• incorporates an asialoglycoprotein receptor (ASGPR) ligand with PEG linker and carboxylic acid group reactive handle ready for conjugation to a target protein ligand. (bio-techne.com)
  • Asialoglycoprotein receptor (ASGPR) and glycyrrhetinic acid receptor (GAR) are most often used as the targeting moieties, which are overexpressed on hepatocytes. (eurekaselect.com)
  • A more directed approach to the delivery of therapeutic oligonucleotides specifically to the liver has been to target the asialoglycoprotein receptor (ASGPR) using a suitable glycoconjugate. (genelink.com)
  • The specificity to only target hepatocytes is achieved by conjugation of the siRNA to GalNAc (N-acetylgalactosamine) [1], which recognizes the asialoglycoprotein receptor (ASGPR) that is highly expressed on the surface of hepatocytes. (pace-cme.org)
  • Tri-GalNAc-NHS ester is a LYsosome TArgeting Chimera (LYTAC) and a ligand of asialoglycoprotein receptor (ASGPR). (dcchemicals.com)
  • ASGPR is a lysosomal targeting receptor specifically expressed on liver cells, for the degradation of extracellular proteins including membrane proteins. (dcchemicals.com)
  • Furthermore, use of delivery systems allows surface modification of the nanoparticles (NPs) and incorporation of targeting ligands that bind specifically to receptors on target cells to induce receptor-mediated endocytosis and improve cellular uptake. (jims.org.il)
  • Meanwhile, the asialoglycoprotein receptor (ASGR) is an ideal hepatocyte-specific candidate for targeted drug delivery due to its high capacity for substrate clearance from serum via receptor-mediated endocytosis and high hepatocyte expression that conserved across species. (chandigarhherald.in)
  • Mechanistically, GalNAc binds to the ASGR receptor to activate receptor-mediated endocytosis rapidly. (chandigarhherald.in)
  • The RHL-1 subunit of the asialoglycoprotein receptor of thyroid cells: cellular localization and its role in thyroglobulin endocytosis. (cnr.it)
  • This receptor is a transmembrane protein that plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins with exposed terminal galactose or N-acetylgalactosamine residues. (unige.ch)
  • Endocytosis by the asialoglycoprotein receptor is independent of cytoplasmic serine residues. (unige.ch)
  • BACKGROUND: Antibody drug conjugates (ADCs) targeting the epidermal growth factor receptor (EGFR), such as depatuxizumab mafodotin (Depatux-M), is a promising therapeutic strategy for glioblastoma (GBM) but recent clinical trials did not demonstrate a survival benefit. (stanford.edu)
  • incorporates an E3 ligase ligand plus a PEG5 linker with terminal amine ready for conjugation to a target protein ligand. (tocris.com)
  • They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. (tocris.com)
  • C-C motif chemokine receptor 5 [Sou. (gsea-msigdb.org)
  • PF4 is chemotactic for neutrophils , fibroblasts and monocytes , and interacts with a splice variant of the chemokine receptor CXCR3 , known as CXCR3B. (wikidoc.org)
  • LYTACs that engage the asialoglycoprotein receptor for targeted protein degradation. (stanford.edu)
  • The first lysosome-targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging a target protein to the cation-independent mannose-6-phosphate receptor (CI-M6PR). (stanford.edu)
  • The receptor recognizes terminal galactose and N-acetylgalactosamine units. (joplink.net)
  • The galactose binding Ricinus communis lectin was used for the determination of in vitro ligand binding capacity. (ijpsr.com)
  • N-Acetylgalactosamine (GalNAc) is an amino sugar derivative of galactose and can be used as a targeting ligand in antisense oligonucleotides (ASO) and siRNA therapeutics. (chandigarhherald.in)
  • When examined from the viewpoint of the bound sugar, the structural information accumulated so far on lectins and other proteins that are specific to galactose and glucose (or mannose), provides suggestive evidence for distinct ligand-dependent distribution of hydrogen-bond partners in the combining site. (embl.de)
  • Among the range of proteins shown to co-localize to WPB is angiopoietin-2 (Angpt-2), a ligand of the receptor tyrosine kinase Tie-2. (imperial.ac.uk)
  • They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released. (umassmed.edu)
  • Cell surface receptors that bind signalling molecules released by neurons and convert these signals into intracellular changes influencing the behavior of cells. (wakehealth.edu)
  • They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. (umassmed.edu)
  • A chromatographic technique that utilizes the ability of biological molecules to bind to certain ligands specifically and reversibly. (lookformedical.com)
  • Second, T cell therapies using Tregs (either polyclonal, antigen-specific, or genetically engineered to express chimeric antigen receptors) to establish active dominant immune tolerance or T cells (engineered to express chimeric antigen receptors) to delete pathogenic immune cells. (frontiersin.org)
  • To enable tumor-localized immunotherapy following intravenous administration, we chemically conjugated a polyspecific integrin-binding peptide (PIP) to an immunostimulant (Toll-like receptor 9 [TLR9] agonist: CpG) to generate a tumor-targeted immunomodulatory agent, referred to as PIP-CpG. (stanford.edu)
  • Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of pleiotropic therapies. (harvard.edu)
  • To enhance the delivery capability of siRNA candidate drugs to target cells, BOC Sciences' expert team can design and synthesize siRNAs based on targeting receptors while combining GalNAc molecules to form GalNAc-siRNA conjugates. (chandigarhherald.in)
  • Utilizing the power of RNAi molecules, we have developed different GalNAc-siRNA conjugates for efficient drug delivery to targeting receptors, including hard-to-transfect cells. (chandigarhherald.in)
  • The structure and chemical composition of the siRNA such as sugars, bases and the phosphate backbone, single-stranded or duplex structure and the presence of a targeting ligand, play an essential role in its potency and is the key in the extraordinary long activity of inclisiran, an LDL-c-lowering siRNA that is in phase 3 development. (pace-cme.org)
  • Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Adrenomedullin Receptor (AMR) in Tissue homogenates, cell lysates and other biological fluids. (lipidx.org)
  • A class of cellular membrane receptors that either have an intrinsic guanylate cyclase activity or are closely coupled to specific guanylate cyclases within the cell. (bvsalud.org)
  • The aim of this study was to define the anti-atherosclerotic role of liver-X-receptors (LXRs) under lesion progressive and lesion regressive conditions, to establish a temporal line of events, and to gain insights into the mechanisms underlying the anti-atherogenic potency of LXRs. (tno.nl)
  • NMDA receptor-dependent GABA(B) receptor internalization via CaMKII phosphorylation of serine 867 in GABA(B1). (unibas.ch)
  • NMR sample optimization and backbone assignment of a stabilized neurotensin receptor. (harvard.edu)
  • The receptor has an unusual composition in that it shares some structural similarities with G-PROTEIN-COUPLED RECEPTORS and functions as an ubiquitin protein ligase when internalized. (uams.edu)
  • Description: A sandwich ELISA kit for detection of Adrenomedullin Receptor from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (lipidx.org)
  • Receptors, G-Protein-Coupled" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • The most notable examples are the THROMBIN RECEPTORS. (uchicago.edu)
  • Recently, more attention has been paid to multifunctional DDS containing various ligands such as polymer moieties, targeting moieties, and acid-labile linkages. (eurekaselect.com)
  • The H1 and H2 polypeptides associate to form the asialoglycoprotein receptor in human hepatoma cells. (unige.ch)
  • Asialoglycoprotein receptor facilitates infection of PLC/PRF/5 cells by HEV through interaction with ORF2. (unige.ch)
  • This graph shows the total number of publications written about "Receptors, G-Protein-Coupled" by people in Harvard Catalyst Profiles by year, and whether "Receptors, G-Protein-Coupled" was a major or minor topic of these publication. (harvard.edu)
  • Methamphetamine decreases K+ channel function in human fetal astrocytes by activating the trace amine-associated receptor type-1. (rush.edu)
  • Sequence of human asialoglycoprotein receptor cDNA. (unige.ch)
  • Fatty acylation of the rat and human asialoglycoprotein receptors. (unige.ch)
  • Below are the most recent publications written about "Receptors, G-Protein-Coupled" by people in Profiles. (harvard.edu)
  • Below are the most recent publications written about "Receptors, Autocrine Motility Factor" by people in Profiles over the past ten years. (uams.edu)
  • A class of receptors that are activated by the action of PROTEINASES. (uchicago.edu)
  • Optimum conditions (pH, temperature, time and ligand concentration) for 68 Ga-DKFZ-PSMA-617 preparation were studied. (sinap.ac.cn)
  • 96% and specific activity of 308.3 TBq/mmol at the optimized conditions (pH of 3.5-4, ligand amount of 2.4 nmol, temperature of 90-95°C and reaction time of 10 min). (sinap.ac.cn)
  • Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS. (lookformedical.com)