This initiative will focus specifically on one sub-group of the superfamily, the orphan nuclear receptors (ONR). (nih.gov)
It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. (bvsalud.org)
Lacking an intrinsic catalytic activity, cytokine receptors respond to ligand binding by first dimerizing and then activating one or more cytosolic protein tyrosine kinases, many of which belong to the Janus (JAK) kinase family. (horizondiscovery.com)

The CD40LG gene provides instructions for making a protein called CD40 ligand, which is found on the surface of immune system cells known as T cells. (medlineplus.gov)
CD40 ligand attaches like a key in a lock to its receptor protein, CD40, which is located on the surface of immune system cells known as B cells. (medlineplus.gov)
These mutations lead to the production of an abnormal CD40 ligand or prevent production of this protein. (medlineplus.gov)
CD137 ligand (CD137L) is a type II membrane protein and part of the TNF superfamily. (fishersci.com)
Human LIGHT, also known as TNFSF14, is a type II membrane protein that is a member of the TNF superfamily. (rndsystems.com)
CD30 Ligand, also known as TNFSF8, is a type II membrane protein belonging to the TNF superfamily. (rndsystems.com)
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. (wikipedia.org)
CD154 , takođe poznat kao CD40 ligand ili CD40L, je protein koji je prvenstveno izražen u aktiviranim T ćelijama . (wikipedia.org)
This protein specifically binds to its ligand, osteoprotegerin ligand, both of which are key extracellular regulators of osteoclast development. (novusbio.com)
Studies of the mouse counterpart also suggest that this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. (novusbio.com)
2sigma(F). The protein belongs to the papain superfamily of cysteine proteases and has some unique properties compared to other members of the family. (rcsb.org)
The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form. (bvsalud.org)
RESULTS: Structural comparisons ofrepresentative members of already known protein families structurallyrelated to Bet v 1 with all entries of the Protein Data Bank yielded 47structures with non-identical sequences. (embl.de)
The taxonomicdistribution of these families extracted from the Pfam protein familydatabase showed that members of the polyketide cyclase family and theactivator of Hsp90 ATPase homologue 1 family were distributed among allthree superkingdoms, while members of some bacterial families wereconfined to a small number of species. (embl.de)
During evolution,this protein diversified into numerous families with low sequencesimilarity but with a common fold that succeeded as a versatile scaffoldfor binding of bulky ligands. (embl.de)
It occurs as transmembrane protein that can be cleaved to release a secreted form that specifically binds to LYMPHOTOXIN BETA RECEPTOR and TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY, MEMBER 14 . (nih.gov)
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. (nih.gov)
This gene encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. (nih.gov)

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. (nih.gov)
CD40 Ligand has been shown to induce cytokine production and tumoricidal activity in peripheral blood monocytes. (thermofisher.com)
35. Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions. (nih.gov)
TNFSF8, also known as CD30 ligand, is a cytokine belonging to the tumor necrosis factor (TNF) ligand family. (nih.gov)
The Mouse siGENOME RTF Cytokine Receptor siRNA Library is a collection of rationally designed siRNAs targeting distinct members of the cytokine receptor superfamily. (horizondiscovery.com)
This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. (nih.gov)
TNFSF10, a proapoptotic cytokine of the TNF superfamily, is a mediator of amyloid-β neurotoxicity. (nih.gov)

CD86 is an 80 kD immunoglobulin superfamily member also known as B7-2, B70, and Ly-58. (biolegend.com)
RAGE, an immunoglobulin superfamily member, mediates the binding of AGEs to endothelial cells and mononuclear phagocytes, interacts with a lactoferrin-like polypeptide that also binds AGEs, and appears to activate intracellular signal transduction mechanisms consequent to its interaction with the glycated ligand. (nih.gov)

In order for B cells to mature into the cells that produce antibodies of a different class, the CD40 receptor must interact with CD40 ligand. (medlineplus.gov)
CD40 ligand is also necessary for T cells to interact with other cells of the immune system, and it plays a key role in T cell differentiation (the process by which cells mature to carry out specific functions). (medlineplus.gov)
If CD40 ligand does not attach to its receptor on B cells, these cells cannot produce IgG, IgA, or IgE antibodies. (medlineplus.gov)
CD40 ligand je prvenstveno izražen na aktiviranim CD4+ T limfocitima, ali se takođe može naći u rastvornom obliku. (wikipedia.org)
The CD40 Ligand stimulates B cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. (thermofisher.com)

In addition, determination of the Bet v 1structure revealed the existence of a large superfamily of structurallyrelated proteins. (embl.de)

The AHR is a ligand-dependent transcription factor and key regulator in xenobiotic metabolism and immunity. (frontiersin.org)
In this context, the AHR, a ligand-activated transcription factor and key regulator in xenobiotic metabolism and immunity, seems to be a promising molecular target. (frontiersin.org)
Farnesoid X receptor (FXR), a ligand-activated transcription factor and a member of the nuclear receptor superfamily, is expressed in intestine and liver where it is activated by bile acid metabolites and controls bile acid homeostasis. (nih.gov)

In sandwich immunoassays, no significant cross-reactivity or interference with recombinant human (rh) Fas Ligand, rhAPRIL, recombinant mouse TRANCE, rhTNF-alpha or rhTRAIL is observed. (rndsystems.com)

To explore the association of circulating lymphocytes and serum levels of B- cell related TNF/TNFR superfamily members with response to Belimumab in SLE patients. (nih.gov)
OX40 is a costimulatory receptor member of the tumor necrosis factor receptor (TNFR) superfamily expressed predominantly on activated T cells. (asiaone.com)

RAGE expression and its signaling are regulated both by its ligands and by RAGE isoforms known collectively as soluble RAGE (sRAGE). (nature.com)

sRAGE contains the extracellular domain of RAGE and can bind to circulating pro-inflammatory ligands preventing their binding to mRAGE thereby preventing RAGE activation. (nature.com)

A member of tumor necrosis factor superfamily found on ENDOTHELIAL CELLS that plays a role in the inhibition of endothelial cell growth and PHYSIOLOGIC ANGIOGENESIS . (nih.gov)

To assess the possible correlation between single nucleotide polymorphisms (SNPs) of two members of TNF ligand superfamily genes, tumor necrosis factor-α (TNF-α) and lymphotoxin-α (LTA), and HCV chronic disease. (nih.gov)

It is a multi-ligand receptor and regarded as a central mediator in chronic inflammatory and immune responses 3 . (nature.com)

CD48 is the ligand of CD244. (biolegend.com)

The discovery of RAGE and development of reagents to block its interaction with AGEs should provide insights into the role of this ligand-receptor interaction in the pathogenesis of diabetic complications and, potentially, atherosclerosis. (nih.gov)

Patients with systemic lupus erythematosus (SLE) show increased serum levels of tumor necrosis factor (TNF)/TNF receptor (R) superfamily member, e.g. (nih.gov)
In healthy adults, serum levels of sRAGE and RAGE ligands are well matched 11 . (nature.com)

The ligation of OX40 by its ligand OX40L leads to enhanced T cell survival, proliferation, and effector functions. (asiaone.com)

The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin superfamily of cell surface molecules. (nature.com)
It is a member of the CD2 subset of the immunoglobulin superfamily (IgSF) molecules. (biolegend.com)

Serum AGE and AGE/sRAGE ratios were high in diabetics but not in CF. A complex, multifaceted approach was used to assess the role of RAGE and its ligands which is fundamental to determining their impact on airway inflammation. (nature.com)

A member of tumor necrosis factor superfamily found on activated LYMPHOCYTES and MONOCYTES . (nih.gov)

My lab studies all aspects of GPCR structure and function ranging from the atomic-level analysis of ligand-receptor interactions to in vivo studies. (nih.gov)

Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 13 (TNFSF13) in samples from Serum, plasma, tissue homogenates and other biological fluids with no significant corss-reactivity with analogues from other species. (bioemm.com)

Description: A sandwich quantitative ELISA assay kit for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 13 (TNFSF13) in samples from serum, plasma, tissue homogenates or other biological fluids. (bioemm.com)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Tumor Necrosis Factor Ligand Superfamily, Member 13 (TNFSF13) in serum, plasma, tissue homogenates and other biological fluids. (bioemm.com)

A vast knowledge of the structure of the Cys-loop superfamily and its impact on channel function have been accrued over the last few years, leading to exciting new proposals on how ion channels open and close in response to agonist binding. (portlandpress.com)
The GABA-A receptor is a member of the superfamily of fast acting ligand-gated ion channels. (avivasysbio.com)

Anatomy10

Organisms6

Chemicals and Drugs70

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes41

Disciplines and Occupations1

Information Science4

Nuclear9

Receptors5

Tumor necrosis factor re1

FasL2

Tumour necros1

Protein8

Induces2

RANKL2

Apoptosis1

Binds2

TNFSF93

Osteoprotegerin1

CD1543

Gene1

CD304

Residues1

Physiological1

Isoforms1

Inflammation1

Activin1

Proteins1

Family2

Activation1

Domain1

Receptors11

Protein18

Cytokine7

Immunoglobulin superfamily member2

CD40 LIGAND5

Large superfamily1

Transcription3

Recombinant1

TNFR2

Soluble1

Extracellular1

Endothelial cells1

Genes1

Mediator1

CD481

Interaction1

Serum levels2

Ligation1

Molecules2

RAGE1

Monocytes1

Vivo1

Species1

Sandwich2

Channels2