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  • pathway
  • This marked diversity in the transcription/translation of the GR gene allows cells/tissues to accommodate appropriately to the circulating concentrations of glucocorticoids depending on their needs(Chrousos and Kino, 2005a) and is responsible for the highly stochastic nature of the glucocorticoid-signaling pathway (Chrousos and Kino, 2005b). (atlasgeneticsoncology.org)
  • Ecdysone is a direct regulator of transcription and, like other steroid hormones acts through a nuclear receptor pathway. (mdpi.com)
  • Although the xenobiotic-activating pathway of AhR has been well established for a large number of exogenous ligands, the receptor has been shown to participate in important developmental and cell-regulatory processes, except foreign compound metabolism. (beds.ac.uk)
  • In this review, we will summarize the current knowledge of the mechanisms underlying Wnt/β-catenin signaling and how the pathway regulates normal differentiation of stem cells in the intestine, mammary gland, and prostate. (jove.com)
  • Here, we demonstrate a new function for PTK7 in Xenopus neural crest migration and use this system in combination with in vitro assays to define the intersection of PTK7 with the non-canonical Wnt signaling pathway that regulates PCP. (biologists.org)
  • Thus, PTK7 regulates neural crest migration by recruiting dsh, providing molecular evidence of how PTK7 intersects with the PCP signaling pathway to regulate vertebrate cell movements. (biologists.org)
  • Precise regulation is necessary for many developmental processes and misregulation of several components of the canonical Wnt signaling pathway has been implicated in cancer formation ( Polakis, 2007 ). (biologists.org)
  • Dishevelled (dsh) is a key regulator of both the canonical as well as the PCP signaling pathway and regulates cell fate specification as well as cell movements such as convergent extension. (biologists.org)
  • As downstream effectors of dsh are distinct for canonical and PCP signaling, it remains unclear how dsh selectively activates one or the other pathway. (biologists.org)
  • This paper will discuss the development of two groups of agents designed to activate LRP5 (and the related LRP6) signaling pathway to increase bone mass. (hindawi.com)
  • We will first review the core components of the Wnt signaling pathway to put the development of these agents into a cellular context. (hindawi.com)
  • mechanisms
  • Although much attention has been given to understanding the mechanisms of action for both of these hormones, currently a great deal more is known about signaling by ecdysone than by JH. (mdpi.com)
  • In contrast to the extensive knowledge of ecdysone signaling, the molecular mechanisms underlying JH function remain poorly understood. (mdpi.com)
  • A detailed depiction of TGF‐β signalling mechanisms will have broad significance in understanding human development as well as pathogenesis of major human diseases, including cancer, fibrosis and autoimmunity. (embopress.org)
  • immunofluorescence
  • Fourteen days after IT CD exposure and 1 day after the last intraperitoneal BNF injection, AhR immunofluorescence indicated that proportional AhR nuclear expression and the percentage of cells with nuclear AhR were significantly increased in rats receiving IT saline and BNF injections compared to vehicle controls. (biomedcentral.com)
  • In addition, we used soft agar assay, immunoblotting, flow cytometry, and immunofluorescence confocal microscopy for examinations of nMET functions including stem-like cell formation, cell signaling, cell cycle regulation, and co-localization with regulators of cell signaling. (springer.com)
  • corepressors
  • However, ligand binding triggers the dissociation of these corepressors and the concomitant recruitment of coactivators. (asm.org)
  • Mediates
  • The RGG box of FMRP mediates interactions with G quartet sequences in mRNA ligands. (alzforum.org)
  • We previously showed that nuclear MET (nMET), a member of RTKs, mediates cancer stem-like cells self-renewal to promote cancer recurrence. (springer.com)
  • regulation
  • Conversely, reduction or loss of function of Wnt signaling leads to general developmental defects or loss of organs, demonstrating the need for a tight regulation of the levels of Wnt signaling ( Logan and Nusse, 2004 ). (biologists.org)
  • transmembrane
  • We identified the Drosophila melanogaster Signal peptide peptidase gene ( Spp ) that encodes a multipass transmembrane aspartyl protease. (genetics.org)
  • Cyp1a1
  • In addition, co-localization of CYP1A1 and cytokeratin 8/18 expression in alveoli allowed detection of CYP1A1 expression in intact AT-II cells within the lung [ 3 , 4 ], and demonstrated decreased PAH-induced CYP1A1 in AT-II cells. (biomedcentral.com)
  • assay
  • A region containing the NES in Kap95p was sufficient to mediate active nuclear export in a microinjection assay. (nih.gov)
  • A) To assay nuclear import, wild-type (SWY1312) and kap95-L63A (SWY1313) strains were transformed with the plasmid expressing NLS-β-galactosidase under GAL10 (pNLS-E1). (nih.gov)
  • deletion
  • Supporting the in vivo role of PTK7 in the localization of dsh, a PTK7 deletion construct deficient in dsh binding inhibits neural crest migration. (biologists.org)
  • Furthermore, the PTK7-mediated membrane localization of a dsh deletion mutant lacking PCP activity inhibits neural crest migration. (biologists.org)
  • Drosophila
  • Drosophila SPP is homologous to the human signal peptide peptidase (SPP) and is distantly related to the presenilins. (genetics.org)
  • We show that, like human SPP, Drosophila SPP can proteolyze a model signal peptide and is sensitive to an SPP protease inhibitor and that it localizes to the endoplasmic reticulum. (genetics.org)
  • Here we report the identification of a Drosophila signal peptide peptidase (SPP), an I-CLiP with activity against the TMD of signal peptides. (genetics.org)
  • inhibitors
  • One group, the focus of this paper, is based on antagonizing the functions of putative inhibitors of Wnt signaling, Dickkopf-1 (DKK1), and Sclerostin (SOST). (hindawi.com)